公开(公告)号：US20210251599A1

公开(公告)日：2021-08-19

申请号：US16967929

申请日：2019-02-07

Applicant: Norwegian University of Science and Technology (NTNU)

Inventor： Hans Torp ,  Torbjørn Hergum

IPC: A61B8/06 ,  A61B8/08 ,  A61B8/00

Abstract: The invention provides a method of monitoring blood flow in a vertebrate animal subject. Unfocussed plane-wave ultrasound pulses are transmitted into the subject, along a transmission axis, from a single-element ultrasound transducer (2) fastened to the subject (5). Reflections of the ultrasound pulses are received, generating a succession of pulse-Doppler response signals over time. Each pulse-Doppler response signal is processed to determine a first respective spatial-maximum velocity value for blood flowing towards the single transducer element (2), and a second respective spatial-maximum velocity value for blood flowing away. Heartbeats are identified from said spatial-maximum velocity values and a quality metric is assigned to each identified heartbeat. A subset of the spatial-maximum velocity values is identified for which the assigned quality metric exceeds a threshold level. The values from the subset are monitored, and, when a set of values from the subset satisfies a predetermined alert criterion an audible or visual alert is signalled.

公开(公告)号：US11071516B2

公开(公告)日：2021-07-27

申请号：US16329568

申请日：2017-09-01

Applicant: Norwegian University of Science and Technology (NTNU)

Inventor： Hans Torp ,  Lasse Lovstakken

IPC: A61B8/06 ,  A61B8/14 ,  A61B8/08

Abstract: An ultrasound imaging method in which ultrasound signals are transmitted into a living organism, reflected from fluid flowing along a path within the organism, and received by an ultrasound transceiver system with a resolution limit in a first direction. These signals are used to generate data representing a sequence of images over time; each image including a speckle pattern arising from interference within the reflected ultrasound signals. A peak-sharpening operation is applied to the image data, generating data representing a sequence of resolution-enhanced images, each having a resolution in the first direction finer than the resolution limit of the transceiver system in that direction, and including a respective peak-sharpened speckle pattern. A combining operation is applied to generate data representing an output image in which the path of the fluid is represented by a superimposition of the peak-sharpened speckle patterns from the resolution-enhanced images.

公开(公告)号：US20200323953A1

公开(公告)日：2020-10-15

申请号：US16683188

申请日：2019-11-13

Applicant: Norwegian University of Science and Technology

Inventor： Marit Otterlei

IPC: A61K38/17 ,  A61K38/08 ,  A61K47/64 ,  A61K45/06

Abstract: The present invention provides an agent, or composition containing an agent, for use in treating or preventing hypercytokinemia in a subject resulting from cytokine release from non-proliferating immune cells in blood, wherein said agent comprises: (i) an oligopeptidic compound comprising a PCNA interacting motif and a domain that facilitates the cellular uptake of said compound, wherein the PCNA interacting motif is X1X2X3X4X5 (SEQ ID NO: 1) and wherein: X1 is a basic amino acid; X2 is an aromatic amino acid; X3 is an uncharged amino acid other than an aromatic amino acid, Glycine (G) and Proline (P); X4 is any amino acid other than Proline (P), an acidic amino acid or an aromatic amino acid; and X5 is a basic amino acid or Proline (P); or (ii) a nucleic acid molecule comprising a sequence encoding the oligopeptidic compound of (i). In certain aspects the agent and compositions of the invention may be used as single agents. In other aspects of the invention agents and compositions of the invention may be used in conjunction with one or more additional active agents, such as kinase inhibitors.

公开(公告)号：US10714337B2

公开(公告)日：2020-07-14

申请号：US15749228

申请日：2016-08-01

Applicant: CRAYONANO AS ,  NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU)

Inventor： Dong Chul Kim ,  Ida Marie Høiaas ,  Mazid Munshi ,  Bjørn Ove Fimland ,  Helge Weman ,  Dingding Ren ,  Dasa Dheeraj

IPC: H01L21/02

Abstract: A process for growing nanowires or nanopyramids comprising: (I) providing a graphitic substrate and depositing AlGaN, InGaN, AlN or AlGa(In)N on said graphitic substrate at an elevated temperature to form a buffer layer or nanoscale nucleation islands of said compounds; (II) growing a plurality of semiconducting group III-V nanowires or nanopyramids, preferably III-nitride nanowires or nanopyramids, on the said buffer layer or nucleation islands on the graphitic substrate, preferably via MOVPE or MBE.

公开(公告)号：US20190247516A1

公开(公告)日：2019-08-15

申请号：US16181723

申请日：2018-11-06

Applicant: Norwegian University of Science and Technology (NTNU) ,  University of Connecticut

Inventor： Justin Cotney ,  Clifford Kentros ,  Stefan Blankvoort ,  Rajeevkumar Raveendran Nair

IPC: A61K48/00 ,  C12N7/00 ,  C12N15/113 ,  A61P25/28

CPC classification number: A61K48/0041 ,  A61P25/28 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/122 ,  C12N2310/3519 ,  C12N2310/531 ,  C12N2750/14143 ,  C12N2750/14171

Abstract: A delivery vehicle which comprises a nucleic acid construct, wherein the nucleic acid construct comprises (i) an enhancer which specifically drives gene expression in cells of the entorhinal cortex (ii) a promoter; and (iii) a therapeutic gene, wherein said enhancer, promoter and therapeutic gene are operatively linked, said enhancer and therapeutic gene are heterologous, and said delivery vehicle is suitable for delivery of the nucleic acid construct to the brain of a mammal.

公开(公告)号：US10347791B2

公开(公告)日：2019-07-09

申请号：US15744457

申请日：2016-07-13

Applicant: CRAYONANO AS ,  NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU)

Inventor： Dong Chul Kim ,  Ida Marie E. Høiaas ,  Carl Philip J. Heimdal ,  Bjørn Ove M. Fimland ,  Helge Weman

IPC: H01L31/00 ,  H01L33/00 ,  H01L33/08 ,  H01L31/0352 ,  H01L33/18 ,  H01L33/24 ,  H01L33/44 ,  H01L33/06

Abstract: A composition of matter comprising: a graphitic substrate optionally carried on a support; a seed layer having a thickness of no more than 50 nm deposited directly on top of said substrate, opposite any support; and an oxide or nitride masking layer directly on top of said seed layer; wherein a plurality of holes are present through said seed layer and through said masking layer to said graphitic substrate; and wherein a plurality of nanowires or nanopyramids are grown from said substrate in said holes, said nanowires or nanopyramids comprising at least one semiconducting group III-V compound.

公开(公告)号：US20190202568A1

公开(公告)日：2019-07-04

申请号：US16326762

申请日：2017-08-22

Applicant: NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Kasper T. BORUP ,  Tor A. JOHANSEN ,  Kim L. SØRENSEN

IPC: B64D15/22 ,  B64D15/12 ,  B64C39/02

CPC classification number: B64D15/22 ,  B64C39/024 ,  B64C2201/00 ,  B64D15/12

Abstract: Disclosed herein is a method for determining if icing has occurred on a surface of an aircraft, the method comprising: heating a surface of an air craft, after the heating has stopped, measuring the temperature of the surface as it cools, and determining if icing has occurred on the surface in dependence on the measured temperature. Advantageously, embodiments provide improved techniques for the detection of icing and the prevention, or mitigation, of icing when it has formed. Embodiments are particularly advantageous when implemented on small UAVs in civilian applications for which autonomous and energy efficient operation is particularly important.

公开(公告)号：US20190175138A1

公开(公告)日：2019-06-13

申请号：US16323174

申请日：2017-08-04

Applicant: Norwegian University of Science and Technology (NTNU)

Inventor： Hans TORP ,  Torbjorn HERGUM

IPC: A61B8/06 ,  A61B8/00 ,  A61B8/08

Abstract: A system for monitoring blood flow in a patient comprises a first unit having an ultrasound transducer and a fastener for fastening the unit to the patient. A controller subsystem comprises the first unit and a separate second unit. The controller subsystem is configured to: control the ultrasound transducer to transmit plane-wave pulses into the patient in a propagation direction; sample reflections of the plane-wave pulses, received at the ultrasound transducer, from a region within the patient, to generate pulse-Doppler response signals; and process the pulse-Doppler response signals to estimate a series of values, over time, of a measure proportional, but not equal, to the total blood volume flow passing through the region. A monitoring subsystem is configured to monitor the series of values over time and to generate a signal if a set of one or more of the values satisfies a predetermined criterion.

公开(公告)号：US20180355836A1

公开(公告)日：2018-12-13

申请号：US16108287

申请日：2018-08-22

Applicant: Norwegian University of Science and Technology

Inventor： Jørgen Hals TODALSHAUG

IPC: F03B13/18 ,  F03B13/20

CPC classification number: F03B13/181 ,  F03B13/1845 ,  F03B13/1885 ,  F03B13/1895 ,  F03B13/20 ,  F05B2260/502 ,  Y02E10/38

Abstract: A wave energy convertor for extracting energy from ocean waves. The wave energy convertor may include a buoy arranged to oscillate relative to a reference point about an equilibrium position and a negative spring device connected between the buoy and the reference point, wherein the negative spring device is for applying a positive force in the direction of displacement when the buoy moves away from the equilibrium position.

公开(公告)号：USD830551S1

公开(公告)日：2018-10-09

申请号：US29483969

申请日：2014-03-05

Applicant: Norwegian University of Science and Technology (NTNU)

Designer： Daniel Fossum Bratbak ,  Ståle Nordgård