-
公开(公告)号：US20200278491A1
公开(公告)日：2020-09-03
申请号：US16647118
申请日：2018-09-11
Applicant: University of Southampton
Inventor： Francesco POLETTI , Gregory Teofil JASION , Natalie WHEELER , Thomas David BRADLEY , Mubassira B Syed NAWAZUDDIN , John HAYES
IPC: G02B6/02 , G02B6/024 , C03B37/012
Abstract: A preform (10) for an antiresonant hollow core optical fibre comprises an outer jacket tube (12) having an inner surface and a central longitudinal axis (24); a plurality of antiresonant cladding tubes (14) spaced apart at predefined peripheral locations around the inner surface of the outer jacket tube (12), each antiresonant cladding tube (14) in contact with the inner surface such that a central longitudinal axis (26) of each antiresonant cladding tube (14) is at a first radial distance from the central longitudinal axis (24) of the outer jacket tube (12); and a plurality of spacing elements (22) disposed alternately with the antiresonant cladding tubes (14) and each in contact with an outer surface of each of two adjacent antiresonant cladding tubes (14) at one or more contact points (28), the contact points (28) at a second radial distance from the central longitudinal axis (24) of the outer jacket tube (12), the second radial distance being greater than the first radial distance.
-
公开(公告)号：US10736933B2
公开(公告)日：2020-08-11
申请号：US15774681
申请日：2016-11-09
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Salim Iqbal Khakoo
IPC: A61K38/03 , C07K14/18 , C12N5/0783 , A61K35/17 , C12N15/62
Abstract: The invention relates to a peptide capable of activating NK cell-mediated immunity, the peptide comprising or consisting of the amino acid sequence XnAX2X1, Wherein Xn is an amino acid sequence of between 5 and 12 residues, and X1 is any amino acid; or leucine or phenylalanine; and X2 is alanine, threonine or serine. The invention further relates to an MHC class I molecule and the peptide, nucleic acids encoding the peptide, activated NK cells, and related compositions and methods, including use in methods of treatment.
-
公开(公告)号：US20200206319A1
公开(公告)日：2020-07-02
申请号：US16631281
申请日：2018-07-17
Applicant: University of Cape Town , University of Southampton
Abstract: Surfactant protein A (SP-A) is described for preventing and/or treating a sexually transmitted infection (STI) in a subject. The STI is caused by a DNA virus, such as Human papillomavirus (HPV) and/or Herpes simplex virus (HSV). SP-A can thus be used to prevent cervical cancer, genital warts and/or genital ulcers. Pharmaceutical compositions and kits comprising SP-A are also described, as is a method for preventing and/or treating STIs caused by DNA viruses, the method comprising administering an effective amount of SP-A to a subject in need thereof.
-
公开(公告)号：US20200049695A1
公开(公告)日：2020-02-13
申请号：US16487478
申请日：2018-02-22
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Ali TAVASSOLI , Catrin SOHRABI , Martin FISCHLECHNER
Abstract: A method for co-compartmentalising a cyclic polypeptide with a polynucleotide encoding the cyclic polypeptide, comprising the steps of a) forming a compartment containing a polynucleotide encoding the cyclic polypeptide, b) expressing a polypeptide from the polynucleotide, and c) cyclising the polypeptide. Co-compartmentalised cyclic polypeptides and encoding polynucleotides. Libraries of co-compartmentalised cyclic polypeptide and encoding polynucleotide. Methods for screening libraries of co-compartmentalised cyclic polypeptide and encoding polynucleotide. Incorporation of non-canonical nucleic acids into such libraries.
-
公开(公告)号：US10448158B2
公开(公告)日：2019-10-15
申请号：US16084795
申请日：2017-03-14
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： Filippo Maria Fazi , Marcos Felipe Simón Gálvez
IPC: H04R3/12 , H04S7/00 , G10L21/0224 , H04R5/02 , H04R5/04
Abstract: A sound reproduction system and filter set comprising an array of loudspeakers, comprises a plurality of delay-gain filter elements, and further wherein the filter set comprises a plurality of loudspeaker-specific filter elements (12) which are each associated with different respective speakers of the loudspeaker array, and further comprising a plurality of loudspeaker-independent filter elements (10) which are each common to a plurality of the loudspeakers of the array.
-
Patent Agency Ranking
公开(公告)号：US20190247542A1
公开(公告)日：2019-08-15
申请号：US16274047
申请日：2019-02-12
Applicant: University of Southampton
Inventor： Richard Oreffo , Jonathan Dawson , David Gibbs , Jons Hilborn , Dmitri Ossipov
CPC classification number: A61L27/446 , A61K38/1875 , A61K47/02 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2300/64 , A61L2400/12 , A61L2430/02 , C08J3/075 , C08J2305/08 , C08K3/346 , C08K2201/006 , C08L5/08
Abstract: The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.
-
37.发明申请公开(公告)号：US20190224008A1
公开(公告)日：2019-07-25
申请号：US16339217
申请日：2017-10-03
Applicant: University of Southampton
Inventor： Neil W. Bressloff , Jonathan Bailey
Abstract: A frame for an implantable medical device, comprising: a first member, comprising a plurality of struts defining a plurality of cells, wherein the first member is annular and defines a longitudinal direction which is parallel to the axis of the first member, a radial direction, and a circumferential direction; a second member, comprising a plurality of struts and coupled to the first member at circumferentially distributed locations; wherein the second member overlaps a first end portion of the first member and extends beyond the first end portion of the first member.
-
公开(公告)号：US20190169306A1
公开(公告)日：2019-06-06
申请号：US16321367
申请日：2017-07-28
Applicant: University of Southampton
Inventor： Martin John Glennie , Aymen Al-Shamkhani , Mark Steven Cragg , Sean Hua Lim
Abstract: The disclosure relates to a method of treatment or prevention of B-cell related disease in a subject comprising the administration of a binding molecule capable of binding to a B-cell and promoting killing of the B-cell; and an immunostimulatory agent arranged to stimulate effector lymphocytes, such as NK and/or T cells. Additionally, an anti-CD27 binding agent for use in a combination therapy with an anti-CD20 binding agent for the treatment or prevention of B-cell related disease in a subject. The disclosure also relates to a method of treatment or prevention of cancer in a subject comprising the administration of a cancer-cell-depleting binding agent capable of binding to the cancer cell and promoting killing of the cancer cell; and an immunostimulatory agent arranged to stimulate NK and/or T-cell activation. Additionally, an anti-CD27 binding agent for use in a combination therapy with a cancer-cell-depleting binding agent for the treatment or prevention of cancer in a subject.
-
公开(公告)号：US20190035632A1
公开(公告)日：2019-01-31
申请号：US16072013
申请日：2017-01-23
Applicant: UNIVERSITY OF SOUTHAMPTON
Inventor： David John THOMSON , Graham Trevor REED , Robert TOPLEY
IPC: H01L21/265 , H01L21/324 , H01L21/67 , H01L21/66 , H01L21/268
Abstract: A method of trimming the refractive index of material forming at least part of one or more structures integrated in one or more pre-fabricated devices, the method comprising: implanting one or more first regions of material of one or more pre-fabricated devices, encompassing at least partially one or more device structures, with ions to alter the crystal form of the material within the one or more first regions and change the refractive index of the material within the one or more first regions; and heat treating one or more second regions of material of the one or more devices, encompassing at least partially the one or more first regions, to alter the crystal form of the material within the one or more first regions encompassed by the one or more second regions and change the refractive index thereof, thereby trimming the refractive index of the material of at least part of the one or more device structures, such that the one or more device structures provide one or more predetermined device outputs.
-
公开(公告)号：US20190002885A1
公开(公告)日：2019-01-03
申请号：US16001265
申请日：2018-06-06
Applicant: UNIVERSITY OF MASSACHUSETTS , UNIVERSITY OF SOUTHAMPTON
Inventor： Jonathan Watts , Hans Michael Haitchi , Hannah Pendergraff
IPC: C12N15/113
Abstract: The present disclosure provides antisense compounds, methods, and compositions for silencing ADAM33 mRNA. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with ADAM33 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with ADAM33.
-
-
-
-
-
-
-
-
-
Search Results
298
records
(took 0.033 seconds)
