公开(公告)号：USD484681S1

公开(公告)日：2004-01-06

申请号：US29173195

申请日：2002-12-26

Applicant: James B. Eldon, III ,  David D. McClanahan ,  Kevin Foley ,  James O'Halloran

Designer： James B. Eldon, III ,  David D. McClanahan ,  Kevin Foley ,  James O'Halloran

公开(公告)号：USD484305S1

公开(公告)日：2003-12-30

申请号：US29160421

申请日：2002-05-10

Applicant: James B. Eldon, III ,  David D. McClanahan ,  Kevin Foley ,  James S. O'Halloran

Designer： James B. Eldon, III ,  David D. McClanahan ,  Kevin Foley ,  James S. O'Halloran

公开(公告)号：US06423095B1

公开(公告)日：2002-07-23

申请号：US08603676

申请日：1996-02-20

Applicant: James E. Van Hoeck ,  Troy McDonald ,  Bradley J. Coates ,  Regis W. Haid, Jr. ,  Stephen E. Heim ,  Kevin Foley ,  Eugene C. Eckstein

Inventor： James E. Van Hoeck ,  Troy McDonald ,  Bradley J. Coates ,  Regis W. Haid, Jr. ,  Stephen E. Heim ,  Kevin Foley ,  Eugene C. Eckstein

IPC: A61F244

CPC classification number: A61F2/442 ,  A61F2/30724 ,  A61F2/30767 ,  A61F2/4455 ,  A61F2/4611 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30112 ,  A61F2002/30153 ,  A61F2002/30187 ,  A61F2002/30261 ,  A61F2002/30271 ,  A61F2002/30677 ,  A61F2002/3092 ,  A61F2002/30929 ,  A61F2002/4475 ,  A61F2002/4623 ,  A61F2002/4627 ,  A61F2210/0004 ,  A61F2230/0004 ,  A61F2230/0019 ,  A61F2230/0034 ,  A61F2230/0082 ,  A61F2310/00161 ,  A61F2310/00293 ,  A61F2310/00491 ,  A61F2310/00544 ,  A61F2310/00796 ,  A61L31/024 ,  A61L31/026 ,  A61L31/044 ,  A61L31/047 ,  A61L31/048 ,  A61L31/06 ,  A61L2430/38 ,  Y10S606/907 ,  Y10S606/908

Abstract: One embodiment of a hollow spinal spacer (10) includes a curved anterior wall (11) having opposite ends (12, 13), a posterior wall (15) having opposite ends (16, 17), two lateral walls (20, 21), each integrally connected between the opposite ends (12, 13, 16, 17) of the anterior (11) and posterior (15) walls to define a chamber (30). The walls (11, 15, 20, 21) include a superior face (35) and an inferior face (40). The superior face (35) defines a first opening (36) in communication with the chamber (30) and includes a first vertebral engaging surface (37). The inferior face (40) defines a second opening (41) in communication with the chamber (30) and includes a second vertebral engaging surface (42). In one embodiment, a lateral wing projects from an external surface of each of the lateral walls. In another embodiment, the anterior wall defines an anterior superior surface and an anterior inferior surface. The anterior superior surface has a concave shape defining a first radius which is configured to correspond to the anterior shape of an inferior vertebral endplate. The anterior inferior surface has a convex shape defining a second radius which is configured to correspond to the anterior shape of a superior vertebral endplate. In other embodiments, the lateral walls define a convex lateral superior surface and a convex lateral inferior surface. Each of the lateral surfaces define a radius configured to correspond to the shape of a vertebral endplate.

Abstract translation: 空心脊椎间隔件（10）的一个实施例包括具有相对端（12,13）的弯曲前壁（11），具有相对端（16,17）的后壁（15），两个侧壁（20,21） ，每个整体连接在前（11）和后（15）壁的相对端（12,13,16,17）之间，以限定室（30）。 壁（11,15,20,21）包括上表面（35）和下表面（40）。 上表面（35）限定与腔室（30）连通的第一开口（36）并且包括第一椎骨接合表面（37）。 下表面（40）限定与腔室（30）连通的第二开口（41），并且包括第二椎骨接合表面（42）。在一个实施例中，侧翼从每个侧壁的外表面突出 。 在另一个实施例中，前壁限定前上表面和前下表面。 前上表面具有限定第一半径的凹形，其构造成对应于下椎骨终板的前形状。 前下表面具有限定第二半径的凸形形状，其被配置为对应于上椎骨终板的前形状。 在其他实施例中，侧壁限定凸的侧向上表面和凸的侧向下表面。 每个侧表面限定了被配置为对应于椎体终板的形状的半径。

公开(公告)号：US20140094436A1

公开(公告)日：2014-04-03

申请号：US14103420

申请日：2013-12-11

Applicant: Weiwen Ying ,  Zhenjian Du ,  Kevin Foley

Inventor： Weiwen Ying ,  Zhenjian Du ,  Kevin Foley

IPC: C07D233/84 ,  C07F9/6506 ,  C07D233/88 ,  C07D403/10

CPC classification number: A61K31/4164 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/675 ,  C07D233/70 ,  C07D233/84 ,  C07D233/88 ,  C07D403/02 ,  C07D403/04 ,  C07D403/10 ,  C07F9/6506

Abstract: Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.

Abstract translation: 式（I）化合物，包含式（I）化合物的药物组合物和抑制细胞中Hsp90的方法，治疗或预防哺乳动物中的增殖病症并治疗哺乳动物的癌症，其包括给予式（I）化合物至 患者或细胞。 变量R5是任选取代的杂芳基; 任选取代的6至14元芳基; 任选在任何可取代的氮或碳原子上取代的双环9元杂环; 或本文定义的取代基R18。 环A是除了R3之外任选进一步被一个或多个取代基取代的芳基或杂芳基。 取代基R 3在本文中定义。

公开(公告)号：US20130218740A1

公开(公告)日：2013-08-22

申请号：US13614758

申请日：2012-09-13

Applicant: Howard W. Lutnick ,  Kevin Foley ,  Philip Marber ,  Bill Rice ,  Andrew Fishkind

Inventor： Howard W. Lutnick ,  Kevin Foley ,  Philip Marber ,  Bill Rice ,  Andrew Fishkind

IPC: G06Q40/04

CPC classification number: G06Q40/04 ,  G06Q40/00

Abstract: A trading platform and trading method that allows access to additional pools of liquidity is described. Other embodiments are also described.

公开(公告)号：US20130097065A1

公开(公告)日：2013-04-18

申请号：US13613862

申请日：2012-09-13

Applicant: Howard W. Lutnick ,  Mark Miller ,  Dean P. Alderucci ,  Bill Rice ,  Kevin Foley ,  Andrew Fishkind ,  Philip Marber ,  Brian Gay

Inventor： Howard W. Lutnick ,  Mark Miller ,  Dean P. Alderucci ,  Bill Rice ,  Kevin Foley ,  Andrew Fishkind ,  Philip Marber ,  Brian Gay

IPC: G06Q40/04

CPC classification number: G06Q40/04 ,  G06Q40/02

Abstract: An electronic trading marketplace (ETM) communicates with interfacing modules interfacing directly with order management systems (OMS's) at trading institutions. The interfacing modules automatically transmit orders from the OMS databases to the ETM and update the OMS databases in response to orders executed at the ETM. Traders can communicate with the ETM to anonymously negotiate trades of securities.

公开(公告)号：US08269017B2

公开(公告)日：2012-09-18

申请号：US12883883

申请日：2010-09-16

Applicant: Lijun Sun ,  Christopher Borella ,  Hao Li ,  Jun Jiang ,  Shoujun Chen ,  Keizo Koya ,  Takayo Inoue ,  Zhenjian Du ,  Kevin Foley ,  Yaming Wu ,  Mei Zhang ,  Weiwen Ying

Inventor： Lijun Sun ,  Christopher Borella ,  Hao Li ,  Jun Jiang ,  Shoujun Chen ,  Keizo Koya ,  Takayo Inoue ,  Zhenjian Du ,  Kevin Foley ,  Yaming Wu ,  Mei Zhang ,  Weiwen Ying

IPC: C07D261/02 ,  A61K31/42

CPC classification number: C07D413/14 ,  A61K31/42 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/675 ,  A61K45/06 ,  C07D261/08 ,  C07D413/04 ,  C07D413/10 ,  C07F9/653

Abstract: The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.

Abstract translation: 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。

公开(公告)号：US20120005062A1

公开(公告)日：2012-01-05

申请号：US13031834

申请日：2011-02-22

Applicant: Howard W. Lutnick ,  Mark Miller ,  Kevin Foley ,  Brian Gay ,  Andrew Fishkind

Inventor： Howard W. Lutnick ,  Mark Miller ,  Kevin Foley ,  Brian Gay ,  Andrew Fishkind

IPC: G06Q40/00

CPC classification number: G06Q40/04 ,  G06Q40/06

Abstract: A trading platform and trading method that may allow access to additional pools of liquidity is described. Other embodiments are also described.

Abstract translation: 描述了可能允许访问额外的流动性池的交易平台和交易方法。 还描述了其它实施例。

公开(公告)号：US20110313312A1

公开(公告)日：2011-12-22

申请号：US13221192

申请日：2011-08-30

Applicant: Michael Hoey ,  Corbett W. Stone ,  Kevin Foley

Inventor： Michael Hoey ,  Corbett W. Stone ,  Kevin Foley

IPC: A61B5/05

CPC classification number: A61B5/4869 ,  A61B5/0537 ,  A61B5/0538 ,  A61B5/4893 ,  A61B17/7001 ,  A61B18/02 ,  A61B18/04 ,  A61B2017/00022

Abstract: A system and method for discriminating tissue types, controlling the level of therapy to tissue, and determining the health of a known tissue by measuring the characteristics of an electrical signal applied to a conductive element located within or by the tissue. Additionally, the system and method may be used for determining whether the conductive tip of a pedicle probe or pedicle screw is located in one of cortical bone, cancellous bone, and cortical bone near a boundary with soft tissue, whether the conductive tip of a cannula is located adjacent to one of nerve tissue and annulus tissue, and whether the conductive tip of a cathode is located adjacent to one of nerve tissue and prostate gland tissue.

Abstract translation: 一种用于鉴别组织类型，控制对组织的治疗水平以及通过测量施加到位于组织内或由组织内的导电元件的电信号的特性来确定已知组织的健康的系统和方法。 此外，该系统和方法可用于确定椎弓根探针或椎弓根螺钉的导电尖端是否位于与软组织边界附近的皮层骨，松质骨和皮质骨之一中，无论导管的导管末端 位于神经组织和环带组织之间，以及阴极的导电末端是否位于神经组织和前列腺组织之一附近。

公开(公告)号：US08082205B2

公开(公告)日：2011-12-20

申请号：US12113602

申请日：2008-05-01

Applicant: Howard W. Lutnick ,  Mark Miller ,  Dean P. Alderucci ,  Bill Rice ,  Kevin Foley ,  Andrew Fishkind ,  Philip Marber ,  Brian Gay

Inventor： Howard W. Lutnick ,  Mark Miller ,  Dean P. Alderucci ,  Bill Rice ,  Kevin Foley ,  Andrew Fishkind ,  Philip Marber ,  Brian Gay

IPC: G06Q40/00

CPC classification number: G06Q40/04 ,  G06Q40/00 ,  G06Q40/06

Abstract: An electronic trading marketplace (ETM) communicates with interfacing modules interfacing directly with order management systems (OMS's) at trading institutions. The interfacing modules automatically transmit orders from the OMS databases to the ETM and update the OMS databases in response to orders executed at the ETM. Traders can communicate with the ETM to anonymously negotiate trades of securities.

Abstract translation: 电子交易市场（ETM）与交易机构直接与订单管理系统（OMS）接口的接口模块进行通信。 接口模块自动将订单从OMS数据库发送到ETM，并根据在ETM执行的订单更新OMS数据库。 交易者可以与ETM通信以匿名协商证券交易。