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公开(公告)号：US20150313955A1
公开(公告)日：2015-11-05
申请号：US14648868
申请日：2013-03-07
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Shashank Potnis , Ravi Subramanyam , Rajitha Nair
IPC: A61K36/61 , A61K31/125 , A61K31/085
CPC classification number: A61K9/0053 , A61K8/042 , A61K8/34 , A61K8/347 , A61K8/35 , A61K8/922 , A61K31/085 , A61K31/125 , A61K36/61 , A61K47/34 , A61Q11/00 , A61K2300/00
Abstract: Disclosed herein are orally acceptable topical analgesic gels comprising a mixture of analgesic oils comprising (a) clove oil and/or eugenol, (b) a cooling agent, and (c) camphor; in an orally acceptable gel base, the gel base providing controlled release of the mixture of analgesic oils following application to a tooth; together with methods of making and using the same.
Abstract translation: 本文公开了口服可接受的局部止痛凝胶，其包含镇痛油的混合物，其包含（a）丁香油和/或丁子香油，（b）冷却剂和（c）樟脑; 在口服可接受的凝胶基质中，凝胶基质在施用于牙齿后提供镇痛油混合物的控制释放; 以及制作和使用方法。
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公开(公告)号：US08895929B2
公开(公告)日：2014-11-25
申请号：US14322897
申请日：2014-07-02
Applicant: Colgate-Palmolive Company
Inventor： Jennifer Gronlund , Guofeng Xu , Deborah A. Peru , Ravi Subramanyam
CPC classification number: G01N21/33 , A46B15/0002 , A46B15/0004 , A46B15/0034 , A46B2200/1066 , A61B5/0075 , A61B5/4547 , A61B5/4552 , A61B5/6887 , G01N21/359
Abstract: Improved analytical, diagnostic, monitoring, and other methods (and their associated devices) for evaluating the extent of deposition of an agent onto a substrate are described. Exemplary methods may be used in the in the monitoring of the dental health of patients or in the fast, efficient screening and/or characterization of formulations in terms of their use for depositing oral actives onto tooth surfaces. The methods involve the direct or in situ analysis of substrates, onto which agents are deposited, using Near-IR spectroscopy and/or UV spectroscopy.
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公开(公告)号：US11690833B2
公开(公告)日：2023-07-04
申请号：US16955160
申请日：2018-12-07
Applicant: Colgate-Palmolive Company
Inventor： Viktor Dubovoy , Junhong Mao , Ravi Subramanyam , Long Pan , Tatiana Brinzari
IPC: A61K31/4425 , A61K47/52
CPC classification number: A61K31/4425 , A61K47/52
Abstract: Described herein are complexes comprising a cationic antibacterial agent and a metal salt, personal care compositions comprising same; along with methods of making and using these complexes and compositions.
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Patent Agency Ranking
公开(公告)号：US11384101B2
公开(公告)日：2022-07-12
申请号：US16889093
申请日：2020-06-01
Applicant: Colgate-Palmolive Company
Inventor： Viktor Dubovoy , Long Pan , Ravi Subramanyam , Tatiana Brinzari
Abstract: Described herein are complexes comprising a cationic antibacterial agent and a metal salt; oral care compositions comprising same; along with methods of making and using these complexes and compositions.
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公开(公告)号：US11091502B2
公开(公告)日：2021-08-17
申请号：US16714884
申请日：2019-12-16
Applicant: Colgate-Palmolive Company
Inventor： Zhigang Hao , Chi-Yuan Cheng , Tatiana Brinzari , Long Pan , Ravi Subramanyam
IPC: C07F3/06 , A61K8/27 , A61K8/44 , C07C229/26
Abstract: Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc halide and amino acid free base in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
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公开(公告)号：US10952943B2
公开(公告)日：2021-03-23
申请号：US16714972
申请日：2019-12-16
Applicant: Colgate-Palmolive Company
Inventor： Zhigang Hao , Chi-Yuan Cheng , Tatiana Brinzari , Long Pan , Ravi Subramanyam
Abstract: The disclosure provides a zinc-arginine complex, methods of making the same, and methods of using the same in oral care compositions.
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公开(公告)号：US10350151B2
公开(公告)日：2019-07-16
申请号：US15539275
申请日：2014-12-26
Applicant: Colgate-Palmolive Company
Inventor： Baohua Qiao , Long Pan , Gregory Szewczyk , Ravi Subramanyam , Shiri Nawrocki , Viktor Dubovoy
Abstract: A soluble zinc polyphosphate complex made by combining ingredients which include an organic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the organic zinc salt and long chain polyphosphates being mixed in amounts that provide a phosphorus to zinc mole ratio of 15:1 to about 55:1. Further provided is a method of making this soluble zinc polyphosphate.
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公开(公告)号：US20160143978A1
公开(公告)日：2016-05-26
申请号：US14648715
申请日：2013-03-07
Applicant: Colgate-Palmolive Company
Inventor： Shashank Potnis , Ravi Subramanyam , Rajitha Nair
IPC: A61K36/61 , A61K31/045 , A61K31/125 , A61K9/06 , A61K9/00
CPC classification number: A61K36/61 , A61K9/0053 , A61K9/06 , A61K31/045 , A61K31/085 , A61K31/125 , A61K36/185 , A61K36/48 , A61K47/183 , A61K47/32 , A61K2300/00
Abstract: Disclosed herein are orally acceptable topical analgesic gels comprising a mixture of analgesic oils comprising (a) clove oil and/or eugenol, (b) a cooling agent, and (c) camphor, in an orally acceptable gel base, the gel base comprising an anionic polymer and a basic amino acid, and the analgesic gel providing controlled release of the mixture of analgesic oils following application to a tooth together with a methods of making and using the same.
Abstract translation: 本文公开了口服可接受的局部止痛凝胶，其包含镇痛油的混合物，其包含（a）丁香油和/或丁子香酚，（b）冷却剂和（c）樟脑，在口腔可接受的凝胶基质中，所述凝胶基质包含 阴离子聚合物和碱性氨基酸，并且镇痛凝胶与施用于牙齿的镇痛油混合物以及制备和使用止痛剂的方法一起提供控制释放。
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