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公开(公告)号：US20080226564A1
公开(公告)日：2008-09-18
申请号：US12012827
申请日：2008-02-05
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： A respiratory dispersion is provided for the pulmonary delivery of at least two bioactive agents. The dispersion comprises a propellant suspension medium having dispersed therein a plurality of perforated microstructures, wherein the two bioactive agents are incorporated into individual perforated microstructures.
摘要翻译： 为肺部递送至少两种生物活性剂提供呼吸分散体。 分散体包括其中分散有多个穿孔微结构的推进剂悬浮介质，其中两种生物活性剂并入单独的穿孔微结构中。
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公开(公告)号：US06630169B1
公开(公告)日：2003-10-07
申请号：US09720536
申请日：2000-12-22
申请人： Adrian I. Bot , Thomas E. Tarara , Jeffry G. Weers , Alexev Kabalnov , Ernest G. Schutt , Luis A. Dellamary
发明人： Adrian I. Bot , Thomas E. Tarara , Jeffry G. Weers , Alexev Kabalnov , Ernest G. Schutt , Luis A. Dellamary
IPC分类号： A61K914
CPC分类号： C07K16/4241 , A61K9/0043 , A61K9/0075 , A61K9/008 , A61K9/1617 , A61K9/1694 , A61K39/12 , A61K39/145 , A61K2039/505 , A61K2039/525 , A61K2039/543 , A61K2039/55555 , A61K2039/55566 , C12N2760/16134 , Y02A50/41 , Y02A50/466 , Y02A50/472
摘要： Compositions and methods are provided for the administration of particulates comprising at least one bioactive agent which, in selected embodiments, may comprise and immunoactive agent. In this respect, the invention provides for both topical and systemic delivery of the bioactive agent using, for example, the respiratory, gastrointestinal or urogenital tracts. The particulates may be in the form of dry powders or combined with a non-aqueous suspension medium to provide stabilized dispersions. In preferred embodiments, the disclosed compositions will be used in conjunction with inhalation devices such as metered dose inhalers, dry powder inhalers, atomizers or nebulizers for targeted delivery of the agent to mucosal surfaces.
摘要翻译： 提供组合物和方法用于施用包含至少一种生物活性剂的颗粒，所述生物活性剂在选定的实施方案中可以包含和免疫活性剂。 在这方面，本发明提供了使用例如呼吸道，胃肠道或泌尿生殖道的局部和全身递送的生物活性剂。 颗粒可以是干粉的形式或与非水悬浮介质组合以提供稳定的分散体。 在优选的实施方案中，所公开的组合物将与吸入装置如计量吸入器，干粉吸入器，雾化器或喷雾器结合使用，用于将试剂靶向递送至粘膜表面。
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公开(公告)号：US5733526A
公开(公告)日：1998-03-31
申请号：US572859
申请日：1995-12-14
CPC分类号： A61K9/0026 , A61K9/113 , Y10S514/937 , Y10S977/786 , Y10S977/795 , Y10S977/902 , Y10S977/904 , Y10S977/905 , Y10S977/915 , Y10S977/926 , Y10S977/927 , Y10S977/962
摘要： Novel hydrocarbon oil/fluorochemical preparations and methods for their use are provided. The preparations, which preferably comprise a fluorophilic dispersing agent, may be in the form of hydrocarbon oil-in-fluorochemical dispersions or in the form of a multiple emulsion comprising a polar liquid continuous phase and are particularly useful for administering bioactive agents. In particular the preparations of the present invention may be used to control the bioavailability and improve the efficacy of lipophilic bioactive agents having limited solubility in an aqueous physiological environment.
摘要翻译： 提供新型烃油/含氟化合物制剂及其使用方法。 优选包含嗜氟分散剂的制剂可以是烃油中的含氟化合物分散体的形式或者包含极性液体连续相的多重乳液的形式，并且特别可用于施用生物活性剂。 特别地，本发明的制剂可用于控制生物利用度并改善在水性生理环境中溶解度有限的亲脂性生物活性剂的功效。
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34.发明授权
公开(公告)号：US5667809A
公开(公告)日：1997-09-16
申请号：US482176
申请日：1995-06-07
CPC分类号： A61K9/0026 , Y10S514/937
摘要： A method for preparing a pharmaceutical microdispersion exhibiting enhanced bioavailability, including the steps of providing a thermodynamically stable pharmaceutical composition comprising at least one lipophilic pharmaceutical agent incorporated in a physiologically acceptable liquid carrier, the liquid carrier comprising one or more lipophilic solvents such as fluorochemicals and preferably at least one nonfluorinated co-solvent, and combining the stable pharmaceutical composition with an amount of at least one miscible diluent sufficient to initiate phase separation of the lipophilic pharmaceutical agent from the pharmaceutical composition wherein a microdispersion of the pharmaceutical composition is formed. Also disclosed are microdisperse pharmaceutical compositions and kits for forming such compositions.
摘要翻译： 一种制备显示增强的生物利用度的药物微分散体的方法，包括以下步骤：提供包含至少一种引入生理学上可接受的液体载体的亲脂性药剂的热力学稳定的药物组合物，所述液体载体包含一种或多种亲脂性溶剂如含氟化合物， 至少一种非氟化共溶剂，并将稳定的药物组合物与一定量的至少一种可混溶的稀释剂组合，所述至少一种可混溶的稀释剂足以引发亲脂性药剂与药物组合物的相分离，其中形成药物组合物的微分散体。 还公开了用于形成这种组合物的微分散药物组合物和试剂盒。
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35.发明申请公开(公告)号：US20160354388A1
公开(公告)日：2016-12-08
申请号：US15238842
申请日：2016-08-17
IPC分类号： A61K31/58 , A61K9/00 , A61K31/40 , A61K9/16 , A61K31/4704
CPC分类号： A61K31/58 , A61K9/0075 , A61K9/145 , A61K9/1611 , A61K9/1617 , A61K9/1682 , A61K31/40 , A61K31/4704 , A61K45/06 , A61K47/02 , A61K47/24 , Y10S514/826 , A61K2300/00
摘要： Embodiments of the present invention provide a dry powder composition comprising porous carrier particles associated with one, two, three or more micronized drugs or APIs wherein an ordered mixture between the micronized drug or drugs and the carrier particle results, such that the micronized drug or drugs adhere strongly to the carrier particles forming a stable ordered mixture of respirable agglomerates. Embodiments of the present invention further comprise a spray-drying process to create the respirable agglomerates. Embodiments of the present invention further relate to the use of the dry powder formulation comprising respirable agglomerates for the treatment of a patient having a disease or condition which is treatable thereby.
摘要翻译： 本发明的实施方案提供一种干粉组合物，其包含与一种，两种，三种或更多种微粉化药物或API相关联的多孔载体颗粒，其中微粉化药物或载体颗粒之间的有序混合物导致微粉化药物或药物 强烈地粘附到形成可呼吸团聚体的稳定有序混合物的载体颗粒。 本发明的实施方案还包括喷雾干燥方法以产生可呼吸团聚体。 本发明的实施方案还涉及包含可吸入附聚物的干粉制剂用于治疗具有可治疗疾病或病症的患者的用途。
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公开(公告)号：US20140206638A1
公开(公告)日：2014-07-24
申请号：US14247546
申请日：2014-04-08
IPC分类号： A61K31/7036 , A61K9/00 , A61K9/16
CPC分类号： A61K9/0075 , A61K9/1617 , A61K31/7036
摘要： The present invention is directed to the administration of aminoglycosides. In particular, the present invention is directed to compositions and methods for the pulmonary administration of aminoglycosides. According to a preferred embodiment, compositions and methods are provided for the localized treatment of respiratory infections.
摘要翻译： 本发明涉及氨基糖苷类的施用。 特别地，本发明涉及用于肺部给予氨基糖苷类的组合物和方法。 根据优选的实施方案，提供组合物和方法用于呼吸道感染的局部治疗。
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公开(公告)号：US08715623B2
公开(公告)日：2014-05-06
申请号：US11981986
申请日：2007-10-31
IPC分类号： A61K9/12 , A61K9/14 , A61K31/7036 , A61K9/00 , A61K9/16
CPC分类号： A61K9/0075 , A61K9/1617 , A61K31/7036
摘要： A dispersible powder composition comprises aminoglycoside for delivery to the lungs. The composition is effective to provide a therapeutically effective therapy via administration of less than 6 respirable unit doses by inhalation, wherein each unit dose comprises a volume of 0.30 to 0.95 mL.
摘要翻译： 可分散的粉末组合物包含用于递送至肺的氨基糖苷。 该组合物有效地通过通过吸入施用少于6个可呼吸单位剂量来提供治疗有效的治疗，其中每个单位剂量包含0.30至0.95mL的体积。
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公开(公告)号：US08709484B2
公开(公告)日：2014-04-29
申请号：US12258163
申请日：2008-10-24
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/0082 , A61K9/10 , A61K9/1611 , A61K9/1617 , A61K9/1694 , A61K38/29 , A61K47/02 , A61M15/0065 , A61M2205/3306
摘要： Phospholipid based powders for drug delivery applications are disclosed. The powders may include a polyvalent cation in an amount effective to increase the gel-to-liquid crystal transition temperature of the particle compared to particles without the polyvalent cation. The powders are hollow and porous and are preferably administered via inhalation.
摘要翻译： 公开了用于药物递送应用的基于磷脂的粉末。 与没有多价阳离子的颗粒相比，粉末可以包括有效增加颗粒的凝胶 - 液晶的转变温度的多价阳离子。 粉末是中空的和多孔的，并且优选通过吸入给药。
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公开(公告)号：US08080263B2
公开(公告)日：2011-12-20
申请号：US12154731
申请日：2008-05-27
IPC分类号： A61K9/12 , A61K9/00 , A61K31/56 , A61K31/135 , A61K38/28
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments the stabilized dispersions may be directly administered to the lung of a patient using an endotracheal tube or bronchoscope.
摘要翻译： 提供稳定的分散体用于递送生物活性剂。 分散体优选包括分散在通常包含液体含氟化合物的悬浮介质中的多个穿孔微结构。 随着悬浮颗粒和悬浮介质之间的密度变化被最小化，微结构之间的吸引力减弱，所公开的分散体特别地耐降解，例如通过沉降或絮凝。 在特别优选的实施方案中，稳定的分散体可以使用气管内导管或支气管镜直接施用于患者的肺。
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公开(公告)号：US20110097412A1
公开(公告)日：2011-04-28
申请号：US12984110
申请日：2011-01-04
IPC分类号： A61K9/14 , A61K31/7036 , A61P31/04
CPC分类号： A61K9/0075 , A61K31/70
摘要： The present invention provides methods for the treatment of an endobronchial infection in a patient by administering to the endobronchial system of the patient a dry powder aerosol composition comprising from 90 to 130 mg of an aminoglycoside antibiotic one to three times a day for a first treatment period of 20 to 36 days.
摘要翻译： 本发明提供了通过向患者的支气管系统施用干粉气溶胶组合物来治疗患者内支气管感染的方法，所述干粉气溶胶组合物包含90至130mg的氨基糖苷类抗生素，每天一至三次，用于第一治疗期 为20至36天。
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