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    Microelectronic sensor device for optical examinations on a wetted surface
    32.
    发明授权
    Microelectronic sensor device for optical examinations on a wetted surface 有权
    用于在湿润表面进行光学检查的微电子传感器装置

    公开(公告)号：US08411274B2

    公开(公告)日：2013-04-02

    申请号：US12666814

    申请日：2008-06-24

    申请人： Coen Adrianus Verschuren ,  Albert Hendrik Jan Immink

    发明人： Coen Adrianus Verschuren ,  Albert Hendrik Jan Immink

    IPC分类号： G01N21/55 ,  G01J1/10

    CPC分类号： G01N21/552 ,  G01N21/11 ,  G01N21/648

    摘要： A method and a microelectronic sensor device for making optical examinations in an investigation region at the contact surface of a carrier, wherein an input light beam is sent from a light source towards the investigation region, and wherein an output light beam coming from the investigation region is detected by a light detector. An evaluation unit that is coupled to the light detector is adapted to determine the wetting grade of the investigation region based on a characteristic parameter of the output light beam. The evaluation unit may be adapted to determine a change in the light intensity caused by a liquid contacting the contact surface. The wetting grade may be detected in a test region that is located adjacent to the investigation region and that has a higher roughness than the investigation region.

    摘要翻译： 一种用于在载体的接触表面处的调查区域中进行光学检查的方法和微电子传感器装置，其中输入光束从光源向调查区域发送，并且其中来自调查区域的输出光束 由光检测器检测。 耦合到光检测器的评估单元适于基于输出光束的特征参数来确定调查区域的润湿等级。 评估单元可以适于确定由接触表面的液体引起的光强度的变化。 可以在位于与调查区域相邻并且具有比调查区域更高的粗糙度的测试区域中检测润湿等级。

    TEMPERATURE SENSOR AND BIOSENSOR USING THE SAME
    35.
    发明申请
    TEMPERATURE SENSOR AND BIOSENSOR USING THE SAME 审中-公开
    使用温度传感器和生物传感器

    公开(公告)号：US20100272608A1

    公开(公告)日：2010-10-28

    申请号：US12743827

    申请日：2008-11-17

    申请人： Roel Penterman ,  Steven Van Lierop ,  Albert Hendrik Jan Immink ,  Dirk Jan Broer

    发明人： Roel Penterman ,  Steven Van Lierop ,  Albert Hendrik Jan Immink ,  Dirk Jan Broer

    IPC分类号： G01N30/96 ,  G01K11/12 ,  G01N25/00

    CPC分类号： G01K11/125 ,  G01K11/00

    摘要： Embodiments of the invention relates to a temperature sensor and an analytical device comprising the same. The temperature sensor comprises a carrier (11) with a detection surface (12) on which temperature indicating agents (14) are present and, optionally, at which target components can collect and optionally bind to specific capture elements. An incident light beam (L1) is transmitted into the carrier and evanescent wave excitation is induced at the detection surface (12). The amount of light in the reflected light beam (L2) or an optical, e.g. luminescence response is then detected by a light detector (31). In one example, evanescent light is affected (absorbed, scattered) by temperature indicating agents and optionally target components and/or label particles at the binding surface (12) and will therefore be missing in a frustrated total internal reflected light beam (L2). This can be used to determine the temperature of the detection area and optionally the amount of target components at the binding surface (12) from the amount of light in the reflected light beam (L2, L2a, L2b). A magnetic field generator (41) is optionally used to generate a magnetic field (B) at the binding surface (12) by which magnetic label particles (1) can be manipulated, for example attracted or repelled.

    摘要翻译： 本发明的实施例涉及一种温度传感器和包括该温度传感器的分析装置。 温度传感器包括具有检测表面（12）的载体（11），其上存在温度指示剂（14），并且可选地，目标组分可以收集并任选地结合到特定捕获元件。 入射光束（L1）被传输到载体中，并且在检测表面（12）处诱导ev逝波激发。 反射光束（L2）中的光量或光学器件的光量。 然后通过光检测器（31）检测发光响应。 在一个实例中，渐逝光受温度指示剂影响（吸收，散射），并且可选地在结合表面（12）处的靶组分和/或标记颗粒，因此将在沮丧的全内反射光束（L2）中丢失。 这可以用于根据反射光束（L2，L2a，L2b）中的光量来确定检测区域的温度和可选地在结合表面（12）处的目标成分的量。 可选地，磁场发生器（41）用于在绑定表面（12）处产生磁场（B），通过该磁场可以操纵磁性标签颗粒（1），例如吸引或排斥磁场。

    MAGNETIC WASHING FOR BIOSENSOR
    36.
    发明申请
    MAGNETIC WASHING FOR BIOSENSOR 审中-公开
    生物传感器的磁性清洗

    公开(公告)号：US20100253323A1

    公开(公告)日：2010-10-07

    申请号：US12746182

    申请日：2008-12-04

    申请人： Femke Karina De Theije ,  Dominique Maria Bruls ,  Thea Van Der Wijk ,  Coen Adrianus Verschuren ,  Albert Hendrik Jan Immink

    发明人： Femke Karina De Theije ,  Dominique Maria Bruls ,  Thea Van Der Wijk ,  Coen Adrianus Verschuren ,  Albert Hendrik Jan Immink

    IPC分类号： G01N27/74

    CPC分类号： G01N33/54326 ,  G01N21/552 ,  G01N21/648 ,  G01N27/745

    摘要： Detecting magnetized or magnetizable target components in a fluid containing the magnetized or magnetizable target components amongst other magnetized or magnetizable components, uses a magnetic field generator (M1, 28) to attract the magnetized or magnetizable components towards a binding surface. A magnetic field controller (C1) applies the magnetic field to concentrate the magnetized or magnetizable components in columns on the binding surface, subsequently reduces the magnetic field to enable the columns to collapse, to allow more components to reach the binding surface, and reapplies the magnetic field so as to cause other components to be pulled off the binding surface to reform columns based on the bound target components. A surface sensitive sensor (S1, 26, 29) detects the bound magnetized or magnetizable target components. The reapplication of the magnetic field acts as a magnetic washing step to release unwanted aspecific adsorption binding, leaving the targets, to improve sensitivity with simplified hardware and a reduction in cost and size.

    摘要翻译： 检测包含磁化或可磁化的目标部件的流体中的磁化或可磁化的目标部件在其他磁化或可磁化部件之间，使用磁场发生器（M1,28）将磁化或可磁化的部件吸引到装订表面。 磁场控制器（C1）施加磁场以将磁化的或可磁化的组件在列中集中在结合表面上，随后减小磁场以使柱能够塌陷，以允许更多的部件到达结合表面，并重新应用 磁场，以便使其他组分从结合表面上拉出，以便根据结合的目标组分重新制备柱。 表面敏感传感器（S1,26,29）检测结合的磁化或可磁化的目标部件。 磁场的重新应用充当磁性洗涤步骤以释放不期望的特异性吸附结合，留下目标，以通过简化的硬件提高灵敏度并降低成本和尺寸。

    Optical Scanning Device
    40.
    发明申请
    Optical Scanning Device 审中-公开
    光学扫描装置

    公开(公告)号：US20080186831A1

    公开(公告)日：2008-08-07

    申请号：US11817806

    申请日：2006-03-06

    申请人： Teunis Willem Tukker ,  Coen Theodorus Hubertus Fransiscus Liedenbaum ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Sjoerd Stallinga ,  Albert Hendrik Jan Immink ,  Stein Kuiper ,  Ming Song Chen

    发明人： Teunis Willem Tukker ,  Coen Theodorus Hubertus Fransiscus Liedenbaum ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Sjoerd Stallinga ,  Albert Hendrik Jan Immink ,  Stein Kuiper ,  Ming Song Chen

    IPC分类号： G11B7/00

    CPC分类号： G11B7/1369 ,  G11B7/0909 ,  G11B7/1381

    摘要： An optical scanning device (1) includes a radiation source (7), a detector (23) and a beam splitter (9). The radiation source (7) provides an incident radiation beam (4, 20) along a first optical path (19a) for scanning an information layer (2) of an optical record carrier (3). The detector (23) detects at least a portion of the radiation beam (22) reflected from the optical record carrier (3). The beam splitter (9) transmits the incident radiation beam (4) received from the radiation source along the first optical path (19a) towards the optical record carrier. The beam splitter (9) also transmits the reflected beam (22) received from the optical record carrier (3) along a second, different optical path (19b) towards the detector. The optical scanning device further includes a beam-deflecting element (30; 130; 230; 330; 630; 830; 930) positioned on the second optical path (19b) between the beam splitter (9) and the detector (23). The beam-deflecting element (30; 130; 230; 330; 630; 830; 930) is arranged to controllably deflect the path of the reflected radiation beam (22) for adjusting the lateral position of said reflected radiation beam incident upon the detector (23) over a predetermined range.

    摘要翻译： 光学扫描装置（1）包括辐射源（7），检测器（23）和分束器（9）。 辐射源（7）沿着第一光路（197）提供入射辐射束（4,20），用于扫描光学记录载体（3）的信息层（2）。 检测器（23）检测从光学记录载体（3）反射的辐射束（22）的至少一部分。 分束器（9）将从辐射源接收的入射辐射束（4）沿着第一光路（21a）传送到光学记录载体。 分束器（9）还将从光学记录载体（3）接收的反射光束（22）沿着第二不同的光路（20b）传送到检测器。 光学扫描装置还包括位于分束器（9）和检测器（23）之间的位于第二光路（19b）上的光束偏转元件（30; 130; 230; 330; 630; 830; 930）。 光束偏转元件（30; 130; 230; 330; 630; 830; 930）被布置成可控地偏转反射的辐射束（22）的路径，用于调节入射到检测器上的所述反射的辐射束的横向位置（ 23）超过预定范围。