公开(公告)号：US08550799B2

公开(公告)日：2013-10-08

申请号：US13311616

申请日：2011-12-06

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Giovanni Rodriguez

IPC: B29C45/17 ,  B29C45/44

CPC classification number: B29C45/1701 ,  B29C37/0007 ,  B29C45/006 ,  B29C45/1753 ,  B29C45/40 ,  B29C45/42 ,  B29C2045/1797 ,  B29C2791/005

Abstract: At least one of first and second mold portions defines a mold cavity to receive molten plastic and form therefrom at least one molded part, and is movable relative to the other between (i) a closed position for sealing the mold cavity or cavities and molding at least one part therein, and (ii) an open position defining a fluid passageway between the mold portions and permitting the passage of a fluid sterilant therein. A fluid sterilant source is connectable in fluid communication with the fluid passageway for introducing the sterilant therein in the open position, contacting with the sterilant the surfaces of the first and second mold portions forming the fluid passageway and located adjacent to the at least one mold cavity, but not contacting an interior surface of a molded part within the mold cavity, to sterilize the exposed mold surfaces and thereby prevent contamination of the molded part.

Abstract translation: 第一和第二模具部分中的至少一个限定了模腔以接收熔融塑料并从其形成至少一个模制部件，并且可以在（i）用于密封模腔或空腔的闭合位置和相对于另一模制部件 其中至少一部分，以及（ii）在模具部分之间限定流体通道并允许其中的流体灭菌剂通过的打开位置。 流体灭菌剂源可连接到流体通道，用于将灭菌剂在其中引入打开位置，与杀菌剂接触，形成第一和第二模具部分的形成流体通道的表面并且邻近于至少一个模腔 但是不与模腔内的模制部件的内表面接触，对暴露的模具表面进行消毒，从而防止模制部件的污染。

公开(公告)号：US08376003B2

公开(公告)日：2013-02-19

申请号：US12861354

申请日：2010-08-23

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Brian Tulley ,  Jeffrey Willey

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  Brian Tulley ,  Jeffrey Willey

IPC: B65B3/04 ,  A61J9/00

CPC classification number: A61J11/0005 ,  A61J1/1406 ,  A61J9/003 ,  A61J11/04 ,  B65D51/002

Abstract: A container is provided for storing a product, such as a fat containing liquid product, and includes a body defining a chamber for receiving the product; and a container closure including a sealing portion for sealing the product within the chamber. The container closure includes a member forming a substantially fluid-tight seal between the container closure and the body; a nipple in fluid communication with the chamber that seals the chamber with respect to the ambient atmosphere during storage of the product in the chamber and that can be opened to dispense product from the chamber therethrough; and a needle penetrable and laser resealable portion that is penetrable by the needle for aseptically filling the chamber with the product, and that is thermally resealable by the application of laser radiation thereto to seal the product within the chamber.

Abstract translation: 提供容器用于储存诸如含脂肪的液体产品的产品，并且包括限定用于容纳产品的室的主体; 以及容器封闭件，其包括用于密封腔室内的产品的密封部分。 容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件; 与腔室流体连通的乳头，其在产品在腔室中储存期间相对于环境大气密封腔室，并且可以打开以从腔室通过其分配产品; 以及针可穿透和可激光重新密封的部分，其可由针穿透，用于用产品无菌填充腔室，并且通过施加激光辐射可热再密封以密封腔室内的产品。

公开(公告)号：US20120138186A1

公开(公告)日：2012-06-07

申请号：US13352235

申请日：2012-01-17

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy

IPC: B65B1/04

CPC classification number: B65B3/006 ,  A61L2/10 ,  A61M5/1782 ,  B29C66/80 ,  B65B3/003 ,  B65B43/00 ,  B65B51/00 ,  Y10T29/49716

Abstract: An assembly includes a support and drive assembly, a first structure and a second structure. The first structure is in operable communication with and supported by the support and drive assembly. The first structure includes at least one filling or needle assembly and is adjustable to receive a plurality of filling or needle assemblies. The second structure is supported by the support and drive assembly. The second structure includes at least one seal assembly and is adjustable to receive a plurality of seal assemblies. A method includes determining a number of containers or vials that are to be filled concurrently and adjusting an assembly to include at least one filling or needle assembly and at least one seal assembly. A number of the filling or needle assemblies and the seal assemblies equals the number of containers or vials.

Abstract translation: 组件包括支撑和驱动组件，第一结构和第二结构。 第一结构与支撑和驱动组件可操作地连通并由其支撑。 第一结构包括至少一个填充物或针头组件，并且可调节以容纳多个填充物或针头组件。 第二个结构由支撑和驱动组件支撑。 第二结构包括至少一个密封组件，并且可调节以接收多个密封组件。 一种方法包括确定要同时填充的多个容器或小瓶，并且调整组件以包括至少一个填充物或针组件和至少一个密封组件。 许多填充物或针组件和密封组件等于容器或小瓶的数量。

公开(公告)号：US08104644B2

公开(公告)日：2012-01-31

申请号：US12901422

申请日：2010-10-08

Applicant: Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

Inventor： Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

IPC: B65D37/00

CPC classification number: B67D1/108 ,  B05B11/00444 ,  B65B39/004 ,  B65D51/002 ,  B65D51/1616 ,  B67D1/0004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/0801 ,  B67D1/10 ,  B67D1/1279 ,  B67D3/0067 ,  B67D3/04 ,  B67D2001/0827 ,  F04B53/1037

Abstract: A flexible pouch and valve assembly is provided for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The flexible pouch and valve assembly are receivable within a relatively rigid housing, and are adapted to cooperate with a pump for pumping discrete portions of substance from the pouch and through the one-way valve to dispense the substance therefrom. The assembly comprises a flexible pouch defining therein a variable-volume storage chamber sealed with respect to the ambient atmosphere for aseptically storing therein multiple portions of the substance. A one-way valve of the assembly includes a valve body defining an axially-extending valve seat and at least one flow aperture extending through the valve body and/or the valve seat.

Abstract translation: 提供了一种柔性袋和阀组件，用于无菌存储物质，从其中分配多部分储存物质，并将残留在袋中的物质保持在相对于环境大气密封的无菌状态。 柔性袋和阀组件可接收在相对刚性的壳体内，并且适于与泵协作，用于泵送物质的离散部分并且通过单向阀从其分配物质。 组件包括柔性袋，其中限定有相对于环境大气密封的可变容积存储室，用于将物质的多个部分无菌存储。 组件的单向阀包括限定轴向延伸的阀座的阀体和延伸穿过阀体和/或阀座的至少一个流动孔。

公开(公告)号：US07278553B2

公开(公告)日：2007-10-09

申请号：US11295274

申请日：2005-12-05

Applicant: Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

Inventor： Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

IPC: B65D37/00

CPC classification number: B67D1/0004 ,  B65B39/004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/10 ,  B67D1/108 ,  B67D1/1279 ,  B67D3/04 ,  B67D2001/0827 ,  F04B43/1238 ,  F04B53/1037 ,  Y10T137/7761

Abstract: An apparatus has a valve body defining a first passageway, a valve seat, and a flow aperture extending through the valve body and coupled in fluid communication with the first passageway. An elastic valve cover includes a valve portion overlying the valve seat, forming an interference fit with the valve seat, and defining an axially-extending valve opening therebetween. The valve portion is movable between a normally closed position with the valve portion engaging the valve seat, and an open position with at least a segment of the valve portion spaced away from the valve seat to allow the passage of fluid from the flow aperture through the valve opening. A hermetically sealed variable-volume storage chamber is connectible in fluid communication with the one-way valve assembly. A pump is coupled between the variable-volume storage chamber and the one-way valve assembly to dispense discrete portions of fluid through the valve assembly.

Abstract translation: 一种装置具有限定第一通道，阀座和延伸穿过阀体并与第一通道流体连通地联接的流动孔的阀体。 弹性阀盖包括覆盖在阀座上的阀部分，与阀座形成过盈配合，并在其间限定一个轴向延伸的阀开口。 阀部分可以在与阀座接合的阀部分的常闭位置和打开位置之间移动，打开位置具有与阀座间隔开的阀部分的至少一段，以允许流体从流动孔通过通过 阀门开启。 密封的可变容积的储存室可与单向阀组件流体连通地连接。 泵连接在可变体积存储室和单向阀组件之间，以通过阀组件分配流体的离散部分。

公开(公告)号：US10426701B2

公开(公告)日：2019-10-01

申请号：US15410762

申请日：2017-01-19

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61J1/20 ,  A61M5/162 ,  A61M39/10 ,  A61M39/18 ,  A61M39/26

Abstract: Connector assembly including a piercing member having a flow port therein attached to a first piece, with the piercing member slidingly receivable within a second piece, wherein the piercing member and the second pierce are movable relative to each other between a first position where the second pieces closes the flow port and a second position where the flow port is open. The first piece contains a locking mechanism that lockingly engages with a device when connected thereto, preventing subsequent disconnection of first piece and the device. Upon initial connection of the first piece to the device, the second piece is moved from the first position to the second position.

公开(公告)号：US09737435B2

公开(公告)日：2017-08-22

申请号：US13745721

申请日：2013-01-18

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61F9/00 ,  B23P15/00 ,  B05B11/00 ,  B65D83/00

CPC classification number: A61F9/0008 ,  B05B11/0056 ,  B05B11/0062 ,  B05B11/0067 ,  B05B11/007 ,  B05B11/0097 ,  B23P15/001 ,  B65D83/0022 ,  Y10T29/49412

Abstract: A device has a first part with a valve seat and storage chamber, and a second part with a flexible valve cover and actuator. The storage chamber may be formed from a pre-form blow-molded into a flexible pouch defining a variable-volume storage chamber. The flexible valve cover and valve seat form a normally closed valve seam therebetween. The valve cover is movable in response to fluid at an inlet to the seam exceeding a valve opening pressure of the one-way valve between (i) a normally closed position with valve cover and valve seat in contact with each other and defining the normally closed seam, and (ii) a second position with at least a portion of the valve cover spaced away from the valve seat to allow the fluid to pass through the seam. The one-way valve may have anti-spritz features for using the device to dispense a substance, such as to the eye. The device may contain prostaglandins without the device material absorbing the prostaglandins material and/or without the material being adsorbed into the drug.

公开(公告)号：US09725228B2

公开(公告)日：2017-08-08

申请号：US13572145

申请日：2012-08-10

Applicant: Daniel Py ,  Joseph M. Ting

Inventor： Daniel Py ,  Joseph M. Ting

IPC: B65D37/00 ,  B65D83/00 ,  A61F9/00 ,  B05B11/00 ,  B65D81/24

CPC classification number: B65D83/0055 ,  A61F9/0008 ,  B05B11/00412 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3092 ,  B05B11/3094 ,  B65D81/245

Abstract: A dispenser for dispensing a fluid includes a rigid vial that has a main fluid chamber containing a fluid, and a pump assembly that is in fluid communication with the main fluid chamber and is configured to dispense a predetermined quantity of fluid from the main fluid chamber. A flexible bladder is provided which is located within the main fluid chamber and is configured to expand to fill the ullage created within the main fluid chamber during dispensing of fluid by the pump assembly. The resilient bladder tends to force itself outwardly toward the rigid vial and, in turn, increases the pressure within the main fluid chamber in comparison to the interior of the bladder to thereby prevent the ingress of air or vapors through the bladder or otherwise into the main fluid chamber.

公开(公告)号：US20170190456A1

公开(公告)日：2017-07-06

申请号：US15438231

申请日：2017-02-21

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D1/02 ,  B65D47/36 ,  B05B11/00 ,  B65B7/16 ,  B65B51/22 ,  A61J1/14 ,  B65D55/08 ,  B65B3/04

CPC classification number: B65D1/0215 ,  A61J1/05 ,  A61J1/1406 ,  A61J1/1412 ,  B05B11/00412 ,  B05B11/3028 ,  B29C48/0011 ,  B29C48/12 ,  B29C49/04 ,  B29C49/22 ,  B29C65/665 ,  B29C66/7371 ,  B29C2791/001 ,  B29C2793/0027 ,  B29K2101/12 ,  B29L2031/565 ,  B65B3/04 ,  B65B7/16 ,  B65B51/22 ,  B65D1/0223 ,  B65D1/0276 ,  B65D1/0284 ,  B65D47/36 ,  B65D55/0818 ,  B65D77/06 ,  B65D2501/0036 ,  B65D2501/0063 ,  B65D2501/0072 ,  B67C2003/227

Abstract: A device that includes a first portion including a first polymer, a second portion including a second polymer, and a third portion defining a third polymer. The second polymer is substantially not bondable to the first polymer, and the third polymer is bondable to the first polymer and fixedly secures the first portion to the second portion. A device that includes a body and a closure and including and a first polymer, a second polymer and a third polymer, wherein the first polymer is bondable with the second polymer, and the third polymer is substantially not bondable to the first polymer.

公开(公告)号：US09211983B2

公开(公告)日：2015-12-15

申请号：US13847277

申请日：2013-03-19

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D35/56 ,  B65D47/24 ,  B65D23/02 ,  B65D47/32 ,  B05B11/00 ,  B29C47/00 ,  B29C47/06 ,  B29C49/04 ,  B29L9/00 ,  B29L31/00

CPC classification number: B65D47/24 ,  B05B11/3028 ,  B29C47/0021 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/065 ,  B29C47/068 ,  B29C49/04 ,  B29L2009/00 ,  B29L2031/7158 ,  B65D23/02 ,  B65D47/205 ,  B65D47/32

Abstract: A device comprises a first portion including a first polymer, and a second portion that is relatively flexible in comparison to the first portion and includes a second polymer that is substantially not bondable to the first polymer. A chamber of the device is hermetically sealable with respect to ambient atmosphere and is defined by (i) an interior of the second portion, and/or (ii) a space formed between the first and second portions. A third portion of the device includes a third polymer that is bondable to the first and second polymers and fixedly secures the first and second portions to each other.

Abstract translation: 一种装置包括包含第一聚合物的第一部分和与第一部分相比具有相对柔性的第二部分，并且包括基本上不能与第一聚合物结合的第二聚合物。 该装置的腔室相对于环境气氛可气密地密封，并且由（i）第二部分的内部和/或（ii）形成在第一和第二部分之间的空间限定。 该装置的第三部分包括可与第一和第二聚合物结合的第三聚合物，并将第一和第二部分彼此固定地固定。