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公开(公告)号：US08187854B2
公开(公告)日：2012-05-29
申请号：US12161582
申请日：2007-01-22
申请人： Jesper Vind , Jürgen Carsten Franz Knötzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
发明人： Jesper Vind , Jürgen Carsten Franz Knötzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
摘要： The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译： 本发明提供了变体脂肪酶，优选具有通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味产生倾向的变体。
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公开(公告)号：US20110158976A1
公开(公告)日：2011-06-30
申请号：US11597273
申请日：2005-05-24
申请人： Allan Svendsen , Svend Kaasgaard , Kim Borch , Morten Fischer , Dan Pettersson , Peter Colin Gregory
发明人： Allan Svendsen , Svend Kaasgaard , Kim Borch , Morten Fischer , Dan Pettersson , Peter Colin Gregory
CPC分类号： A61K38/482 , A61K38/465 , A61K38/47 , A61K2300/00
摘要： The pharmaceutical use of proteases related to a protease derived from Nocardiopsis sp. NRRL 18262 (SEQ ID NO: 1), optionally in combination with a lipase and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.
摘要翻译： 与来自诺卡氏菌属的蛋白酶有关的蛋白酶的药物用途 NRRL 18262（SEQ ID NO：1），任选与脂肪酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。
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33.发明授权公开(公告)号：US07919298B2
公开(公告)日：2011-04-05
申请号：US12393283
申请日：2009-02-26
申请人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
发明人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
CPC分类号： C12N9/20
摘要： The invention provides polypeptides obtained by introducing mutations in one or more regions identified in a parent lipase. The polypeptides of the present invention have surprisingly been found to have a low specific activity towards short chain fatty acids leading to a reduced odor generation and an increased BR over the lipases known in the art.
摘要翻译： 本发明提供通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的多肽。 令人惊奇地发现本发明的多肽对短链脂肪酸具有低比活性，导致气味产生减少，并且在本领域已知的脂肪酶上增加BR。
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公开(公告)号：US07465570B2
公开(公告)日：2008-12-16
申请号：US10556511
申请日：2004-04-29
CPC分类号： A21D8/042 , C12N9/18 , C12N9/20 , C12Y301/01032
摘要： The inventors have developed improved polypeptides by substituting or deleting specified amino acids in fungal lipolytic enzymes. More particularly, the polypeptides result in a reduction of dough stickiness when they are added to a dough. The polypeptides may particularly have activity on polar lipids.
摘要翻译： 本发明人通过在真菌脂肪分解酶中取代或缺失特定的氨基酸而开发了改进的多肽。 更具体地说，当将多肽加入面团时，多肽导致面团粘性降低。 多肽可以特别地对极性脂质具有活性。
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公开(公告)号：US20080293120A1
公开(公告)日：2008-11-27
申请号：US12169679
申请日：2008-07-09
IPC分类号： C12N9/20
CPC分类号： A21D8/042 , C12N9/18 , C12N9/20 , C12Y301/01032
摘要： The inventors have developed improved polypeptides by substituting or deleting specified amino acids in fungal lipolytic enzymes. More particularly, the polypeptides result in a reduction of dough stickiness when they are added to a dough. The polypeptides may particularly have activity on polar lipids.
摘要翻译： 本发明人通过在真菌脂肪分解酶中取代或缺失特定的氨基酸而开发了改进的多肽。 更具体地说，当将多肽加入面团时，多肽导致面团粘性降低。 多肽可以特别地对极性脂质具有活性。
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公开(公告)号：US07396657B2
公开(公告)日：2008-07-08
申请号：US11602553
申请日：2006-11-21
申请人： Signe Munk , Jesper Vind , Kim Borch , Shamkant Anant Patkar , Sanne O. Schroder Glad , Allan Svendsen
发明人： Signe Munk , Jesper Vind , Kim Borch , Shamkant Anant Patkar , Sanne O. Schroder Glad , Allan Svendsen
CPC分类号： C11D3/38627
摘要： Attaching a peptide extension to the C-terminal amino acid of a lipase reduces the tendency to form odor. This may lead to lipase variants with a reduced odor generation when washing textile soiled with fat which includes relatively short-chain fatty acyl groups (e.g., up to C8) such as dairy stains containing butter fat or tropical oils such as coconut oil or palm kernel oil.
摘要翻译： 将肽延伸连接到脂肪酶的C末端氨基酸可降低形成气味的倾向。 当洗涤用脂肪污染的纺织品时，可能导致脂肪酶变体具有减少的气味产生，所述脂肪包括相对短链的脂肪酰基（例如高达C 8 N 8），例如含有脂肪或热带 油如椰子油或棕榈仁油。
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公开(公告)号：US20050059130A1
公开(公告)日：2005-03-17
申请号：US10779427
申请日：2004-11-22
申请人： Kirsten Bojsen , Allan Svendsen , Claus Fuglsang , Shamkant Patkar , Kim Borch , Jesper Vind , Andreas Petri , Sanne Schroder Glad , Gitte Budolfsen
发明人： Kirsten Bojsen , Allan Svendsen , Claus Fuglsang , Shamkant Patkar , Kim Borch , Jesper Vind , Andreas Petri , Sanne Schroder Glad , Gitte Budolfsen
IPC分类号： A23C17/02 , A21D8/04 , A23L7/104 , C11B3/00 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N9/20 , C12N15/09 , C12P9/00 , C07H21/04
CPC分类号： C12Y301/01003 , A21D8/042 , C11B3/003 , C11D3/38627 , C12N9/20 , C12P9/00
摘要： The substrate specificity of a lipolytic enzyme can be modified by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a desired activity or to decrease the level of an undesired activity. Thus, the inventors have developed lipolytic enzyme variants with a modified amino acid sequence with a substrate specificity which can be tailored for specific uses.
摘要翻译： 可以通过改变脂肪分解酶的限定区域中的氨基酸序列来修饰脂解酶的底物特异性，从而增加所需活性的水平或降低不需要的活性的水平。 因此，本发明人已经开发了具有修饰的氨基酸序列的脂肪分解酶变体，其具有底物特异性，其可以针对特定用途进行定制。
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公开(公告)号：US20120207741A1
公开(公告)日：2012-08-16
申请号：US13456781
申请日：2012-04-26
申请人： Allan Svendsen , Svend Kaasgaard , Kim Borch , Morten Fischer , Dan Pettersson , Peter Colin Gregory
发明人： Allan Svendsen , Svend Kaasgaard , Kim Borch , Morten Fischer , Dan Pettersson , Peter Colin Gregory
CPC分类号： A61K38/482 , A61K38/465 , A61K38/47 , A61K2300/00
摘要： The pharmaceutical use of proteases related to a protease derived from Nocardiopsis sp. NRRL 18262 (SEQ ID NO: 1), optionally in combination with a lipase and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.
摘要翻译： 与来自诺卡氏菌属的蛋白酶有关的蛋白酶的药物用途 NRRL 18262（SEQ ID NO：1），任选与脂肪酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。
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公开(公告)号：US07879587B2
公开(公告)日：2011-02-01
申请号：US12443625
申请日：2007-10-02
申请人： Allan Svendsen , Jesper Vind , Shamkant Anant Patkar , Kim Borch
发明人： Allan Svendsen , Jesper Vind , Shamkant Anant Patkar , Kim Borch
CPC分类号： C12N9/20 , C07K2299/00
摘要： Variants with increased acyl transferase activity can be designed on the basis of a three-dimensional model by making amino acid alterations near the active Ser of lipolytic enzymes such as C. antarctica lipase A or the lipase/acyl transferase from C. parapsilosis.
摘要翻译： 具有增加的酰基转移酶活性的变体可以在三维模型的基础上通过在脂肪分解酶如南极洲洲脂肪酶A或来自副杆菌病的脂肪酶/酰基转移酶的活性Ser附近进行氨基酸改变来设计。
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公开(公告)号：US20100291262A1
公开(公告)日：2010-11-18
申请号：US12849911
申请日：2010-08-04
申请人： Kirsten Bojsen , Allan Svendsen , Claus Crone Fuglsang , Shamkant Anant Patkar , Kim Borch , Jesper Vind , Andreas Petri , Sanne O. Schroder Glad , Gitte Budolfsen
发明人： Kirsten Bojsen , Allan Svendsen , Claus Crone Fuglsang , Shamkant Anant Patkar , Kim Borch , Jesper Vind , Andreas Petri , Sanne O. Schroder Glad , Gitte Budolfsen
CPC分类号： C12Y301/01003 , A21D8/042 , C11B3/003 , C11D3/38627 , C12N9/20 , C12P9/00
摘要： The substrate specificity of a lipolytic enzyme can be modified by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a desired activity or to decrease the level of an undesired activity. Thus, the inventors have developed lipolytic enzyme variants with a modified amino acid sequence with a substrate specificity which can be tailored for specific uses.
摘要翻译： 可以通过改变脂肪分解酶的限定区域中的氨基酸序列来修饰脂解酶的底物特异性，从而增加所需活性的水平或降低不需要的活性的水平。 因此，本发明人已经开发了具有修饰的氨基酸序列的脂肪分解酶变体，其具有底物特异性，其可以针对特定用途进行定制。
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