公开(公告)号：US20070156056A1

公开(公告)日：2007-07-05

申请号：US11686784

申请日：2007-03-15

申请人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery Snell ,  Gene Bornzin ,  Jong Kil

发明人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery Snell ,  Gene Bornzin ,  Jong Kil

IPC分类号： A61B5/04

CPC分类号： A61B5/0452 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7242 ,  A61N1/3627 ,  A61N1/3702

摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

摘要翻译： 提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。 由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发病的方法。 简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。 如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。 本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

公开(公告)号：US06430448B1

公开(公告)日：2002-08-06

申请号：US09707828

申请日：2000-11-07

申请人： Yougandh Chitre ,  Phong Doan

发明人： Yougandh Chitre ,  Phong Doan

IPC分类号： A61N106

CPC分类号： A61N1/056

摘要： An implantable stimulating electrode for directly contacting the endocardium of a human heart exhibits low polarization values of less than about 0.3 mV and is intended for use with an implantable lead having an electrical connector coupled to the proximal end of a conductor for releasable attachment to a stimulating pulse generator. The electrode is comprised of a metallic substrate having an initially exposed outer surface substantially covered with a first inner layer of titanium nitride and a second outer layer of platinum black. The first inner layer of titanium nitride has a thickness of less than about 15 microns and the second outer layer of platinum black overlying the layer of titanium nitride, similarly, has a thickness of less than about 15 microns. The invention includes a method of making the implantable stimulating electrode.

公开(公告)号：US07991484B1

公开(公告)日：2011-08-02

申请号：US11748915

申请日：2007-05-15

申请人： Shimul Sengupta ,  Yougandh Chitre ,  Cheuk Tang

发明人： Shimul Sengupta ,  Yougandh Chitre ,  Cheuk Tang

IPC分类号： A61N1/37

CPC分类号： A61N1/3702 ,  A61N1/0573

摘要： An implantable medical lead of the invention comprises an electrically active helix electrode extendable and retractable relative to a distal tip of the lead, an electrically conductive mapping collar disposed at the lead's distal tip and a proximal end carrying an electrical connector assembly. The electrical connector assembly comprises a first terminal connected to the helix electrode and a second terminal separately connected to the mapping collar. An advantage of the independent helix electrode and mapping collar circuits is that the implanting physician can confirm from separate electrode impedance readings that the helix is in fact extended and fully embedded within the myocardium. Further, the independent mapping collar and helix electrode circuits may be used, in conjunction with a configurable or programmable switch network, to provide the implanting physician with a choice of electrode impedances.

摘要翻译： 本发明的可植入医疗引线包括相对于引线的远侧末端可延伸和缩回的电活动螺旋电极，设置在引线的远侧末端处的导电映射颈圈和承载电连接器组件的近端。 电连接器组件包括连接到螺旋电极的第一端子和分开连接到测绘套环的第二端子。 独立螺旋电极和映射环电路的优点是，植入医生可以从单独的电极阻抗读数确认螺旋实际上被扩展并完全嵌入心肌内。 此外，独立的映射环和螺旋电极电路可以与可配置或可编程的开关网络一起使用，以向植入医生提供电极阻抗的选择。

公开(公告)号：US07925343B1

公开(公告)日：2011-04-12

申请号：US11539576

申请日：2006-10-06

申请人： Xiaoyi Min ,  Scott Salys ,  Yougandh Chitre ,  Eric Falkenberg ,  Gene A. Bornzin

发明人： Xiaoyi Min ,  Scott Salys ,  Yougandh Chitre ,  Eric Falkenberg ,  Gene A. Bornzin

IPC分类号： A61N1/39

CPC分类号： A61N1/3956 ,  A61B5/04014 ,  A61B5/046 ,  A61B5/7203 ,  A61N1/0563 ,  A61N1/37288

摘要： A subcutaneous implantable cardiac device system applies defibrillation currents in pathways aligned with the heart's own electrical system to decrease defibrillation thresholds. In one implementation, one or more subcutaneous sensors detect ventricular fibrillation. Positioning of subcutaneous sensors and filtering result in improved sensing with reduced noise. A subcutaneous patch component of the system that is in communication with a subcutaneous pacemaker or cardioverter-defibrillator may perform the sensing and apply the defibrillation. The subcutaneous patch may include one or more electrodes that perform both sensing and defibrillation. Variations of the subcutaneous patch may include battery and capacitor for generating onboard defibrillation current and may also include a microprocessor for advanced programmable operation.

摘要翻译： 皮下植入式心脏装置系统在与心脏自身的电气系统对准的途径中应用除颤电流以降低除颤阈值。 在一个实施方案中，一个或多个皮下传感器检测心室颤动。 皮下传感器的定位和过滤导致改进的感测，噪音降低。 与皮下起搏器或心律转复除颤器连通的系统的皮下补片部件可以执行感测并施加除颤。 皮下补片可以包括执行感测和除颤的一个或多个电极。 皮下贴片的变化可以包括用于产生板上除颤电流的电池和电容器，并且还可以包括用于高级可编程操作的微处理器。

公开(公告)号：US07894915B1

公开(公告)日：2011-02-22

申请号：US11553842

申请日：2006-10-27

申请人： Yougandh Chitre ,  Mark W. Kroll

发明人： Yougandh Chitre ,  Mark W. Kroll

IPC分类号： A61N1/05

CPC分类号： A61N1/372 ,  A61N1/05 ,  A61N1/37205 ,  A61N1/3756

摘要： Techniques related to implantable medical devices (IMDs) are described. One such IMD includes first and second electrodes and a continuous body joined with and extending between the electrodes. Processing electronics are located within the body and are coupled with the first and second electrodes.

摘要翻译： 描述与植入式医疗装置（IMD）相关的技术。 一个这样的IMD包括第一和第二电极以及与电极连接并在电极之间延伸的连续体。 处理电子器件位于主体内并且与第一和第二电极耦合。

公开(公告)号：US07797059B1

公开(公告)日：2010-09-14

申请号：US11560297

申请日：2006-11-15

申请人： Gene A. Bornzin ,  Yougandh Chitre ,  John W. Poore

发明人： Gene A. Bornzin ,  Yougandh Chitre ,  John W. Poore

IPC分类号： A61N1/05

CPC分类号： A61N1/0587

摘要： A system for pericardial lead implantation is disclosed herein. The system includes an implantation tool and a stimulation lead. The implantation tool includes a tubular body, a first lumen, a second lumen, a stylet or guidewire, a first port, and a second port. The first and second lumens longitudinally extend through tubular body. The first port is in communication with the first lumen, and the second port is in communication with the second lumen. The stylet or guidewire is longitudinally displaceable in the first lumen and across the first port. A tissue adhesive is selectively administrable through the second port via the second lumen. The stimulation lead includes a distal end and an engagement feature. Placing the engagement feature in the first port and causing the stylet or guidewire to displace in a first direction across the first port causes the lead to attach to the implantation tool. Displacing the stylet or guidewire in a second direction opposite the first direction allows the lead to detach from the implantation tool.

摘要翻译： 本文公开了用于心包线植入的系统。 该系统包括植入工具和刺激引线。 植入工具包括管状体，第一腔，第二腔，探针或导丝，第一端口和第二端口。 第一和第二管腔纵向延伸穿过管状体。 第一端口与第一管腔连通，第二端口与第二管腔连通。 探针或导丝可在第一管腔中纵向移动并穿过第一端口。 组织粘合剂可经由第二内腔通过第二端口选择性地施用。 刺激引线包括远端和接合特征。 将接合特征放置在第一端口中并且导致探针或导丝沿第一方向跨越第一端口移位导致引线附着到植入工具。 在与第一方向相反的第二方向上置换探针或导丝允许引线从植入工具脱离。

公开(公告)号：US07369901B1

公开(公告)日：2008-05-06

申请号：US11056666

申请日：2005-02-10

申请人： Kevin L. Morgan ,  John R. Helland ,  Sheldon Williams ,  Yougandh Chitre ,  Andrew W. McGarvey ,  Christopher Fleck ,  Jnyan Patel ,  Scott Salys ,  Kerwyn Schimke

发明人： Kevin L. Morgan ,  John R. Helland ,  Sheldon Williams ,  Yougandh Chitre ,  Andrew W. McGarvey ,  Christopher Fleck ,  Jnyan Patel ,  Scott Salys ,  Kerwyn Schimke

IPC分类号： A61N1/362 ,  A61N1/05

CPC分类号： A61N1/059

摘要： An implantable myocardial stimulation lead comprises a lead body having a distal end and a proximal end, and an electrical connector carried by the proximal end of the lead body. An electrode header carried by the distal end of the lead body has an axis and includes a helical fixation element extending along the axis, the electrode header having a surface configured to receive a driver for rotating the electrode header to screw the helical fixation element into the tissue of the heart. The lead body carries along its length a strain relief member resisting excessive bending of the lead body.

摘要翻译： 植入式心肌刺激引线包括具有远端和近端的引线主体和由引线主体的近端承载的电连接器。 由引线主体的远端承载的电极头具有轴线并且包括沿着轴线延伸的螺旋固定元件，电极头具有被配置为接收驱动器的表面，该驱动器用于旋转电极头以将螺旋固定元件拧入 心脏的组织 引线体沿其长度方向承载抵抗引线体的过度弯曲的应变消除部件。

公开(公告)号：US07218960B1

公开(公告)日：2007-05-15

申请号：US10606299

申请日：2003-06-24

申请人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

发明人： Xiaoyi Min ,  Yougandh Chitre ,  Jeffery D. Snell ,  Gene A. Bornzin ,  Jong Kil

IPC分类号： A61B5/0452

CPC分类号： A61B5/0452 ,  A61B5/0031 ,  A61B5/7242 ,  A61N1/3702

摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

摘要翻译： 提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。 由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发病的方法。 简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。 如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。 本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

公开(公告)号：US07174221B1

公开(公告)日：2007-02-06

申请号：US10736082

申请日：2003-12-12

申请人： Cole H. Chen ,  Phong D. Doan ,  Yougandh Chitre ,  John R. Helland

发明人： Cole H. Chen ,  Phong D. Doan ,  Yougandh Chitre ,  John R. Helland

IPC分类号： A61N1/05

CPC分类号： A61N1/0568

摘要： A drug-eluting endocardial lead and method of manufacture. The silicone elastomer of the present invention is ideally suited to a manufacturing environment due to its extended pot life and decreased curing time. A preferred silicone elastomer is comprised of a multi-part mixture having at least a base portion and a curing portion. Additionally, since curing does not begin until the base and curing portions are combined, the mixing can be physically undertaken closer to the location of the endocardial lead and the curing “clock” does not start until the mixing occurs and external heat is applied. Since the silicone elastomer formed by base and curing components have improved the pot life and curing characteristics, the mixture is suitable for mixing with a steroid and then dispensing into an endocardial lead tip thus eliminating current design limitations imposed by current art while concomitantly minimizing manufacturing costs.

摘要翻译： 药物洗脱心内膜铅及其制造方法。 本发明的有机硅弹性体由于其使用寿命延长并且固化时间缩短而理想地适用于制造环境。 优选的有机硅弹性体由至少具有基部分和固化部分的多部分混合物组成。 此外，由于固化直到基部和固化部分组合才开始固化，所以混合可以在物理上更接近于心内膜的位置，并且固化“钟”不会开始，直到混合发生并且外部加热。 由于由碱和固化组分形成的硅氧烷弹性体已经改善了适用期和固化特性，所以该混合物适用于与类固醇混合，然后分配到心内膜引导末端，从而消除了当前技术所施加的当前设计限制，同时最小化制造成本 。

公开(公告)号：US06973352B1

公开(公告)日：2005-12-06

申请号：US10313699

申请日：2002-12-05

申请人： Duane Tsutsui ,  Yougandh Chitre

发明人： Duane Tsutsui ,  Yougandh Chitre

IPC分类号： A61B5/042 ,  A61M25/00 ,  A61M25/01 ,  A61N1/00 ,  A61N1/05

CPC分类号： A61M25/0152 ,  A61B5/042 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0136 ,  A61M2025/0039 ,  A61M2025/004 ,  A61N1/056 ,  A61N2001/0578

摘要： An assist device for an implantable cardiac stimulation lead system includes a handle for a steerable guidewire system. An inner conductive guidewire with a distal tip electrode is pre-shaped into a free state curved configuration. An outer sheath is coaxial with the guidewire and relatively slidable between a first position restraining the guidewire to a straight condition and a second position withdrawn from a freed length of the guidewire allowing it to assume its free state curved condition. A collar on the outer sheath is movable along the handle for moving the sheath between the first and second positions. An electrical terminal is in electrical continuity with the tip electrode such that a pacing system analyzer connected between the electrical terminal and a reference electrode in the body is operable for seeking a location at which optimal pacing parameters can be determined prior to final implantation of the lead system.

摘要翻译： 用于可植入心脏刺激引导系统的辅助装置包括用于可转向导丝系统的手柄。 具有远端尖端电极的内导电导线预成形为自由状态弯曲构型。 外护套与导丝线同轴，并且可在将导丝限制到直线状态的第一位置和从引导线的释放长度引出的第二位置之间相对滑动，从而允许其呈现其自由状态弯曲状态。 外护套上的套环可沿手柄移动，用于在第一和第二位置之间移动护套。 电端子与尖端电极电连通，使得连接在电气端子和身体中的参考电极之间的起搏系统分析仪可操作用于寻找在最终植入引线之前可以确定最佳起搏参数的位置 系统。