Patent search ap:"Lianyun Zhao" Page 4

31.

发明申请
FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS 有权
Title translation: 熔融三氯化合物作为新型抑制剂

公开(公告)号：US20120178744A1

公开(公告)日：2012-07-12

申请号：US13379685

申请日：2010-06-30

Applicant: Cliff C. Cheng , Hongbo Zeng , Gerald W. Shipps, JR. , Yongqi Deng , Zhaoyang Meng , Lianyun Zhao , Yang Nan , Binyuan Sun , Duan Liu , Panduranga A. Reddy , M. Arshad Siddiqui

Inventor： Cliff C. Cheng , Hongbo Zeng , Gerald W. Shipps, JR. , Yongqi Deng , Zhaoyang Meng , Lianyun Zhao , Yang Nan , Binyuan Sun , Duan Liu , Panduranga A. Reddy , M. Arshad Siddiqui

IPC: A61K31/541 , A61K31/519 , A61P35/00 , C07D487/14

CPC classification number: C07D487/14

Abstract: The present invention provides Fused Tricyclic Compounds of the Formula (I) wherein Q, R1, R2, R3, and R4 are as defined herein, and pharmaceutically acceptable salts of such Fused Tricyclic Compounds. The Fused Tricyclic Compounds are useful in the treatment of cancer and other proliferative disorders.

Abstract translation: 本发明提供了其中Q，R 1，R 2，R 3和R 4如本文所定义的式（I）的稠合三环化合物和这种稠合的三环化合物的药学上可接受的盐。融合的三环化合物可用于治疗癌症和其他增殖性疾病。

32.

发明申请
Thiazole Derivatives as Protein Kinase Inhibitors 有权
Title translation: 噻唑衍生物作为蛋白激酶抑制剂

公开(公告)号：US20100331313A1

公开(公告)日：2010-12-30

申请号：US12738487

申请日：2008-10-27

Applicant: Panduranga Adulla P. Reddy , Tzu T. Wong , Lianyun Zhao , Shuyi Tang , Marc A. Labroli , Timothy J. Guzi , M. Arshad Siddiqui

Inventor： Panduranga Adulla P. Reddy , Tzu T. Wong , Lianyun Zhao , Shuyi Tang , Marc A. Labroli , Timothy J. Guzi , M. Arshad Siddiqui

IPC: A61K31/551 , C07D417/14 , A61K31/496 , A61K31/5377 , A61K31/517 , C07D491/056 , C07D495/04 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/28 , A61P25/16 , A61P35/00 , A61P31/00 , A61P31/12 , A61P31/10

CPC classification number: C07D417/12 , C07D417/14 , C07D471/10 , C07D491/056 , C07D495/04

Abstract: The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.

Abstract translation: 本发明涉及新的噻唑衍生物，包含噻唑衍生物的组合物，以及使用噻唑衍生物治疗或预防增殖性疾病，抗增殖性疾病，炎症，关节炎，中枢神经系统疾病，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒感染，真菌感染或与蛋白激酶活性相关的病症。

33.

发明申请
COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 失效
Title translation: 用于治疗炎症性疾病的化合物

公开(公告)号：US20100145048A1

公开(公告)日：2010-06-10

申请号：US12582341

申请日：2009-10-20

Applicant: Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, JR. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao

Inventor： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, JR. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao

IPC: C07D405/12 , C07D417/12 , C07D413/14 , C07D409/12

CPC classification number: C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04

Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-α或其组合介导的疾病或病症。

34.

发明申请
2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS 有权
Title translation: 作为蛋白激酶抑制剂的2-氨基噻唑-4-羧酰胺

公开(公告)号：US20100130465A1

公开(公告)日：2010-05-27

申请号：US12447710

申请日：2007-10-29

Applicant: Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga A. Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi

Inventor： Gerald W. Shipps, JR. , Cliff C. Cheng , Xiaohua Huang , Thierry O. Fischmann , Jose S. Duca , Matthew Richards , Hongbo Zeng , Binyuan Sun , Panduranga A. Reddy , Lianyun Zhao , Shuyi Tang , Tzu T. Wong , Praveen K. Tadikonda , Luis E. Torres , M. Arshad Siddiqui , Michael P. Dwyer , Kartik M. Keertikar , Timothy J. Guzi

IPC: A61K31/438 , C07D417/14 , A61K31/497 , C07D471/10 , C07D413/14 , A61K31/5377 , A61K31/551

CPC classification number: C07D277/56 , A61K31/435 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04 , A61K2300/00

Abstract: The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

Abstract translation: 本发明涉及式（I）的新型苯胺基哌嗪衍生物，包含苯胺基哌嗪衍生物的组合物，以及使用苯胺基哌嗪衍生物治疗或预防增殖性病症，抗增殖病症，炎症，关节炎，中枢神经系统疾病，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒性疾病，真菌感染或与蛋白激酶活性相关的病症。

35.

发明授权
Imidazopyrazines as protein kinase inhibitors 失效
Title translation: 咪唑吡嗪作为蛋白激酶抑制剂

公开(公告)号：US07557104B2

公开(公告)日：2009-07-07

申请号：US11758243

申请日：2007-06-05

Applicant: Lianyun Zhao , Panduranga Adulla P. Reddy , Neng-Yang Shih , Kamil Paruch , Timothy J. Guzi , M. Arshad Siddiqui

Inventor： Lianyun Zhao , Panduranga Adulla P. Reddy , Neng-Yang Shih , Kamil Paruch , Timothy J. Guzi , M. Arshad Siddiqui

IPC: A61K31/497

CPC classification number: C07D487/04

Abstract: In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.

Abstract translation: 在其许多实施方案中，本发明提供了一类新颖的咪唑并吡嗪化合物作为蛋白质和/或检查点激酶的抑制剂，制备此类化合物的方法，包含一种或多种此类化合物的药物组合物，制备药物制剂的方法，包括一种或多种化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与蛋白质或检查点激酶相关的一种或多种疾病的方法。

36.

发明授权
High affinity quinoline-based kinase ligands 有权
Title translation: 高亲和力喹啉类激酶配体

公开(公告)号：US07511063B2

公开(公告)日：2009-03-31

申请号：US11504869

申请日：2006-08-16

Applicant: Yongqi Deng , Patrick J. Curran , Gerald W. Shipps, Jr. , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry

Inventor： Yongqi Deng , Patrick J. Curran , Gerald W. Shipps, Jr. , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry

IPC: A61K31/47 , C07D215/14

CPC classification number: C07D409/04 , C07D215/48 , C07D215/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10

Abstract: Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

Abstract translation: 描述了基于喹啉的细胞周期蛋白依赖性激酶2抑制剂，包括抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。本发明还提供了制备CDK-2抑制剂化合物的方法，抑制CDK-2的方法以及治疗疾病或疾病症状的方法。

37.

发明申请
Heterocyclic Kinase Inhibitors: Methods of Use and Synthesis 审中-公开
Title translation: 杂环激酶抑制剂：使用和合成方法

公开(公告)号：US20080119515A1

公开(公告)日：2008-05-22

申请号：US10547959

申请日：2004-03-10

Applicant: M Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Lianyun Zhao

Inventor： M Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Lianyun Zhao

IPC: A61K31/47 , A61P19/02 , C07D215/00

CPC classification number: C07D401/06 , C07D405/14

Abstract: Inhibitors of kinases, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptom.

Abstract translation: 描述了激酶抑制剂，包括抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。本发明还提供了制备激酶抑制剂化合物的方法，抑制激酶活性的方法，以及治疗疾病或疾病症状的方法。

38.

发明申请
Novel high affinity quinoline-based kinase ligands 有权
Title translation: 新型高亲和性喹啉类激酶配体

公开(公告)号：US20080045568A1

公开(公告)日：2008-02-21

申请号：US11504869

申请日：2006-08-16

Applicant: Yongqi Deng , Patrick J. Curran , Gerald W. Shipps , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry

Inventor： Yongqi Deng , Patrick J. Curran , Gerald W. Shipps , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry

IPC: A61K31/4709 , A61K31/4706 , C07D215/38

CPC classification number: C07D409/04 , C07D215/48 , C07D215/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10

Abstract: Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

Abstract translation: 描述了基于喹啉的细胞周期蛋白依赖性激酶2抑制剂，包括抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。本发明还提供了制备CDK-2抑制剂化合物的方法，抑制CDK-2的方法以及治疗疾病或疾病症状的方法。

39.

发明申请
Imidazopyrazines as protein kinase inhibitors 审中-公开
Title translation: 咪唑吡嗪作为蛋白激酶抑制剂

公开(公告)号：US20070117804A1

公开(公告)日：2007-05-24

申请号：US11598186

申请日：2006-11-08

Applicant: Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , Kamil Paruch , Timothy Guzi , Michael Dwyer , M. Siddiqui , Praveen Tadikonda

Inventor： Lianyun Zhao , Patrick Curran , David Belanger , Blake Hamann , Panduranga Reddy , Kamil Paruch , Timothy Guzi , Michael Dwyer , M. Siddiqui , Praveen Tadikonda

IPC: A61K31/498 , C07D487/04

CPC classification number: C07D487/04

Abstract: In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.

Abstract translation: 在其许多实施方案中，本发明提供了一类新颖的咪唑并吡嗪化合物作为蛋白质和/或检查点激酶的抑制剂，制备此类化合物的方法，包含一种或多种此类化合物的药物组合物，制备药物制剂的方法，包括一种或多种化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与蛋白质或检查点激酶相关的一种或多种疾病的方法。