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    Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
    35.
    发明授权
    Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders 有权
    用于治疗ORL-1受体介导的疾病的羟基烷基取代的1,3,8-三氮杂螺[4.5]癸-4-酮衍生物

    公开(公告)号：US07582649B2

    公开(公告)日：2009-09-01

    申请号：US11242654

    申请日：2005-10-04

    申请人： Kathleen Battista ,  Gilles Bignan ,  Peter J. Connolly ,  Allen B. Reitz ,  Tina Morgan Ross ,  Malcolm Scott ,  Steven A. Middleton ,  Michael Orsini

    发明人： Kathleen Battista ,  Gilles Bignan ,  Peter J. Connolly ,  Allen B. Reitz ,  Tina Morgan Ross ,  Malcolm Scott ,  Steven A. Middleton ,  Michael Orsini

    IPC分类号： A61K31/438 ,  C07D471/10

    CPC分类号： C07D471/10

    摘要： The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain, migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.

    摘要翻译： 本发明涉及新的羟基烷基取代的1,3,8-三氮杂螺[4.5]癸-4-酮衍生物，其中所有变量如本文所定义，可用于治疗由ORL介导的病症和病症 -1 G蛋白偶联受体。 更具体地，本发明的化合物可用于治疗诸如焦虑，抑郁，恐慌，痴呆，躁狂症，双相情感障碍，物质滥用，神经性疼痛，急性疼痛，慢性疼痛，偏头痛，哮喘，咳嗽等疾病和病症 ，精神病，精神分裂症，癫痫，高血压，肥胖，进食障碍，渴望，糖尿病，心律失常，肠易激综合征，克罗恩病，尿失禁，肾上腺疾病，注意力缺陷障碍（ADD），注意缺陷多动障碍（ADHD） 疾病，用于改善认知或记忆和情绪稳定。

    Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders
    37.
    发明授权
    Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders 有权
    用于治疗orl-1受体介导的疾病的羟基烷基取代的1,3,8-三氮杂螺[4.5]癸-4-酮衍生物

    公开(公告)号：US07081463B2

    公开(公告)日：2006-07-25

    申请号：US10656934

    申请日：2003-09-05

    申请人： Kathleen Battista ,  Gilles Bignan ,  Peter J. Connolly ,  Allen B. Reitz ,  Tina Morgan Ross ,  Malcolm Scott ,  Steven A. Middleton ,  Michael Orsini

    发明人： Kathleen Battista ,  Gilles Bignan ,  Peter J. Connolly ,  Allen B. Reitz ,  Tina Morgan Ross ,  Malcolm Scott ,  Steven A. Middleton ,  Michael Orsini

    IPC分类号： H61K31/438 ,  C07D401/04

    CPC分类号： C07D471/10

    摘要： The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain, migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.

    摘要翻译： 本发明涉及新的羟基烷基取代的1,3,8-三氮杂螺[4.5]癸-4-酮衍生物，其中所有变量如本文所定义，可用于治疗由ORL介导的病症和病症 -1 G蛋白偶联受体。 更具体地，本发明的化合物可用于治疗诸如焦虑，抑郁，恐慌，痴呆，躁狂症，双相情感障碍，物质滥用，神经性疼痛，急性疼痛，慢性疼痛，偏头痛，哮喘，咳嗽等疾病和病症 ，精神病，精神分裂症，癫痫，高血压，肥胖，进食障碍，渴望，糖尿病，心律失常，肠易激综合征，克罗恩病，尿失禁，肾上腺疾病，注意力缺陷障碍（ADD），注意缺陷多动障碍（ADHD） 疾病，用于改善认知或记忆和情绪稳定。

    1,4-dithiin and 1,4-dithiepin-1,1,4,4, tetroxide derivatives useful as antagonists of the human galanin receptor
    39.
    发明授权
    1,4-dithiin and 1,4-dithiepin-1,1,4,4, tetroxide derivatives useful as antagonists of the human galanin receptor 有权
    可用作人甘丙肽受体拮抗剂的1,4-二硫辛酸和1,4-二硫辛啶-1,1,4,4四氧化物衍生物

    公开(公告)号：US06407136B1

    公开(公告)日：2002-06-18

    申请号：US09563147

    申请日：2000-05-02

    申请人： Malcolm K. Scott ,  Daniel H. S. Lee ,  Allen B. Reitz ,  Tina Morgan Ross ,  Haou-Yan Wang

    发明人： Malcolm K. Scott ,  Daniel H. S. Lee ,  Allen B. Reitz ,  Tina Morgan Ross ,  Haou-Yan Wang

    IPC分类号： A61K31385

    CPC分类号： C07D409/04 ,  C07D339/00 ,  C07D339/08

    摘要： The invention is directed to 1,4-dithiin- and 1,4-dithiepin-1,1,4,4-tetroxide derivatives useful as galanin receptor antagonists for treating disorders of the central nervous system. Pharmaceutical compositions comprising the compounds of the present invention and methods of treating conditions such as an eating disorder, obesity, bulimia nervosa, anorexia nervosa, binge eating, diabetes, dyslipidemia, hypertension, memory loss, sleep disturbances, pain, depression, anxiety, Alzheimer's disease, senile dementia, cerebral hemorrhage, or diarrhea are also described.

    摘要翻译： 本发明涉及用作治疗中枢神经系统疾病的甘丙肽受体拮抗剂的1,4-二硫辛酸和1,4-二硫辛啶-1,1,4,4-四氧化物衍生物。 包含本发明化合物的药物组合物和治疗诸如进食障碍，肥胖症，神经性贪食症，神经性厌食症，暴饮暴食症，糖尿病，血脂异常，高血压，记忆丧失，睡眠障碍，疼痛，抑郁，焦虑，阿尔茨海默病 还描述了疾病，老年性痴呆，脑出血或腹泻。