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公开(公告)号:US07579488B2
公开(公告)日:2009-08-25
申请号:US10579563
申请日:2004-11-16
申请人: Jianliang Lu , Tianwei Ma , Sunil Nagpal , Quanrong Shen , Alan M. Warshawsky , Jason Matthew Ochoada , Ying Kwong Yee
发明人: Jianliang Lu , Tianwei Ma , Sunil Nagpal , Quanrong Shen , Alan M. Warshawsky , Jason Matthew Ochoada , Ying Kwong Yee
IPC分类号: C07D307/87 , C07D307/00
CPC分类号: C07D405/12 , C07D307/80 , C07D407/12
摘要: The present invention relates to novel, non-secosteroidal, phenyl-benzofuran compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译: 本发明涉及具有维生素D受体(VDR)调节活性的新颖非壬基苯基 - 苯并呋喃化合物,其比1α,25二羟基维生素D3低高钙血症。 这些化合物可用于治疗骨病和牛皮癣。
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公开(公告)号:US20090069400A1
公开(公告)日:2009-03-12
申请号:US12160460
申请日:2007-01-17
申请人: Thomas John Bleisch , Christian Alexander Clarke , Jeffrey Alan Dodge , Scott Alan Jones , Jose Eduardo Lopez , Charles Willis Lugar, III , Brian Stephen Muehl , Timothy Ivo Richardson , Ying Kwong Yee , Kuo-Long Yu
发明人: Thomas John Bleisch , Christian Alexander Clarke , Jeffrey Alan Dodge , Scott Alan Jones , Jose Eduardo Lopez , Charles Willis Lugar, III , Brian Stephen Muehl , Timothy Ivo Richardson , Ying Kwong Yee , Kuo-Long Yu
IPC分类号: A61K31/404 , C07D209/14
CPC分类号: C07D209/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/24 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要: Compounds of Formula (I), wherein n is 1 or 2, and R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, their preparation, pharmaceutical compositions, and methods of use are disclosed.
摘要翻译: 其中n为1或2,R 1,R 2,R 3,R 4,R 5,R 6,R 7和R 8如本文所定义的式(I)化合物,其制备,药物组合物和使用方法公开。
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公开(公告)号:US4859692A
公开(公告)日:1989-08-22
申请号:US852798
申请日:1986-04-16
IPC分类号: C07D209/12 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/535 , A61K31/5355 , A61K31/536 , A61K31/538 , A61K31/54 , A61K31/541 , A61K31/5415 , A61P9/00 , A61P11/00 , A61P11/14 , A61P17/00 , A61P27/16 , A61P29/00 , A61P37/04 , A61P37/08 , A61P43/00 , C07D209/08 , C07D209/18 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D249/18 , C07D265/36 , C07D275/04 , C07D279/16 , C07D333/52 , C07D333/56 , C07D333/58 , C07D333/60 , C07D401/12 , C07D403/10 , C07D405/12 , C07D409/10 , C07D409/12 , C07D413/10 , C07D413/12
CPC分类号: C07D231/56 , C07D209/18 , C07D235/04 , C07D249/18 , C07D265/36 , C07D333/60 , C07D403/10
摘要: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process. ##STR1##
摘要翻译: 本发明涉及式I的某些苯并杂环基链烷酸(和相关的四唑和酰基磺酰胺)及其盐的新颖的,药学上可用的酰胺衍生物,其中R1,R2,L,X,Y,Z,A1,Q,A2和 M具有说明书中列出的含义。 本发明还包括掺入式I化合物或其盐的药物组合物,制备所述化合物的方法,以及用于后一方法的中间体。
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公开(公告)号:US07943795B2
公开(公告)日:2011-05-17
申请号:US11721109
申请日:2005-12-19
IPC分类号: C07C63/00
CPC分类号: C07C235/42 , C07C65/24 , C07C65/40 , C07C217/80 , C07C271/30
摘要: The present invention relates to novel, non-secosteroidal, phenyl-naphthalene compounds of Formula (I): wherein R, R1, RP, ZP, LP1, LP2 LNP, RP3, RN, and ZNP are defined herein, their preparation, pharmaceutical compositions, and methods of use.
摘要翻译: 本发明涉及式(I)的新型非异构体苯基萘化合物:其中R,R1,RP,ZP,LP1,LP2 LNP,RP3,RN和ZNP在本文中定义,其制备,药物组合物 ,和使用方法。
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公开(公告)号:US20090234001A1
公开(公告)日:2009-09-17
申请号:US11721109
申请日:2005-12-19
IPC分类号: A61K31/27 , A61K31/192 , C07C59/90 , C07C271/16 , A61P25/00
CPC分类号: C07C235/42 , C07C65/24 , C07C65/40 , C07C217/80 , C07C271/30
摘要: The present invention relates to novel, non-secosteroidal, phenyl-naphthalene compounds of Formula (I): wherein R, R1, RP, ZP, LP1, LP2 LNP, RP3, RN, and ZNP are defined herein, their preparation, pharmaceutical compositions, and methods of use.
摘要翻译: 本发明涉及式(I)的新型非异构体苯基萘化合物:其中R,R1,RP,ZP,LP1,LP2 LNP,RP3,RN和ZNP在本文中定义,其制备,药物组合物 ,和使用方法。
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公开(公告)号:US20090018058A1
公开(公告)日:2009-01-15
申请号:US10534920
申请日:2003-11-20
申请人: Emilio Enrique Bunel , Robert Peter Gajewski , Charles David Jones , Jianliang Lu , Tianwei Ma , Sunil Nagpal , Ying Kwong Yee
发明人: Emilio Enrique Bunel , Robert Peter Gajewski , Charles David Jones , Jianliang Lu , Tianwei Ma , Sunil Nagpal , Ying Kwong Yee
IPC分类号: A61K31/195 , C07C235/52 , A61K31/56 , A61K31/59 , A61K38/23 , A61P19/10 , A61P17/06
CPC分类号: C07D207/27 , C07C59/48 , C07C59/64 , C07C59/66 , C07C59/90 , C07C65/24 , C07C65/34 , C07C65/40 , C07C69/732 , C07C69/734 , C07C69/738 , C07C69/76 , C07C69/94 , C07C235/34 , C07C235/42 , C07C311/51 , C07C317/28 , C07D207/26 , C07D233/78 , C07D257/04 , C07D257/06 , C07D261/12 , C07D271/113 , C07D277/34 , C07D295/185
摘要: The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating and psoriasis.
摘要翻译: 本发明涉及具有维生素D受体(VDR)调节和牛皮癣的新型非甾体二芳基化合物。
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公开(公告)号:US20080200552A1
公开(公告)日:2008-08-21
申请号:US10579562
申请日:2004-11-16
申请人: Emilio Enrique Bunel , Robert Peter Gajewski , Charles David Jones , Jianliang Lu , Sunil Nagpal , Tianwei Ma , Ying Kwong Yee
发明人: Emilio Enrique Bunel , Robert Peter Gajewski , Charles David Jones , Jianliang Lu , Sunil Nagpal , Tianwei Ma , Ying Kwong Yee
IPC分类号: A61K31/166 , C07C233/64 , A61P13/08 , A61P35/04 , A61P17/06 , A61P19/10
CPC分类号: C07C235/42 , C07C65/19 , C07C69/92 , C07C235/84 , C07C2601/08 , C07C2601/14 , C07D257/04 , C07D257/06
摘要: The present invention relates to novel, non-secosteroidal, hydroxyl substituted, carbon-linked diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译: 本发明涉及具有维生素D受体(VDR)调节活性的新颖的非甾体,羟基取代的碳链的二芳基化合物,其比1α,25二羟基维生素D3低的高钙血症。 这些化合物可用于治疗骨病和牛皮癣。
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公开(公告)号:US07897789B2
公开(公告)日:2011-03-01
申请号:US12497983
申请日:2009-07-06
申请人: Jianliang Lu , Tainwei Ma , Sunil Nagpal , Quanrong Shen , Alan M. Warshawsky , Ying Kwong Yee , Michael John Rupp
发明人: Jianliang Lu , Tainwei Ma , Sunil Nagpal , Quanrong Shen , Alan M. Warshawsky , Ying Kwong Yee , Michael John Rupp
IPC分类号: C07D333/00 , A01N43/12
CPC分类号: C07D333/68 , C07D333/70
摘要: The present invention relates to novel, non-secosteroidal, phenyl-benzothiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译: 本发明涉及具有维生素D受体(VDR)调节活性的新颖的非甾体甾体苯并噻吩化合物,其比1α,25二羟基维生素D3低钙血红素。 这些化合物可用于治疗骨病和牛皮癣。
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公开(公告)号:US20100076065A1
公开(公告)日:2010-03-25
申请号:US12497983
申请日:2009-07-06
申请人: Jianliang Lu , Tainwei Ma , Sunil Nagpal , Quanrong Shen , Alan M. Warshawsky , Ying Kwong Yee , Michael John Rupp
发明人: Jianliang Lu , Tainwei Ma , Sunil Nagpal , Quanrong Shen , Alan M. Warshawsky , Ying Kwong Yee , Michael John Rupp
IPC分类号: A61K31/381 , A61P17/10 , A61P17/12
CPC分类号: C07D333/68 , C07D333/70
摘要: The present invention relates to novel, non-secosteroidal, phenyl-benzothiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译: 本发明涉及具有维生素D受体(VDR)调节活性的新颖的非甾体甾体苯并噻吩化合物,其比1α,25二羟基维生素D3低钙血红素。 这些化合物可用于治疗骨病和牛皮癣。
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公开(公告)号:US20090227604A1
公开(公告)日:2009-09-10
申请号:US12470677
申请日:2009-05-22
申请人: Emilio Enrique Bunel , Robert Peter Gajewski , Charles David Jones , Jianliang Lu , Tianwei Ma , Sunil Nagpal , Ying Kwong Yee
发明人: Emilio Enrique Bunel , Robert Peter Gajewski , Charles David Jones , Jianliang Lu , Tianwei Ma , Sunil Nagpal , Ying Kwong Yee
IPC分类号: A61K31/515 , C07D239/02 , A61P19/10
CPC分类号: C07D207/27 , C07C59/48 , C07C59/64 , C07C59/66 , C07C59/90 , C07C65/24 , C07C65/34 , C07C65/40 , C07C69/732 , C07C69/734 , C07C69/738 , C07C69/76 , C07C69/94 , C07C235/34 , C07C235/42 , C07C311/51 , C07C317/28 , C07D207/26 , C07D233/78 , C07D257/04 , C07D257/06 , C07D261/12 , C07D271/113 , C07D277/34 , C07D295/185
摘要: The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1a,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译: 本发明涉及具有维生素D受体(VDR)调节活性的新型非非甾体二芳基化合物,其比1a,25二羟基维生素D3低钙血红素。 这些化合物可用于治疗骨病和牛皮癣。
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