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    Preparations comprising a fluorocarbon or highly fluorinated compound and a lipophilic/fluorophilic organic compound, and their uses
    6.
    发明授权
    Preparations comprising a fluorocarbon or highly fluorinated compound and a lipophilic/fluorophilic organic compound, and their uses 失效
    包含氟碳化合物或高度氟化的化合物和亲油/氟亲有机化合物的制剂及其用途

    公开(公告)号：US06528545B1

    公开(公告)日：2003-03-04

    申请号：US09587169

    申请日：2000-06-02

    申请人： Jean G. Riess ,  Michele Postel ,  Luis Sole-Violan ,  Marie-Pierre Krafft ,  Chantal Cornelus

    发明人： Jean G. Riess ,  Michele Postel ,  Luis Sole-Violan ,  Marie-Pierre Krafft ,  Chantal Cornelus

    IPC分类号： B01F308

    CPC分类号： A61K9/0026 ,  B01F17/0035 ,  B01F17/0057 ,  B01F17/0085 ,  Y10S514/832 ,  Y10S514/833 ,  Y10S514/938

    摘要： Fluorocarbon emulsions comprising a stabilizing, particle size controlling fluorophilic/hydrophilic compound which can have the formula RF1—W—RH1  (I) wherein RF1 is a linear, branched or cyclic C2-14 fluorocarbon group; RH1 is a linear, branched or cyclic C2-18 saturated or unsaturated hydrocarbon group; and W is absent or is a bivalent species chosen from the group consisting of —O—, —S—, or various fluorinated structures. Use of the fluorophilic/lipophilic compound in the dispersions of the invention provides stable particle size and efficient emulsification. The dispersions of the invention can comprise biologically useful additive and can be used for various purposes, as oxygen carriers, contrast agents, or diagnostic agents.

    摘要翻译： 包含稳定的粒径控制的氟/亲水性化合物的氟碳乳液，其可以具有直链，支链或环状的C2-14碳氟化合物基团; RH1是直链，支链或环状的C2-18饱和或不饱和烃基; 并且W不存在或是选自-O - ， - S-或各种氟化结构的二价物质。 在本发明的分散体中使用富氟/亲脂性化合物提供稳定的粒度和有效的乳化。 本发明的分散体可以包含生物有用的添加剂，并且可以用于各种目的，如氧载体，造影剂或诊断剂。

    Multiple emulsions comprising a hydrophobic continuous phase
    7.
    发明授权
    Multiple emulsions comprising a hydrophobic continuous phase 失效
    包含疏水性连续相的多重乳液

    公开(公告)号：US5980936A

    公开(公告)日：1999-11-09

    申请号：US908821

    申请日：1997-08-07

    申请人： Marie-Pierre Krafft ,  Jean G. Riess ,  Leila Zarif

    发明人： Marie-Pierre Krafft ,  Jean G. Riess ,  Leila Zarif

    IPC分类号： A61K9/00 ,  A61K9/113 ,  A61K9/127 ,  A61K9/66

    CPC分类号： A61K9/0026 ,  A61K9/113 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/948

    摘要： Multiple emulsions comprising a discontinuous emulsified phase incorporating a highly polar liquid, a second component selected from the group consisting of fluorocarbons and hydrocarbons and a continuous hydrophobic phase are disclosed. In preferred embodiments, the hydrophobic phase may comprise a fluorocarbon or hydrocarbon. Additionally, the stable multiple emulsions of the present invention may further incorporate a bioactive agent and are particularly suitable for drug delivery including pulmonary drug delivery.

    摘要翻译： 公开了包含包含高极性液体的不连续乳化相，选自碳氟化合物和烃的第二组分和连续疏水相的多重乳液。 在优选的实施方案中，疏水相可以包含碳氟化合物或烃。 此外，本发明的稳定的多重乳液可以进一步掺入生物活性剂，并且特别适用于药物递送，包括肺部药物递送。

    Stable reverse and multiple fluorocarbon emulsions
    8.
    发明授权
    Stable reverse and multiple fluorocarbon emulsions 失效
    稳定的反向和多氟碳乳液

    公开(公告)号：US5904933A

    公开(公告)日：1999-05-18

    申请号：US478824

    申请日：1995-06-07

    申请人： Jean G. Riess ,  Marie-Pierre Krafft

    发明人： Jean G. Riess ,  Marie-Pierre Krafft

    IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K9/113 ,  A61K47/06 ,  B01J13/00 ,  A61K9/127

    CPC分类号： A61K9/0026 ,  A61K9/113 ,  B01F2003/0838 ,  Y10S514/832 ,  Y10S514/937 ,  Y10S514/938

    摘要： Stable reverse water-in-fluorocarbon emulsions and water-in-fluorocarbon-in-water multiple emulsions comprising the reverse fluorocarbon emulsions. The reverse emulsions comprise a continuous phase which is a highly fluorinated or perfluorinated compound, a discontinuous aqueous phase and a fluorinated surfactant or mixture of surfactants. The multiple emulsions comprise an aqueous continuous phase and a discontinuous phase comprising globules formed of aqueous droplets dispersed into a highly fluorinated or perfluorinated compound. The emulsions can contain pharmacologically active agents, and are particularly suitable for pulmonary drug delivery.

    摘要翻译： 包含反向碳氟化合物乳液的稳定的反向含氟碳乳液和含氟碳水化合物的多重乳液。 反向乳液包括连续相，其是高度氟化或全氟化合物，不连续水相和氟化表面活性剂或表面活性剂的混合物。 多重乳液包含水性连续相和不连续相，其包含由分散在高度氟化或全氟化合物中的水性液滴形成的小球。 乳剂可以含有药理活性剂，特别适用于肺部药物递送。