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公开(公告)号：US10551285B2
公开(公告)日：2020-02-04
申请号：US15543326
申请日：2016-01-14
发明人： Leander Gaechter , Günther Bock , Thomas Pfeifer
摘要： The invention relates to a sample transfer device (10) for reception of a sample, having a transfer rod (4) that is configured for reception of a sample holder, the sample holder to be arranged in a chamber (1) of the sample transfer device (10) for the purpose of transferring the sample to a processing unit or analytical unit (200), at least one measurement device (3, 8) for measuring a physical variable being arranged inside the sample transfer device (10).
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公开(公告)号：US10539360B2
公开(公告)日：2020-01-21
申请号：US15526355
申请日：2014-11-13
发明人： Robert Lange , Cveta Tomova
摘要： The invention relates to a freezing machine (150) for freezing samples, encompassing: a freezing device (140) for freezing a sample received in the freezing machine (150); a container (100) for receiving the frozen sample, having a reservoir (105) for liquid nitrogen; and a transfer apparatus for transferring the frozen sample from the freezing device (140) into the container (100), the container (100) comprising at least two receiving devices (104), separated from one another, each for at least one frozen sample; a selection apparatus being provided for selecting one of the receiving devices (104) for a frozen sample that is to be transferred into the container (100), the freezing machine (150) being configured to carry out the transfer of the frozen sample, by means of the transfer apparatus, into the respectively selected receiving device (104) of the container (100); and to a method for transferring frozen samples into a container provided therefor.
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33.发明申请公开(公告)号：US20180290144A1
公开(公告)日：2018-10-11
申请号：US15943763
申请日：2018-04-03
摘要： The invention relates to a holding apparatus (100) for sample carriers (200) for use in cryomicroscopy, encompassing: a body having at least one sample carrier receptacle that comprises at least one sample carrier support surface against which at least one sample carrier (200) is abuttable; at least one first sample carrier holding means (121); and at least one second sample carrier holding means (131) that is configured to impinge upon the sample carrier (200) with force against the first sample carrier holding means (121); and to an arrangement having a manipulation container and such a holding apparatus (100), and to methods for introducing and withdrawing a sample carrier (200).
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公开(公告)号：US10073016B2
公开(公告)日：2018-09-11
申请号：US14953313
申请日：2015-11-28
发明人： Reinhard Lihl , Michael Zimmermann
CPC分类号： G01N1/286 , G01N1/42 , G01N2001/2873
摘要： A freeze fracture machine (100) comprises a vacuum chamber (110); a sample receptacle (160) for receiving a sample to be processed and a knife receptacle (150) for receiving a knife (110) for processing of the sample arranged in the vacuum chamber (155); a transfer lock (130) on the vacuum chamber (110) through which a sample and a knife (155) are introducible into the vacuum chamber (155) and positionable in the vacuum chamber (110) by means of a positioning apparatus (135); the sample and the sample receptacle (160) being positionable with respect to one another such that the sample is mountable on the sample receptacle (160) by means of the positioning apparatus (135); and the knife (155) and the knife receptacle (150) being positionable with respect to one another such that the knife (155) is mountable on the knife receptacle (150) by means of the positioning apparatus (135).
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公开(公告)号：US20170213694A1
公开(公告)日：2017-07-27
申请号：US15329716
申请日：2015-07-15
发明人： Reinhard LIHL , Leander GAECHTER
CPC分类号： H01J37/20 , G01N1/06 , G01N1/32 , G01N1/42 , G02B21/00 , H01J37/18 , H01J37/26 , H01J2237/16 , H01J2237/20221 , H01J2237/262
摘要： A loading station (100, 200) for translocating a frozen sample for electron microscopy, encompassing a chamber (104, 204), open toward the top, that is fillable at least partly with a coolant, the chamber (104, 204) comprising in its side wall at least two ports (101a, 102a, 103a) each for different sample transfer devices (101, 102, 103), the ports (101a, 102a, 103a) permitting introduction of a frozen sample into the chamber (104, 204) via a selected sample transfer device and withdrawal of a frozen sample from the chamber via a respective different sample transfer device; and wherein a receptacle (108, 208) for at least two differently configured sample holders (109, 110) is arranged in the chamber (104, 204), the at least two sample holders (109, 110) being detachably fastenable to at least one of the sample transfer devices (101) for introduction of the frozen sample into the chamber (104, 204) and for withdrawal of the frozen sample from the chamber (104, 204).
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公开(公告)号：US20130323407A1
公开(公告)日：2013-12-05
申请号：US13906469
申请日：2013-05-31
发明人： Paul WURZINGER , Anton LANG
IPC分类号： C23C16/448
CPC分类号： C23C16/4485 , C23C14/0605 , C23C14/26 , C23C14/546
摘要： An apparatus for depositing a material layer on a sample inside a vacuum chamber comprises a sample stage (100) for arranging at least one sample (103a, 103b, 103c, 103d); an evaporation source (101, 201), connected to a current source, for a thread-shaped evaporation material (102, 202); a quartz oscillator (105) for measuring the deposited material layer thickness; and an evaluation device (113) associated with the oscillator (105). An electronic control system (112) associated with the evaporation source (101, 201) is configured to deliver electric current in the form of at least two current pulses having a pulse length less than or equal to 1 s. The evaluation device (113) takes into account transient decay behavior of the oscillator (105) immediately after a current pulse to derive the material layer thickness deposited after each pulse. The invention further relates to a method that can be carried out using said apparatus.
摘要翻译： 用于在真空室内的样品上沉积材料层的装置包括：用于布置至少一个样品（103a，103b，103c，103d）的样品台（100）; 连接到电流源的用于螺纹形蒸发材料（102,202）的蒸发源（101,201）; 用于测量沉积材料层厚度的石英振荡器（105）; 以及与振荡器（105）相关联的评估装置（113）。 与蒸发源（101,201）相关联的电子控制系统（112）被配置为以脉冲长度小于或等于1s的至少两个电流脉冲的形式传送电流。 评估装置（113）在电流脉冲之后立即考虑振荡器（105）的瞬态衰减行为，以导出每个脉冲之后沉积的材料层厚度。 本发明还涉及可以使用所述装置执行的方法。
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公开(公告)号：US20040178371A1
公开(公告)日：2004-09-16
申请号：US10735397
申请日：2003-12-12
发明人： Reinhard Lihl , Hubert Goll , Anton Lang , Paul Wurzinger
IPC分类号： G06M007/00
CPC分类号： G01N1/06 , G01N2001/066 , Y10T83/04 , Y10T83/855 , Y10T83/86
摘要： In microtomes or ultramicrotomes, it is necessary to preset the specimen (14) onto the knife (16). In order to facilitate and automate this presetting operation, which is intended to guarantee the fastest and most accurate possible positioning of the knife (16) relative to the specimen (14), the spacing (13) between the trimmed surface (15) of the specimen (14) and the specimen holder (22) is ascertained and is transferred to the microtome or ultramicrotome (10). The spacing (13) is preferably ascertained in the trimming device (12).
摘要翻译： 在切片机或超薄切片机中，需要将样品（14）预先设置在刀具（16）上。 为了促进和自动化这种预设操作，其旨在确保刀（16）相对于试样（14）的最快和最准确的可能的定位，即修剪表面（15）之间的间隔（13） 确定样品（14）和样品架（22），并将其转移到切片机或超薄切片机（10）。 间隔（13）优选地在修剪装置（12）中确定。
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公开(公告)号：US20040120862A1
公开(公告)日：2004-06-24
申请号：US10732076
申请日：2003-12-10
发明人： Anton Lang , Rainer Wogritsch , Andreas Nowak
IPC分类号： B01L003/00
CPC分类号： G01Q30/20 , G01N1/06 , Y10T436/25 , Y10T436/2525
摘要： A specimen holder (10) is proposed in order to create a capability for preparing, in a cutting device, in particular a microtome or ultramicrotome, a specimen that is to examined in an AFM. The specimen holder (10) is embodied in several parts. It comprises an insert (12) in which the specimen is secured. Also provided is a receiving ring (14) in which the insert (12) can be received. The insert together with the receiving ring (14) is mounted, in particular thread-joined, on a base element (16). As a result of the mounting of the receiving ring (14) on the base element (16), the insert together with the specimen is fixed in its position.
摘要翻译： 提出了一种标本保持器（10），以便创建在切割装置中特别是切片机或超切片机，在AFM中检查的样本的能力。 样本保持器（10）被体现在几个部分中。 它包括其中固定有试样的插入件（12）。 还设置有可以接收插入件（12）的接收环（14）。 插入件与接收环（14）一起安装在基部元件（16）上，特别是螺纹接合。 由于将接收环（14）安装在基座元件（16）上，插入物与试样一起被固定在其位置上。
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40.发明申请Apparatus for tissue processing for the tissue embedding and mounting for the processing containers for tissue processing 有权用于组织处理的装置，用于组织处理用于组织处理的处理容器的嵌入和安装公开(公告)号：US20020185391A1
公开(公告)日：2002-12-12
申请号：US10100849
申请日：2002-03-18
发明人： Michael Zimmermann
IPC分类号： A01N001/00
摘要： An apparatus (1) for tissue preparation for the tissue embedding, having a transport plate (15) defining a circumferential edge (15c). At the circumferential edge (15c) several recesses (16) are formed, each of which comprises a plurality of several circular cut outs (16a) being arranged so that it has an opening into the direction of the circumferential edge (15c). The transport plate (15) is surrounded by a housing (5) which defines an inner upper side (8a) on which a heating and cooling device (3) is provided.
摘要翻译： 一种用于组织包埋的组织制备的装置（1），具有限定周缘（15c）的传送板（15）。 在圆周边缘（15c）处形成有多个凹槽（16），每个凹槽（16）包括多个多个圆形切口（16a），以使得其具有沿圆周边缘（15c）的方向的开口。 传送板（15）由限定内部上侧（8a）的壳体（5）包围，在其上设置有加热和冷却装置（3）。
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