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    Image-based assay using mark-assisted machine learning
    33.
    发明授权
    Image-based assay using mark-assisted machine learning 有权

    公开(公告)号：US11463608B2

    公开(公告)日：2022-10-04

    申请号：US17179319

    申请日：2021-02-18

    Applicant: Essenlix Corporation

    Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Jun Tian ,  Wei Dong

    IPC: H04N5/225 ,  G01N21/84

    Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.

    Homogeneous Assay
    34.
    发明申请
    Homogeneous Assay 有权

    公开(公告)号：US20210140957A1

    公开(公告)日：2021-05-13

    申请号：US16621185

    申请日：2018-06-12

    Applicant: Essenlix Corporation

    Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Li ,  Ji Qi ,  Jun Tian

    IPC: G01N33/543 ,  G06T7/00

    Abstract: Among other things, the present invention is related to devices and methods of performing biological and chemical assays, such as but not limited to immunoassays and nucleic assay acid, particularly the homogeneous assay that does not use the step of wash and that is fast (e.g. 60 seconds from dropping a sample to displaying results).

    ASSAY WITH AMPLIFICATION
    38.
    发明申请
    ASSAY WITH AMPLIFICATION 审中-公开

    公开(公告)号：US20200225161A1

    公开(公告)日：2020-07-16

    申请号：US16484803

    申请日：2018-02-08

    Applicant: Essenlix Corporation

    Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Ji Li

    IPC: G01N21/65 ,  G01N33/543 ,  G01N33/58 ,  G01N21/66 ,  G01N21/64

    Abstract: A homogeneous assay method that employs a device is provided. In some embodiments, the device contains a pair of plates that can be opened and closed. The sample is placed between two plates. In some embodiments, the thickness of the sample in a closed configuration, the concentration of labels, and amplification factor of the amplification surface are configured to make the label(s) bound on the amplification surface visible without washing away of the unbound labels.

    NUCLEIC ACID HYBRIDIZATION ASSAY
    39.
    发明申请
    NUCLEIC ACID HYBRIDIZATION ASSAY 审中-公开

    公开(公告)号：US20200095629A1

    公开(公告)日：2020-03-26

    申请号：US16483833

    申请日：2018-02-08

    Applicant: Essenlix Corporation

    Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Yufan Zhang ,  Ji Li

    IPC: C12Q1/6837 ,  C12Q1/686 ,  B01L3/00 ,  B01L7/00 ,  G01N21/65

    Abstract: Provided herein is a method and device for performing a homogeneous nucleic acid detection assay. The device can contain a pair of plates where one of the plates comprises (i) surface amplification surface; and (ii) target-specific nucleic acid probes that are immobilized on said amplification surface and that specifically binds to a part of the target nucleic acid; and the second plate comprises a sample contact area comprising a reagent storage site that comprises target-specific nucleic acid detection agents that specifically binds to another part of the target nucleic acid. In some embodiments, the device can be read without a washing unbound label from the surface of the device.

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