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公开(公告)号：US07652020B2
公开(公告)日：2010-01-26
申请号：US11142601
申请日：2005-06-01
申请人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, Jr. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, Jr. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号： A61K31/519 , A61K31/506 , A61K31/4709 , A61K31/43 , A61K31/4245 , C07D413/00 , C07D241/36 , C07D471/00 , C07D295/00 , C07D471/02 , C07D401/00 , C07D513/00 , C07D277/22 , C07D277/62 , C07D263/30 , C07D261/06 , C07D235/00 , C07D209/04 , C07D207/00 , C07D205/00 , C07D409/00 , C07D307/00
CPC分类号： C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-α或其组合介导的疾病或病症。
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公开(公告)号：US20100145048A1
公开(公告)日：2010-06-10
申请号：US12582341
申请日：2009-10-20
申请人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, JR. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert D. Mazzola , Tin-Yau Chan , Henry A. Vaccaro , Brian McKittrick , Joseph A. Kozlowski , Brian J. Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline C. Ting , Kristin E. Rosner , Gerald W. Shipps, JR. , M. Arshad Siddiqui , David B. Belanger , Chaoyang Dai , Dansu Li , Vinay M. Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号： C07D405/12 , C07D417/12 , C07D413/14 , C07D409/12
CPC分类号： C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-α或其组合介导的疾病或病症。
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公开(公告)号：US20060252778A1
公开(公告)日：2006-11-09
申请号：US11142601
申请日：2005-06-01
申请人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert Mazzola , Tin-Yau Chan , Henry Vaccaro , Brian McKittrick , Joseph Kozlowski , Brian Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline Ting , Kristin Rosner , Gerald Shipps , M. Siddiqui , David Belanger , Chaoyang Dai , Dansu Li , Vinay Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
发明人： Zhuyan Guo , Peter Orth , Zhaoning Zhu , Robert Mazzola , Tin-Yau Chan , Henry Vaccaro , Brian McKittrick , Joseph Kozlowski , Brian Lavey , Guowei Zhou , Sunil Paliwal , Shing-Chun Wong , Neng-Yang Shih , Pauline Ting , Kristin Rosner , Gerald Shipps , M. Siddiqui , David Belanger , Chaoyang Dai , Dansu Li , Vinay Girijavallabhan , Janeta Popovici-Muller , Wensheng Yu , Lianyun Zhao
IPC分类号： C07D471/02 , C07D498/02 , A61K31/519 , A61K31/506 , A61K31/4709 , A61K31/43 , A61K31/4245
CPC分类号： C07D409/14 , C07C235/06 , C07C235/08 , C07C235/10 , C07C2601/08 , C07D207/20 , C07D207/26 , C07D209/44 , C07D215/14 , C07D217/06 , C07D263/32 , C07D295/185 , C07D307/52 , C07D333/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D513/04
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-α或其组合介导的疾病或病症。
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公开(公告)号：US07034057B2
公开(公告)日：2006-04-25
申请号：US10716890
申请日：2003-11-19
申请人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian J. Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
发明人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian J. Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
IPC分类号： A61K31/165 , A61K31/18 , A61K31/21 , A61K31/27
CPC分类号： C07D213/30 , C07C62/34 , C07C69/757 , C07C235/40 , C07C255/54 , C07C259/08 , C07C279/08 , C07C311/29 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/40 , C07D213/73 , C07D213/74 , C07D215/06 , C07D215/14 , C07D215/18 , C07D215/233 , C07D215/26 , C07D215/38 , C07D219/02 , C07D221/16 , C07D233/60 , C07D233/64 , C07D251/10 , C07D277/24 , C07D277/64 , C07D311/04 , C07D311/58 , C07D317/08 , C07D317/64 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/12 , C07D417/12 , Y02P20/582
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.
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公开(公告)号：US06838466B2
公开(公告)日：2005-01-04
申请号：US10323511
申请日：2002-12-19
申请人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian J. Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
发明人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian J. Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
IPC分类号： C07D249/06 , A61K31/165 , A61K31/167 , A61K31/194 , A61K31/216 , A61K31/277 , A61K31/36 , A61K31/4164 , A61K31/4192 , A61K31/428 , A61K31/435 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/5377 , A61P1/00 , A61P1/02 , A61P3/10 , A61P9/00 , A61P11/00 , A61P11/02 , A61P13/12 , A61P17/06 , A61P19/00 , A61P19/02 , A61P25/00 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/18 , A61P33/06 , A61P35/04 , A61P37/06 , A61P37/08 , C07C61/39 , C07C62/34 , C07C69/757 , C07C233/63 , C07C235/40 , C07C255/54 , C07C259/08 , C07C279/08 , C07C311/21 , C07C311/29 , C07C317/22 , C07C323/19 , C07D213/30 , C07D213/40 , C07D213/73 , C07D213/74 , C07D215/14 , C07D215/18 , C07D215/22 , C07D215/233 , C07D215/26 , C07D215/38 , C07D219/02 , C07D221/16 , C07D233/54 , C07D233/58 , C07D271/06 , C07D277/24 , C07D277/44 , C07D277/64 , C07D295/18 , C07D311/58 , C07D317/64 , C07D401/04 , C07D401/12 , C07D413/12 , C07D417/12
CPC分类号： C07D213/30 , C07C62/34 , C07C69/757 , C07C235/40 , C07C255/54 , C07C259/08 , C07C279/08 , C07C311/29 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/40 , C07D213/73 , C07D213/74 , C07D215/06 , C07D215/14 , C07D215/18 , C07D215/233 , C07D215/26 , C07D215/38 , C07D219/02 , C07D221/16 , C07D233/60 , C07D233/64 , C07D251/10 , C07D277/24 , C07D277/64 , C07D311/04 , C07D311/58 , C07D317/08 , C07D317/64 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/12 , C07D417/12 , Y02P20/582
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.
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公开(公告)号：US07598242B2
公开(公告)日：2009-10-06
申请号：US11255130
申请日：2005-10-20
申请人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian J. Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
发明人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian J. Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
IPC分类号： A61K31/535 , A61K31/497 , C07D401/12 , C07D413/04 , C07D295/02 , C07D217/06 , C07C255/03 , C07C69/76
CPC分类号： C07D213/30 , C07C62/34 , C07C69/757 , C07C235/40 , C07C255/54 , C07C259/08 , C07C279/08 , C07C311/29 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/40 , C07D213/73 , C07D213/74 , C07D215/06 , C07D215/14 , C07D215/18 , C07D215/233 , C07D215/26 , C07D215/38 , C07D219/02 , C07D221/16 , C07D233/60 , C07D233/64 , C07D251/10 , C07D277/24 , C07D277/64 , C07D311/04 , C07D311/58 , C07D317/08 , C07D317/64 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/12 , C07D417/12 , Y02P20/582
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂化物或异构体，其可用于治疗由MMP，TNF-α或其组合介导的疾病或病症。
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公开(公告)号：US20060063843A1
公开(公告)日：2006-03-23
申请号：US11255130
申请日：2005-10-20
申请人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
发明人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
IPC分类号： A61K31/66 , A61K31/165
CPC分类号： C07D213/30 , C07C62/34 , C07C69/757 , C07C235/40 , C07C255/54 , C07C259/08 , C07C279/08 , C07C311/29 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/40 , C07D213/73 , C07D213/74 , C07D215/06 , C07D215/14 , C07D215/18 , C07D215/233 , C07D215/26 , C07D215/38 , C07D219/02 , C07D221/16 , C07D233/60 , C07D233/64 , C07D251/10 , C07D277/24 , C07D277/64 , C07D311/04 , C07D311/58 , C07D317/08 , C07D317/64 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/12 , C07D417/12 , Y02P20/582
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）的化合物：
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公开(公告)号：US07879997B2
公开(公告)日：2011-02-01
申请号：US11502116
申请日：2006-08-10
IPC分类号： C07D205/08 , A61K31/397
CPC分类号： C07D401/12
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, wherein n, M, V, T, W, X, U, R1 and R2 are as disclosed in the present specification, and which compounds are useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其中n，M，V，T，W，X，U，R 1和R 2如本说明书中所公开的， 哪些化合物可用于治疗由MMPs，TNF-α或其组合介导的疾病或病症。
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公开(公告)号：US07012066B2
公开(公告)日：2006-03-14
申请号：US09908955
申请日：2001-07-19
申请人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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公开(公告)号：US07595299B2
公开(公告)日：2009-09-29
申请号：US11089192
申请日：2005-03-24
申请人： Anil Saksena , Viyyoor M. Girijavallabhan , Stephane L. Bogen , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin X. Chen , Srikanth Venkatraman , Tejal Parekh , Patrick A. Pinto , Bama Santhanam , F. George Njoroge , Ashit K. Ganguly , Henry A. Vaccaro , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura
发明人： Anil Saksena , Viyyoor M. Girijavallabhan , Stephane L. Bogen , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. McCormick , Haiyan Wang , Russell E. Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin X. Chen , Srikanth Venkatraman , Tejal Parekh , Patrick A. Pinto , Bama Santhanam , F. George Njoroge , Ashit K. Ganguly , Henry A. Vaccaro , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K38/05 , C07C205/51 , C07K5/101 , C07K7/02 , A61K2300/00
摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型肽化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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