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    Dental demineralization detection, methods and systems
    31.
    发明授权
    Dental demineralization detection, methods and systems 有权

    公开(公告)号：US10888230B2

    公开(公告)日：2021-01-12

    申请号：US15868623

    申请日：2018-01-11

    Applicant: University of Washington through its Center for Commercialization

    Inventor： Eric J. Seibel ,  Leonard Y. Nelson

    IPC: A61B5/00 ,  G01J3/02 ,  G01J3/06 ,  G01J3/44 ,  G01J3/10 ,  G01N21/64 ,  A61B1/00 ,  A61B1/015 ,  A61B1/07 ,  A61B1/247 ,  A61C19/04

    Abstract: Methods and systems for detecting early stage dental caries and decays are provided. In particular, in an embodiment, laser-induced autofluorescence (AF) from multiple excitation wavelengths is obtained and analyzed. Endogenous fluorophores residing in the enamel naturally fluoresce when illuminated by wavelengths ranging from ultraviolet into the visible spectrum. The relative intensities of the AF emission changes between different excitation wavelengths when the enamel changes from healthy to demineralized. By taking a ratio of AF emission spectra integrals between different excitation wavelengths, a standard is created wherein changes in AF ratios within a tooth are quantified and serve as indicators of early stage enamel demineralization. The techniques described herein may be used in conjunction with a scanning fiber endoscope (SFE) to provide a reliable, safe and low-cost means for identifying dental caries or decays.

    Methods of lowering the error rate of massively parallel DNA sequencing using duplex consensus sequencing
    34.
    发明授权
    Methods of lowering the error rate of massively parallel DNA sequencing using duplex consensus sequencing 有权

    公开(公告)号：US10752951B2

    公开(公告)日：2020-08-25

    申请号：US16514931

    申请日：2019-07-17

    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

    Inventor： Jesse Salk ,  Lawrence A. Loeb ,  Michael Schmitt

    IPC: C12Q1/68 ,  C12Q1/6876 ,  C12Q1/6806 ,  C12Q1/6869

    Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands.

    Microstructure-based wound closure devices
    35.
    发明授权
    Microstructure-based wound closure devices 有权

    公开(公告)号：US10751050B2

    公开(公告)日：2020-08-25

    申请号：US14408244

    申请日：2013-06-17

    Applicant: University of Washington through its Center for Commercialization

    Inventor： Marco Rolandi ,  Vittorio Ruvolo ,  Ronald J. Berenson ,  Chase Ruebel ,  Jungho Jin

    IPC: A61B17/08 ,  A61M37/00 ,  A61F13/00

    Abstract: The present invention relates generally to wound closure devices comprising one or more microstructures. The devices are designed such that the microstructures are able to grip the skin or tissue surrounding a wound, optionally closing the wound, or securing the tissue or skin in place. Also provided are wound closure systems that comprise one or more microstructure wound closure devices along with other components, such as protective covers and wound healing therapeutics. A variety of packaging specifications are disclosed, as is a dispenser apparatus configured to enable simple one-handed application of the wound closure devices. Methods described herein provide for the closure of various wounds with the wound closure devices and systems.

    METHODS AND SYSTEMS FOR PERFORMING DIGITAL MEASUREMENTS
    36.
    发明申请
    METHODS AND SYSTEMS FOR PERFORMING DIGITAL MEASUREMENTS 审中-公开

    公开(公告)号：US20200157615A1

    公开(公告)日：2020-05-21

    申请号：US16783037

    申请日：2020-02-05

    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

    Inventor： Daniel T. CHIU ,  Bryant S. FUJIMOTO ,  Alexander R. GANSEN ,  Gloria S. YEN ,  Robert M. LORENZ

    IPC: C12Q1/6851 ,  C12Q1/6806

    Abstract: Methods and systems for digital measurements are provided. In an embodiment, the method includes producing a plurality of droplets, wherein at least one of the droplets of the plurality of droplets contains an analyte molecule from a sample; measuring at least a first portion of the plurality of droplets to determine individual volumes of droplets in the first portion of the plurality of droplets; analyzing at least a second portion of the plurality of droplets to determine a number of droplets in the second portion of the plurality of droplets that contain the analyte molecule; and using individual volumes of the droplets in the first portion of the plurality of droplets and the number of droplets in the second portion of the plurality of droplets that contain the analyte molecule to determine the concentration of the analyte molecule in the sample.

    Methods of lowering the error rate of massively parallel DNA sequencing using duplex consensus sequencing
    37.
    发明授权
    Methods of lowering the error rate of massively parallel DNA sequencing using duplex consensus sequencing 有权

    公开(公告)号：US10570451B2

    公开(公告)日：2020-02-25

    申请号：US16120019

    申请日：2018-08-31

    Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

    Inventor： Jesse Salk ,  Lawrence A. Loeb ,  Michael Schmitt

    IPC: C12Q1/68 ,  C12Q1/6876 ,  C12Q1/6806 ,  C12Q1/6869

    Abstract: Next Generation DNA sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of DNA sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes. These scattered errors can be tolerated in some applications but become extremely problematic when “deep sequencing” genetically heterogeneous mixtures, such as tumors or mixed microbial populations. To overcome limitations in sequencing accuracy, a method Duplex Consensus Sequencing (DCS) is provided. This approach greatly reduces errors by independently tagging and sequencing each of the two strands of a DNA duplex. As the two strands are complementary, true mutations are found at the same position in both strands. In contrast, PCR or sequencing errors will result in errors in only one strand. This method uniquely capitalizes on the redundant information stored in double-stranded DNA, thus overcoming technical limitations of prior methods utilizing data from only one of the two strands.

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