公开(公告)号：US20180242894A1

公开(公告)日：2018-08-30

申请号：US15967338

申请日：2018-04-30

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Robert J. Boock ,  Monica A. Rixman ,  Peter C. Simpson ,  Mark C. Brister ,  Mark C. Shults

IPC: A61B5/1486 ,  G01N33/66 ,  A61B5/145 ,  C12Q1/00 ,  A61B5/00 ,  G01N33/543 ,  A61B5/1473

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/411 ,  A61B5/418 ,  A61B5/6848 ,  A61B2562/08 ,  C12Q1/006 ,  G01N33/54366 ,  G01N33/66 ,  Y02A50/55 ,  Y02A50/58

Abstract: Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.

公开(公告)号：US20160022186A1

公开(公告)日：2016-01-28

申请号：US14875539

申请日：2015-10-05

Applicant: DexCom, Inc.

Inventor： Mark A. Tapsak ,  Rathbun K. Rhodes ,  Mark C. Shults ,  Jason D. McClure

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/1486 ,  A61B2562/028 ,  A61B2562/125 ,  A61L31/12 ,  B01D69/141 ,  B01D71/54 ,  B01D71/80 ,  B05D3/007 ,  B05D5/00 ,  C12Q1/002 ,  C12Q1/006 ,  Y10T428/31551

Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.

公开(公告)号：US20150374270A1

公开(公告)日：2015-12-31

申请号：US14842276

申请日：2015-09-01

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Rathbun K. Rhodes ,  Stuart J. Updike ,  James H. Brauker

IPC: A61B5/1486 ,  A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/6846

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.

Abstract translation: 本发明一般涉及用于测量宿主中分析物的系统和方法。 更具体地，本发明涉及用于经皮和皮下测量宿主中葡萄糖的系统和方法。

公开(公告)号：US20140128700A1

公开(公告)日：2014-05-08

申请号：US14144497

申请日：2013-12-30

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Stuart J. Updike ,  Rathbun K. Rhodes

IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/145

CPC classification number: A61B5/14865 ,  A61B5/0004 ,  A61B5/14532 ,  A61B5/1495 ,  C12Q1/006

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract translation: 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品递送到植入的装置。 这些设备包括传感器区域中的独特的微架构布置，允许在长时间段内获得准确的数据。

公开(公告)号：US20130030273A1

公开(公告)日：2013-01-31

申请号：US13631780

申请日：2012-09-28

Applicant: DexCom, Inc.

Inventor： Mark A. Tapsak ,  Rathbun K. Rhodes ,  Mark C. Shults ,  Jason D. McClure

IPC: A61B5/145 ,  B05D5/00

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/1486 ,  A61B2562/028 ,  A61B2562/125 ,  A61L31/12 ,  B01D69/141 ,  B01D71/54 ,  B01D71/80 ,  B05D3/007 ,  B05D5/00 ,  C12Q1/002 ,  C12Q1/006 ,  Y10T428/31551

Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.

Abstract translation: 本发明提供了一种用于调节分析物通过其的运输的可植入膜，其包括包含第一聚合物的基质; 和分散在整个基质中的第二种聚合物，其中第二种聚合物形成微区网络，当400×放大倍率或更小时，使用光学显微镜不能观察到水合。 在一个方面，本发明的均质膜具有基本上分散在疏水性基质上的亲水性畴，以提供氧和葡萄糖转运到电化学葡萄糖传感器之间的最佳平衡。

公开(公告)号：US20240252071A1

公开(公告)日：2024-08-01

申请号：US18592440

申请日：2024-02-29

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew Wightlin ,  Mark C. Shults

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/1473 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/6848 ,  A61B2562/028

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US20200146595A1

公开(公告)日：2020-05-14

申请号：US16732121

申请日：2019-12-31

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew Wightlin ,  Mark C. Shults

IPC: A61B5/1473 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/145

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US10561352B2

公开(公告)日：2020-02-18

申请号：US16027103

申请日：2018-07-03

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew D. Wightlin ,  Mark C. Shults

IPC: A61B5/05 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1486

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US20190239782A1

公开(公告)日：2019-08-08

申请号：US16388752

申请日：2019-04-18

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Stuart J. Updike ,  Rathbun K. Rhodes ,  Barbara J. Gilligan ,  Mark A. Tapsak

IPC: A61B5/145 ,  A61B5/1455 ,  C12Q1/00 ,  A61B5/1486 ,  A61B5/00

CPC classification number: A61B5/0031 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14558 ,  A61B5/1459 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/17 ,  C12Q1/006

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

公开(公告)号：US10039480B2

公开(公告)日：2018-08-07

申请号：US14619651

申请日：2015-02-11

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Mark C. Shults ,  Mark A. Tapsak

IPC: A61B5/00 ,  A61F2/02 ,  G01N27/40 ,  A61B5/1473 ,  A61B5/07 ,  A61B5/1486 ,  A61L31/10 ,  A61L31/14 ,  A61B5/145

Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.