摘要:
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
摘要:
A re-enterable enclosure for a cable splice includes a first cover member and a second cover member configured for engagement with each other, and movable between an open position and a closed position. The first and second cover members form a cavity for enclosing the cable splice when the cover members are in the closed position. Internal walls in at least one of the first and second cover members are configured to define a sealant containment space that at least partially surrounds the cavity. At least one latch is configured to maintain the first and second cover members in the closed position, the at least one latch configured to exert a compression force along a line extending through the sealant containment space.
摘要:
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
摘要:
A magnetic recording media with a multilayer structure and methods for forming the media are described. The magnetic recording media includes a substrate, an underlayer on top of the substrate and a magnetic layer over the underlayer. The underlayer includes a CrN film formed by sputter depositing chromium in the presence of nitrogen or nitrogen containing compounds.
摘要:
A modular framework for data import/export in an application that allows modules/components to be independently developed for importing and exporting data related to specific entities, including the handling of dependencies between entities. The framework is metadata driven which allows new entities to be introduced in the application with new modules for importing/exporting data related to those entities, without updating modules for exporting existing entities. Each type of entity is defined with a schema that represents the logical entity such that the entity is agnostic as to how the entity data is stored in database tables. A master configuration file is created for the application that lists each entity that can be imported or exported by the application, and defines how the framework imports or exports the business entity. Additionally, dynamic batching is provided to divide large datasets into multiple batches for suitable consumption by consumers of the exported data.
摘要:
The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
摘要:
A system and method for determining unknown values of certain motor parameters includes a motor input device connectable to an electric motor having associated therewith values for known motor parameters and an unknown value of at least one motor parameter. The motor input device includes a processing unit that receives a first input from the electric motor comprising values for the known motor parameters for the electric motor and receive a second input comprising motor data on a plurality of reference motors, including values for motor parameters corresponding to the known motor parameters of the electric motor and values for motor parameters corresponding to the at least one unknown motor parameter value of the electric motor. The processor determines the unknown value of the at least one motor parameter from the first input and the second input and determines a motor management strategy for the electric motor based thereon.
摘要:
A system and method for measuring and controlling stator winding temperature in an AC motor while idling is disclosed. The system includes a circuit having an input connectable to an AC source and an output connectable to an input terminal of a multi-phase AC motor. The circuit further includes a plurality of switching devices to control current flow and terminal voltages in the multi-phase AC motor and a controller connected to the circuit. The controller is configured to activate the plurality of switching devices to create a DC signal in an output of the motor control device corresponding to an input to the multi-phase AC motor, determine or estimate a stator winding resistance of the multi-phase AC motor based on the DC signal, and estimate a stator temperature from the stator winding resistance. Temperature can then be controlled and regulated by DC injection into the stator windings.
摘要:
Data in tables with foreign key relationship is synchronized in batches employing a two-pass process during playback based on whether the foreign key constraint is a linear dependency, self-referencing, or cyclic. A separate table containing a primary key of records and database timestamp columns for change operations may also be used for batch synchronization in addition to or instead of adding database timestamp columns to existing tables.
摘要:
An end cap (30) for sealing an end of a closure about a cable member directed therein. The end cap (30) includes a wall member (32) having a first surface (34), an exterior surface and an outer circumferential edge. A longitudinal port (40) extends through the wall member (32) from the first surface to the exterior surface. The port (40) has a transverse cross-sectional shape defined by first and second lobed portions (42, 44) joined at a waist (46), the cross-sectional shape of the port configured for receiving a cable assembly having a corresponding transverse cross-section.