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139 条记录 (耗时 0.031 秒)

    Thiophenopyrimidines
    32.
    发明授权
    Thiophenopyrimidines 失效
    噻吩并嘧啶

    公开(公告)号：US06255310B1

    公开(公告)日：2001-07-03

    申请号：US09117715

    申请日：1998-12-28

    申请人： Thomas R. Webb ,  Chen Chen ,  James R. McCarthy ,  Terence J. Moran

    发明人： Thomas R. Webb ,  Chen Chen ,  James R. McCarthy ,  Terence J. Moran

    IPC分类号： A61K31519

    CPC分类号： C07D495/04

    摘要： This invention concerns compounds of formula including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, wherein X is S, SO or SO2; R1 is NR4R5 or OR5; R2 is C1-6alkyl, C1-6alkyloxy or C1-6alkylthio; R3 is hydrogen, C1-6alkyl, C1-6alkylsulfonyl, C1-6alkylsulfoxy or C1-6alkylthio; R4 is hydrogen, C1-6alkyl, mono- or di(C3-6cycloalkyl)methyl, C3-6cycloalkyl, C3-6alkenyl, hydroxyC1-6alkyl, C1-6alkylcarbonyloxyC1-6alkyl or C1-6alkyloxyC1-6alkyl; R5 is C1-8alkyl, mono- or di(C3-6cycloalkyl)methyl, Ar1CH2, C1-6alkyloxy-C1-6alkyl, hydroxyC1-6alkyl, C3-6alkenyl, thienylmethyl, furanylmethyl, C1-6alkylthioC1-6alkyl, morpholinyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)amino, C1-6alkylcarbonylC1-6alkyl, C1-6alkyl substituted with imidazolyl; or a radical of formula —Alk—O—CO—Ar1; or R4 and R5 taken together with the nitrogen atom to which they are attached may form an optionally substituted pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl group; Ar is phenyl, substituted phenyl, pyridinyl or substituted pyridinyl; having CRF receptor antagonistic properties; pharmaceutical compositions containing such compounds as active ingredients; methods of treating disorders related to hypersecretion of CRF such as depression, anxiety, substance abuse, by administering an effective amount of a compound of formula (I).

    摘要翻译： 本发明涉及包括立体异构体及其药学上可接受的酸加成盐形式的化合物，其中X是S，SO或SO 2; R1是NR4R5或OR5; R2是C1-6烷基，C1-6烷氧基或C1-6烷硫基; R3是氢，C1-6烷基，C1-6烷基磺酰基，C1-6烷基亚磺酰基或C1-6烷硫基; R4是氢，C1-6烷基，一或二（C3-6环烷基）甲基，C3-6环烷基，C3-6烯基，羟基C1-6烷基，C1-6烷基羰基氧基C 1-6烷基或C 1-6烷氧基C 1-6烷基; R 5是C 1-8烷基，一或二（C 3-6环烷基）甲基，Ar 1 CH 2，C 1-6烷氧基-C 1-6烷基，羟基C 1-6烷基，C 3-6烯基，噻吩基甲基，呋喃基甲基，C 1-6烷硫基C 1-6烷基，吗啉基，单或 二（C 1-6烷基）氨基C 1-6烷基，二（C 1-6烷基）氨基，C 1-6烷基羰基C 1-6烷基，被咪唑基取代的C 1-6烷基; 或式-Alk-O-CO-Ar1基团; 或R 4和R 5与它们所连接的氮原子一起可以形成任选取代的吡咯烷基，哌啶基，高哌啶基或吗啉基; Ar是苯基，取代的苯基，吡啶基或取代的吡啶基; 具有CRF受体拮抗特性; 含有这些化合物作为活性成分的药物组合 通过施用有效量的式（I）化合物来治疗与CRF过度分泌有关的疾病的方法，例如抑郁症，焦虑症，药物滥用。

    Golf cart seat cover assemble
    34.
    外观设计
    Golf cart seat cover assemble 有权

    公开(公告)号：USD1032246S1

    公开(公告)日：2024-06-25

    申请号：US29867770

    申请日：2022-11-07

    申请人： Chen Chen

    设计人： Chen Chen

    摘要： FIG. 1 is a top and front side perspective view of a golf cart seat cover assemble, showing my new design;
    FIG. 2 is a top, front and right side perspective view thereof;
    FIG. 3 is a top, front and left side perspective view thereof;
    FIG. 4 is a top and back side perspective view thereof; and,
    FIG. 5 is a back and bottom side perspective view thereof.
    The broken lines shown in the FIG. 5 illustrate portions of the golf cart seat cover that form no part of the claimed design.

    Dual-mode low-power low-jitter noise phased locked loop system
    36.
    发明授权
    Dual-mode low-power low-jitter noise phased locked loop system 有权

    公开(公告)号：US10200189B1

    公开(公告)日：2019-02-05

    申请号：US15605220

    申请日：2017-05-25

    申请人： Qiang Li ,  Chen Chen

    发明人： Qiang Li ,  Chen Chen

    IPC分类号： H04L7/033 ,  H02M3/07 ,  H03L7/08 ,  H03L7/093

    摘要： A Dual-mode forward path PLL system and method are disclosed. The forward path PLL system includes a phase frequency detector (PFD) circuit including a first input node a second input node, a first output node a second output node, where the PFD receives a first input signal, a second input signal and generates a first output signal and second output signal, and where the first input signal is a reference frequency signal and the second input signal is a divided frequency value signal, a charge pump circuit including a third input node, a fourth input node and a third output node, where the third input node and the fourth input node are coupled to the first output node and the second output node of the PFD and where the Charge pump is programmable; and a loop filter circuit including a fifth input node and fourth output node, where the fifth input node is coupled to the third output node of the charge pump and where the loop filter circuit is programmable. In some aspects, the up-side switch and the down-side switch are current sources and the divided frequency value is signal is a fractional frequency value signal.

    Frequency capping and throttling of calls in a pay-per-call advertising solution
    38.
    发明授权
    Frequency capping and throttling of calls in a pay-per-call advertising solution 有权
    每个呼叫广告解决方案中的呼叫频率上限和调节

    公开(公告)号：US08588383B2

    公开(公告)日：2013-11-19

    申请号：US12971195

    申请日：2010-12-17

    申请人： Surojit Chatterjee ,  Anshul Kothari ,  Chen Chen

    发明人： Surojit Chatterjee ,  Anshul Kothari ,  Chen Chen

    IPC分类号： H04M15/00

    CPC分类号： H04M15/8083 ,  H04M2215/0192

    摘要： Various methods, systems, and computer program products are disclosed for controlling a number of calls based on promotional message impressions. The method may include receiving a request to communicate at least one promotional message, wherein the at least one promotional message is associated with one or more phone numbers. The method may include communicating the at least one promotional message and the one or more phone numbers. The method may include receiving one or more calls associated with the at least one promotional message. The method may include determining a call through rate for the at least one promotional message based on the one or more calls. The method may include determining a number of impressions of the at least one promotional message based on the determined call through rate.

    摘要翻译： 公开了各种方法，系统和计算机程序产品，用于基于促销消息印象控制多个呼叫。 该方法可以包括接收至少一个促销消息的通信请求，其中至少一个促销消息与一个或多个电话号码相关联。 所述方法可以包括传达所述至少一个促销消息和所述一个或多个电话号码。 该方法可以包括接收与至少一个促销消息相关联的一个或多个呼叫。 该方法可以包括基于一个或多个呼叫确定至少一个促销消息的呼叫通过率。 该方法可以包括基于所确定的呼叫通过率来确定至少一个促销消息的展示次数。

    Compounds, pharmaceutical composition and methods relating thereto
    39.
    发明授权
    Compounds, pharmaceutical composition and methods relating thereto 有权
    化合物，药物组合物和与其有关的方法

    公开(公告)号：US08481731B2

    公开(公告)日：2013-07-09

    申请号：US12821219

    申请日：2010-06-23

    申请人： Joe A. Tran ,  Chen Chen

    发明人： Joe A. Tran ,  Chen Chen

    IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D487/04 ,  A61K31/4427 ,  A61K31/506 ,  A61P3/04 ,  A61P3/10

    CPC分类号： C07D471/04 ,  C07D401/14 ,  C07D403/14

    摘要： New compounds are disclosed which have utility in the treatment of a variety of metabolic related conditions in a patient. The compounds of this invention have the structure (I): wherein X1, X2, X3, X4, Y1, Y2, A, R1, R2, R3, R4, m, n, p, and q are as defined herein, including stereoisomers, esters, and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof in a patient in need thereof.

    摘要翻译： 公开了可用于治疗患者中各种代谢相关病症的新化合物。 本发明的化合物具有结构（I）：其中X1，X2，X3，X4，Y1，Y2，A，R1，R2，R3，R4，m，n，p和q如本文所定义，包括立体异构体 ，酯及其药学上可接受的盐。 还公开了含有本发明化合物与药学上可接受的载体组合的组合物，以及与其在有需要的患者中的用途有关的方法。

    System and method for integrated timing control for an LCD display panel
    40.
    发明授权
    System and method for integrated timing control for an LCD display panel 有权
    LCD显示面板集成定时控制系统及方法

    公开(公告)号：US08405785B1

    公开(公告)日：2013-03-26

    申请号：US12547143

    申请日：2009-08-25

    申请人： David Auld ,  Lei He ,  Chen Chen ,  Gerard Kuang-Chang Yeh

    发明人： David Auld ,  Lei He ,  Chen Chen ,  Gerard Kuang-Chang Yeh

    IPC分类号： H04N3/14 ,  G09G3/20 ,  G09G5/00 ,  G06F3/038 ,  G06K9/36

    CPC分类号： G09G3/3611 ,  G09G2370/08

    摘要： A television display system including a display system controller, a transmitter, and an integrated timing controller. The display system controller receives pixel data and pixel timing and control data, and responsive to a pixel data format corresponding to a selected communication standard of a plurality of communication standards that includes LVDS and at least one of RSDS and mini-LVDS, provides formatted pixel data formatted according to the pixel data format of the selected communication standard. The transmitter receives the formatted pixel data, and transmits the formatted pixel data for receipt according to a pixel data rate corresponding to the selected communication standard. The integrated timing controller receives the pixel timing and control data, and responsive to the selected communication standard being one of RSDS and mini-LVDS, generates pixel display timing and control signals to display the formatted pixel data at the pixel data rate corresponding to the selected communication standard on a television display.

    摘要翻译： 一种电视显示系统，包括显示系统控制器，发射机和集成定时控制器。 显示系统控制器接收像素数据和像素定时和控制数据，并且响应于与包括LVDS和RSDS和迷你LVDS中的至少一个的多个通信标准的所选通信标准相对应的像素数据格式，提供格式化的像素 根据所选通信标准的像素数据格式格式化的数据。 发送器接收格式化的像素数据，并根据与选择的通信标准对应的像素数据速率发送用于接收的格式化的像素数据。 集成定时控制器接收像素定时和控制数据，并且响应所选择的通信标准为RSDS和小型LVDS之一，生成像素显示定时和控制信号，以对应于所选择的像素数据速率的像素数据速率显示格式化的像素数据 电视显示器上的通信标准。