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公开(公告)号：US09048076B2
公开(公告)日：2015-06-02
申请号：US14122534
申请日：2012-05-25
CPC分类号： H01J49/0459 , G01N1/22 , G01N1/24 , G01N2001/022 , G01N2001/024 , H01J49/00 , H01J49/02 , H01J49/04
摘要： Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the airflow travelling through the desorption channel. An ionizer forms ions from vapor molecules in the portion of the airflow. At least one mass spectrometer analyzes the ions to detect the target substance. The flow travels without interruption from the subject to the at least one mass spectrometer. The desorption channel causes a sufficient quantity of molecules to desorb from the analyte to enable the at least one mass spectrometer to detect the target substance.
摘要翻译： 公开了用于在不接触受试者的情况下检测被检物体上的目标物质的方法和装置。 至少一个空气喷射器将被分析物从受试者的表面吹入气流，夹带分析物的气流。 解吸通道在通过解吸通道行进的气流的一部分中从分析物解吸分子。 电离器在气流的一部分形成来自蒸气分子的离子。 至少一个质谱仪分析离子以检测目标物质。 该流动不间断地从受试者移动到至少一个质谱仪。 解吸通道导致足够数量的分子从分析物解吸，使得至少一个质谱仪能够检测目标物质。
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公开(公告)号：US07439498B2
公开(公告)日：2008-10-21
申请号：US11260663
申请日：2005-10-28
申请人： Albert Edward Litherland , Jonathan P. Doupe , William Edward Kieser , Xiao-Lei Zhao , Gholamreza Javahery , Lisa Cousins , Ilia Tomski , Charles Jolliffe
发明人： Albert Edward Litherland , Jonathan P. Doupe , William Edward Kieser , Xiao-Lei Zhao , Gholamreza Javahery , Lisa Cousins , Ilia Tomski , Charles Jolliffe
CPC分类号： H01J49/0086 , B01D59/44 , H01J49/0077 , H01J49/06
摘要： This invention relates to a method and apparatus for separation of rare stable or radioactive isotopes from their atomic or molecular isobars in mass spectrometry (MS). In the present invention, the approach taken to removing atomic isobars utilizes a high transmission device for decelerating ions in combination with low energy reactions, such as ion-molecule reactions or near resonant electron transfer, in RF ion guides. The isobar is selectively depleted by electron transfer or other reactions between negative ions and gaseous targets in pressurized RF ion guides at low energies. The energy is controlled in such a way as to prevent reaction of the ion of interest while inducing reactions with the undesired isobar interference. The technique is of particular relevance to accelerator mass spectrometry (AMS) for which it allows substantial reductions in the necessary terminal voltage. The effect is to allow reductions in the size and cost of AMS installations.
摘要翻译： 本发明涉及在质谱（MS）中从其原子或分子等值线分离稀有稳定或放射性同位素的方法和装置。 在本发明中，用于除去原子等压线的方法利用高传输装置，用于在RF离子导向器中结合低能量反应（例如离子分子反应或接近谐振电子转移）来减速离子。 在低能量下，加压RF离子导向器中的等离子体被电子转移或负离子与气态靶之间的其它反应选择性地耗尽。 控制能量以防止感兴趣的离子的反应，同时诱导与不期望的等压线干涉的反应。 该技术与加速器质谱（AMS）特别相关，其能够显着降低必需的终端电压。 其效果是可以减少AMS安装的尺寸和成本。
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公开(公告)号：US07405398B2
公开(公告)日：2008-07-29
申请号：US11406462
申请日：2006-04-18
IPC分类号： H01J49/00
CPC分类号： H01J49/0422 , H01J49/04 , H01J49/044 , H01J49/0468 , H01J49/06 , H01J49/26 , Y10T436/24
摘要： A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.
摘要翻译： 公开了具有改进的灵敏度和降低的化学背景的质谱仪界面。 质谱仪界面提供改进的去溶剂化学选择性和离子迁移。 部分溶剂化离子的流动沿曲折路径输送到流动扰动区域，其中离子和中性分子碰撞和混合。 热能被施加到扰动区域以促进至少一些离子化颗粒从任何附着的杂质的释放，从而增加流动中具有特征m / z比的离子化颗粒的浓度。 还可以进行分子反应和低压离子化方法以选择性去除或增强特定的离子。
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公开(公告)号：US06799355B2
公开(公告)日：2004-10-05
申请号：US10221479
申请日：2002-09-13
IPC分类号： H01J4940
CPC分类号： H01J49/004 , G01N27/624
摘要： A method and an apparatus for selectively transmitting ions produced by an inductively coupled plasma ionization technique is disclosed. Ions produced within the plasma source are provided to a FAIMS analyzer within a low pressure chamber of a mass spectrometer and in fluid communication with the plasma source for receiving ions therefrom. The ions are separated in FAIMS and at least some of the ions are provided to the mass spectrometer after separation.
摘要翻译： 公开了一种用于选择性地传输由电感耦合等离子体电离技术产生的离子的方法和装置。 在等离子体源内产生的离子被提供给质谱仪的低压室内的FAIMS分析仪，并与等离子体源流体连通以接收离子。 离子在FAIMS中分离，分离后至少有一些离子被提供给质谱仪。
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公开(公告)号：US06093929A
公开(公告)日：2000-07-25
申请号：US66556
申请日：1998-04-28
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/4215 , H01J49/4285
摘要： A mass spectrometer system in which ions are mass selected in an RF-only quadrupole at relatively high pressure (1 to 7 torr) using FNF or SWIFT, and are then fragmented in a following collision cell which is in the same vacuum chamber, thus reducing pumping needs. The fragments can be mass analyzed in any desired way, including by another RF-only quadrupole in the same vacuum chamber and also using FNF or SWIFT. Triple MS can be performed in the same way.
摘要翻译： 使用FNF或SWIFT在相对较高压力（1至7托）的RF仅四极杆中质量选择离子的质谱仪系统，然后在处于相同真空室中的后续碰撞池中碎裂，从而减少 抽水需要。 可以以任何所需的方式对片段进行质量分析，包括在同一真空室中使用另一个仅RF的四极杆，并使用FNF或SWIFT。 三重MS可以以相同的方式执行。
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公开(公告)号：US07932488B2
公开(公告)日：2011-04-26
申请号：US12437203
申请日：2009-05-07
CPC分类号： H01J49/066
摘要： An ion guide includes multiple stages. An electric field within each stage guides ions along a guide axis. Within each stage, amplitude and frequency, and resolving potential of the electric field may be independently varied. The geometry of the rods maintains a similarly shaped field from stage to stage, allowing efficient guidance of the ions along the axis. In particular, each rod segment of the ith of stage has a cross sectional radius ri, and a central axis located a distance Ri+ri from the guide axis. The ratio ri/Ri and is substantially constant along the guide axis, thereby preserving the shape of the field.
摘要翻译： 离子导向器包括多个阶段。 每个阶段内的电场沿引导轴引导离子。 在每个阶段内，可以独立地改变振幅和频率以及电场的分辨能力。 杆的几何形状保持了从阶段到阶段的类似形状的场，允许离子沿轴线的有效引导。 特别地，平台的第i个的每个杆段具有横截面半径ri，并且中心轴线位于与引导轴线的距离Ri + ri。 比率ri / Ri并且沿引导轴线基本上恒定，从而保持场的形状。
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公开(公告)号：US20090194687A1
公开(公告)日：2009-08-06
申请号：US12024752
申请日：2008-02-01
CPC分类号： H01J49/10 , H01J49/24 , Y10S438/961
摘要： An ion source and method for providing ionized particles to a molecular/atomic analyser, such as a mass spectrometer, are disclosed. The ion source includes a vessel defining a channel; a gas inlet extending from the gas source into the channel, for introducing a gas flow into the channel; a sample inlet extending into the channel for introducing sample within the channel; and an ionizer to ionize the sample in the channel. The vessel is sufficiently sealed to allow the channel to be pressurized, at a pressure in excess of 100 Torr. At least one gas source maintains the pressure of the channel at a pressure in excess of 100 Torr and the pressure exterior to the channel at a pressure in excess of 0.1 Torr and provides a gas flow that sweeps across the ionizer to guide and entrain ions from the ionizer to the outlet.
摘要翻译： 公开了用于向分子/原子分析仪（例如质谱仪）提供离子化颗粒的离子源和方法。 离子源包括限定通道的容器; 从气体源延伸到通道中的气体入口，用于将气流引入通道中; 延伸到通道中的样品入口，用于将样品引入通道内; 以及电离器，用于使通道中的样品电离。 容器被充分密封，以允许通道在超过100托的压力下被加压。 至少一个气体源将通道的压力保持在超过100托的压力和在超过0.1托的压力下的通道外部的压力，并提供扫过电离器以引导和夹带离子的气流 电离器到出口。
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公开(公告)号：US07569811B2
公开(公告)日：2009-08-04
申请号：US11331153
申请日：2006-01-13
CPC分类号： H01J49/066
摘要： An ion guide includes multiple stages. An electric field within each stage guides ions along a guide axis. Within each stage, amplitude and frequency, and resolving potential of the electric field may be independently varied. The geometry of the rods maintains a similarly shaped field from stage to stage, allowing efficient guidance of the ions along the axis. In particular, each rod segment of the ith of stage has a cross sectional radius ri, and a central axis located a distance Ri+ri from the guide axis. The ratio ri/Ri and is substantially constant along the guide axis, thereby preserving the shape of the field.
摘要翻译： 离子导向器包括多个阶段。 每个阶段内的电场沿引导轴引导离子。 在每个阶段内，可以独立地改变振幅和频率以及电场的分辨能力。 杆的几何形状保持了从阶段到阶段的类似形状的场，允许离子沿轴线的有效引导。 特别地，平台的第i个的每个杆段具有横截面半径ri，并且中心轴线与引导轴线定位距离Ri + ri。 比率ri / Ri并且沿引导轴线基本上恒定，从而保持场的形状。
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9.发明申请METHOD AND APPARATUS FOR DETECTING POSITIVELY CHARGED AND NEGATIVELY CHARGED IONIZED PARTICLES 有权用于检测正确充电和负电荷离子化颗粒的方法和装置公开(公告)号：US20080073530A1
公开(公告)日：2008-03-27
申请号：US11467720
申请日：2006-08-28
IPC分类号： G21K7/00
CPC分类号： H01J49/025 , H01J49/0095
摘要： An ion detector includes collision surfaces for converting both positively and negatively charged ions into emitted secondary electrons. Secondary electrons may be detected using an electron detector, than may, for example include an electron multiplier. Conveniently, secondary electrons (or electrons emitted by the multiplier) may be detected using an electron pulse counter.
摘要翻译： 离子检测器包括用于将正电荷和带负电荷的离子转换成发射的二次电子的碰撞表面。 可以使用电子检测器检测二次电子，例如可以包括电子倍增器。 方便地，可以使用电子脉冲计数器检测二次电子（或乘法器发射的电子）。
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公开(公告)号：US20060186334A1
公开(公告)日：2006-08-24
申请号：US11406462
申请日：2006-04-18
IPC分类号： H01J49/00
CPC分类号： H01J49/0422 , H01J49/04 , H01J49/044 , H01J49/0468 , H01J49/06 , H01J49/26 , Y10T436/24
摘要： A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.
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