公开(公告)号：US20180369538A1

公开(公告)日：2018-12-27

申请号：US15780834

申请日：2016-11-04

Applicant: THE ASAN FOUNDATION ,  AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Deok Hee LEE ,  Ji Hoon SHIN ,  Seon Moon HWANG ,  Tae Il KIM ,  Ga Young LEE ,  Eun Joung KIM ,  Jin Ho YOON ,  Seng Yong CHUN ,  Ki Dong PARK ,  Yun Ki LEE

IPC: A61M25/00 ,  A61L29/14

Abstract: Provided is a catheter to be inserted into an object. The catheter includes a main body having a tubular shape and an expansion layer formed on an outer circumferential surface of the main body, and the expansion layer contains an expandable material which is expanded by contact with a liquid.

公开(公告)号：US09802994B2

公开(公告)日：2017-10-31

申请号：US14408275

申请日：2013-06-14

Applicant: THE ASAN FOUNDATION

Inventor： Jung-Min Koh ,  Ghi Su Kim ,  Seung Hun Lee ,  Young-Sun Lee ,  Beom-Jun Kim

IPC: A61K38/17 ,  C07K14/47 ,  A61P19/10 ,  G01N33/68 ,  C07K14/705 ,  G01N33/50 ,  A23L33/195 ,  A61K38/00

CPC classification number: C07K14/47 ,  A23L33/195 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/70503 ,  G01N33/5023 ,  G01N33/6893 ,  G01N2500/10 ,  G01N2800/108

Abstract: A pharmaceutical composition for preventing or treating a fracture or osteoporosis, includes, as an active ingredient, a gene selected from a group consisting of slit1, slit2, slit3, robo1, robo2 and vilse, or an expressed protein of the gene. A marker composition for predicting the risk of the occurrence of a fracture or osteoporosis includes the protein. A kit for predicting the risk of the occurrence of a fracture or osteoporosis includes an antibody that specifically binds to the protein. An information provision method for predicting the risk of the occurrence of a fracture or osteoporosis includes measuring the level of expression of the slit protein through an antigen-antibody binding reaction using an antibody that specifically binds to the protein. The slit3 may increase bone formation and decrease bone reabsorption in a cellular and animal model, and has a negative correlation with the incidence rate of osteoporosis.

公开(公告)号：US20170106214A1

公开(公告)日：2017-04-20

申请号：US15293293

申请日：2016-10-14

Applicant: THE ASAN FOUNDATION

Inventor： Jung Won KWAK ,  Nurihyun JUNG ,  Byung Chul CHO ,  Seung Do AHN ,  Sang Wook LEE ,  Jae Beom BAE

IPC: A61N5/10

CPC classification number: A61N5/1065 ,  A61N5/1042 ,  A61N5/1071 ,  A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/1096

Abstract: Disclosed is a tumor surface dose enhancing radiotherapy apparatus using a magnetic field, including a radiation beam generating unit that irradiates a radiation beam towards a tumor of a patient, a magnetic field generating unit that forms a magnetic field that is parallel to the radiation beam between the radiation beam generating unit and the tumor of the patient, and a control unit that controls a surface dose of the tumor by adjusting an intensity and an effective area of the magnetic field of the magnetic field generating unit.

公开(公告)号：US20160171689A1

公开(公告)日：2016-06-16

申请号：US15049666

申请日：2016-02-22

Applicant: The Asan Foundation

Inventor： Min Ho Lee ,  Nam Kug Kim ,  Joon Beom Seo

IPC: G06T7/00 ,  G06K9/46 ,  A61B6/00 ,  G06K9/40 ,  A61B6/03 ,  G06T5/20 ,  G06K9/62

CPC classification number: G06T7/0012 ,  A61B6/032 ,  A61B6/50 ,  A61B6/5211 ,  A61B6/5258 ,  G06K9/3233 ,  G06K9/40 ,  G06K9/46 ,  G06K9/6267 ,  G06T5/20 ,  G06T7/62 ,  G06T2207/10081 ,  G06T2207/30061

Abstract: A method of quantifying a medical image is disclosed herein. The method of quantifying a medical image includes acquiring regions of interest based on a medical image; filtering the sizes of the acquired regions of interest using length scale analysis; classifying the regions of interest whose sizes have been filtered, according to the sizes of the regions of interest; and visualizing the regions of interest whose sizes have been filtered, so that the regions of interest whose sizes have been filtered are distinguished from each other in the medical image according to the sizes of the regions of interest.

Abstract translation: 本文公开了一种量化医学图像的方法。 定量医学图像的方法包括基于医学图像获取感兴趣的区域; 使用长度尺度分析过滤所获取的感兴趣区域的大小; 根据感兴趣区域的大小分类大小已被过滤的感兴趣区域; 并且可视化大小被滤波的感兴趣区域，使得根据感兴趣区域的大小，在医学图像中区分大小被滤波的感兴趣区域。

公开(公告)号：US20160120858A1

公开(公告)日：2016-05-05

申请号：US14932812

申请日：2015-11-04

Applicant: ACADEMIA SINICA ,  INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  THE ASAN FOUNDATION

Inventor： Eun-Joon KIM ,  Eun-Jae LEE ,  Hye-Jin LEE ,  Yi-Ping HSUEH ,  Tzyy-Nan Huang ,  Jae-Young KOH

IPC: A61K31/47 ,  A61K9/00

CPC classification number: A61K31/47 ,  A61K9/0019

Abstract: The present invention relates to a pharmaceutical composition for treating autism spectrum disorders, which includes clioquinol or pharmaceutically acceptable salt thereof. In addition, the present invention relates to a food composition for treating autism spectrum disorders, which includes clioquinol or pharmaceutically acceptable salt thereof.

Abstract translation: 本发明涉及用于治疗孤独症谱系障碍的药物组合物，其包括氯碘喹啉或其药学上可接受的盐。 此外，本发明涉及用于治疗自闭症谱系障碍的食品组合物，其包括氯碘喹啉或其药学上可接受的盐。

公开(公告)号：US20160108041A1

公开(公告)日：2016-04-21

申请号：US14977011

申请日：2015-12-21

Applicant: The Asan Foundation

Inventor： Gilnam Lee ,  Hye Sun Jeon ,  Ki Joon Jeon ,  Chul Yun Rhim ,  Jin Sung Kim ,  Jeongbeob Seo ,  Suk Young Cho ,  Choung Soo Kim ,  Jung Shin Lee ,  Eun Kyung Choi ,  Jung Jin Hwang ,  Bongcheol Kim

IPC: C07D471/04 ,  C07D413/04 ,  C07D221/04

CPC classification number: C07D471/04 ,  C07D221/04 ,  C07D271/10 ,  C07D271/113 ,  C07D413/04

Abstract: The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.

Abstract translation: 本发明提供由式I和式II表示的新型取代的杂环化合物或其药学上可接受的盐，溶剂合物，多晶型物，酯，互变异构体或前药，以及包含这些化合物的组合物。 所提供的化合物可用作MEK的抑制剂，并且可用于治疗炎性疾病，癌症和其它过度增生性疾病。 本发明还提供了一种治疗哺乳动物，特别是人类的炎性疾病，癌症和其它过度增生性疾病的方法。

公开(公告)号：US20150175673A1

公开(公告)日：2015-06-25

申请号：US14408275

申请日：2013-06-14

Applicant: THE ASAN FOUNDATION

Inventor： Jung-Min Koh ,  Ghi Su Kim ,  Seung Hun Lee ,  Young-Sun Lee ,  Beom-Jun Kim

IPC: C07K14/47 ,  A23L1/305 ,  G01N33/50

CPC classification number: C07K14/47 ,  A23L33/195 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/70503 ,  G01N33/5023 ,  G01N33/6893 ,  G01N2500/10 ,  G01N2800/108

Abstract: A pharmaceutical composition for preventing or treating a fracture or osteoporosis, includes, as an active ingredient, a gene selected from a group consisting of slit1, slit2, slit3, robo1, robo2 and vilse, or an expressed protein of the gene. A marker composition for predicting the risk of the occurrence of a fracture or osteoporosis includes the protein. A kit for predicting the risk of the occurrence of a fracture or osteoporosis includes an antibody that specifically binds to the protein. An information provision method for predicting the risk of the occurrence of a fracture or osteoporosis includes measuring the level of expression of the slit protein through an antigen-antibody binding reaction using an antibody that specifically binds to the protein. The slit3 may increase bone formation and decrease bone reabsorption in a cellular and animal model, and has a negative correlation with the incidence rate of osteoporosis.

Abstract translation: 用于预防或治疗骨折或骨质疏松症的药物组合物包括作为活性成分的选自由狭缝1，狭缝2，裂缝3，robo1，robo2和vilse组成的组的基因或所述基因的表达蛋白质。 用于预测骨折或骨质疏松症发生风险的标记物组合物包括蛋白质。 用于预测骨折或骨质疏松症发生风险的试剂盒包括特异性结合蛋白质的抗体。 用于预测骨折或骨质疏松症发生风险的信息提供方法包括使用特异性结合蛋白质的抗体通过抗原 - 抗体结合反应来测定狭缝蛋白的表达水平。 狭缝3可能在细胞和动物模型中增加骨形成并减少骨重吸收，并与骨质疏松症的发生率呈负相关。

公开(公告)号：US20140303657A1

公开(公告)日：2014-10-09

申请号：US14355831

申请日：2012-11-01

Applicant: THE ASAN FOUNDATION

Inventor： Song Cheol Kim ,  Ha Na Park ,  Si Nae Park

IPC: A61B17/11

CPC classification number: A61B17/11 ,  A61B17/12045 ,  A61B2017/00862 ,  A61B2017/00867 ,  A61B2017/00898 ,  A61B2017/1107 ,  A61B2017/1132 ,  A61B2017/22069 ,  A61L31/022 ,  A61L31/14 ,  A61L2400/06

Abstract: The present invention relates to an anastomosis device for blood vessels using a self-expandable material or body, and to an anastomosis method for blood vessels using same, and more particularly, to an anastomosis device for blood vessels using a self-expandable material or body, which is self-expandable in response to external stimulation and which is removable after a procedure, and to an anastomosis method for blood vessels using same.

Abstract translation: 本发明涉及一种使用自发性材料或身体的血管吻合装置及使用其的血管吻合方法，更具体地，涉及使用自发性材料或身体的血管吻合装置 ，其可以响应于外部刺激自发展，并且在手术之后是可移除的，以及使用其的血管的吻合方法。

公开(公告)号：US20250102786A1

公开(公告)日：2025-03-27

申请号：US18817025

申请日：2024-08-27

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION ,  THE ASAN FOUNDATION ,  FOUNDATION FOR INDUSTRY COOPERATION UNIVERSITY OF ULSAN

Inventor： Ki Hean KIM ,  Won Yeong PARK ,  Su Il JEON ,  Seung-Mo HONG ,  Jinho SHIN

IPC: G02B21/00 ,  G01N21/64 ,  G02B21/08

Abstract: Disclosed are an open-top two-photon light sheet microscope and an operating method thereof. The open-top two-photon light sheet microscope is capable of obtaining high-depth imaging, high-contrast resolution, and double contrast based on a Bessel beam, and enables rapid three-dimensional imaging by continuously capturing tissue on a per-plane basis without an optical clearing process or a sectioning process, and an operating method thereof.

公开(公告)号：US20240379229A1

公开(公告)日：2024-11-14

申请号：US18564601

申请日：2022-05-30

Applicant: GC GENOME CORPORATION ,  THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： CHANG-SEOK KI ,  EUN HAE CHO ,  JUNNAM LEE ,  JIN MO AHN ,  SOOK RYUN PARK

IPC: G16H50/20 ,  C12Q1/6806 ,  C40B50/06 ,  G16B30/10 ,  G16B40/20 ,  G16H30/40

Abstract: The present invention relates to a method of diagnosing cancer and predicting cancer type using cell-free nucleic acid fragments and image analysis technology, and more particularly, to a method of diagnosing cancer and predicting cancer type by extracting nucleic acids from a biological sample to obtain sequence information (reads), aligning the obtained reads, generating an image including size and coverage information of nucleic acid fragments based on the aligned reads, and then analyzing values calculated by inputting the image into a trained artificial intelligence model. The method of diagnosing cancer and predicting cancer type using size and coverage information of cell-free nucleic acid fragments according to the present invention advantageously shows high sensitivity and accuracy because it generates vectorized data and performs analysis using an AI algorithm.