公开(公告)号：US4785090A

公开(公告)日：1988-11-15

申请号：US704077

申请日：1985-02-21

申请人： Takashi Tsuruoka ,  Seiji Shibahara ,  Katsuyoshi Iwamatsu ,  Tsuneo Okonogi ,  Satoru Nakabayashi ,  Yasushi Murai ,  Hiroko Ogino ,  Kiyoaki Katano ,  Takashi Yoshida ,  Shigeharu Inoue ,  Shunzo Fukatsu ,  Shinichi Kondo

发明人： Takashi Tsuruoka ,  Seiji Shibahara ,  Katsuyoshi Iwamatsu ,  Tsuneo Okonogi ,  Satoru Nakabayashi ,  Yasushi Murai ,  Hiroko Ogino ,  Kiyoaki Katano ,  Takashi Yoshida ,  Shigeharu Inoue ,  Shunzo Fukatsu ,  Shinichi Kondo

IPC分类号： C07D213/64 ,  C07D213/68 ,  C07D221/04 ,  C07D501/36 ,  C07D501/38 ,  A61K31/545

CPC分类号： C07D221/04 ,  C07D213/64 ,  C07D213/68

摘要： This is a class of antibacterial compounds of the formula: ##STR1## wherein Y is straight or branched alkyl or alkenyl chain, cycloalkanomethyl of 3-6 carbon atoms, each group being optionally substituted by halogen, or a group ##STR2## wherein n is 0 or an integer of 1-3, A is a group --COR.sup.3 wherein R.sup.3 is hydroxy, a group ##STR3## wherein R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or alkyl of 1-5 carbon atoms, a group ##STR4## or a 5- or 6-membered heterocyclic group containing nitrogen and/or sulfur, and R.sup.1 and R.sup.2, which may be the same or different, are hydrogen, alkyl of 1-5 carbon atoms, or R.sup.1 and R.sup.2 may be combined together to form cycloalkylidene of 3-5 carbon atoms, and Z is a group of the formula: ##STR5## wherein m is 0 or an integer of 3-5, R.sup.6 is hydrogen or alkyl of 1-3 carbon atoms, and R.sup.7, when m is an integer of 3-5, is alkyl of 1-5 carbon atoms, alkenyl, cyclopropyl, a group --(CH.sub.2).sub.p B wherein p is 0 or an integer of 1-3 and B is amino, alkyl-substituted amino, hydroxy, carboxy, carbamoyl, trifluoromethyl, sulfonic acid, sulfonic acid amide, alkylthio or cyano or, when m is 0, is alkyl of 1-5 carbon atoms, which may optionally be substituted by halogen, alkenyl, a group ##STR6## wherein R.sup.8 is hydrogen, alkyl of 1-4 carbon atoms or phenyl, or cyclopropyl, and a salt thereof.

摘要翻译： 这是一类具有下式的抗菌化合物：其中Y是直链或支链烷基或烯基链，3-6个碳原子的环烷基甲基，每个基团任选被卤素取代，或基团< 其中n为0或1-3的整数，A为基团-COR 3，其中R 3为羟基，其中R 4和R 5可以相同或不同，为氢或1-5碳的烷基 原子，基团或含有氮和/或硫的5-或6-元杂环基，R 1和R 2可以相同或不同，为氢，1-5个碳原子的烷基或R1 并且R 2可以组合在一起形成3-5个碳原子的亚烷基，Z是下式的基团：其中m是0或3-5的整数，R6是氢或1-3个碳的烷基 原子和R 7，当m是3-5的整数时，是1-5个碳原子的烷基，烯基，环丙基，基团 - （CH 2）pB，其中p是0或1-3的整数，B是氨基 ，烷基取代的氨基 羟基，羧基，氨基甲酰基，三氟甲基，磺酸，磺酸酰胺，烷硫基或氰基，或当m为0时，其为1-5个碳原子的烷基，其可任选被卤素，链烯基，基团 其中R8是氢，1-4个碳原子的烷基或苯基，或环丙基及其盐。

公开(公告)号：US4534898A

公开(公告)日：1985-08-13

申请号：US515422

申请日：1983-07-20

申请人： Seiji Shibahara ,  Tsuneo Okonogi ,  Yasushi Murai ,  Shunzo Fukatsu ,  Tadashi Wakazawa ,  Taro Niida ,  Burton G. Christensen

发明人： Seiji Shibahara ,  Tsuneo Okonogi ,  Yasushi Murai ,  Shunzo Fukatsu ,  Tadashi Wakazawa ,  Taro Niida ,  Burton G. Christensen

IPC分类号： C07D498/04 ,  C07D205/085 ,  C07D403/12 ,  C07D505/00 ,  C07F9/568 ,  C07D419/14

CPC分类号： C07D403/12 ,  C07D205/085 ,  C07D505/00 ,  C07F9/5683

摘要： This invention relates to 1-oxa-1-dethia-cephalosporins which are useful as anti-biotics.

摘要翻译： 本发明涉及可用作抗生物素的1-氧杂-1-脱氢头孢菌素。

公开(公告)号：US4290972A

公开(公告)日：1981-09-22

申请号：US92940

申请日：1979-11-09

申请人： Toshio Yoneta ,  Seiji Shibahara ,  Shigeo Seki ,  Shunzo Fukatsu

发明人： Toshio Yoneta ,  Seiji Shibahara ,  Shigeo Seki ,  Shunzo Fukatsu

IPC分类号： C07C227/04 ,  A61K31/19 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C227/00 ,  C07C227/06 ,  C07C227/26 ,  C07C229/04 ,  C07C229/06 ,  C07C229/22 ,  C07C229/26 ,  C07C99/10 ,  C07C121/42 ,  C07C121/453

CPC分类号： C07C255/00 ,  Y02P20/55

摘要： 4-Amino-2-hydroxybutyric acid or 2,4-diaminobutyric acid may be readily produced by a new process comprising reacting a propionic acid compound containing a .beta.-carboxamido substituent (-CONH.sub.2) on the carbon atom at the 3-position and optionally containing hydroxyl substituent and protected or unprotected amino substituent on the .alpha.-carbon atom thereof, with an alkanoic acid anhydride in liquid pyridine to convert the carboxamido group into a nitrile group, with occasional acylation of a .alpha.-hydroxyl group, occasionally removing the alkanoyl group from the .alpha.-acyloxyl group of the resulting nitrile intermediate, and then reducing the resultant nitrile compound with hydrogen to convert the nitrile group into an aminomethyl group, and further optionally removing the residual amino-protecting group from the resultant 4-aminobutyric acid compound.

摘要翻译： 4-氨基-2-羟基丁酸或2,4-二氨基丁酸可以通过一种新方法容易地产生，包括使含有β-羧酰胺基取代基（-CONH 2）的丙酸化合物在3-位上的碳原子上和任选地 在其α-碳原子上含有羟基取代基和被保护或未被保护的氨基取代基，与链烷酸酐在液体吡啶中，将羧酰胺基转化为腈基，偶尔酰化α-羟基，偶尔除去烷酰基 由得到的腈中间体的α-酰氧基，然后用氢还原得到的腈化合物，将腈基转化为氨基甲基，进一步任选地从所得的4-氨基丁酸化合物中除去残留的氨基保护基。

公开(公告)号：US10698272B2

公开(公告)日：2020-06-30

申请号：US13253276

申请日：2011-10-05

申请人： Seiji Shibahara ,  Shizuo Mizukami

发明人： Seiji Shibahara ,  Shizuo Mizukami

IPC分类号： G02F1/1345 ,  G02F1/1333

摘要： A display device including: a display cell that includes a first substrate and a second substrate that are arranged to be opposing, includes a wiring region that is wider than the first substrate on the second substrate, and includes an electrode in the wiring region; a wiring substrate in which at least a portion is arranged to be opposing the wiring region and which is electrically connected to the electrode; a front panel that is provided on a front surface of the first substrate; and a desiccating bonding agent that fixes the front panel to the first substrate while covering from at least a portion of a side surface of the first substrate to a connection portion between the electrode and the wiring substrate.

公开(公告)号：US08643810B2

公开(公告)日：2014-02-04

申请号：US12875666

申请日：2010-09-03

申请人： Seiji Shibahara

发明人： Seiji Shibahara

IPC分类号： G02F1/1335

CPC分类号： G02F1/1335 ,  G02F1/133504 ,  G02F1/133514 ,  G02F1/133528 ,  G02F2201/086

摘要： A liquid crystal display device includes: one side substrate; the other side substrate that is disposed to be opposed to the one side substrate; a liquid crystal layer that is sandwiched between the one side substrate and the other side substrate; and a light source that illuminates light on the liquid crystal layer from the outside of the other side substrate. At a specific peak wavelength, in a region shorter than a wavelength of blue light in a visible light region of the light illuminated from the light source, a transmittance from the other side substrate to the liquid crystal layer is smaller than a transmittance from the one side substrate to the liquid crystal layer.

摘要翻译： 液晶显示装置包括：一侧基板; 设置成与一侧基板相对的另一侧基板; 夹在所述一侧基板和所述另一侧基板之间的液晶层; 以及从另一侧基板的外侧照射液晶层上的光的光源。 在特定峰值波长处，在从光源照射的光的可见光区域中比蓝色光的波长短的区域中，从另一侧基板到液晶层的透射率小于来自该光源的透射率 侧基板到液晶层。

公开(公告)号：US20130010244A1

公开(公告)日：2013-01-10

申请号：US13527738

申请日：2012-06-20

申请人： Shunichi Suwa ,  Seiji Shibahara ,  Masashi Miyakawa ,  Masahiko Nakamura ,  Tadaaki Isozaki

发明人： Shunichi Suwa ,  Seiji Shibahara ,  Masashi Miyakawa ,  Masahiko Nakamura ,  Tadaaki Isozaki

IPC分类号： G02F1/1337

CPC分类号： G02F1/133711 ,  C09K19/10 ,  C09K19/3001 ,  C09K19/56 ,  G02F1/133703 ,  G02F1/133707 ,  G02F1/133723 ,  G02F1/133753 ,  G02F1/133788 ,  G02F2001/133726 ,  G02F2001/133742 ,  G02F2001/133757 ,  G02F2001/13712 ,  Y10T428/10 ,  Y10T428/1005

摘要： Disclosed herein is a liquid crystal display having a liquid crystal display element, the liquid crystal display element including: a pair of alignment films provided on mutually facing sides of a pair of substrates; and a liquid crystal layer which is provided between the pair of alignment films and contains a liquid crystal molecule having a negative dielectric anisotropy, wherein at least one of the pair of alignment films contains a cross-linked compound obtained by cross-linking a polymer compound having a cross-linkable functional group as a side chain, the liquid crystal layer further contains a molecule which has a ring structure and a spacer linking the ring structure, and the liquid crystal molecule is given a pre-tilt by the cross-linked compound.

摘要翻译： 本发明是一种具有液晶显示元件的液晶显示器，该液晶显示元件包括：设置在一对基板的相对面侧的一对取向膜; 以及液晶层，其设置在所述一对取向膜之间并且包含具有负介电各向异性的液晶分子，其中所述一对取向膜中的至少一个包含通过交联高分子化合物获得的交联化合物 具有可交联官能团作为侧链的情况下，液晶层还含有具有环结构的分子和连接环结构的间隔基，并且通过交联化合物给予液晶分子的预倾斜 。

公开(公告)号：US08318684B2

公开(公告)日：2012-11-27

申请号：US12300468

申请日：2007-05-15

申请人： Keiichi Numata ,  Noriyuki Okujo ,  Siew Eim Khor ,  Lee Li Tan ,  Annie George ,  Szu Ting Ng ,  Chin Jye Tan ,  Hironobu Iinuma ,  Yasuo Fukagawa ,  Kunimoto Hotta ,  Seiji Shibahara ,  Shinichi Kondo ,  Satoshi Nimura

发明人： Keiichi Numata ,  Noriyuki Okujo ,  Siew Eim Khor ,  Lee Li Tan ,  Annie George ,  Szu Ting Ng ,  Chin Jye Tan ,  Hironobu Iinuma ,  Yasuo Fukagawa ,  Kunimoto Hotta ,  Seiji Shibahara ,  Shinichi Kondo ,  Satoshi Nimura

IPC分类号： A61K31/70 ,  C07H17/08 ,  C12P19/62

CPC分类号： C07H17/04 ,  A61K31/04 ,  A61K31/7048 ,  C12P17/08 ,  A61K2300/00

摘要： Seven novel antibiotic substances can be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below: These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in humans and animals.

摘要翻译： 可以通过培养已经从土壤样品中分离并被称为微双歧杆菌（Microbispora sp。）的微生物菌株来生产七种新型抗生素物质。 A 34030（根据布达佩斯条约保存在访问号FERM BP-10505）。 这七种抗生素物质分别被称为双吡啶A1，双吡啶B2，双吡哆醛A3，双吡啶B1，双吡啶B2a，双吡啶B2b和双吡啶B3。 这些双吡啶衍生物是具有如以下通式（III）统称为化学结构的新型化合物：这些双酚化物对各种细菌，特别是革兰氏阳性菌及其抗生素抗性菌株具有高抗菌活性， 因此这些双吡哆醇各自对于治疗性地治疗人和动物中革兰氏阳性菌的细菌感染是有效和有用的。

公开(公告)号：US08111358B2

公开(公告)日：2012-02-07

申请号：US11991791

申请日：2006-06-14

申请人： Seiji Shibahara

发明人： Seiji Shibahara

IPC分类号： G02F1/1335

CPC分类号： G02F1/134309 ,  G02F1/1337 ,  G02F1/134363

摘要： Scanning signal lines (41) and data signal lines (47) are arranged so as to cross each other, and common signal lines (42) and the scanning signal lines (41) are arranged to be parallel to each other. Moreover, a polarlizer (37) provided to an upper substrate (36) and a polarlizer (38) provided to a lower substrate (30) are arranged such that absorption axial directions (37a) and (38a) cross at an angle that is orthogonal. Moreover, the absorption axial directions (37a) and (38a) are arranged so as to be perpendicular to or parallel to directions in which the data signal lines (47), the scanning signal lines (41), and the common signal lines (42) are extended, respectively. This realizes an improved response speed and an increased transmissivity.

摘要翻译： 扫描信号线（41）和数据信号线（47）被布置为彼此交叉，并且公共信号线（42）和扫描信号线（41）被布置为彼此平行。 此外，设置到上基板（36）的极化器（37）和设置在下基板（30）上的极化装置（38）被布置成使得吸收轴向（37a）和（38a）以正交的角度交叉 。 此外，吸收轴方向（37a）和（38a）被布置成垂直于或并联于数据信号线（47），扫描信号线（41）和公共信号线（42）的方向 ）分别扩展。 这实现了改进的响应速度和增加的透射率。

公开(公告)号：US06985200B2

公开(公告)日：2006-01-10

申请号：US10680574

申请日：2003-10-07

申请人： Koichi Miyachi ,  Seiji Shibahara

发明人： Koichi Miyachi ,  Seiji Shibahara

IPC分类号： G02F1/1337

CPC分类号： G02F1/133711 ,  G02F1/141 ,  G02F2001/133726 ,  G02F2001/133769 ,  G02F2001/1412

摘要： A liquid crystal optical element includes: first and second substrates; a liquid crystal layer provided between the substrates; first and second electrode layers provided on the first and second substrates, respectively, so as to face each other with the liquid crystal layer interposed between them; and first and second switching layers, which are provided between the first electrode layer and the liquid crystal layer and between the second electrode layer and the liquid crystal layer, respectively, and each of which includes molecules changing their orientation directions in response to a voltage applied between the first and second electrode layers. The liquid crystal layer changes its orientation state as the molecules in the first and second switching layers change their orientation directions. Each of the molecules included in one of the first and second switching layers and an associated one of the molecules included in the other switching layer behave as enantiomers.

摘要翻译： 液晶光学元件包括：第一和第二基板; 设置在所述基板之间的液晶层; 分别设置在第一和第二基板上的第一和第二电极层，以便彼此间夹着液晶层而彼此面对; 以及分别设置在第一电极层和液晶层之间以及第二电极层和液晶层之间的第一和第二开关层，并且其中的每一个包括响应于施加的电压而改变其取向方向的分子 在第一和第二电极层之间。 当第一和第二开关层中的分子改变其取向方向时，液晶层改变其取向状态。 包括在第一和第二开关层中的一个中的每个分子以及包含在另一个开关层中的相关联的一个分子表现为对映异构体。

公开(公告)号：US20050185131A1

公开(公告)日：2005-08-25

申请号：US11035401

申请日：2005-01-14

申请人： Koichi Miyachi ,  Seiji Shibahara ,  Iichiro Inoue ,  Shoichi Ishihara ,  Takako Koide

发明人： Koichi Miyachi ,  Seiji Shibahara ,  Iichiro Inoue ,  Shoichi Ishihara ,  Takako Koide

IPC分类号： G02F1/1333 ,  C09K19/00 ,  C09K19/02 ,  C09K19/42 ,  C09K19/58 ,  G02F1/07 ,  G02F1/133 ,  G02F1/137 ,  G09G3/36

CPC分类号： C09K19/586 ,  C09K19/02 ,  C09K2019/0418 ,  C09K2019/0492 ,  G02F1/07 ,  G02F1/13718 ,  G02F2001/13775

摘要： Each of a pair of substrates respectively comprises an electrode and a rubbed alignment film on one surface, while the other surface is provided with a polarizer. The substrates are placed so that the surfaces provided with the alignment films are opposed to each other, and the area between the substrates is filled with a medium to form a material layer. Then, a medium made of a negative-type liquid crystalline compound sing a photopolymerizable monomer and a polymerization initiator is injected into the material layer held between the substrates. Further, ultra violet irradiation is performed with the medium exhibiting a liquid crystal phase, so that the photopolymerized monomer is polymerized, thus forming a polymer chain. In this manner, obtained is a display element, that causes change in degree of optical anisotropy in response to application of electric (external) field, which display element can be driven by a lower intensity electric (external) field.

摘要翻译： 一对基板中的每一个分别在一个表面上包括电极和摩擦取向膜，而另一个表面设置有偏振器。 将基板放置成使得设置有取向膜的表面彼此相对，并且用介质填充基板之间的区域以形成材料层。 然后，将由可聚合单体和聚合引发剂的负型液晶化合物制成的介质注入保持在基板之间的材料层。 此外，在显示液晶相的介质中进行紫外线照射，使得光聚合单体聚合，从而形成聚合物链。 以这种方式，获得的是显示元件，其响应于电（外部）场的应用而导致光学各向异性程度的变化，该显示元件可以由较低强度的电（外部）场驱动。