-
公开(公告)号：US6006128A
公开(公告)日：1999-12-21
申请号：US88562
申请日：1998-06-02
CPC分类号： A61B5/0073 , A61B5/0066 , G01B9/02045 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02083 , G01B9/02091 , A61B5/7257 , G01B2290/35 , G01B2290/60
摘要： A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.
摘要翻译： 一种用于在光学相干断层摄影系统中产生样本的速度指示断层图像的方法包括以下步骤：（a）从干涉仪获取互相关数据; （b）从指示样品中散射体的深度相关位置的互相关数据中生成灰度图像; （c）处理互相关数据以产生样品中运动散射体的速度值和位置; （d）为速度值分配颜色; 以及（f）在指示运动散射体的位置的灰度图像中将颜色合并成灰度图像，以产生速度指示的断层图像。 优选地，将第一颜色分配给正速度值，并且将第二颜色分配给负速度值。
-
公开(公告)号：US09273950B2
公开(公告)日：2016-03-01
申请号：US13335211
申请日：2011-12-22
申请人： Siavash Yazdanfar , Sora Kim , Chulmin Joo
发明人： Siavash Yazdanfar , Sora Kim , Chulmin Joo
CPC分类号： G01B9/02044 , A61B3/102 , A61B3/12 , G01B9/02048 , G01B9/02063 , G01B9/02064 , G01B9/02091
摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm.
摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从样品臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动测距过程以使参考臂与样本臂匹配的逻辑的控制器。
-
公开(公告)号：US08878923B2
公开(公告)日：2014-11-04
申请号：US12422363
申请日：2009-04-13
IPC分类号： H04N5/225
CPC分类号： G02B21/244 , G02B21/002 , G02B21/245 , G02B21/365
摘要： In an imaging device having an objective and a stage for holding a sample to be imaged, a method for autofocusing is presented. The method includes determining a measured focus value corresponding to at least a first of a plurality of logical image segments. Further, the method includes imaging the first logical image segment using the measured focus value. The method also includes determining a predicted focus value for a second of the plurality of logical image segments using the measured focus value and a stored focus variation parameter. In addition, the method includes imaging the second logical image segment using the predicted focus value.
摘要翻译： 在具有用于保持要成像的样品的目标和阶段的成像装置中，提出了一种用于自动聚焦的方法。 该方法包括确定对应于多个逻辑图像片段中的至少第一个的测量焦点值。 此外，该方法包括使用测量的聚焦值对第一逻辑图像片段进行成像。 该方法还包括使用测量的聚焦值和存储的聚焦变化参数来确定多个逻辑图像片段中的第二个的预测聚焦值。 此外，该方法包括使用预测的聚焦值来成像第二逻辑图像片段。
-
公开(公告)号：US08842287B2
公开(公告)日：2014-09-23
申请号：US13335175
申请日：2011-12-22
申请人： Siavash Yazdanfar , Sora Kim , Chulmin Joo
发明人： Siavash Yazdanfar , Sora Kim , Chulmin Joo
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , G01B9/02044 , G01B9/02063 , G01B9/02064 , G01B9/02068
摘要： A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus.
摘要翻译： 在一个实施例中，系统包括具有被配置为发光的光源的光学相干断层摄影（OCT）成像系统。 OCT成像系统还包括分束器，其被配置为接收来自光源的光，将光分成沿着包括样本的样本臂引导的第一光部分和沿着包括参考反射镜的参考臂引导的第二光部分， 从采样臂接收第一反射光部分和从参考臂的第二反射光部分，组合第一和第二反射光部分以在检测器处获得干涉信号。 此外，OCT成像系统包括具有被配置为执行自动聚焦处理以确定样本臂中的透镜的最佳位置以便使样本聚焦的逻辑的控制器。
-
公开(公告)号：US08778682B2
公开(公告)日：2014-07-15
申请号：US13221161
申请日：2011-08-30
申请人： Vasile Bogdan Neculaes , Kenneth Roger Conway , Allen Lawrence Garner , Evelina Roxana Loghin , Siavash Yazdanfar , Dmitry Vladimirovich Dylov , Brian Michael Davis , Chulmin Joo
发明人： Vasile Bogdan Neculaes , Kenneth Roger Conway , Allen Lawrence Garner , Evelina Roxana Loghin , Siavash Yazdanfar , Dmitry Vladimirovich Dylov , Brian Michael Davis , Chulmin Joo
CPC分类号： C12N13/00 , A61K48/0083 , C12N15/87
摘要： A method of delivering exogenous molecules, comprising: providing a plurality of cells having a cell membrane; adding a plurality of exogenous molecules to the cells; exposing the cells to a defocused infrared (IR) light to permeabilize the cell membrane of the cells; and delivering the exogenous molecules to the cells through the permeablized cell membrane, wherein an intensity of the IR light at the optical focus is at least greater than or equal to an order of 104 W/cm2.
摘要翻译： 一种递送外源性分子的方法，包括：提供多个具有细胞膜的细胞; 向细胞中加入多种外源性分子; 将细胞暴露于散焦的红外（IR）光以使细胞的细胞膜透化; 并且通过透过细胞膜将外源性分子递送至细胞，其中所述光学焦点处的IR光的强度至少大于或等于104W / cm 2。
-
公开(公告)号：US20130261415A1
公开(公告)日：2013-10-03
申请号：US13435966
申请日：2012-03-30
IPC分类号： A61B5/0205 , A61B5/02 , A61B5/0295 , A61B5/026 , A61B5/024 , A61B5/029 , A61B5/1455 , A61B5/08
CPC分类号： A61B5/14552 , A61B5/02427 , A61B5/029 , A61B5/08
摘要： Embodiments of devices, methods, and non-transitory computer readable media for monitoring a subject are presented. The monitoring device includes at least one sensor configured to monitor one or more physiological parameters of a subject and a processing unit operatively coupled to the sensor. The sensor comprises a plurality of radiation sources and detectors disposed on a flexible substrate in a designated physical arrangement. The processing unit is configured to dynamically configure an operational geometry of the sensor by controlling the intensity of one or more of the radiation sources and the gain of one or more of the detectors so as to satisfy at least one quality metric associated with one or more physiological parameters of the subject.
摘要翻译： 呈现用于监测对象的设备，方法和非暂时性计算机可读介质的实施例。 监测装置包括至少一个被配置成监测被摄体的一个或多个生理参数的传感器和可操作地耦合到传感器的处理单元。 传感器包括以指定的物理布置设置在柔性基板上的多个辐射源和检测器。 处理单元被配置为通过控制一个或多个辐射源的强度和一个或多个检测器的增益来动态地配置传感器的操作几何，以满足与一个或多个检测器相关联的至少一个质量度量 受试者的生理参数。
-
公开(公告)号：US08179432B2
公开(公告)日：2012-05-15
申请号：US11843754
申请日：2007-08-23
申请人： Siavash Yazdanfar , Robert John Filkins , Elizabeth Lockenberg Dixon , Walter Vincent Dixon, legal representative , Krenar Tasimi , Kevin Bernard Kenny
发明人： Siavash Yazdanfar , Robert John Filkins , Elizabeth Lockenberg Dixon , Krenar Tasimi , Kevin Bernard Kenny
CPC分类号： G02B21/244 , G02B21/365
摘要： A method of autofocusing includes capturing first, second and third images of a sample, at respective first, second and third sample distances and respective first, second and third lateral positions determined with respect to an objective; determining a quantitative characteristic for the first, second and third images; determining a primary sample distance based upon at least the quantitative characteristics for the first, second, and third images; and capturing a primary image of the sample at the primary sample distance and at a primary lateral position that is offset from the first, second and third lateral positions.
摘要翻译： 自动对焦的方法包括：以相对于目标确定的各自的第一，第二和第三采样距离以及相应的第一，第二和第三横向位置捕获样本的第一，第二和第三图像; 确定第一，第二和第三图像的定量特性; 至少基于第一，第二和第三图像的定量特性来确定主样本距离; 以及在所述主要采样距离处和在偏离所述第一，第二和第三横向位置的主横向位置处捕获所述样本的主要图像。
-
公开(公告)号：US08144411B2
公开(公告)日：2012-03-27
申请号：US12263677
申请日：2008-11-03
CPC分类号： G02B26/008 , G02B7/006 , G02B21/16 , G02B21/361 , G02B23/2407
摘要： Multimodal optical imaging is disclosed. Possible devices include a filter assembly that is capable of rotary action during real time image acquisition. Systems are disclosed that include such filter assemblies, which are detachable or integrated in the systems. Various techniques for capturing image targets using multiple light sources such as white light and fluorescent light are also disclosed.
-
公开(公告)号：US07885011B1
公开(公告)日：2011-02-08
申请号：US12543785
申请日：2009-08-19
CPC分类号： G02B23/243
摘要： A wide angle hybrid refractive-diffractive endoscope objective is provided. The objective comprises a negative meniscus lens having a first surface and a second surface; a stop adjacent to the negative meniscus lens; a positive lens adjacent to the negative lens and having a first surface and a second surface; and a hybrid refractive-diffractive element adjacent to the positive lens and having a first surface and a second surface, wherein one of the first surface, or the second surface comprises a diffractive surface, wherein the objective has an effective focal length in a range from about 0.8 mm to about 1.6 mm.
摘要翻译： 提供广角混合折射衍射内窥镜目的。 该目的包括具有第一表面和第二表面的负凹凸透镜; 靠近负弯月透镜的止动件; 与透镜相邻并具有第一表面和第二表面的正透镜; 以及与所述正透镜相邻并且具有第一表面和第二表面的混合折射衍射元件，其中所述第一表面或所述第二表面中的一个包括衍射表面，其中所述物镜具有在以下范围内的有效焦距： 约0.8mm至约1.6mm。
-
公开(公告)号：US20090242797A1
公开(公告)日：2009-10-01
申请号：US12059749
申请日：2008-03-31
CPC分类号： G01N21/6456 , A61B1/0005 , A61B1/00165 , A61B1/042 , A61B1/043 , A61B5/0035 , A61B5/0084 , G01N21/49 , G01N2021/6439 , G01N2021/6493 , H04N5/2256 , H04N5/332 , H04N9/045 , H04N2005/2255
摘要： A technique is provided for multi-mode optical imaging. The technique includes directing a visible light and an excitation light multiplexed in time towards a specimen. The excitation light is configured to induce luminescence in the specimen. The technique also includes detecting visible light scattered or reflected from the specimen and luminescent light emitted via luminescence via a single detector that is in synchronization with the one or more illumination sources.
摘要翻译： 提供了一种多模光学成像技术。 该技术包括将可见光和在时间上多路复用的激发光引向样本。 激发光被配置为在样品中诱导发光。 该技术还包括通过与一个或多个照明源同步的单个检测器检测从样本散射或反射的可见光和通过发光发射的发光。
-
-
-
-
-
-
-
-
-
搜索结果
44 条记录 (耗时 0.058 秒)
