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公开(公告)号：US20190119733A1
公开(公告)日：2019-04-25
申请号：US16178101
申请日：2018-11-01
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Doron Lipson , Geoffrey Alan Otto , Alexander Nevin Parker , Philip James Stephens , Sean R. Downing , Mirna Jarosz , Mikhail G. Shapiro , Roman Yelensky
IPC: C12Q1/6827 , C12Q1/6874
Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
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公开(公告)号：US09907798B2
公开(公告)日：2018-03-06
申请号：US15200088
申请日：2016-07-01
Applicant: FOUNDATION MEDICINE, INC. , UCL Business PLC
Inventor： Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/55 , A61K31/497 , A61K31/52 , A61K31/505 , A61K31/445 , A61K31/40 , A61K38/48 , A61K39/00 , C12Q1/68 , A61K31/519 , C12Q1/70 , A61K31/506 , A61K31/454 , A61K31/404 , A61K31/4196 , A61K33/24 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , A61K31/366 , A61K31/555 , A61K31/439 , A61K31/4745 , C07K16/28 , G01N33/571 , A61N5/10
CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K39/39558 , A61K2039/505 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/571 , A61K2300/00
Abstract: Methods of treating a head and neck cancer are disclosed.
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公开(公告)号：US20150073036A1
公开(公告)日：2015-03-12
申请号：US14473508
申请日：2014-08-29
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Matthew J. Hawryluk , Doron Lipson , Vincent A. Miller , Philip James Stephens
IPC: C12Q1/68 , A61K45/06 , C12N15/113 , A61K31/553 , A61K31/519
CPC classification number: C12Q1/6886 , A61K31/519 , A61K31/553 , A61K45/06 , C07K14/47 , C12N9/12 , C12N15/1138 , C12N2310/14 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
Abstract: Novel NTRK1 fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing and/or treating a subject having a cancer are disclosed.
Abstract translation: 公开了用于评估，鉴定，评估和/或治疗患有癌症的受试者的新型NTRK1融合分子，检测试剂和用途和试剂盒。
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公开(公告)号：US11578372B2
公开(公告)日：2023-02-14
申请号：US16683575
申请日：2019-11-14
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Matthew J. Hawryluk , Doron Lipson , Vincent A. Miller , Philip James Stephens
IPC: C12Q1/6886 , C12N15/113 , C12N9/12 , C07K14/47 , A61K31/519 , A61K31/553 , A61K45/06
Abstract: Novel NTRK1 fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing and/or treating a subject having a cancer are disclosed.
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公开(公告)号：US20220096483A1
公开(公告)日：2022-03-31
申请号：US17344777
申请日：2021-06-10
Applicant: FOUNDATION MEDICINE, INC. , UCL BUSINESS LTD
Inventor： Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/519 , C12Q1/70 , A61K31/506 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , C12Q1/6886 , A61K31/366 , A61K31/505 , A61K31/555 , A61K33/243 , A61K33/24 , A61K31/439 , A61K31/4745 , C07K16/28 , C12Q1/6883 , G01N33/571 , A61N5/10
Abstract: Methods of treating a head and neck cancer are disclosed.
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Patent Agency Ranking
公开(公告)号：US11136619B2
公开(公告)日：2021-10-05
申请号：US16178101
申请日：2018-11-01
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Doron Lipson , Geoffrey Alan Otto , Alexander Nevin Parker , Philip James Stephens , Sean R. Downing , Mima Jarosz , Mikhail G. Shapiro , Roman Yelensky
IPC: C12Q1/6827 , C12Q1/6874 , C12Q1/6886 , G16B20/00 , G16B30/00
Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
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公开(公告)号：US11118213B2
公开(公告)日：2021-09-14
申请号：US15897824
申请日：2018-02-15
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Doron Lipson , Geoffrey Alan Otto , Alexander N. Parker , Philip James Stephens , Sean R. Downing , Mirna Jarosz , Mikhail G. Shapiro , Roman Yelensky
IPC: C12Q1/6827 , C12Q1/6874 , C12Q1/6886 , G16B20/00 , G16B30/00
Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
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公开(公告)号：US20190233897A1
公开(公告)日：2019-08-01
申请号：US16122286
申请日：2018-09-05
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Maureen T. Cronin , Garrett Michael Frampton , Doron Lipson , Vincent A. Miller , Gary Palmer , Jeffrey S. Ross , Philip James Stephens , Roman Yelensky
IPC: C12Q1/6886 , A61K31/675 , A61K31/4196 , A61K31/439 , A61K45/06 , A61K31/567 , A61K31/565 , A61K31/436 , A61K31/4439 , C07K16/28 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/472 , A61K31/536 , A61K31/5415 , C07K14/72
CPC classification number: C12Q1/6886 , A61K31/416 , A61K31/4196 , A61K31/423 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/4439 , A61K31/472 , A61K31/536 , A61K31/5415 , A61K31/565 , A61K31/567 , A61K31/675 , A61K45/06 , C07K14/72 , C07K16/2869 , C07K2317/34 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156
Abstract: Novel mutant ESR1 molecules and uses are disclosed.
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公开(公告)号：US20190136301A1
公开(公告)日：2019-05-09
申请号：US16245301
申请日：2019-01-11
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Doron Lipson , Geoffrey Alan Otto , Alexander Nevin Parker , Philip James Stephens , Sean R. Downing , Mirna Jarosz , Mikhail G. Shapiro , Roman Yelensky
IPC: C12Q1/6827 , C12Q1/6874
Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
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公开(公告)号：US20190032118A1
公开(公告)日：2019-01-31
申请号：US15897824
申请日：2018-02-15
Applicant: FOUNDATION MEDICINE, INC.
Inventor： Doron Lipson , Geoffrey Alan Otto , Alexander N. Parker , Philip James Stephens , Sean R. Downing , Mirna Jarosz , Mikhail G. Shapiro , Roman Yelensky
IPC: C12Q1/6827 , C12Q1/6874
Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
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