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    MDMA RESPONSE PREDICTION
    32.
    发明申请
    MDMA RESPONSE PREDICTION 有权

    公开(公告)号：US20210386704A1

    公开(公告)日：2021-12-16

    申请号：US17230588

    申请日：2021-04-14

    Applicant: Universitätsspital Basel

    Inventor： Matthias Emanuel LIECHTI ,  Patrick Raphael VIZELI

    IPC: A61K31/36 ,  G16H10/20 ,  G16H20/10 ,  G16H70/40 ,  G16H10/60

    Abstract: A method of dosing an empathogen/entactogen in treating patients, by assessing patient characteristics before empathogen/entactogen use, administering empathogen/entactogen to the patient based on the patient characteristics, and producing maximum positive subjective acute effects in the patient. A method of determining a dose of an empathogen/entactogen based on body weight, sex, and CYP2D6 activity by assessing patient characteristics of body weight, sex, and CYP2D6 activity before empathogen/entactogen use, administering the empathogen/entactogen to the patient based on the patient characteristics, and producing maximum positive subjective acute effects in the patient. A method of refining dosing of an empathogen/entactogen. A method of predicting future dosing with an empathogen/entactogen. A method of evaluating feasibility of patients to receive an empathogen/entactogen as treatment. A method of optimizing empathogen/entactogen treatment in a patient.

    LSD DOSE IDENTIFICATION
    33.
    发明申请
    LSD DOSE IDENTIFICATION 有权

    公开(公告)号：US20210315884A1

    公开(公告)日：2021-10-14

    申请号：US17225715

    申请日：2021-04-08

    Applicant: Universitätsspital Basel

    Inventor： Matthias Emanuel LIECHTI ,  Friederike Sophie HOLZE

    IPC: A61K31/48 ,  A61K31/4045 ,  A61K31/675 ,  A61K31/137 ,  A61P25/24 ,  G01N33/68

    Abstract: A method of dosing and treating patients with a psychedelic, by administering a psychedelic at a dose of a microdose, minidose, psychedelic dose, good effect dose, ego-dissolution dose, or cardiovascular safe dose, and producing maximum positive subjective acute effects that are known to be associated with more positive long-term outcomes and minimizing negative acute effects. A method of determining a dose of a psychedelic for an individual, by administering a dose of a psychedelic to the individual of a microdose, minidose, psychedelic dose, good effect dose, ego-dissolution dose, or cardiovascular safe dose, determining positive acute effects and negative acute effects in the individual, and adjusting the dose to provide more positive acute effects than negative acute effects in the individual. Methods of treating psychiatric conditions or providing therapy. A method of defining therapeutic doses of a psychedelic in clinical trials. A method of monitoring individuals for depression after treatment with LSD.

    Devices and Methods for Determining Heart Function of a Living Subject
    35.
    发明申请
    Devices and Methods for Determining Heart Function of a Living Subject 审中-公开

    公开(公告)号：US20190381226A1

    公开(公告)日：2019-12-19

    申请号：US16479438

    申请日：2018-01-19

    Applicant: HIGHDIM GMBH ,  Universitätsspital Basel

    Inventor： Oleksii Morozov ,  Patrick Hunziker

    IPC: A61M1/10 ,  A61B5/0205 ,  A61B5/01 ,  A61M1/12 ,  A61B5/00 ,  A61B5/029 ,  A61B5/05 ,  A61B8/06

    Abstract: The present invention relates to systems, methods and algorithms for determination of heart pump function and their use in livings subject are described.The invention further relates to complementary parts of such systems that work best in combination.Medical catheters, sheaths and shafts are disclosed that carry an arrangement of integrated digital sensor systems-on-chip (SoC) in the portion thereof residing inside the body. These devices combine at their portion that resides inside the body, the complete chain of signal transduction, signal analog-to-digital conversion and digital signal transmission, and allow to acquire single and multiple physical entities in a single setup. In specific instances the devices integrate wireless data transfer functionality, and in specific instances they integrate wireless energy harvesting for battery-free functionality.The present invention further describes complementary monitor systems that are suited for reception, processing and analysis of data acquired by such catheters/sheaths/shafts to yield a robust assessment of cardiac performance.Moreover, the present invention relates to innovations which render such systems applicable to patients with and without cardiac assist devices.

    ARTIFICIAL VASCULAR GRAFT
    36.
    发明申请
    ARTIFICIAL VASCULAR GRAFT 审中-公开

    公开(公告)号：US20190159880A1

    公开(公告)日：2019-05-30

    申请号：US16215690

    申请日：2018-12-11

    Applicant: UNIVERSITÄTSSPITAL BASEL

    Inventor： Bernhard WINKLER ,  Martin GRAPOW ,  Friedrich ECKSTEIN ,  Aldo FERRARI ,  Dimos POULIKAKOS ,  Simone BOTTAN ,  Maximilian FISCHER ,  Tobias LENDENMANN

    IPC: A61F2/06 ,  A61F2/07 ,  C12N1/20 ,  A61F2/90

    Abstract: The invention relates to an artificial vascular graft comprising a primary scaffold structure encompassing an inner space of the artificial vascular graft, said primary scaffold structure having an inner surface facing towards said inner space and an outer surface facing away from said inner space, a coating on said inner surface, wherein a plurality of grooves is comprised in said coating of said inner surface. The primary scaffold structure comprises further a coating on said outer surface. The primary scaffold structure and the coating on said inner surface and on said outer surface are d designed in such a way that cells, in particular progenitor cells, can migrate from the periphery of said artificial vascular graft through said outer surface of said coating, said primary scaffold structure and said inner surface to said inner space, if the artificial vascular graft is used as intended. The invention relates further to a method for providing said graft.

    CONTROLLING A SURGICAL INTERVENTION TO A BONE
    37.
    发明申请
    CONTROLLING A SURGICAL INTERVENTION TO A BONE 审中-公开
    控制骨科手术干预

    公开(公告)号：US20170007328A1

    公开(公告)日：2017-01-12

    申请号：US15113636

    申请日：2015-01-30

    Applicant: UNIVERSITÄT BASEL ,  UNIVERSITÄTSSPITAL BASEL

    Inventor： Philippe Cattin ,  Gregory Jost ,  Jonas Walti

    IPC: A61B34/10 ,  G05B15/02 ,  A61B34/20

    CPC classification number: A61B34/10 ,  A61B34/20 ,  A61B2017/00221 ,  A61B2017/564 ,  A61B2034/107 ,  A61B2034/2048 ,  A61B2034/2068 ,  A61B2090/364 ,  G05B15/02

    Abstract: A method of controlling a surgical intervention to a bone (31) comprises: obtaining a three-dimensional image or multiplanar reconstruction of the bone (31), defining a position and an axis of intervention on the three-dimensional image or multi-planar reconstruction of the bone (31), and controlling the orientation of an intervention instrument (1) equipped with an orientation sensor (2) during the surgical intervention by evaluating a signal provided by the orientation sensor (2). The method further comprises referencing the intervention instrument (1) with respect to the bone (31) before the surgical intervention by arranging the intervention instrument (1) along an anatomic landmark (32) being an edge of the bone (31) and rotating the orientation sensor (2) into a predefined position, or by arranging the intervention instrument (1) essentially perpendicular to an anatomic landmark (32) being an essentially flat surface of the bone (31) and rotating the orientation sensor (2) into a predefined position. The method according to the invention allows for efficiently achieving correct orientation and position of the intervention instrument in a bone surgical intervention. Furthermore, the method according to the invention provides an efficient real-time control at comparably low efforts. Still further, with the method according to the invention radiation exposure to the operational staff as well as patients can be reduced.

    Abstract translation: 控制对骨骼（31）的外科手术的方法包括：获得骨骼（31）的三维图像或多平面重建，在三维图像或多平面重建上定义干涉的位置和轴线 ，并且通过评估由所述取向传感器（2）提供的信号来控制在手术介入期间配备有方位传感器（2）的介入器械（1）的取向。 该方法还包括通过沿着作为骨骼（31）的边缘的解剖标志（32）布置介入器械（1），在外科手术之前相对于骨头（31）参考介入器械（1） 或者通过将干涉仪器（1）基本上垂直于作为骨骼（31）的基本上平坦的表面的解剖学标记（32）布置并将定向传感器（2）旋转到预定义的位置 位置。 根据本发明的方法允许在骨手术介入中有效地实现干预器械的正确取向和位置。 此外，根据本发明的方法在相当低的努力下提供了有效的实时控制。 此外，根据本发明的方法，可以减少对操作人员以及患者的辐射照射。

    CARBOHYDRATE-GLYCOLIPID CONJUGATE VACCINES
    38.
    发明申请
    CARBOHYDRATE-GLYCOLIPID CONJUGATE VACCINES 审中-公开
    碳水化合物 - 甘氨酸联合疫苗

    公开(公告)号：US20150238597A1

    公开(公告)日：2015-08-27

    申请号：US14385948

    申请日：2013-03-19

    Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ,  UNIVERSITÄTSSPITAL BASEL

    Inventor： Peter H. Seeberger ,  Pierre Stallforth ,  Gennaro De Libero ,  Marco Cavallari

    IPC: A61K39/39 ,  A61K39/09

    Abstract: The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure which allows applying the vaccine to a whole variety of pathogenes. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.

    Abstract translation: 本发明涉及一类新型的基于碳水化合物的疫苗的合成和生物学评价领域。 新疫苗由多模块结构组成，允许将疫苗应用于各种病原体。 该方法允许针对表达免疫原性糖抗原的所有病原体制备疫苗。 由于不需要抗原性碳水化合物与蛋白质的缀合，所以缀合疫苗特别热稳定。 不需要制冷，这是基于蛋白质的疫苗的主要缺点。

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