公开(公告)号：US20080265154A1

公开(公告)日：2008-10-30

申请号：US11742203

申请日：2007-04-30

Applicant: Lisa Cousins ,  Gholamreza Javahery ,  Ilia Tomski

Inventor： Lisa Cousins ,  Gholamreza Javahery ,  Ilia Tomski

IPC: H01J49/04

CPC classification number: H01J49/063

Abstract: An ion guide includes a plurality of rods, arranged about an axis that extends lengthwise from one end to the other of the guide. The rods guide ions in a guide region along and about the axis. A conductive casing surrounds the rods. The casing and the rods are geometrically arranged to produce an axial electric field along the axis. Specifically, the geometry is such that a first constant applied DC voltage (UDC), applied to the rods, and a second constant applied DC voltage (UCASE) applied to the casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis.

Abstract translation: 离子导向器包括多个杆，其围绕从引导件的一端到另一端纵向延伸的轴线布置。 杆沿引导区域沿轴线引导离子。 导电套管围绕着棒。 壳体和杆几何地布置成沿轴线产生轴向电场。 特别地，几何形状使得施加到杆上的第一恒定施加的DC电压（U SUB DC）和施加到杆的第二恒定施加的DC电压（U> CASE ）施加到 所述壳体在所述壳体和所述轴线之间产生在所述轴线的不同位置处具有不同大小的电压梯度。

公开(公告)号：US07034292B1

公开(公告)日：2006-04-25

申请号：US10448495

申请日：2003-05-30

Applicant: Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins

Inventor： Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/00 ,  B01D59/44

CPC classification number: H01J49/4225 ,  H01J49/004 ,  H01J49/063

Abstract: A mass spectrometer is configured with individual multipole ion guides, configured in an assembly in alignment along a common centerline wherein at least a portion of at least one multipole ion guide mounted in the assembly resides in a vacuum region with higher background pressure, and the other portion resides in a vacuum region with lower background pressure. Said multipole ion guides are operated in mass to charge selection and ion fragmentation modes, in either a high or low pressure region, said region being selected according to the optimum pressure or pressure gradient for the function performed. The diameter, lengths and applied frequencies and phases on these contiguous ion guides may be the same or may differ. A variety of MS and MS/MSn analysis functions can be achieved using a series of contiguous multipole ion guides operating in either higher background vacuum pressures, or along pressure gradients in the region where the pressure drops from high to low pressure, or in low pressure regions. Individual sets of RF, +/−DC and resonant frequency waveform voltage supplies provide potentials to the rods of each multipole ion guide allowing the operation of ion transmission, ion trapping, mass to charge selection and ion fragmentation functions independently in each ion guide. The presence of background pressure maintained sufficiently high to cause ion to neutral gas collisions along a portion of each multiple ion guide linear assembly allows the conducting of Collisional Induced Dissociation (CID) fragmentation of ions by axially accelerating ions from one multipole ion guide into an adjacent ion guide. Alternatively ions can be fragmented in one or more multipole ion guides using resonant frequency excitation CID. A multiple multipole ion guide assembly can be configured as the primary mass analyzer in single or triple quadrupole mass analyzers with or without mass selective axial ejection. Alternatively, the multiple multipole ion guide linear assembly can be configured as part of a hybrid Time-Of-Flight, Magnetic Sector, Ion Trap or Fourier Transform mass analyzer.

公开(公告)号：US07868289B2

公开(公告)日：2011-01-11

申请号：US11742203

申请日：2007-04-30

Applicant: Lisa Cousins ,  Gholamreza Javahery ,  Ilia Tomski

Inventor： Lisa Cousins ,  Gholamreza Javahery ,  Ilia Tomski

IPC: H01J49/42

CPC classification number: H01J49/063

Abstract: An ion guide includes a plurality of rods, arranged about an axis that extends lengthwise from one end to the other of the guide. The rods guide ions in a guide region along and about the axis. A conductive casing surrounds the rods. The casing and the rods are geometrically arranged to produce an axial electric field along the axis. Specifically, the geometry is such that a first constant applied DC voltage (UDC), applied to the rods, and a second constant applied DC voltage (UCASE) applied to the casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis.

Abstract translation: 离子导向器包括多个杆，其围绕从引导件的一端到另一端纵向延伸的轴线布置。 杆沿引导区域沿轴线引导离子。 导电套管围绕着棒。 壳体和杆几何地布置成沿轴线产生轴向电场。 具体地，几何形状使得施加到杆的第一恒定施加的DC电压（UDC）和施加到壳体的第二恒定施加的DC电压（UCASE）在所述壳体和所述轴线之间产生电压梯度，所述电压梯度具有 沿着所述轴的不同位置处的不同大小。

公开(公告)号：US07858926B1

公开(公告)日：2010-12-28

申请号：US11409169

申请日：2006-04-21

Applicant: Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins

Inventor： Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/24 ,  H01J49/40

CPC classification number: H01J49/4225 ,  H01J49/004 ,  H01J49/063

Abstract: A mass spectrometer includes an ion source and at least one vacuum stage, a means for delivering ions from the ion source to the vacuum stage, a collision cell, a detector, at least two multipole ion guide segments, and independent RF frequency and DC voltage sources applied to the multipole ion guide segments, the RF frequency and DC voltage sources being controlled independently of each other.

Abstract translation: 质谱仪包括离子源和至少一个真空级，用于将离子从离子源输送到真空级的装置，碰撞池，检测器，至少两个多极离子导向段以及独立的RF频率和DC电压 施加到多极离子导向段的源，RF频率和DC电压源彼此独立地控制。

公开(公告)号：US08334507B1

公开(公告)日：2012-12-18

申请号：US11435034

申请日：2006-05-16

Applicant: Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins ,  Sergey Rakov

Inventor： Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins ,  Sergey Rakov

IPC: H01J49/42 ,  H01J49/26 ,  B01D59/44

CPC classification number: H01J49/147 ,  H01J49/0054

Abstract: Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided.

Abstract translation: 提供了能够使低能电子和正电子与样品离子相互作用的装置和方法，以便分别在多极离子导向结构内的电子俘获解离（ECD）和正电子俘获解离（PCD）。 最近已经发现，许多生物分子通过ECD的质子化离子的碎裂通常沿着不被其它解离方法接近的断裂途径进行，导致分子结构信息不容易获得。 然而，这种分析仅限于昂贵的傅里叶变换离子回旋共振（FTICR）质谱仪; 在常用的多极离子导向结构中的ECD的实现是由于RF场在这种装置内的干扰效应而成问题的。 本文描述的装置和方法成功地克服了这些困难，并且允许ECD（和PCD）在多极离子导向器中单独进行，或者与传统的离子碎裂方法组合进行。 因此，提供了利用多极离子导向器的质谱仪的改进的分析性能和功能性。

公开(公告)号：US07049584B1

公开(公告)日：2006-05-23

申请号：US11184387

申请日：2005-07-19

Applicant: Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins ,  Sergey Rakov

Inventor： Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins ,  Sergey Rakov

IPC: H01J49/26

CPC classification number: H01J49/147 ,  H01J49/0054

Abstract: Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided.

Abstract translation: 提供了能够使低能电子和正电子与样品离子相互作用的装置和方法，以便分别在多极离子导向结构内的电子俘获解离（ECD）和正电子俘获解离（PCD）。 最近已经发现，许多生物分子通过ECD的质子化离子的碎裂通常沿着不被其它解离方法接近的断裂途径进行，导致分子结构信息不容易获得。 然而，这种分析仅限于昂贵的傅里叶变换离子回旋共振（FTICR）质谱仪; 在常用的多极离子导向结构中的ECD的实现是由于RF场在这种装置内的干扰效应而成问题的。 本文描述的装置和方法成功地克服了这些困难，并且允许ECD（和PCD）在多极离子导向器中单独进行，或者与传统的离子碎裂方法组合进行。 因此，提供了利用多极离子导向器的质谱仪的改进的分析性能和功能性。

公开(公告)号：US06919562B1

公开(公告)日：2005-07-19

申请号：US10448477

申请日：2003-05-30

Applicant: Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins ,  Sergey Rakov

Inventor： Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins ,  Sergey Rakov

IPC: H01J49/26

CPC classification number: H01J49/147 ,  H01J49/0054

Abstract: Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided.

Abstract translation: 提供了能够使低能电子和正电子与样品离子相互作用的装置和方法，以便分别在多极离子导向结构内的电子俘获解离（ECD）和正电子俘获解离（PCD）。 最近已经发现，许多生物分子通过ECD的质子化离子的碎裂通常沿着不被其它解离方法接近的断裂途径进行，导致分子结构信息不容易获得。 然而，这种分析仅限于昂贵的傅里叶变换离子回旋共振（FTICR）质谱仪; 在常用的多极离子导向结构中的ECD的实现是由于RF场在这种装置内的干扰效应而成问题的。 本文描述的装置和方法成功地克服了这些困难，并且允许ECD（和PCD）在多极离子导向器中单独进行，或者与传统的离子碎裂方法组合进行。 因此，提供了利用多极离子导向器的质谱仪的改进的分析性能和功能性。

公开(公告)号：US06799355B2

公开(公告)日：2004-10-05

申请号：US10221479

申请日：2002-09-13

Applicant: Roger Guevremont ,  Randy Purves ,  David Barnett ,  Gholamreza Javahery ,  William Ronald Stott

Inventor： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Gholamreza Javahery ,  William Ronald Stott

IPC: H01J4940

CPC classification number: H01J49/004 ,  G01N27/624

Abstract: A method and an apparatus for selectively transmitting ions produced by an inductively coupled plasma ionization technique is disclosed. Ions produced within the plasma source are provided to a FAIMS analyzer within a low pressure chamber of a mass spectrometer and in fluid communication with the plasma source for receiving ions therefrom. The ions are separated in FAIMS and at least some of the ions are provided to the mass spectrometer after separation.

Abstract translation: 公开了一种用于选择性地传输由电感耦合等离子体电离技术产生的离子的方法和装置。 在等离子体源内产生的离子被提供给质谱仪的低压室内的FAIMS分析仪，并与等离子体源流体连通以接收离子。 离子在FAIMS中分离，分离后至少有一些离子被提供给质谱仪。

公开(公告)号：US09048076B2

公开(公告)日：2015-06-02

申请号：US14122534

申请日：2012-05-25

Applicant: William R. Stott ,  Gholamreza Javahery

Inventor： William R. Stott ,  Gholamreza Javahery

IPC: H01J49/04 ,  H01J49/00 ,  G01N1/22 ,  G01N1/24 ,  H01J49/02 ,  G01N1/02

CPC classification number: H01J49/0459 ,  G01N1/22 ,  G01N1/24 ,  G01N2001/022 ,  G01N2001/024 ,  H01J49/00 ,  H01J49/02 ,  H01J49/04

Abstract: Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the airflow travelling through the desorption channel. An ionizer forms ions from vapor molecules in the portion of the airflow. At least one mass spectrometer analyzes the ions to detect the target substance. The flow travels without interruption from the subject to the at least one mass spectrometer. The desorption channel causes a sufficient quantity of molecules to desorb from the analyte to enable the at least one mass spectrometer to detect the target substance.

Abstract translation: 公开了用于在不接触受试者的情况下检测被检物体上的目标物质的方法和装置。 至少一个空气喷射器将被分析物从受试者的表面吹入气流，夹带分析物的气流。 解吸通道在通过解吸通道行进的气流的一部分中从分析物解吸分子。 电离器在气流的一部分形成来自蒸气分子的离子。 至少一个质谱仪分析离子以检测目标物质。 该流动不间断地从受试者移动到至少一个质谱仪。 解吸通道导致足够数量的分子从分析物解吸，使得至少一个质谱仪能够检测目标物质。