公开(公告)号：US07226752B1

公开(公告)日：2007-06-05

申请号：US11336569

申请日：2006-01-19

申请人： Daniel B. Roitman

发明人： Daniel B. Roitman

IPC分类号： G01N33/00

CPC分类号： G01N33/54306 ,  G01N33/581 ,  G01N33/582 ,  G01N2458/30

摘要： Methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include mixing a sample with an indirectly-detectable labeled binding member that includes a label moiety. The mixing produces a first composition. Unbound labeled binding member is then separated from any resultant binding complexes to produce a second composition that includes the binding complexes. A second light emitted by a light wavelength converter that is excited by a first light generated by the labeled binding member of the binding complexes of the second composition is then detected to detect the presence of the analyte in the sample. Embodiments also include kits and systems that find use in practicing the subject methods.

摘要翻译： 提供了用于检测样品中分析物的存在的方法。 方法的方面包括将样品与包含标记部分的间接可检测的标记结合成员混合。 混合产生第一组合物。 然后将未结合的标记结合成员与任何所得的结合复合物分离，以产生包含结合复合物的第二组合物。 然后检测由光波长转换器发射的由第二组合物的结合复合物的标记结合成员产生的第一光激发的第二光，以检测样品中分析物的存在。 实施例还包括用于实践主题方法的套件和系统。

公开(公告)号：US06706204B2

公开(公告)日：2004-03-16

申请号：US10027598

申请日：2001-12-19

申请人： Daniel B. Roitman ,  Dietrich W. Vook ,  Theodore I. Kamins

发明人： Daniel B. Roitman ,  Dietrich W. Vook ,  Theodore I. Kamins

IPC分类号： H01L2100

CPC分类号： B81C1/00119 ,  B81B2201/058 ,  B81B2203/0338 ,  B81B2203/0353 ,  B82Y5/00 ,  G01N33/48721

摘要： A method of fabricating nanosized holes with controlled geometries employs tools and methods developed in the microelectronics industry. The method exploits the fact that epitaxially grown film thicknesses can be controlled within a few atomic monolayers and that by using etching techniques, trenches and channels can be created that are only a few nanometers wide. The method involves bonding two shallow channels at an angle such that a nanopore is defined by the intersection. Thus, a nanopore-defining device includes a nanopore with dimensions that are determined by the dimensions and orientations of the intersecting channels, with the dimensions being accurately controlled within a few monolayers.

摘要翻译： 制造具有受控几何形状的纳米孔的方法采用在微电子工业中开发的工具和方法。 该方法利用了外延生长的膜厚度可以控制在几个原子单层内的事实，并且通过使用蚀刻技术，可以产生只有几纳米宽的沟槽和沟道。 该方法包括以一定角度键合两个浅沟道，使得纳米孔由交点定义。 因此，纳米孔限定装置包括具有由相交通道的尺寸和取向决定的尺寸的纳米孔，其尺寸被准确地控制在几个单层内。

公开(公告)号：US06706203B2

公开(公告)日：2004-03-16

申请号：US10022452

申请日：2001-10-30

申请人： Philip W. Barth ,  Daniel B. Roitman ,  Joel Myerson

发明人： Philip W. Barth ,  Daniel B. Roitman ,  Joel Myerson

IPC分类号： H01L2100

CPC分类号： G01N33/48721 ,  B01D67/0058 ,  B01D67/0072 ,  B01D69/02 ,  B01D69/12 ,  B01D71/02 ,  B01D2325/02 ,  B81B3/0059 ,  B81B5/00 ,  B81B2201/0214 ,  B81B2201/047 ,  B81B2203/0353 ,  B81C99/002 ,  B82Y15/00 ,  B82Y30/00

摘要： An adjustable nanopore is fabricated by placing the surfaces of two planar substrates in contact, wherein each substrate contains a hole having sharp corners and edges. A corner is brought into proximity with an edge to define a triangular aperture of variable area. Ionic current in a liquid solution and through the aperture is monitored as the area of the aperture is adjusted by moving one planar substrate with respect to the other along two directional axes and a rotational axis. Piezoelectric positioners can provide subnanometer repeatability in the adjustment process. The invention is useful for characterizing, cleaving, and capturing molecules, molecular complexes, and supramolecular complexes which pass through the nanopore, and provides an improvement over previous devices in which the hole size of nanopores fabricated by etching and/or redeposition is fixed after fabrication.

摘要翻译： 通过将两个平面基板的表面放置接触来制造可调纳米孔，其中每个基板包含具有锐角和边缘的孔。 一个角落靠近一个边缘以限定可变区域的三角形孔。 通过沿着两个方向轴和旋转轴线相对于另一个移动一个平面基板来调节在液体溶液中并通过孔的离子电流，因为孔的面积被调整。 压电定位器可以在调整过程中提供亚纳米计重复性。 本发明可用于表征，切割和捕获通过纳米孔的分子，分子复合物和超分子复合物，并且对先前的装置提供了改进，其中通过蚀刻和/或再沉积制造的纳米孔的孔径在制造后被固定 。

公开(公告)号：US06627331B1

公开(公告)日：2003-09-30

申请号：US09401691

申请日：1999-09-22

申请人： Daniel B. Roitman ,  Seiji Inaoka ,  Riogoberto C. Advincula

发明人： Daniel B. Roitman ,  Seiji Inaoka ,  Riogoberto C. Advincula

IPC分类号： H05B3314

CPC分类号： H05B33/14 ,  C09K11/06 ,  C09K2211/14 ,  H01L27/3211 ,  H01L27/3281 ,  H01L51/0006 ,  H01L51/0036 ,  H01L51/0044 ,  H01L51/56 ,  Y10S428/917 ,  Y10T428/24917

摘要： A display device and a method for fabricating the display device. A display device according to the present invention is fabricated from an electrode layer that includes a plurality of electrodes on a substrate. The electrode layer is immersed in a solution of a first precursor polymer in a first solvent. The first precursor polymer includes a plurality of electrochemical polymerizable monomers. Each monomer has first and second polymer-forming active sites that can be joined by electrochemical polymerization and third and fourth polymer-forming active sites that can be joined chemically in solution. The first precursor polymer is soluble in the first solvent whereas a first polymer formed by electrochemical polymerization of the first and second polymer-forming active sites is insoluble in the first solvent. A layer of the first polymer is deposited on the a first one of the electrodes by connecting that electrode to an electric circuit while leaving the others of the electrodes disconnected from the circuit. The electrode is then immersed in a solution of said first precursor polymer. The circuit applies a potential to the electrode sufficient to cause the first and second polymer active sites to polymerize by electrochemical polymerization thereby depositing a first polymer layer includes the first polymer precursor on the first one of the electrodes. A second electrode layer is then deposited over the first polymer layer. In multi-color displays, the different polymer layers corresponding to the various colors are deposited on different ones of the electrodes by sequentially depositing each polymer layer in a similar manner.

摘要翻译： 一种显示装置及其制造方法。 根据本发明的显示装置由在基板上包括多个电极的电极层制成。 将电极层浸渍在第一前体聚合物在第一溶剂中的溶液中。 第一前体聚合物包括多个电化学可聚合单体。 每个单体具有可以通过电化学聚合连接的第一和第二聚合物形成活性位点和可以在溶液中化学连接的第三和第四聚合物形成活性位点。 第一前体聚合物可溶于第一溶剂，而通过第一和第二聚合物形成活性位点的电化学聚合形成的第一聚合物不溶于第一溶剂。 将第一聚合物层沉积在第一电极上，将该电极连接到电路上，同时使电极中的其它电极与电路断开。 然后将电极浸入所述第一前体聚合物的溶液中。 电路向电极施加足以使第一和第二聚合物活性位点通过电化学聚合聚合的电势，从而沉积包含第一聚合物前体在第一电极上的第一聚合物前体。 然后在第一聚合物层上沉积第二电极层。 在多色显示器中，通过以类似的方式依次沉积每个聚合物层，将不同颜色的不同聚合物层沉积在不同的电极上。

公开(公告)号：US6087771A

公开(公告)日：2000-07-11

申请号：US387205

申请日：1999-08-31

申请人： Daniel B. Roitman

发明人： Daniel B. Roitman

IPC分类号： H05B33/10 ,  G09F9/30 ,  H01L27/32 ,  H01L51/50 ,  H05B33/12 ,  H05B33/14

CPC分类号： H01L27/3239 ,  H01L27/3206 ,  H01L51/5036 ,  H01L51/0005 ,  Y10S428/917

摘要： In the method of the present invention, a bottom electrode having a planar sheet of conducting material is first deposited on a substrate. A mask is then deposited on the bottom electrode to define wells. For at least first and second ones of the wells defined by the mask, an electroluminescent material is dispensed into the wells. The electroluminescent material dispensed into the first well emits a different spectrum of light from the electroluminescent material dispensed into the second well. In one embodiment of the invention, an isolation layer is deposited over the electroluminescent material after the electroluminescent material has dried. A top electrode is then deposited over the isolation layer. In a display according to the present invention, a plurality of pixels are deposited on a bottom electrode and then a top electrode is provided for energizing the pixels. The plurality of pixels includes first and second pixels, the first pixel having a first mixture of at least two electroluminescent dyes and the second pixel having a second mixture of the electroluminescent dyes. The first mixture differs in the ratios of the electroluminescent dyes from the second mixture.

摘要翻译： 在本发明的方法中，首先将具有导电材料的平板的底电极沉积在基板上。 然后将掩模沉积在底部电极上以限定孔。 对于由掩模限定的至少第一和第二阱，将电致发光材料分配到孔中。 分配到第一阱中的电致发光材料从分配到第二阱中的电致发光材料发射不同光谱的光。 在本发明的一个实施例中，在电致发光材料干燥之后，在电致发光材料上沉积隔离层。 然后将顶部电极沉积在隔离层上。 在根据本发明的显示器中，多个像素沉积在底部电极上，然后提供顶部电极用于激励像素。 多个像素包括第一和第二像素，第一像素具有至少两个电致发光染料的第一混合物，第二像素具有电致发光染料的第二混合物。 第一混合物的电致发光染料与第二混合物的比例不同。

公开(公告)号：US5948552A

公开(公告)日：1999-09-07

申请号：US704476

申请日：1996-08-27

申请人： Homer Antoniadis ,  Daniel B. Roitman ,  William R. Shiang ,  Edmund P. Woo ,  Weishi Wu

发明人： Homer Antoniadis ,  Daniel B. Roitman ,  William R. Shiang ,  Edmund P. Woo ,  Weishi Wu

IPC分类号： H05B33/10 ,  C09K11/06 ,  G09F9/30 ,  H01L51/00 ,  H01L51/30 ,  H01L51/50 ,  H05B33/14 ,  H05B33/00 ,  B05D5/12

CPC分类号： H05B33/14 ,  H01L51/0035 ,  H01L51/0059 ,  H01L51/5012 ,  H01L2251/308 ,  H01L51/0081 ,  Y10S428/917 ,  Y10T428/31678

摘要： An organic electroluminescent device that comprises a substrate, a first conductive layer on the substrate, an electron-transporting and light-emitting layer, a second conductive layer adjacent the electron-transporting and light-emitting layer and remote from the first conductive layer, and a hole-conducting layer sandwiched between the first conductive layer and the electron-transporting and light-emitting layer. The hole-conducting layer comprises a poly(arylamine) including at least one compound of formula (I): ##STR1## In this: R is independently in each occurrence a C.sub.1-24 hydrocarbyl, hydrocarboxyl, hydrothiocarboxy, hydroarylcarboxy, or hydrothioarylcarboxy; Ar.sub.1 and Ar.sub.2 are independently in each occurrence a C.sub.6-18 aryl moiety optionally substituted with one or more C.sub.1-24 hydrocarbyl, hydrocarboxyl, hydrothiocarboxy, hydroarycarboxy, or hydrothioarylcarboxy; A is independently in each occurrence hydrogen or a halogen; x is independently in each occurrence a positive number between 0 and 1; n is a whole number from 0 to 4; and m is a number from about 5 to about 1000.

摘要翻译： 一种有机电致发光器件，包括衬底，衬底上的第一导电层，电子传输和发光层，与电子传输和发光层相邻并远离第一导电层的第二导电层，以及 夹在第一导电层和电子传输和发光层之间的空穴传导层。 空穴传导层包括包含至少一种式（I）化合物的聚（芳基胺）：其中：R在每次出现时独立地为C 1-4烃基，氢化羧基，氢硫代羧基，​​氢化芳基羧基或氢硫代芳基羧基; Ar 1和Ar 2在每次出现时独立地为任选被一个或多个C 1-4烃基，氢羧基，氢硫代羧基，​​羟基羧基或氢硫代芳基羧基取代的C 6-18芳基部分; 在每次出现氢时，A独立地为氢或卤素; x在每次出现时独立地为0和1之间的正数; n是从0到4的整数; m为约5至约1000的数。

公开(公告)号：US08632730B2

公开(公告)日：2014-01-21

申请号：US11285413

申请日：2005-11-22

申请人： John F. Petrilla ,  Daniel B. Roitman

发明人： John F. Petrilla ,  Daniel B. Roitman

IPC分类号： G01N21/75

CPC分类号： G01N21/8483 ,  G01N21/253 ,  G01N33/54366 ,  G01N33/54386 ,  Y10T403/18 ,  Y10T436/110833

摘要： In one aspect, a diagnostic test system includes a receptacle, optical detectors, and a logic circuit. Each of the optical detectors has a corresponding view in the receptacle and produces an electrical signal at a respective detector output in response to light from the corresponding view. The logic circuit includes logic inputs that are respectively coupled to the detector outputs and that produce an output logic signal corresponding to a logical combination of signals received at the logic inputs. In another aspect, respective detection signals are produced in response to light received from respective ones of multiple views of the test strip, and at least one output logic signal corresponding to a respective logical combination of the detection signals is generated.

摘要翻译： 一方面，诊断测试系统包括插座，光学检测器和逻辑电路。 每个光学检测器在插座中具有对应的视图，并且响应于来自相应视图的光而在相应的检测器输出处产生电信号。 逻辑电路包括分别耦合到检测器输出并且产生对应于在逻辑输入处接收的信号的逻辑组合的输出逻辑信号的逻辑输入。 在另一方面，响应于从测试条的多个视图的相应视图接收的光产生相应的检测信号，并且产生与检测信号的相应逻辑组合对应的至少一个输出逻辑信号。

公开(公告)号：US20120129272A1

公开(公告)日：2012-05-24

申请号：US13360081

申请日：2012-01-27

申请人： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

发明人： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

IPC分类号： G01N33/543

CPC分类号： G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

摘要： In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of the localized regions is characterized by at least one surface dimension smaller than the first dimension. The data analyzer identifies ones of the light intensity measurements obtained from the at least one test region and computes at least one parameter from the identified ones of the light intensity measurements. In another aspect, the reader obtains a respective set of light intensity measurements from each of multiple corresponding regions of the exposed surface area of the detection zone, and the data analyzer computes at least one parameter from at least one of the sets of light intensity measurements.

摘要翻译： 一方面，诊断测试系统包括壳体，读取器和数据分析器。 壳体包括用于接收测试条的端口。 读取器从暴露于光学检查的检测区域的区域的局部区域获得可分离的光强度测量值，其中每个局部区域的特征在于至少一个小于第一维度的表面尺寸。 数据分析器识别从至少一个测试区域获得的光强度测量结果中的一个，并从所识别的光强测量中计算至少一个参数。 在另一方面，读取器从检测区域的暴露表面区域的多个对应区域中的每一个获得相应的一组光强度测量值，并且数据分析器从至少一个光强度测量集合中计算至少一个参数 。

公开(公告)号：US20090180925A1

公开(公告)日：2009-07-16

申请号：US12409861

申请日：2009-03-24

申请人： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman ,  Bo U. Curry

发明人： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman ,  Bo U. Curry

IPC分类号： G01N31/22

CPC分类号： G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

摘要： An assay test strip includes a flow path, a sample receiving zone, a label, a detection zone that includes a region of interest, and at least one position marker. The at least one position marker is aligned with respect to the region of interest such that location of the at least one position marker indicates a position of the region of interest. A diagnostic test system includes a reader that obtains light intensity measurement from exposed regions of the test strip, and a data analyzer that performs at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying at least one operational parameter of the reader based on at least one measurement obtained from the at least one reference feature.

公开(公告)号：US07521260B2

公开(公告)日：2009-04-21

申请号：US11280640

申请日：2005-11-16

申请人： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman ,  Bo U. Curry

发明人： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman ,  Bo U. Curry

IPC分类号： G01N33/533

CPC分类号： G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

摘要： An assay test strip includes a flow path, a sample receiving zone, a label, a detection zone that includes a region of interest, and at least one position marker. The at least one position marker is aligned with respect to the region of interest such that location of the at least one position marker indicates a position of the region of interest. A diagnostic test system includes a reader that obtains light intensity measurement from exposed regions of the test strip, and a data analyzer that performs at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying at least one operational parameter of the reader based on at least one measurement obtained from the at least one reference feature.

摘要翻译： 测定试片包括流路，样品接收区，标签，包括感兴趣区域的检测区和至少一个位置标记。 所述至少一个位置标记相对于所述感兴趣区域对齐，使得所述至少一个位置标记的位置指示所述感兴趣区域的位置。 诊断测试系统包括从测试条的暴露区域获得光强度测量的读取器，以及数据分析器，其执行以下至少一个：（a）基于至少一个（a）识别从测试区域获得的光强度测量中的一个 测量从所述至少一个参考特征获得的，以及（b）基于从所述至少一个参考特征获得的至少一个测量值生成修改所述读取器的至少一个操作参数的控制信号。