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    IMPLANTABLE PROSTHESIS WITH HOLLOW STRUTS AND PASSIVATING COATING, AND METHOD OF MAKING SAME
    31.
    发明申请
    IMPLANTABLE PROSTHESIS WITH HOLLOW STRUTS AND PASSIVATING COATING, AND METHOD OF MAKING SAME 审中-公开
    具有中空砂浆和钝化涂料的可植入物及其制备方法

    公开(公告)号：US20130345793A1

    公开(公告)日：2013-12-26

    申请号：US13533738

    申请日：2012-06-26

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: A61F2/82 ,  B05D7/00

    CPC classification number: A61L31/022 ,  A61F2/86 ,  A61F2250/0068 ,  A61L31/088 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L31/18 ,  B05D5/08

    Abstract: An implantable prosthesis can comprise a passivating coating within a lumen of a strut and on an interior surface of a metal layer surrounding the lumen. A therapeutic agent is disposed in the lumen. A method for making an implantable prosthesis can comprise applying a passivating coating onto an interior surface of a metal layer surrounding a lumen of a strut, and followed by introducing a therapeutic agent into the lumen.

    Abstract translation: 可植入假体可以包括在支柱的内腔内和在围绕内腔的金属层的内表面上的钝化涂层。 治疗剂设置在内腔中。 用于制造可植入假体的方法可以包括将钝化涂层施加到围绕支柱内腔的金属层的内表面上，随后将治疗剂引入内腔。

    Amino acid mimetic copolymers and medical devices coated with the copolymers
    33.
    发明授权
    Amino acid mimetic copolymers and medical devices coated with the copolymers 失效
    用共聚物涂覆的氨基酸模拟共聚物和医疗器械

    公开(公告)号：US08569435B2

    公开(公告)日：2013-10-29

    申请号：US13045467

    申请日：2011-03-10

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: C08F120/58

    CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    Abstract: Biocompatible polymers are manufactured to include an amino acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.

    Abstract translation: 制造生物相容性聚合物以包括氨基酸模拟单体和一种或多种疏水丙烯酸酯单体。 选择氨基酸模拟单体以模拟氨基酸天冬酰胺或谷氨酰胺的侧链。 氨基酸模拟单体可以是2-羟基乙酰胺，3-羟基丙酰胺，丙烯酰胺，乳酰胺或甘氨酰胺的甲基丙烯酰基或丙烯酰基衍生物。 这些酰胺官能团具有中等的亲水性，几乎没有化学反应性的优点。 氨基酸模拟单体可以与一种或多种疏水丙烯酸酯单体共聚以获得所需的涂料性质。

    Method for electrostatic coating of a medical device
    35.
    发明授权
    Method for electrostatic coating of a medical device 有权
    医疗器械的静电涂布方法

    公开(公告)号：US08298607B2

    公开(公告)日：2012-10-30

    申请号：US12464602

    申请日：2009-05-12

    Applicant: Cameron K. Kerrigan ,  Stephen Pacetti

    Inventor： Cameron K. Kerrigan ,  Stephen Pacetti

    IPC: A61K9/50 ,  A61L33/00 ,  B05D3/00 ,  B05C13/00 ,  B05C11/00

    CPC classification number: A61L31/08 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02 ,  B05D1/007

    Abstract: A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.

    Abstract translation: 描述了诸如支架和气囊的医疗装置的静电涂覆方法。 该方法包括将组合物施用于具有很少或不具有导电性的医疗器械的聚合物组分。 聚合物组分可以是制造支架的主体或支柱的材料，或者可以是预先施加在支架上的聚合物涂层。 聚合物组分可以是球囊壁。 然后可以向聚合物组分施加电荷，或者聚合物组分可以接地。 药物，聚合物，生物有益剂或它们的任何组合的带电颗粒然后可以静电沉积在医疗装置或医疗装置上的涂层上。 组合物的一个实例是碘，碘，碘化物，碘酸盐，其复合物或盐，其也可以赋予医疗装置成像能力。

    MULTI-SEGMENT PROTECTIVE SHEATH FOR EXPANDABLE MEDICAL DEVICES
    36.
    发明申请
    MULTI-SEGMENT PROTECTIVE SHEATH FOR EXPANDABLE MEDICAL DEVICES 审中-公开
    用于可扩展医疗设备的多部分保护性护理

    公开(公告)号：US20120136367A1

    公开(公告)日：2012-05-31

    申请号：US12955132

    申请日：2010-11-29

    Applicant: Stephen Pacetti ,  Binh T. Nguyen

    Inventor： Stephen Pacetti ,  Binh T. Nguyen

    IPC: A61B17/00

    CPC classification number: A61B17/00234 ,  A61B46/13 ,  A61B2017/00336 ,  A61B2017/00477 ,  A61B2017/22001 ,  A61M25/0668 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1081

    Abstract: A protective sheath for covering an elongated medical device includes two or more sheath segments. Each sheath segment has a lumen extending the length of the segment with an inner diameter sufficient to receive the elongated medical device within the lumen. Each sheath segment also has a first end and a second end, with the first end of each sheath segment being configured to engage the second end of an adjacent sheath segment in an interlocking engagement. The first end of each sheath segment has a first coupling portion and the second end of each sheath segment has a second coupling portion, which are complementary of one another and configured to couple adjacent sheath segments to one another when the first end of one sheath segment is engaged with the second end of an adjacent sheath segment.

    Abstract translation: 用于覆盖细长医疗装置的护套包括两个或更多个鞘段。 每个鞘段具有延伸段的长度的内腔，其内径足以容纳管腔内的细长医疗装置。 每个鞘段还具有第一端和第二端，每个鞘段的第一端构造成以互锁接合方式接合相邻护套段的第二端。 每个鞘段的第一端具有第一联接部分，并且每个鞘段的第二端具有第二联接部分，第二联接部分彼此互补并且被配置为当一个鞘段的第一端部将相邻的鞘段彼此耦合时 与相邻鞘段的第二端接合。

    Method for coating implantable medical devices
    37.
    发明授权
    Method for coating implantable medical devices 有权
    可植入医疗器械的涂敷方法

    公开(公告)号：US08007855B2

    公开(公告)日：2011-08-30

    申请号：US11825443

    申请日：2007-07-05

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: B05D3/02 ,  A61L33/00 ,  A61F2/06

    CPC classification number: B05D3/0486 ,  A61L31/10

    Abstract: A method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity.

    Abstract translation: 公开了一种涂覆可植入医疗装置的方法，该方法包括将组合物施加到装置上并在具有相对湿度增加的环境中在升高的温度下干燥组合物。

    Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers
    38.
    发明授权
    Copolymers having zwitterionic moieties and dihydroxyphenyl moieties and medical devices coated with the copolymers 有权
    具有两性离子部分和二羟基苯基部分的共聚物以及用共聚物涂覆的医疗装置

    公开(公告)号：US07928176B2

    公开(公告)日：2011-04-19

    申请号：US11942695

    申请日：2007-11-19

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: C08F130/02

    CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    Abstract: Copolymers are manufactured to include a zwitterionic monomer (e.g., methacryloyloxyethyl phosphorylcholine monomer), a dihydroxyphenyl derivatized monomer, and optionally one or more additional monomers. The dihydroxyphenyl derivatized monomer gives the copolymers excellent adhesion properties. Optional monomers include a cationic amino monomer, a hydrocarbon monomer, and/or a hydrophilic monomer. The copolymers are biocompatible and can be used with medical devices.

    Abstract translation: 制备共聚物以包括两性离子单体（例如，甲基丙烯酰氧基乙基磷酸胆碱单体），二羟基苯基衍生的单体和任选的一种或多种另外的单体。 二羟基苯基衍生的单体使共聚物具有优异的粘合性能。 任选的单体包括阳离子氨基单体，烃单体和/或亲水单体。 共聚物是生物相容的并且可以与医疗装置一起使用。

    METHODS FOR MANUFACTURING AMINO ACID MIMETIC COPOLYMERS AND USE OF SAME
    40.
    发明申请
    METHODS FOR MANUFACTURING AMINO ACID MIMETIC COPOLYMERS AND USE OF SAME 失效
    制备氨基酸类共聚物的方法及其用途

    公开(公告)号：US20100022663A1

    公开(公告)日：2010-01-28

    申请号：US12575720

    申请日：2009-10-08

    Applicant: Stephen Pacetti

    Inventor： Stephen Pacetti

    IPC: A61L27/16 ,  C08F222/38

    CPC classification number: A61L27/54 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/00 ,  C08L27/18

    Abstract: Biocompatible polymers are manufactured to include an ammo acid mimetic monomer and one or more hydrophobic acrylate monomers. The amino acid mimetic monomers are selected to mimic the side chain of the amino acids asparagine or glutamine. The amino acid mimetic monomer can be a methacryloyl or acryloyl derivative of 2-hydroxyacetamide, 3-hydroxypropionamide, alaninamide, lactamide, or glycinamide. These amide functional groups offer the advantage of moderate hydrophilicity with little chemical reactivity. The amino acid mimetic monomer can be copolymerized with one or more hydrophobic acrylate monomers to obtain desired coating properties.

    Abstract translation: 制备生物相容性聚合物以包含氨基酸模拟单体和一种或多种疏水性丙烯酸酯单体。 选择氨基酸模拟单体以模拟氨基酸天冬酰胺或谷氨酰胺的侧链。 氨基酸模拟单体可以是2-羟基乙酰胺，3-羟基丙酰胺，丙烯酰胺，乳酰胺或甘氨酰胺的甲基丙烯酰基或丙烯酰基衍生物。 这些酰胺官能团具有中等的亲水性，几乎没有化学反应性的优点。 氨基酸模拟单体可以与一种或多种疏水丙烯酸酯单体共聚以获得所需的涂料性质。

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