公开(公告)号：US20160130299A1

公开(公告)日：2016-05-12

申请号：US14833422

申请日：2015-08-24

Applicant: Bristol-Myers Squibb Company

Inventor： Heidi L. PEREZ ,  Donna WEI ,  Robert M. BORZILLERI ,  Sanjeev GANGWAR ,  Gretchen M. SCHROEDER ,  Heng CHENG ,  Robert J. SCHMIDT

IPC: C07K5/078 ,  A61K47/48 ,  C07K16/30 ,  C07K5/062

CPC classification number: C07K5/06139 ,  A61K47/48438 ,  A61K47/48569 ,  A61K47/48715 ,  A61K47/6817 ,  A61K47/6851 ,  A61K47/6889 ,  C07K5/06026 ,  C07K5/06034 ,  C07K5/06052 ,  C07K16/3038 ,  C07K16/3046

Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.

Abstract translation: 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和Y如本文所定义的式（I）的妥布林类似物是可用于治疗癌症的抗有丝分裂剂，特别是当与靶向缀合时 部分。

公开(公告)号：US20230122249A1

公开(公告)日：2023-04-20

申请号：US17793162

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Matthew COX ,  Liqi HE ,  Daniel O'MALLEY ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Matthias BROEKEMA ,  Prasanna SIVAPRAKASAM ,  Christine M. TARBY ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH,Murugaiah

IPC: C07D487/04 ,  C07D519/00

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230041738A1

公开(公告)日：2023-02-09

申请号：US17793174

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Matthew COX ,  Liqi HE ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Mathias BROEKEMA ,  Christine M. TARBY ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC: A61K31/519 ,  C07D519/00 ,  C07D487/04 ,  A61K31/5386 ,  A61K39/395

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). (I) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20200317672A1

公开(公告)日：2020-10-08

申请号：US16904337

申请日：2020-06-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liqi HE ,  Sanjeev GANGWAR ,  Shoshana L. POSY ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61P37/04 ,  A61K47/60 ,  A61K47/68 ,  A61K31/52

Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20200255429A1

公开(公告)日：2020-08-13

申请号：US16865009

申请日：2020-05-01

Applicant: Bristol-Myers Squibb Company

Inventor： Liqi HE ,  Sanjeev GANGWAR ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61P37/04

Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20200048255A1

公开(公告)日：2020-02-13

申请号：US16660365

申请日：2019-10-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Liqi HE ,  Sanjeev GANGWAR ,  Shoshana L. POSY ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61K47/68 ,  A61K47/60 ,  A61P37/04

Abstract: Compounds having a structure according to formula (I) where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20200024279A1

公开(公告)日：2020-01-23

申请号：US16583869

申请日：2019-09-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Sanjeev GANGWAR ,  Prasanna SIVAPRAKASAM ,  Shoshana L. POSY

IPC: C07D473/18 ,  A61P37/04

Abstract: Compounds having a structure according to formula (I) where R1, R2, and R3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20180079781A1

公开(公告)日：2018-03-22

申请号：US15785675

申请日：2017-10-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yong ZHANG ,  Ivar M. MCDONALD ,  Naidu S. CHOWDARI ,  Tram N. HUYNH ,  Robert M. BORZILLERI ,  Sanjeev GANGWAR

IPC: C07K5/062

CPC classification number: C07K5/06052 ,  A61K47/6843 ,  A61K47/6849 ,  C07D487/04 ,  C07D519/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/76

Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).

公开(公告)号：US20170073357A1

公开(公告)日：2017-03-16

申请号：US15351843

申请日：2016-11-15

Applicant: Bristol-Myers Squibb Company

Inventor： Yong ZHANG ,  Ivar M. MCDONALD ,  Naidu S. CHOWDARI ,  Tram N. HUYNH ,  Robert M. BORZILLERI ,  Sanjeev GANGWAR

IPC: C07D519/00

CPC classification number: C07K5/06052 ,  A61K47/6843 ,  A61K47/6849 ,  C07D487/04 ,  C07D519/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/76

Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).

Abstract translation: 其中式（I），（Ia）和（Ib）中的变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。

公开(公告)号：US20140227298A1

公开(公告)日：2014-08-14

申请号：US14177498

申请日：2014-02-11

Applicant: Bristol-Myers Squibb Company

Inventor： Qiang CONG ,  Heng CHENG ,  Sanjeev GANGWAR

IPC: C07K5/06 ,  A61K47/48

CPC classification number: C07K5/1024 ,  A61K38/05 ,  A61K38/07 ,  A61K47/48246 ,  A61K47/48415 ,  A61K47/48569 ,  A61K47/48592 ,  A61K47/48607 ,  A61K47/48615 ,  A61K47/48638 ,  A61K47/6811 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6861 ,  A61K47/6863 ,  A61K47/6869 ,  C07K5/06 ,  C07K5/06139 ,  C07K5/06165 ,  C07K5/10 ,  C07K5/1016 ,  C07K7/06

Abstract: Tubulysin compounds of the formula (I) where R1, R2R3a, R3b, R4, R5, W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.

Abstract translation: 其中R 1，R 2 R 3 a，R 3b，R 4，R 5，W和n如本文所定义的式（I）的调蛋白素化合物是可用于治疗癌症的抗有丝分裂剂，特别是当与靶向部分缀合时 。