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    PLASMA JET DEPOSITION PROCESS
    33.
    发明申请
    PLASMA JET DEPOSITION PROCESS 有权

    公开(公告)号：US20230032817A1

    公开(公告)日：2023-02-02

    申请号：US17641798

    申请日：2019-09-10

    Applicant: UCL BUSINESS LTD

    Inventor： Mustafa Emre Sener ,  Daren Joseph Caruana

    IPC: C23C16/513 ,  C23C16/448 ,  C23C16/06 ,  C23C28/02

    Abstract: Processes and apparatus are described for atmospheric pressure plasma jet deposition onto a substrate. The process comprises feeding a solution comprising a dissolved metal precursor into a plasma jet. The dissolved metal precursor comprises a precursor metal selected from Groups 2 to 16, with the proviso that the precursor metal does not comprise Mn. The plasma jet is directed towards a surface of the substrate such that material from the plasma jet becomes deposited onto the surface of the substrate. The process provides a means to manufacture conductive, semiconducting or insulating deposits on a substrate in a material-efficient manner without the need for high-temperature post-treatment steps.

    TIME-RESOLVED METHOD OF PROTEIN ANALYSIS
    35.
    发明申请
    TIME-RESOLVED METHOD OF PROTEIN ANALYSIS 有权

    公开(公告)号：US20230003646A1

    公开(公告)日：2023-01-05

    申请号：US17784836

    申请日：2020-12-14

    Applicant: UCL BUSINESS LTD.

    Inventor： John HALES ,  Paul DALBY

    IPC: G01N21/64

    Abstract: A method of quantifying the concentration of a protein of interest, or the concentration of a conformational state of the protein of interest, in a mixture, wherein the protein of interest or conformational state has an intrinsic fluorescence decay signature. The method comprises: addressing the mixture with one or more pulses of light, wherein the light has a wavelength in the 240-295 nm range, preferably in the 250-280 nm range, further preferably wherein the laser light has a wavelength of 266 nm. The method further comprises: taking a series of measurements of the fluorescence intensity of the mixture at a series of time points where the time interval between a fluorescence measurement and a preceding light pulse is recorded. The series of measurements comprises measurements for which the time intervals differ from each other by less than a nanosecond, and where the difference between largest and smallest time intervals is at least 10 nanoseconds (ns) and/or a sufficient time to detect a decay of the fluorescence intensity towards a baseline level, such that the series of measurements defines a fluorescence decay curve. The method further comprises quantifying the concentration of a protein of interest or conformational state of the protein of interest in the sample by reference to the fluorescence decay curve.

    Bi-specific T-cell engager specific for BCMA
    37.
    发明授权
    Bi-specific T-cell engager specific for BCMA 有权

    公开(公告)号：US11492408B2

    公开(公告)日：2022-11-08

    申请号：US15028113

    申请日：2014-10-10

    Applicant: UCL BUSINESS LTD

    Inventor： Martin Pulé ,  Kwee Yong ,  Lydia Lee ,  Neil Chaplin

    IPC: C07K16/28

    Abstract: The present invention provides a bi-specific molecule which comprises: (i) a first domain which binds B cell maturation antigen (BCMA) and comprises at least part of a proliferation-inducing ligand (APRIL); and (ii) a second domain capable of activating a T cell. The invention also provides the use of such a molecule in the treatment of plasma-cell mediated diseases, such as multiple myeloma.

    Therapeutic use of compounds
    39.
    发明授权
    Therapeutic use of compounds 有权

    公开(公告)号：US11419839B2

    公开(公告)日：2022-08-23

    申请号：US16723241

    申请日：2019-12-20

    Applicant: UCL BUSINESS LTD

    Inventor： Robin Simon Brooke Williams ,  Matthew Walker

    IPC: A61K31/20

    Abstract: A compound having the formula (I) R1-COOH. R1 is an alkyl or alkenyl group having a C7-11 backbone, optionally branched with a C1-6 alkyl group at any C position in the backbone, or a pharmaceutically acceptable salt, amide or ester thereof. The backbone of the alkyl or alkenyl group, and/or the branched alkyl groups, are optionally interrupted by one or more heteroatoms, provided that when R1 is an alkyl group having a C7 backbone, the branching does not consist only of a hexyl group at the a carbon of R1, or only of a methyl group at the γ carbon of R1, or of only single methyl groups at both the β and ω-1 carbons of R1, and provided that when R1 is an alkyl group having a C8 or C11 backbone, the branching does not consist only of a propyl group at the a carbon of R1.

    PHOTOACOUSTIC DEVICE
    40.
    发明申请
    PHOTOACOUSTIC DEVICE 有权

    公开(公告)号：US20220095927A1

    公开(公告)日：2022-03-31

    申请号：US17426469

    申请日：2020-01-30

    Applicant: UCL Business Ltd

    Inventor： Edward Zhang ,  Paul Beard ,  Rehman Ansari ,  Nam Trung Hunynh

    IPC: A61B5/00 ,  A61B1/24 ,  A61B1/00 ,  A61B1/04

    Abstract: A photoacoustic probe head (200a, 200b) is disclosed. The probe head (200a, 200b) comprises: a Fabry Perot acoustic sensor (202), an interrogation interface (A), an excitation input (B) and a two-axis mirror (204). The Fabry Perot acoustic sensor (200a, 200b) is operable to reflect an optical interrogation beam to create a reflected interrogation beam and to modulate the reflected interrogation beam in response to an acoustic signal at the acoustic sensor (202). The interrogation interface (A) is configured to receive an interrogation beam, and to receive the reflected interrogation beam from the acoustic sensor (202). The excitation input (B) is configured to receive an excitation beam for generating an acoustic field in a sample adjacent to the acoustic sensor (202). The two axis mirror (240) is configured to scan the interrogation beam between different locations of the acoustic sensor (202).

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