公开(公告)号：US20060136048A1

公开(公告)日：2006-06-22

申请号：US11015313

申请日：2004-12-16

Applicant: Stephen Pacetti ,  Jessica DesNoyer ,  Yung-Ming Chen ,  Lothar Kleiner ,  Syed Hossainy

Inventor： Stephen Pacetti ,  Jessica DesNoyer ,  Yung-Ming Chen ,  Lothar Kleiner ,  Syed Hossainy

IPC: A61F2/82

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/08

Abstract: Embodiments of coatings for implantable medical devices, such as stents, are disclosed. The devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layers. In some embodiments, the luminal side, and all or a majority of the sidewalls are free of at least two of the coating layers.

公开(公告)号：US20050215944A1

公开(公告)日：2005-09-29

申请号：US11101843

申请日：2005-04-07

Applicant: Wendy Young ,  Lothar Kleiner

Inventor： Wendy Young ,  Lothar Kleiner

IPC: A61N1/30 ,  B23P21/00 ,  H05K3/20

CPC classification number: A61N1/0448 ,  Y10T29/49082 ,  Y10T29/49117 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49155 ,  Y10T29/49204

Abstract: An electrotransport reservoir housing which contains, integrally formed therein, at least one region of conductive material which allows for a liquid and moisture tight barrier, while at the same time providing a means for conducting an electric current therethrough.

Abstract translation: 电输送储存器壳体，其一体地形成在其中，至少一个导电材料区域，其允许液体和湿气屏障，同时提供用于传导电流的装置。

公开(公告)号：US20050158379A1

公开(公告)日：2005-07-21

申请号：US10986922

申请日：2004-11-12

Applicant: Zhongli Ding ,  Lothar Kleiner

Inventor： Zhongli Ding ,  Lothar Kleiner

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/355 ,  A61K38/20 ,  A61K38/21 ,  A61K38/24 ,  A61K38/47 ,  A61K47/12 ,  A61K48/00

CPC classification number: A61K47/12 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1694 ,  A61K31/355 ,  A61K47/32 ,  A61K47/34

Abstract: This invention relates to compositions and methods for preventing oxidation of beneficial agents.

Abstract translation: 本发明涉及防止有益剂氧化的组合物和方法。

公开(公告)号：US20050079202A1

公开(公告)日：2005-04-14

申请号：US10857609

申请日：2004-05-28

Applicant: Guohua Chen ,  Paul Houston ,  Lothar Kleiner ,  Aruna Nathan ,  Joel Rosenblatt

Inventor： Guohua Chen ,  Paul Houston ,  Lothar Kleiner ,  Aruna Nathan ,  Joel Rosenblatt

IPC: A61F2/00 ,  A61K9/00

CPC classification number: A61K9/0024

Abstract: Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric polymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

Abstract translation: 描述了用于向受试者全身或局部施用有益剂的方法和组合物，并且包括例如可植入的弹性体贮库组合物，其可以注射到期望的位置并且可以在延长的持续时间内提供有益剂的受控释放 时间。 组合物包括生物相容的弹性体聚合物，具有低水混溶性的生物相容性溶剂，其与聚合物形成弹性体粘性凝胶并限制植入物吸收水分，以及有益剂。

公开(公告)号：US08501079B2

公开(公告)日：2013-08-06

申请号：US12559400

申请日：2009-09-14

Applicant: Thierry Glauser ,  Vincent Gueriguian ,  Bethany Steichen ,  James Oberhauser ,  Manish Gada ,  Lothar Kleiner ,  Mary Beth Kossuth

Inventor： Thierry Glauser ,  Vincent Gueriguian ,  Bethany Steichen ,  James Oberhauser ,  Manish Gada ,  Lothar Kleiner ,  Mary Beth Kossuth

IPC: B29C55/26 ,  B29C35/00

CPC classification number: B29D22/00 ,  A61F2/91 ,  B29C49/0005 ,  B29C49/02 ,  B29C49/04 ,  B29C49/08 ,  B29C49/78 ,  B29C55/26 ,  B29C2793/009 ,  B29K2995/004 ,  B29K2995/0041 ,  B29K2995/0046 ,  B29K2995/0056 ,  B29K2995/006 ,  B29K2995/0077 ,  B29K2995/0089 ,  B29L2031/7542

Abstract: Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stent manufacture and fabrication of a stent therefrom are disclosed.

Abstract translation: 公开了扩展聚合物管的方法，其具有用于支架制造和制造支架的所需或最佳形态和机械性能。

公开(公告)号：US08323678B2

公开(公告)日：2012-12-04

申请号：US12770591

申请日：2010-04-29

Applicant: Yunbing Wang ,  Xiao Ma ,  Lothar Kleiner ,  Thierry Glauser

Inventor： Yunbing Wang ,  Xiao Ma ,  Lothar Kleiner ,  Thierry Glauser

IPC: A61F2/04

CPC classification number: C08L67/04 ,  A61L31/06 ,  A61L31/10 ,  C08L2666/18

Abstract: This invention is directed to implantable medical device comprising a polymeric composition comprising poly[L-lactide-co-(3,6-dialkyl-1,4-dioxane-2,5-dione)], alone or as a blend with one or more polymers selected from the group consisting of poly(L-lactide) and poly(3,6-dialkyl-1,4-dioxane-2,5-dione).

Abstract translation: 本发明涉及包含聚[L-丙交酯 - 共 - （3,6-二烷基-1,4-二恶烷-2,5-二酮）]的聚合物组合物的植入式医疗装置，其单独或作为与一种或多种 更多选自聚（L-丙交酯）和聚（3,6-二烷基-1,4-二恶烷-2,5-二酮）的聚合物。

公开(公告)号：US08062353B2

公开(公告)日：2011-11-22

申请号：US12617593

申请日：2009-11-12

Applicant: Stephen Dirk Pacetti ,  Jessica DesNoyer ,  Yung-Ming Chen ,  Lothar Kleiner ,  Syed F. A. Hossainy

Inventor： Stephen Dirk Pacetti ,  Jessica DesNoyer ,  Yung-Ming Chen ,  Lothar Kleiner ,  Syed F. A. Hossainy

IPC: A61F2/06

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/08

Abstract: Implantable medical devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layers. In some embodiments, the luminal side, and all or a majority of the sidewalls are free of at least two of the coating layers.

Abstract translation: 植入式医疗装置可以包括至少一个结构元件，所述结构元件具有腔内侧，腔侧和在腔和侧腔之间的侧壁。 涂层可以包括至少两个连续的涂层。 在一些实施例中，腔侧和全部或大部分侧壁不含至少两层涂层。

公开(公告)号：US20110270387A1

公开(公告)日：2011-11-03

申请号：US12770591

申请日：2010-04-29

Applicant: Yunbing Wang ,  Xiao Ma ,  Lothar Kleiner ,  Thierry Glauser

Inventor： Yunbing Wang ,  Xiao Ma ,  Lothar Kleiner ,  Thierry Glauser

IPC: A61F2/06 ,  A61F2/00 ,  C08G63/00

CPC classification number: C08L67/04 ,  A61L31/06 ,  A61L31/10 ,  C08L2666/18

Abstract: This invention is directed to implantable medical device comprising a polymeric composition comprising poly[L-lactide-co-(3,6-dialkyl-1,4-dioxane-2,5-dione)], alone or as a blend with one or more polymers selected from the group consisting of poly(L-lactide) and poly(3,6-dialkyl-1,4-dioxane-2,5-dione).

Abstract translation: 本发明涉及包含聚[L-丙交酯 - 共 - （3,6-二烷基-1,4-二恶烷-2,5-二酮）]的聚合物组合物的植入式医疗装置，其单独或作为与一种或多种 更多选自聚（L-丙交酯）和聚（3,6-二烷基-1,4-二恶烷-2,5-二酮）的聚合物。

公开(公告)号：US20110046606A1

公开(公告)日：2011-02-24

申请号：US12925408

申请日：2010-10-18

Applicant: Guohua Chen ,  Paul R. Houston ,  Lothar Kleiner ,  John J. Spaltro

Inventor： Guohua Chen ,  Paul R. Houston ,  Lothar Kleiner ,  John J. Spaltro

IPC: A61M25/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61K47/36 ,  A61K47/32 ,  A61K47/04 ,  A61K47/34 ,  A61K38/43 ,  A61K38/02 ,  A61K38/22 ,  A61K31/715 ,  A61K31/7088 ,  A61K31/56 ,  A61K39/395 ,  A61K38/27 ,  A61K38/18 ,  A61K38/30 ,  A61K38/20 ,  A61K38/21 ,  A61K38/19 ,  A61K9/14 ,  A61P37/06 ,  A61P23/02 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P7/02 ,  A61P27/02

CPC classification number: A61K9/0024 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

Abstract: Catheter injectable depot compositions are provided that include a bioerodible, biocompatible polymer, a solvent having miscibility in water of less than or equal to 7 wt. % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith, a thixotropic agent, and a beneficial agent. The solvent comprises an aromatic alcohol, an ester of an aromatic acid, an aromatic ketone, or mixtures thereof. The compositions are have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.

Abstract translation: 提供导管可注射贮库组合物，其包括生物可腐蚀的生物相容性聚合物，在水中具有小于或等于7重量％的混溶性的溶剂。 ％，以有效塑化聚合物并与其形成凝胶的量，触变剂和有益剂。 溶剂包括芳族醇，芳族酸的酯，芳族酮或其混合物。 组合物已经显着改善了剪切变稀行为和降低的注射力，使得组合物通过注射容易地植入患者体表下方。

公开(公告)号：US20110022163A1

公开(公告)日：2011-01-27

申请号：US12506881

申请日：2009-07-21

Applicant: Yunbing Wang ,  James Oberhauser ,  Manish Gada ,  Thierry Glauser ,  Vincent Gueriguian ,  Bethany Steichen ,  Lothar Kleiner ,  Xiao Ma

Inventor： Yunbing Wang ,  James Oberhauser ,  Manish Gada ,  Thierry Glauser ,  Vincent Gueriguian ,  Bethany Steichen ,  Lothar Kleiner ,  Xiao Ma

IPC: A61F2/06 ,  C08G63/08 ,  C08L67/00 ,  B29C71/02

CPC classification number: A61L31/14 ,  A61L31/06 ,  C08L67/04

Abstract: The present invention relates to implantable medical devices comprising a L-lactide-constitutional unit-containing copolymer having a wt % percent crystallinity of 40% or less.

Abstract translation: 本发明涉及包含具有40％或更低的重量％结晶度的含L-丙交酯结构单元的共聚物的可植入医疗器械。