公开(公告)号：US20160199258A1

公开(公告)日：2016-07-14

申请号：US14990778

申请日：2016-01-07

Applicant: Dr. Py Institute, LLC

Inventor： Daniel Py

IPC: A61J1/20 ,  A61J1/14 ,  A61J1/10

CPC classification number: A61J1/10 ,  A61J1/1406 ,  A61J1/1481 ,  A61J1/1487 ,  A61J1/1493

Abstract: A pouch comprises a film including (i) a fold defining a fold plane and a first marginal edge portion of the pouch, (ii) a first side transverse to the fold plane, and (iii) a second side opposite the first side and transverse to the fold plane. A fitment of the pouch includes a port and a base. The base defines a mid-portion engaging the fold at the fold plane, a first side located on one side of the mid-portion, and a second side located on an opposite side of the mid-portion relative to the first side. The first and second sides of the base are transverse to the fold plane, and are engaged with the first or second sides of the film, respectively. The base or film overlaps the other and defines an overlapping region. The base and film are sealed to each other within the overlapping region and form a fluid-tight seal that extends about the port.

Abstract translation: 袋包括膜，所述膜包括（i）限定所述袋的折叠平面和第一边缘边缘的折叠部，（ii）横向于所述折叠平面的第一侧，以及（iii）与所述第一侧相对的第二侧和横向 到折叠平面。 小袋的配件包括一个端口和一个底座。 基部限定了在折叠平面处接合折叠的中间部分，位于中间部分的一侧上的第一侧和位于中间部分相对于第一侧的相对侧上的第二侧。 底座的第一和第二侧横向于折叠平面，并分别与薄膜的第一或第二面接合。 基底或膜与另一个重叠，并且限定重叠区域。 基底和薄膜在重叠区域内彼此密封，并形成围绕端口延伸的流体密封。

公开(公告)号：US20150225095A1

公开(公告)日：2015-08-13

申请号：US14637050

申请日：2015-03-03

Applicant: Dr. Py Institute LLC

Inventor： Daniel Py

IPC: B65B3/00

CPC classification number: B65B3/003 ,  A61J1/10 ,  A61J1/2027 ,  A61J1/2093 ,  A61J7/0053 ,  B01F11/0065 ,  B01F15/0205 ,  B01F15/0212 ,  B01F15/0223 ,  B65D75/527 ,  B65D81/3266 ,  B67D3/0012 ,  B67D3/0019 ,  B67D3/0061

Abstract: A device and method are provided for storing substances separately, and for mixing the substances prior to use. The device defines at least one first chamber for receiving a first substance, and at least one second chamber for receiving a second substance. A first sealing portion is located between the first and second chambers and is movable between a closed position preventing fluid communication between the chambers, and an open position permitting fluid communication between the first and second chambers for mixing the substances. First and second penetrable and resealable portions in fluid communication with the first and second chamber(s), respectively, may be used for filling by penetrating them with an injection member and introduce the substances therethrough and into the respective chamber, and resealing the injection apertures and the substances within the respective chamber.

Abstract translation: 提供了用于单独存储物质并在使用之前混合物质的装置和方法。 该装置限定用于接收第一物质的至少一个第一室和用于接收第二物质的至少一个第二室。 第一密封部分位于第一和第二室之间，并且可在防止腔室之间的流体连通的关闭位置之间移动，并且允许在第一和第二腔室之间流体连通的打开位置用于混合物质。 可以分别与第一和第二腔室流体连通的第一和第二穿透和可重新密封的部分用于通过用注射构件穿透它们来填充，并将物质通过其引入相应的腔室中，并且重新密封注射孔 和各个室内的物质。

公开(公告)号：US20150122369A1

公开(公告)日：2015-05-07

申请号：US14536566

申请日：2014-11-07

Applicant: Dr. Py Institute LLC

Inventor： Daniel Py

IPC: B65B3/00 ,  B65B39/00

CPC classification number: B65B3/003 ,  A61M39/18 ,  A61M39/26 ,  A61M2039/268 ,  B65B39/004 ,  B65B55/027

Abstract: A valve comprises a shell, a flexible valve member sealingly mounted within the shell, and a valve body mounted atop the flexible valve member within the shell. The flexible member is moveable between closed and open positions to allow the flow of fluid therethrough. The valve is engageable with a filling device having flow ports and a surrounding closure. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s). Alternatively, the valve may comprise a portion of a female connector and the filling device may comprise a portion of a male connector to form an aseptic fluid connector for the aseptic transfer of fluid therethrough.

Abstract translation: 阀包括壳体，密封地安装在壳体内的柔性阀构件和安装在壳体内的柔性阀构件顶部的阀体。 柔性构件可在闭合位置和打开位置之间移动以允许流体流过其中。 该阀可与具有流动端口和周围封闭件的填充装置接合。 所述封闭件和/或所述轴可在（i）第一位置和第二位置之间移动，所述第一位置是所述封闭件关闭所述端口，以及（ii）打开所述端口的第二位置。 或者，阀可以包括阴连接器的一部分，并且填充装置可以包括阳连接器的一部分，以形成无菌流体连接器，用于无菌地传输流体。

公开(公告)号：US20140290770A1

公开(公告)日：2014-10-02

申请号：US14217864

申请日：2014-03-18

Applicant: Dr. Py Institute, LLC

Inventor： Daniel Py

IPC: F16L41/02

CPC classification number: F16L41/02 ,  A61M39/18 ,  A61M39/26 ,  A61M2039/267 ,  Y10T29/49826 ,  Y10T137/0318 ,  Y10T137/87925 ,  Y10T137/87949 ,  Y10T137/87957

Abstract: An aseptic fluid connector having a first connector including a first fluid passageway for receiving a fluid therein; a first port in fluid communication with the first fluid passageway for passage of the fluid therethrough; and a first deflecting member. The first deflecting member includes a first engaging portion radially spaced relative to the first port, and a first valve movable between a closed position and an open position with movement of the first engaging portion between a non-deflected position and a deflected position, respectively. In the non-deflected position, the first valve is located in the closed position forming a fluid-tight seal between the first valve and first port and preventing the passage of fluid therethrough, and in the deflected position, the first valve is located in the open position allowing the aseptic passage of fluid through the first port.

Abstract translation: 一种无菌流体连接器，其具有包括用于在其中接收流体的第一流体通道的第一连接器; 与第一流体通道流体连通以使流体通过其中的第一端口; 和第一偏转构件。 第一偏转构件包括相对于第一端口径向间隔开的第一接合部分，以及在关闭位置和打开位置之间可移动的第一阀，其中第一接合部分分别在非偏转位置和偏转位置之间移动。 在非偏转位置，第一阀位于关闭位置，在第一阀和第一端口之间形成流体密封并防止流体通过，并且在偏转位置，第一阀位于 打开位置允许流体通过第一端口的无菌通道。

公开(公告)号：US20130270820A1

公开(公告)日：2013-10-17

申请号：US13864919

申请日：2013-04-17

Applicant: DR. PY INSTITUTE, LLC

Inventor： Daniel Py

IPC: F16L37/24

CPC classification number: F16L37/24 ,  A61M5/162 ,  A61M5/1626 ,  A61M39/10 ,  A61M39/1011 ,  A61M39/18 ,  A61M2039/0036 ,  A61M2039/0081 ,  A61M2039/1072 ,  A61M2039/267 ,  F16L37/248 ,  F16L37/30

Abstract: An aseptic fluid connector having a male connector and a female connector engageable to aseptically transfer fluid therethrough. The male connector includes a closure and a piercing member comprising a hollow shaft for receiving fluid therein, a tip, and at least one port in fluid communication with the interior of the hollow shaft for passage of the fluid therethrough. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s). The female connector includes a pierceable septum. The male and female connector are engageable such that the piercing member pierces the pierceable septum. Only when the pierceable member has fully penetrated the pierceable septum can the closure and/or the shaft move from the first position, to the second position to aseptically transfer fluid therethrough.

Abstract translation: 一种具有阳连接器和阴连接器的无菌流体连接器，其可接合以将流体无菌地传送通过其中。 阳连接器包括封闭件和穿孔构件，该穿孔构件包括用于在其中接收流体的中空轴，尖端以及与中空轴内部流体连通以使流体通过的至少一个端口。 所述封闭件和/或所述轴可在（i）第一位置和第二位置之间移动，所述第一位置是所述封闭件关闭所述端口，以及（ii）打开所述端口的第二位置。 阴连接器包括可穿透的隔膜。 公连接器和阴连接器可接合，使得穿孔构件穿透可穿透的隔膜。 只有当可刺穿构件已经完全穿透可刺破的隔膜时，封闭件和/或轴可以从第一位置移动到第二位置以无菌地将流体从其中移出。

公开(公告)号：US20200261182A1

公开(公告)日：2020-08-20

申请号：US16630940

申请日：2018-07-14

Applicant: Dr. Py Institute LLC

Inventor： Daniel Py

IPC: A61B90/98 ,  A61M5/14

Abstract: An apparatus and method for electronically tracing primary devices and process devices, and closed transfer formulation and/or filling the traced primary devices. Each of the primary devices and process devices includes an electronic identifier, such as an RFID tag or barcode. Scanners read the electronic identifiers, and transmit the read identification information to a controller. The controller compares the read identification information to required identification information for a respective product specification, and transmits a signal to further proceed with a formulation or filling process, or not, based on the comparison.

公开(公告)号：US10351271B2

公开(公告)日：2019-07-16

申请号：US14536566

申请日：2014-11-07

Applicant: Dr. Py Institute LLC

Inventor： Daniel Py

IPC: F16L37/36 ,  B65B3/00 ,  B65B39/00 ,  A61M39/26 ,  A61M39/18 ,  B65B55/02

Abstract: A valve comprises a shell, a flexible valve member sealingly mounted within the shell, and a valve body mounted atop the flexible valve member within the shell. The flexible member is moveable between closed and open positions to allow the flow of fluid therethrough. The valve is engageable with a filling device having flow ports and a surrounding closure. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s). Alternatively, the valve may comprise a portion of a female connector and the filling device may comprise a portion of a male connector to form an aseptic fluid connector for the aseptic transfer of fluid therethrough.

公开(公告)号：US10273025B2

公开(公告)日：2019-04-30

申请号：US14636954

申请日：2015-03-03

Applicant: DR. PY INSTITUTE LLC

Inventor： Daniel Py

IPC: B65B3/00 ,  B65B55/04 ,  B65B51/02 ,  B65B55/08 ,  B65B61/00 ,  B65B55/10 ,  B65B7/16 ,  B65B39/00

Abstract: An apparatus and method for sterile filling comprises de-contaminating a needle penetrable surface of a device including a needle penetrable septum and a sealed chamber in fluid communication with the needle penetrable septum. A filling needle penetrates the needle penetrable septum, introduces substance through the filling needle and into the chamber and is, in turn, withdrawn from the septum. A liquid sealant is applied to the penetrated region of the septum. Radiation or energy is applied to the liquid sealant to cure the liquid sealant from a liquid phase to a solid phase.

公开(公告)号：US20170071826A1

公开(公告)日：2017-03-16

申请号：US15267131

申请日：2016-09-15

Applicant: Dr. Py Institute, LLC

Inventor： Daniel Py

IPC: A61J1/14 ,  A61J1/20

CPC classification number: A61J1/1406

Abstract: A septum is penetrable by a needle for decontamination by physical interaction. The septum can include a peripheral portion, an exterior surface], and an interior surface. A penetration portion extends between the exterior and interior surfaces, is spaced inwardly of the peripheral portion, and is penetrable by the needle or other penetrating element. A flex portion is located between the penetration portion and the peripheral portion. A thicker portion extends between the flex portion and the penetration portion, and defines an increased thickness between the exterior and interior surfaces relative to the flex portion. The flex portion is flexible inwardly relative to the peripheral portion during penetration of the penetration portion by a needle or other penetrating element. The penetration portion physically interacts with and decontaminates the needle when it penetrates the septum. The septum may also reduce or prevent retrograde contamination when the needle is withdrawn.

Abstract translation: 隔垫可用针穿透，以通过物理相互作用进行去污。 隔膜可以包括周边部分，外表面和内表面。 穿透部分在外表面和内表面之间延伸，与周边部分向内间隔开，并且可被针或其它穿透元件穿透。 弯曲部分位于穿透部分和周边部分之间。 较厚部分在柔性部分和穿透部分之间延伸，并且在外表面和内表面之间相对于柔性部分限定增加的厚度。 弯曲部分在通过针或其它穿透元件穿透穿透部分期间相对于周边部分向内是柔性的。 当穿刺部分穿透隔膜时，穿透部分与物体相互作用并对其进行去污染。 当取出针时，隔膜也可以减少或防止逆行污染。

公开(公告)号：US20160023885A1

公开(公告)日：2016-01-28

申请号：US14811330

申请日：2015-07-28

Applicant: Dr. Py Institute LLC

Inventor： Daniel Py

IPC: B67D3/04 ,  B67B7/00

CPC classification number: B67D3/043 ,  B67B7/24

Abstract: A pouch connector includes a safety cap having a cap base portion and a main connector disposed opposite the safety cap. The main connector and safety cap are configured to receive a portion of a pouch therebetween. The main connector includes a piercing member for piercing the pouch, an actuating portion for actuating the piercing member and a main connector base portion. The piercing member is configured to pierce through a portion of the pouch so as to provide fluid communication between a substance inside the pouch and the interior of the main connector. A polymeric membrane is coupled to at least one of the cap base portion and the main connector base portion.

Abstract translation: 小袋连接器包括具有帽基部的安全帽和与安全帽相对设置的主连接器。 主连接器和安全帽被配置为在其间容纳一部分袋。 主连接器包括用于刺穿小袋的刺穿构件，用于致动刺穿构件的致动部分和主连接器基部。 刺穿构件构造成穿过袋的一部分，以便在袋内的物质和主连接器的内部之间提供流体连通。 聚合物膜联接到帽基部和主连接器基部中的至少一个。