Patent search ap:"James T. Palmer" Page 4

31.

发明申请
AROMATIC AMIDES AND USES THEREOF 有权
Title translation: 芳香剂及其用途

公开(公告)号：US20140135332A1

公开(公告)日：2014-05-15

申请号：US14112735

申请日：2012-04-20

Applicant: David John Haydon , Lloyd George Czaplewski , Neil Robert Stokes , David Davies , Ian Collins , James T Palmer , Jeffrey Peter Mitchell , Gary Robert William Pitt , Daniel Offermann

Inventor： David John Haydon , Lloyd George Czaplewski , Neil Robert Stokes , David Davies , Ian Collins , James T Palmer , Jeffrey Peter Mitchell , Gary Robert William Pitt , Daniel Offermann

IPC: A61K31/5377 , A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/433 , A61K31/427 , A61K31/421 , C07D513/04 , C07D413/12 , C07D285/08 , C07D277/30 , C07D263/32 , A61K31/496 , A61K31/426

CPC classification number: A61K31/5377 , A61K31/166 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/506 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/30 , C07D285/08 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/12 , C07D513/04

Abstract: The present invention provides compounds of Formula (I): and salts, racemates, isomers, diastereoisomers, enantiomers, hydrates, solvates, N-oxides, pharmaceutically acceptable derivatives or prodrugs thereof. Also provided the use of these compounds as antibacterials, compositions comprising them and processes for their manufacture.

Abstract translation: 本发明提供式（I）的化合物：及其盐，外消旋物，异构体，非对映异构体，对映异构体，水合物，溶剂化物，N-氧化物，其药学上可接受的衍生物或前药。还提供这些化合物作为抗菌剂的用途，包含它们的组合物及其制备方法。

32.

发明申请
FLUIDIC AND ELECTRICAL INTERFACE FOR MICROFLUIDIC CHIPS 有权
Title translation: 微流控芯片的流体和电气接口

公开(公告)号：US20130313116A1

公开(公告)日：2013-11-28

申请号：US13677036

申请日：2012-11-14

Applicant: James T. Palmer , Philippe M. Dekleva

Inventor： James T. Palmer , Philippe M. Dekleva

IPC: G01N27/447 , B81B1/00

CPC classification number: G01N27/44791 , B01L3/502715 , B01L3/50273 , B01L9/527 , B01L2300/0816 , B01L2400/0421 , B01L2400/049 , B81B1/00 , G01N35/00069 , Y10T29/49117

Abstract: A microfluidic chip interface for providing fluid communication with external fluid sources and external fluid waste containers, and for providing electrical contact with voltage sources and voltage and current measuring devices, is described. The microchip is first placed into electrical communication with at least one electrical source and at least one electronic measurement device, and reversibly secured in place. Chosen fluids are provided into the microchip and directed through the chip using a fluid manifold having dispensing tubes and fluid aspiration tubes, which is brought into the vicinity of the secured microchip. The distance between the fluid manifold and the microchip is chosen such that the injection tubes are located within wells in the microchip connected to microfluidic channels, and the aspiration tubes are located near the surface of the microchip in the vicinity of the wells such that fluid spillage onto the surface of the microchip during fluid transfer is avoided. The fluid manifold is removed from fluid communication with the microchip during electrical measurements.

Abstract translation: 描述了用于提供与外部流体源和外部流体废物容器的流体连通以及用于提供与电压源和电压和电流测量装置的电接触的微流体芯片接口。微芯片首先被放置成与至少一个电源和至少一个电子测量装置电连通，并且可逆地固定就位。将选择的流体提供到微芯片中并使用具有分配管和流体抽吸管的流体歧管引导到芯片中，流体歧管被带到安全的微芯片附近。选择流体歧管和微芯片之间的距离使得注射管位于连接到微流体通道的微芯片中的孔内，并且抽吸管位于靠近孔附近的微芯片表面，使得流体溢出在流体转移过程中避免了微芯片的表面。在电测量期间，流体歧管与微芯片的流体连通被去除。

33.

发明授权
Cathepsin cysteine protease inhibitors 有权
Title translation: 组织蛋白酶半胱氨酸蛋白酶抑制剂

公开(公告)号：US07973037B2

公开(公告)日：2011-07-05

申请号：US12082104

申请日：2008-04-08

Applicant: Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran

Inventor： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran

IPC: A61K31/535 , A61K31/497 , A61K31/435 , A61K31/385 , C07D265/30 , C07D241/04 , C07D211/08 , C07D333/02 , C07D255/03

CPC classification number: C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract translation: 本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如骨质疏松症

34.

发明申请
INHIBITORS OF TYROSINE KINASES AND USES THEREOF 有权
Title translation: 酪氨酸激酶的抑制剂及其用途

公开(公告)号：US20100035841A1

公开(公告)日：2010-02-11

申请号：US12575425

申请日：2009-10-07

Applicant: Orion D. JANKOWSKI , James T. Palmer , Lee Honigberg

Inventor： Orion D. JANKOWSKI , James T. Palmer , Lee Honigberg

IPC: A61K31/675 , A61K31/496 , A61P37/06 , A61P29/00

CPC classification number: C07D471/04 , C07F9/65685 , C07F9/65846

Abstract: Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-mediated diseases or conditions or tyrosine kinase-dependent diseases or conditions are provided.

Abstract translation: 本文公开了抑制特定酪氨酸激酶活性的化合物。公开了制备这些化合物的方法。还公开了包含化合物的药物组合物。提供了使用单独或与其它治疗剂组合公开的化合物用于治疗酪氨酸激酶介导的疾病或病症或酪氨酸激酶依赖性疾病或病症的方法。

35.

发明授权
Inhibitors of tyrosine kinases and uses thereof 失效
Title translation: 酪氨酸激酶抑制剂及其用途

公开(公告)号：US07625880B2

公开(公告)日：2009-12-01

申请号：US11617651

申请日：2006-12-28

Applicant: Orion D. Jankowski , James T. Palmer , Lee Honigberg

Inventor： Orion D. Jankowski , James T. Palmer , Lee Honigberg

IPC: A61K31/675 , C07D403/00

CPC classification number: C07D471/04 , C07F9/65685 , C07F9/65846

Abstract: Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-mediated diseases or conditions or tyrosine kinase-dependent diseases or conditions are provided.

Abstract translation: 本文公开了抑制特定酪氨酸激酶活性的化合物。公开了制备这些化合物的方法。还公开了包含化合物的药物组合物。提供了使用单独或与其它治疗剂组合公开的化合物用于治疗酪氨酸激酶介导的疾病或病症或酪氨酸激酶依赖性疾病或病症的方法。