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公开(公告)号：US20170363561A1
公开(公告)日：2017-12-21
申请号：US15532233
申请日：2015-12-03
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Andrea Jeannine Peters , Thomas Elliot Stecher , Craig Patrick Galligan , Christopher Michael Puleo , Ralf Lenigk
IPC: G01N27/30 , G01N27/453 , H01G11/86 , C12M1/00 , H01G11/02 , H01G9/22 , H01G9/042 , H01G11/28 , H01G11/48 , H01M4/60
CPC classification number: G01N27/30 , C12M47/06 , G01N27/453 , H01G9/042 , H01G9/22 , H01G11/02 , H01G11/28 , H01G11/48 , H01G11/86 , H01M4/602 , Y02E60/13
Abstract: The present disclosure relates to the manufacture and use of redox electrodes and their use in cell lysis. In certain embodiments, the redox electrodes are manufactured using a hybrid material approach, such as using a redox polymer in combination with a support substrate, such as cellulose fibers or paper. In certain implementations, the redox electrodes are suitable for use at voltages greater than 25 Volts.
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公开(公告)号：US09333463B2
公开(公告)日：2016-05-10
申请号：US13951929
申请日：2013-07-26
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk , Nichole Lea Wood , Li Zhu , Craig Patrick Galligan
IPC: G01N27/447 , B01D57/02
CPC classification number: B01D57/02 , G01N27/4473
Abstract: A device and a system for eluting biomolecules from biological sample by electroelution are provided. The device for electroelution of biomolecules from a biological sample is constituted with a housing configured to receive an electrolyte and the biological sample, at least two electrodes comprising conductive redox polymers operationally coupled to the housing, and a biomolecule impermeable layer disposed on at least one of the electrodes. The biomolecule impermeable layer disposed on at least one of the electrodes to prevent the biomolecules from reaching the electrode. A system is provided, wherein the system comprises a sample collection port, one or more reservoirs comprising a buffer, a solvent, a reagent or combinations thereof, an device for electroelution, and a controller.
Abstract translation: 提供了一种通过电洗脱从生物样品中洗脱生物分子的装置和系统。 用于从生物样品电洗脱生物分子的装置由构造成接收电解质和生物样品的壳体构成，至少两个电极包括可操作地耦合到壳体的导电氧化还原聚合物，以及生物分子不可渗透层，其设置在至少一个 电极。 生物分子不渗透层设置在至少一个电极上以防止生物分子到达电极。 提供了一种系统，其中系统包括样品采集端口，一个或多个包含缓冲液，溶剂，试剂或其组合的储存器，用于电洗脱的装置和控制器。
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公开(公告)号：US20160023206A1
公开(公告)日：2016-01-28
申请号：US14341074
申请日：2014-07-25
Applicant: General Electric Company
Inventor： Ralf Lenigk , Erin Jean Finehout , Xuefeng Wang
CPC classification number: B01L3/5023 , A61B5/150343 , A61B5/150358 , B01L3/0258 , B01L3/0262 , B01L3/502715 , B01L3/561 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/16 , B01L2300/069 , B01L2300/0838 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , C12Q1/6806 , G01N1/14 , G01N2001/149
Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.
Abstract translation: 提供了一种用于样品收集和转移的集成设备。 集成装置包括设置在第一层和第二层之间的毛细通道，其中第一层包括亲水层，该亲水层包括用于将样品流体接收到毛细通道的流体入口，其中毛细通道包括内表面和外表面 表面和用于排出样品流体的出口。 该装置还包括界面组件，其包括：第三层，第四层，第五层和流路。 接口组件设置在毛细管的外表面上，在相对于出口的确定位置处，使得毛细管与接口组件的第三层接触并且出口与界面的流动路径接触 用于从集成装置排出样品流体的组件。
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公开(公告)号：US20150027891A1
公开(公告)日：2015-01-29
申请号：US13951881
申请日：2013-07-26
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , John Richard Nelson , Patrick McCoy Spooner , Ralf Lenigk , Nichole Lea Wood , Li Zhu , Craig Patrick Galligan
IPC: B01D57/02
CPC classification number: B01D57/02 , C12N15/101
Abstract: A method of eluting biomolecules, such as nucleic acids from a biological sample by electroelution is provided. An example of a method includes various steps, such as loading the biological sample to a device comprising a housing, at least two conductive redox polymer electrodes operationally coupled to the housing and a biomolecule impermeable layer disposed on at least one of the electrodes. The loading of sample is followed by initiating an electrical connection to generate an electric field strength sufficient to elute biomolecules from the biological sample; and eluting the biomolecules from the biological sample.
Abstract translation: 提供了通过电洗脱来从生物样品中洗脱生物分子如核酸的方法。 方法的实例包括各种步骤，例如将生物样品装载到包括壳体的装置中，至少两个可操作地耦合到壳体的导电氧化还原聚合物电极和设置在至少一个电极上的生物分子不可渗透层。 样品的负载之后是引发电连接以产生足以从生物样品中洗脱生物分子的电场强度; 并从生物样品中洗脱生物分子。
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35.发明申请公开(公告)号：US20250064348A1
公开(公告)日：2025-02-27
申请号：US18456146
申请日：2023-08-25
Applicant: General Electric Company
Inventor： Andrew Arthur Paul Burns , Azar Alizadeh , Ralf Lenigk , Richard JeanLuc St. Pierre
Abstract: A microneedle actuator for monitoring ISF of a user includes a rigid support defining a slot, a geared cam positioned within the rigid support and including an axle extending through the slot, and a spring positioned within the rigid support and configured to rotate the geared cam about the axle. The microneedle actuator further includes an ISF sensing module and an actuation device. The ISF sensing module is attached to the geared cam and including a plurality of microneedles, each microneedle of the plurality of microneedles including at least one sensor for detecting the ISF of the user. The actuation device is attached to the rigid support and the geared cam. Actuation of the actuation device releases the spring, rotating the geared cam to insert the plurality of microneedles into the user's skin, and wherein the at least one sensor detects constituents of the ISF of the user.
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Patent Agency Ranking
公开(公告)号：US20230219080A1
公开(公告)日：2023-07-13
申请号：US17573311
申请日：2022-01-11
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Ralf Lenigk , Tejas Suresh Khire , Tyler Hammond , Erik Leeming Kvam , Allison Caron
IPC: B01L3/00
CPC classification number: B01L3/5021 , B01L3/502715 , B01L2300/087 , B01L2200/10
Abstract: A closed system centrifuge tube is described and discussed herein that enables removal of waste and transfer and removal of samples via one or more ports of the centrifuge tube within the closed system, without exposing the sample to the outer environment. This may enable greater sample retention during sample processing and centrifugation of the sample.
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公开(公告)号：US11311225B2
公开(公告)日：2022-04-26
申请号：US16027057
申请日：2018-07-03
Applicant: General Electric Company
Inventor： Azar Alizadeh , Andrew A. Burns , Matthew Jeremiah Misner , Ralf Lenigk , Jeffrey Michael Ashe , Obi Aghogho , Nancy Cecelia Stoffel , Juha Virtanen , Otto Pekander , Timo Toivanen , Robert Santala
Abstract: A system for monitoring medical conditions includes a conformable medical monitoring device that includes a first substrate layer, which includes an electronics module, many signal traces, and at least one electrode, such that one or more of the many signal traces electrically couple the at least one electrode to the electronics module. The conformable medical monitoring device includes a second substrate layer positioned over the electronics module, the first substrate layer, or any combination thereof to insulate the electronics module, the first substrate layer, or any combination thereof. The conformable medical monitoring device also includes a third substrate layer positioned over the second substrate layer, such that the third substrate layer reduces electromagnetic interference caused by a voltage pulse and includes an adjustable system coupled to the first substrate layer and that changes a position of the at least one electrode relative to the electronics module.
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公开(公告)号：US20180185843A1
公开(公告)日：2018-07-05
申请号：US15905226
申请日：2018-02-26
Applicant: General Electric Company
Inventor： Ralf Lenigk , Erin Jean Finehout , Xuefeng Wang
Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface; and an outlet for driving out the sample fluid. The device further comprises a third layer comprising an adhesive material such as a patterned adhesive material and a flow path, wherein the third layer is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer and the outlet is in contact with the flow path of the third layer for allowing the sample fluid out from the integrated device.
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公开(公告)号：US20170203292A1
公开(公告)日：2017-07-20
申请号：US15326412
申请日：2015-07-20
Applicant: General Electric Company
Inventor： Ralf Lenigk , Erin Jean Finehout , Xuefeng Wang
CPC classification number: B01L3/5023 , A61B5/150343 , A61B5/150358 , B01L3/0258 , B01L3/0262 , B01L3/502715 , B01L3/561 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/16 , B01L2300/069 , B01L2300/0838 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , C12Q1/6806 , G01N1/14 , G01N2001/149
Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.
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公开(公告)号：US09480981B2
公开(公告)日：2016-11-01
申请号：US14341074
申请日：2014-07-25
Applicant: General Electric Company
Inventor： Ralf Lenigk , Erin Jean Finehout , Xuefeng Wang
CPC classification number: B01L3/5023 , A61B5/150343 , A61B5/150358 , B01L3/0258 , B01L3/0262 , B01L3/502715 , B01L3/561 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/16 , B01L2300/069 , B01L2300/0838 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , C12Q1/6806 , G01N1/14 , G01N2001/149
Abstract: An integrated device for a sample collection and transfer is provided. The integrated device comprises a capillary channel disposed between a first layer and a second layer, wherein the first layer comprises a hydrophilic layer comprising a fluid inlet for receiving a sample fluid to the capillary channel, wherein the capillary channel comprises an inner surface and an outer surface and an outlet for driving out the sample fluid. The device further comprises an interface assembly comprising: a third layer, a fourth layer, a fifth layer, and a flow path. The interface assembly is disposed on the outer surface of the capillary, at a determining position relative to the outlet, such that the capillary is in contact with the third layer of the interface assembly and the outlet is in contact with the flow path of the interface assembly for driving out the sample fluid from the integrated device.
Abstract translation: 提供了一种用于样品收集和转移的集成设备。 集成装置包括设置在第一层和第二层之间的毛细通道，其中第一层包括亲水层，该亲水层包括用于将样品流体接收到毛细通道的流体入口，其中毛细通道包括内表面和外表面 表面和用于排出样品流体的出口。 该装置还包括界面组件，其包括：第三层，第四层，第五层和流路。 接口组件设置在毛细管的外表面上，在相对于出口的确定位置处，使得毛细管与接口组件的第三层接触并且出口与界面的流动路径接触 用于从集成装置排出样品流体的组件。
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