TEMPERATURE SENSOR AND BIOSENSOR USING THE SAME
    1.
    发明申请
    TEMPERATURE SENSOR AND BIOSENSOR USING THE SAME 审中-公开
    使用温度传感器和生物传感器

    公开(公告)号:US20100272608A1

    公开(公告)日:2010-10-28

    申请号:US12743827

    申请日:2008-11-17

    IPC分类号: G01N30/96 G01K11/12 G01N25/00

    CPC分类号: G01K11/125 G01K11/00

    摘要: Embodiments of the invention relates to a temperature sensor and an analytical device comprising the same. The temperature sensor comprises a carrier (11) with a detection surface (12) on which temperature indicating agents (14) are present and, optionally, at which target components can collect and optionally bind to specific capture elements. An incident light beam (L1) is transmitted into the carrier and evanescent wave excitation is induced at the detection surface (12). The amount of light in the reflected light beam (L2) or an optical, e.g. luminescence response is then detected by a light detector (31). In one example, evanescent light is affected (absorbed, scattered) by temperature indicating agents and optionally target components and/or label particles at the binding surface (12) and will therefore be missing in a frustrated total internal reflected light beam (L2). This can be used to determine the temperature of the detection area and optionally the amount of target components at the binding surface (12) from the amount of light in the reflected light beam (L2, L2a, L2b). A magnetic field generator (41) is optionally used to generate a magnetic field (B) at the binding surface (12) by which magnetic label particles (1) can be manipulated, for example attracted or repelled.

    摘要翻译: 本发明的实施例涉及一种温度传感器和包括该温度传感器的分析装置。 温度传感器包括具有检测表面(12)的载体(11),其上存在温度指示剂(14),并且可选地,目标组分可以收集并任选地结合到特定捕获元件。 入射光束(L1)被传输到载体中,并且在检测表面(12)处诱导ev逝波激发。 反射光束(L2)中的光量或光学器件的光量。 然后通过光检测器(31)检测发光响应。 在一个实例中,渐逝光受温度指示剂影响(吸收,散射),并且可选地在结合表面(12)处的靶组分和/或标记颗粒,因此将在沮丧的全内反射光束(L2)中丢失。 这可以用于根据反射光束(L2,L2a,L2b)中的光量来确定检测区域的温度和可选地在结合表面(12)处的目标成分的量。 可选地,磁场发生器(41)用于在绑定表面(12)处产生磁场(B),通过该磁场可以操纵磁性标签颗粒(1),例如吸引或排斥磁场。

    SENSOR CARTRIDGE
    4.
    发明申请
    SENSOR CARTRIDGE 审中-公开
    传感器盒

    公开(公告)号:US20100289483A1

    公开(公告)日:2010-11-18

    申请号:US12669218

    申请日:2008-07-16

    IPC分类号: G01N27/74

    CPC分类号: G01R33/1269

    摘要: The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).

    摘要翻译: 本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒(10)。 传感器盒(10)包括反应室(1)和至少彼此不同的第一和第二区域(2,3)。 第一区域(2)包括用第一类型的探针标记的磁性或可磁化物体(4a),用于特异性地结合第一类型的靶部分,并且第二区域(3)包括用第二类型标记的磁性或可磁化物体(4b) 的用于特异性结合第二类型的靶部分的探针,第一和第二区域(2,3)中的磁性或可磁化物体(4a,4b)可由样品流体直接接触。 本发明还提供了用于制造这种传感器装置(10)的方法以及使用这种传感器盒(10)确定样品流体中至少两种不同靶部分的存在和/或量的方法。

    CONTROLLABLE MAGNETIC SYSTEM FOR BIOSENSORS
    5.
    发明申请
    CONTROLLABLE MAGNETIC SYSTEM FOR BIOSENSORS 审中-公开
    生物传感器的可控磁系统

    公开(公告)号:US20090209042A1

    公开(公告)日:2009-08-20

    申请号:US12299788

    申请日:2007-05-08

    IPC分类号: G01N27/00

    CPC分类号: G01N33/54333 G01N27/745

    摘要: The invention relates to a magnetic system for biosensors and in particular to a magnetic system which can switch between attraction force and repulsion force near the sensor surface with more easy but also more effective means. This is realised with at least one coil (2) and at least two ferromagnetic cores (3) which are arranged in a concentric multilayered package, and a sensor or a sensor surface exposed to or covered with the biomaterial, which is arranged near to the magnetic system.

    摘要翻译: 本发明涉及一种用于生物传感器的磁性系统,特别涉及一种能够以更容易但更有效的方式在传感器表面附近的吸引力和排斥力之间切换的磁性系统。 这是通过布置在同心多层封装中的至少一个线圈(2)和至少两个铁磁芯(3)实现的,以及暴露于或覆盖生物材料的传感器或传感器表面,其布置在 磁系统。

    Data-Dependent Noise Predictor in Data-Aided Timing Recovery
    7.
    发明申请
    Data-Dependent Noise Predictor in Data-Aided Timing Recovery 审中-公开
    数据辅助定时恢复中的数据依赖噪声预测器

    公开(公告)号:US20080219392A1

    公开(公告)日:2008-09-11

    申请号:US11995013

    申请日:2006-07-06

    IPC分类号: H04L7/00 H04L25/00

    摘要: A communication system includes a communication channel (110) for time-synchronous transfer of data symbols a1, . . . , aN to a receiver (130). A sampling unit (132) is used for time-sequential sampling the channel under control of a sampling clock signal that is synchronous with transmittal of the data symbols. Each sample includes a representation of a data symbol and noise. A data-aided timing error detector (133) receives a representation of the samples. The detector includes a data-dependent noise predictor (310) for generating a predicted noise sequence ñ1, . . . , ñN where each predicted noise value nk for the k-th sample of the sequence depends on a cluster of a plurality of sampled data symbols and a noise whitening unit (320) for whitening of noise in the sample sequence by removing the predicted noise value ñk. The detector is arranged to provide a signal for correcting the sampling clock signal in dependence on the whitened sample sequence.

    摘要翻译: 一种通信系统包括用于数据符号a 1的时间同步传送的通信信道(110)。 。 。 ,向接收机(130)发送一个“N”。 采样单元(132)用于在与数据符号的发送同步的采样时钟信号的控制下对信道进行时间序列采样。 每个样本包括数据符号和噪声的表示。 数据辅助定时误差检测器(133)接收样本的表示。 检测器包括用于产生预测噪声序列的数据相关噪声预测器(310)。 。 。 ,其中序列的第k个样本的每个预测噪声值n k k取决于多个采样数据符号的簇和噪声白化单元( 320),用于通过去除预测的噪声值ñN k来采样序列中的噪声增白。 检测器被布置成根据白化样本序列提供用于校正采样时钟信号的信号。

    Accurate Magnetic Biosensor
    8.
    发明申请
    Accurate Magnetic Biosensor 审中-公开
    精确的磁性生物传感器

    公开(公告)号:US20080206104A1

    公开(公告)日:2008-08-28

    申请号:US11917211

    申请日:2006-06-12

    IPC分类号: B01J19/00 G01R33/09

    摘要: The invention provides a method, a device and a system for determining the concentration of at least one sort of targets in a fluid containing at least one sort of polarizable of polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable to specifically attach to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising distinction means for time-resolved distinguishing between magnetic labels specifically attached to the binding sites versus labels non-specifically attached. The method and device according to the present invention may be applied to biomolecular diagnostics.

    摘要翻译: 本发明提供了一种用于确定在流体中含有至少一种可极化的极化磁性标签的流体中的至少一种靶的浓度的方法,装置和系统,所述感测表面包括至少一种结合 所述感测装置还包括至少一个磁性传感器元件,所述感测装置还包括用于时间分辨的区分装置,所述区别装置用于特别附着于所述磁性标签的磁性标签 结合位点与非特异性连接的标记。 根据本发明的方法和装置可以应用于生物分子诊断。

    Spherical Aberration Detector
    10.
    发明申请
    Spherical Aberration Detector 审中-公开
    球面异常检测器

    公开(公告)号:US20080192600A1

    公开(公告)日:2008-08-14

    申请号:US11915633

    申请日:2006-05-22

    IPC分类号: G11B5/58

    摘要: An optical scanning device (1) for scanning at least one information layer (2) of at least one optical record carrier (3). The device includes a radiation source (7) for providing at least a first radiation beam (4) comprising a first wavelength, an objective lens system (8) for converging the first radiation beam on a respective information layer (2), an information detector (23) for detecting at least a portion of the first radiation beam (22) reflected from the respective information layer, for determining information on said layer, and a spherical aberration detection system. The spherical aberration detection system includes an aberration detector (24) for detecting at least a portion of the reflected first radiation beam for determining spherical aberration of the first radiation beam, and a diffractive element (26) for diffracting at least a portion of the reflected first radiation beam towards the aberration detector (24), and for transmitting at least a portion of the reflected first radiation beam towards the information detector (23). In a first mode of operation the grating is arranged to introduce a phase change to an incident portion of a radiation beam for transmitting that portion towards the information detector (23). In a second mode of operation the grating is arranged to introduce a phase change to an incident portion of the reflected first radiation beam for diffracting that portion towards the aberration detector (24).

    摘要翻译: 一种用于扫描至少一个光学记录载体(3)的至少一个信息层(2)的光学扫描装置(1)。 该装置包括用于提供至少包括第一波长的第一辐射束(4)的辐射源(7),用于将第一辐射束会聚在相应的信息层(2)上的物镜系统(8),信息检测器 (23),用于检测从各个信息层反射的第一辐射束(22)的至少一部分,用于确定关于所述层的信息,以及球面像差检测系统。 球面像差检测系统包括:像差检测器(24),用于检测用于确定第一辐射束的球面像差的反射的第一辐射束的至少一部分;以及衍射元件(26),用于衍射至少部分反射 朝向像差检测器(24)的第一辐射束,并且用于将反射的第一辐射束的至少一部分传送到信息检测器(23)。 在第一操作模式中,光栅布置成将相位变化引入辐射束的入射部分,以将该部分传送到信息检测器(23)。 在第二操作模式中,光栅布置成将相变引入到反射的第一辐射束的入射部分,以将该部分衍射到像差检测器(24)。