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31.发明申请公开(公告)号：US20150158926A1
公开(公告)日：2015-06-11
申请号：US14555308
申请日：2014-11-26
申请人： OPKO BIOLOGICS, LTD.
发明人： FUAD FARES , UDI EYAL FIMA
CPC分类号： A61K38/27 , A61K38/24 , A61K47/02 , A61K47/12 , C07K14/505 , C07K14/555 , C07K14/59 , C07K14/61 , C07K2319/00 , C07K2319/31 , G01N33/74 , G01N2333/65 , G01N2800/52
摘要： CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
摘要翻译： 公开了CTP-修饰的人生长激素多肽和药物制剂和包含其的药物组合物以及制备和使用它们的方法。
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公开(公告)号：US11976106B2
公开(公告)日：2024-05-07
申请号：US16317283
申请日：2017-07-11
申请人： OPKO BIOLOGICS LTD.
IPC分类号： A61K38/00 , A61K47/64 , C07K14/745
CPC分类号： C07K14/745 , A61K47/64 , A61K38/00
摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.
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公开(公告)号：US20210371487A1
公开(公告)日：2021-12-02
申请号：US17164438
申请日：2021-02-01
申请人： OPKO BIOLOGICS LTD.
IPC分类号： C07K14/59 , C07K14/61 , C07K14/505 , C07K14/555 , C07K14/575 , C12N9/64 , C12N15/85
摘要： Disclosed herein is a method for manufacturing a recombinant polypeptide of interest modified by a CTP extension in a mammalian cells culture system.
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公开(公告)号：US20200254065A1
公开(公告)日：2020-08-13
申请号：US16787810
申请日：2020-02-11
申请人： OPKO Biologics Ltd.
发明人： Oren Hershkovitz , Ahuva Bar-Ilan , Vered Lev
摘要： Compositions which include glucagon-like peptide-2 (GLP-2) analogs, GLP-2 analogs with reversible or non-reversible linkers attached to one or more amino acid positions of the GLP-2 analog, and GLP-2 analogs linked to one or more polyethylene glycol polymers (PEG) via reversible or non-reversible linkers are disclosed. Also disclosed are pharmaceutical compositions comprising: the GLP-2 analogs; GLP-2 analogs linked solely to reversible or non-reversible linkers; the reverse PEGylated GLP-2 analogs; and the non-reversibly PEGylated GLP-2 analogs, as well as methods of using the same.
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公开(公告)号：US10144921B2
公开(公告)日：2018-12-04
申请号：US15159641
申请日：2016-05-19
申请人： OPKO Biologics Ltd.
发明人： Udi Eyal Fima , Gili Hart
IPC分类号： C07K14/00 , C07K16/00 , A61K38/00 , C12N9/50 , C07K14/505 , C07K14/59 , C07K14/745 , C12N9/64 , A61K47/64
摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
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公开(公告)号：US10119132B2
公开(公告)日：2018-11-06
申请号：US14948890
申请日：2015-11-23
申请人： OPKO Biologics Ltd.
发明人： Udi Eyal Fima , Gili Hart
IPC分类号： A61K38/36 , C07K14/745 , C12N9/64 , C12N9/96 , C07K14/505 , C07K14/59 , A61K38/00 , A61K38/48
摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
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公开(公告)号：US20180186852A1
公开(公告)日：2018-07-05
申请号：US15898384
申请日：2018-02-16
申请人： Opko Biologics Ltd.
发明人： Fuad FARES , Udi Eyal Fima
IPC分类号： C07K14/555 , C07K14/61 , C07K14/505 , C07K14/59 , A61K47/64 , A61K38/19
CPC分类号： C07K14/555 , A61K38/19 , A61K47/64 , C07K14/505 , C07K14/59 , C07K14/61 , C07K2319/00 , C07K2319/31 , C07K2319/35 , C07K2319/91
摘要： A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
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公开(公告)号：US20180087042A1
公开(公告)日：2018-03-29
申请号：US15484776
申请日：2017-04-11
申请人： Opko Biologics Ltd.
发明人： Udi Eyal FIMA , Gili HART
IPC分类号： C12N9/96 , C12N9/64 , C07K14/745 , C07K14/505 , C07K14/59 , A61K38/00
摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
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公开(公告)号：US20180050113A1
公开(公告)日：2018-02-22
申请号：US15801554
申请日：2017-11-02
申请人： OPKO Biologics Ltd.
发明人： Udi Eyal Fima , Oren Hershkovitz
摘要： A composition which includes oxyntomodulin and polyethylene glycol polymer (PEG polymer) linked via a reversible linker such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS) is disclosed. Pharmaceutical compositions comprising the reverse pegylated oxyntomodulin and methods of using same are also disclosed.
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公开(公告)号：US09663778B2
公开(公告)日：2017-05-30
申请号：US14274061
申请日：2014-05-09
申请人： OPKO Biologics Ltd.
发明人： Udi Eyal Fima , Gili Hart
IPC分类号： C12N15/09 , C12N5/00 , C07K14/745 , C12N9/96 , C12N9/64 , C07K14/59 , C07K14/505 , A61K38/00
CPC分类号： C12N9/96 , A61K38/00 , C07K14/505 , C07K14/59 , C07K14/745 , C07K2319/31 , C12N9/6437 , C12N9/644
摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
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