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    Multiple dose device and method
    1.
    发明授权
    Multiple dose device and method 有权

    公开(公告)号：US10265480B2

    公开(公告)日：2019-04-23

    申请号：US14963170

    申请日：2015-12-08

    Applicant: Dr. Py Institute LLC

    Inventor： Daniel Py

    IPC: A61M5/315 ,  B05B11/00 ,  B65D83/14 ,  G01F11/02 ,  A61M5/178 ,  A61J7/00 ,  A61M5/31 ,  A61M5/20 ,  B05B9/04

    Abstract: A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.

    Controlled non-classified filling device and method
    2.
    发明授权
    Controlled non-classified filling device and method 有权

    公开(公告)号：US10202214B2

    公开(公告)日：2019-02-12

    申请号：US15434468

    申请日：2017-02-16

    Applicant: Dr. Py Institute LLC

    Inventor： Daniel Py

    IPC: A61J1/14 ,  B65B55/04 ,  A61M5/00 ,  A61M5/178 ,  A61J3/00 ,  A61J1/20 ,  B65B7/16 ,  B65B39/12 ,  B65B43/42 ,  A61J1/05

    Abstract: An injection member penetrates an elastic septum of a device defining a sealed, empty, sterile chamber in fluid communication with the septum. During penetrating, an annular interface is formed between the septum and the injection member extending axially between a penetration point on an interior surface of the septum in fluid communication with the sterile chamber, and an exterior surface of the septum engaging the injection member. The injection member is de-contaminated by (i) friction between the septum and injection member at the annular interface, and (ii) elongation of the septum at the annular interface. A substance is introduced through the injection member and into the sterile chamber of the device, the injection member is then withdrawn from the septum, the septum reseals itself at the resulting penetration aperture, and the chamber is maintained sterile throughout the foregoing steps.

    Multiple Dose Vial and Method
    4.
    发明申请
    Multiple Dose Vial and Method 审中-公开

    公开(公告)号：US20180064606A1

    公开(公告)日：2018-03-08

    申请号：US15799482

    申请日：2017-10-31

    Applicant: Dr. Py Institute LLC

    Inventor： Daniel Py

    IPC: A61J1/20 ,  A61J1/14 ,  A61J1/10 ,  A61M39/24

    CPC classification number: A61J1/2096 ,  A61J1/10 ,  A61J1/1406 ,  A61J1/1475 ,  A61J1/22 ,  A61M39/24

    Abstract: A vial for storing multiple doses of a substance to be dispensed into one or more syringes or other delivery devices. The vial has a body, a storage chamber within the body for storing multiple doses of the substance therein, a sterile filter configured to sterilize air or other gas flowing into the storage chamber through the filter, and a one-way valve connectable in fluid communication with a syringe or other delivery device. The one-way valve is moveable relative to the body between first and second positions (i) one of which permits the valve to open so that substance from the storage chamber can flow therethrough and into the syringe or other delivery device connected in fluid communication therewith, and (ii) one of which prevents the valve from opening.

    Aseptic connector with deflectable ring of concern and method
    5.
    发明授权
    Aseptic connector with deflectable ring of concern and method 有权

    公开(公告)号：US09726314B2

    公开(公告)日：2017-08-08

    申请号：US14217864

    申请日：2014-03-18

    Applicant: Dr. Py Institute, LLC

    Inventor： Daniel Py

    IPC: F16L41/02 ,  A61M39/18 ,  A61M39/26

    CPC classification number: F16L41/02 ,  A61M39/18 ,  A61M39/26 ,  A61M2039/267 ,  Y10T29/49826 ,  Y10T137/0318 ,  Y10T137/87925 ,  Y10T137/87949 ,  Y10T137/87957

    Abstract: An aseptic fluid connector having a first connector including a first fluid passageway for receiving a fluid therein; a first port in fluid communication with the first fluid passageway for passage of the fluid therethrough; and a first deflecting member. The first deflecting member includes a first engaging portion radially spaced relative to the first port, and a first valve movable between a closed position and an open position with movement of the first engaging portion between a non-deflected position and a deflected position, respectively. In the non-deflected position, the first valve is located in the closed position forming a fluid-tight seal between the first valve and first port and preventing the passage of fluid therethrough, and in the deflected position, the first valve is located in the open position allowing the aseptic passage of fluid through the first port.

    DEVICE WITH SLIDING STOPPER AND RELATED METHOD
    7.
    发明申请
    DEVICE WITH SLIDING STOPPER AND RELATED METHOD 审中-公开
    具有滑动止动器的装置及相关方法

    公开(公告)号：US20170035654A1

    公开(公告)日：2017-02-09

    申请号：US15238011

    申请日：2016-08-16

    Applicant: Dr. Py Institute, LLC

    Inventor： Daniel Py

    IPC: A61J1/20 ,  B65D8/00 ,  B65B7/16 ,  B65B3/00

    CPC classification number: A61J1/2051 ,  A61J1/2096 ,  B65B3/003 ,  B65B7/161 ,  B65D11/04 ,  B65D71/502

    Abstract: A device that has a device body defining an opening at one end thereof, a storage chamber within the device body for storing multiple doses of a substance therein, and a sliding stopper, sealing engageable with the device body, through which the chamber is filled. The stopper has a body and a flexible portion, which may be in the form of a plurality of flexible members, extending therefrom. The flexible portion or members are movable between first and second positions. In the first position, during filling, the portion or members are substantially laterally extending from the stopper body and engaging the opening of the device body. Accordingly, the axial position of the stopper with respect to the device body is secured during filling of the chamber therethrough. In the second position, after filling, the portion or members are substantially axially-extending from the stopper body and disengaged from the rim or opening of the device body. Accordingly, the stopper is axially slideable through the body.

    Abstract translation: 一种装置，其具有在其一端限定开口的装置主体，在装置主体内用于储存多个剂量的物质的储存室，以及滑动止动件，可与装置主体接合，通过该装置主体填充该容器。 止动器具有主体和柔性部分，其可以是从其延伸的多个柔性构件的形式。 柔性部分可在第一和第二位置之间移动。 在第一位置，在填充期间，该部分或部件基本上从止动体横向延伸并与装置主体的开口接合。 因此，塞子相对于装置主体的轴向位置在腔室通过其的填充期间被固定。 在第二位置，在填充之后，部分或部件基本上从止动体轴向延伸并与装置主体的边缘或开口脱离。 因此，止动件可轴向滑动通过本体。

    DEVICE WITH CLOSURE INCLUDING BASE WITH VALVE SEAT AND SUPPORT WITH VALVE MEMBER, PENETRABLE PORTION AND ACTUATOR
    8.
    发明申请
    DEVICE WITH CLOSURE INCLUDING BASE WITH VALVE SEAT AND SUPPORT WITH VALVE MEMBER, PENETRABLE PORTION AND ACTUATOR 审中-公开
    具有闭合装置的装置，其中包括具有阀座的基座和支撑阀门部件，可透气部分和致动器

    公开(公告)号：US20160075488A1

    公开(公告)日：2016-03-17

    申请号：US14930896

    申请日：2015-11-03

    Applicant: Dr. Py Institute LLC

    Inventor： Daniel Py

    IPC: B65D47/24 ,  B65D23/02

    CPC classification number: B65D47/24 ,  B05B11/3028 ,  B29C47/0021 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/065 ,  B29C47/068 ,  B29C49/04 ,  B29L2009/00 ,  B29L2031/7158 ,  B65D23/02 ,  B65D47/205 ,  B65D47/32

    Abstract: A device comprises a first portion including a first polymer, and a second portion that is relatively flexible in comparison to the first portion and includes a second polymer that is substantially not bondable to the first polymer. A chamber of the device is hermetically sealable with respect to ambient atmosphere and is defined by (i) an interior of the second portion, and/or (ii) a space formed between the first and second portions. A third portion of the device includes a third polymer that is bondable to the first and second polymers and fixedly secures the first and second portions to each other.

    Abstract translation: 一种装置包括包含第一聚合物的第一部分和与第一部分相比具有相对柔性的第二部分，并且包括基本上不能与第一聚合物结合的第二聚合物。 该装置的腔室相对于环境气氛可气密地密封，并且由（i）第二部分的内部和/或（ii）形成在第一和第二部分之间的空间限定。 该装置的第三部分包括可与第一和第二聚合物结合的第三聚合物，并将第一和第二部分彼此固定地固定。

    Modular Filling Apparatus and Method
    10.
    发明申请
    Modular Filling Apparatus and Method 审中-公开
    模块化灌装设备及方法

    公开(公告)号：US20150175281A1

    公开(公告)日：2015-06-25

    申请号：US14636954

    申请日：2015-03-03

    Applicant: DR. PY INSTITUTE LLC

    Inventor： Daniel Py

    IPC: B65B3/00 ,  B65B51/02 ,  B65B61/00 ,  B65B55/10

    CPC classification number: B65B3/003 ,  B65B7/16 ,  B65B51/02 ,  B65B55/04 ,  B65B55/08 ,  B65B55/10 ,  B65B61/002 ,  B65B2039/009

    Abstract: An apparatus and method for sterile filling comprises de-contaminating a needle penetrable surface of a device including a needle penetrable septum and a sealed chamber in fluid communication with the needle penetrable septum. A filling needle penetrates the needle penetrable septum, introduces substance through the filling needle and into the chamber and is, in turn, withdrawn from the septum. A liquid sealant is applied to the penetrated region of the septum. Radiation or energy is applied to the liquid sealant to cure the liquid sealant from a liquid phase to a solid phase.

    Abstract translation: 用于无菌填充的装置和方法包括使包括针穿透隔膜的装置的针穿透表面和与针可穿透隔膜流体连通的密封室中的污染。 填充针穿透针穿透隔膜，通过填充针引入物质并进入腔室，然后从隔膜中取出。 将液体密封剂施加到隔膜的穿透区域。 将辐射或能量施加到液体密封剂以将液体密封剂从液相固化至固相。

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