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公开(公告)号：US11078208B1
公开(公告)日：2021-08-03
申请号：US16805933
申请日：2020-03-02
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Elbert Chin , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , John O. Link , Nathan Shapiro , Teresa Alejandra Trejo Martin , Zheng-Yu Yang
IPC: C07D405/14 , C07D487/08 , C07D491/04 , A61P31/18 , A61K45/06 , C07C275/16 , C07D401/12 , C07D471/08 , C07D487/10 , C07C243/28 , A61K31/52 , A61K31/55 , A61K31/553 , A61K31/685 , A61K31/688 , C07D403/12
Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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公开(公告)号：US20190008858A1
公开(公告)日：2019-01-10
申请号：US16005111
申请日：2018-06-11
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil K. Karki , Ashley A. Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-jung Pyun , Michael Sangi , Adam J. Schrier , Dustin Siegel , James G. Taylor , Chinh V. Tran , Teresa A. Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC: A61K31/498 , C07K5/08 , A61K31/10 , C07K5/083 , C07D498/22 , C07D498/16 , C07D403/14 , C07D241/36 , A61K45/06 , A61K38/21 , A61K38/06 , C07K5/087 , A61K31/519 , A61K31/506 , A61K31/4985 , A61K31/4745 , A61K31/401 , A61K38/00
CPC classification number: A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
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公开(公告)号：US20170210756A1
公开(公告)日：2017-07-27
申请号：US15227527
申请日：2016-08-03
Applicant: Gilead Sciences, Inc.
Inventor： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondapally , Christopher Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC: C07D498/18 , C07C271/34 , C07C255/61 , C07C205/57 , C07C233/09 , C07C251/12 , C07D403/12 , C07D241/44
CPC classification number: C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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公开(公告)号：US09296782B2
公开(公告)日：2016-03-29
申请号：US13934090
申请日：2013-07-02
Applicant: Gilead Sciences, Inc.
Inventor： Kyla Bjornson , Eda Canales , Jeromy J. Cottell , Kapil Kumar Karki , Ashley Anne Katana , Darryl Kato , Tetsuya Kobayashi , John O. Link , Ruben Martinez , Barton W. Phillips , Hyung-Jung Pyun , Michael Sangi , Adam James Schrier , Dustin Siegel , James G. Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Randall W. Vivian , Zheng-Yu Yang , Jeff Zablocki , Sheila Zipfel
IPC: A61K6/00 , C07K1/00 , C07K5/08 , C07D498/16 , A61K31/4985 , C07D498/22 , A61K31/4745 , A61K31/506 , A61K31/519 , A61K45/06 , C07K5/087 , C07K5/083 , A61K38/21 , A61K38/06 , A61K38/00
CPC classification number: A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
Abstract translation: 公开的式I化合物及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。
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公开(公告)号：US20250154116A1
公开(公告)日：2025-05-15
申请号：US18918629
申请日：2024-10-17
Applicant: Gilead Sciences, Inc.
Inventor： Hang Chu , Juan A. Guerrero , Anna E. Hurtley , Tae H. Hwang , Lan Jiang , Darryl Kato , Tetsuya Kobayashi , John E. Knox , Scott E. Lazerwith , Xiaofen Li , David W. Lin , Jonathan W. Medley , Michael L. Mitchell , Devan Naduthambi , Zachary Newby , Neil H. Squires , Vickie H. Tsui , Chandrasekar Venkataramani , William J. Watkins , Hong Yang
IPC: C07D267/20 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04
Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
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Patent Agency Ranking
公开(公告)号：US20250042922A1
公开(公告)日：2025-02-06
申请号：US18756455
申请日：2024-06-27
Applicant: Gilead Sciences, Inc.
Inventor： Chaodi Dai , Julie Farand , Juan A. Guerrero , Tezcan Guney , Hongyan Guo , Jason R. Hudlicky , Darryl Kato , Irene N. Kiburu , Scott E. Lazerwith , Paulo A. Machicao Tello , James B.C. Mack , Erik P. McAuley , Jessica L. McKinley , Jonathan William Medley , Hyung-Jung Pyun , Thomas P. Stratton , Maoqun Tian , Jeremy R. Tuck , William J. Watkins , Jie Xu , Jennifer R. Zhang
IPC: C07D519/00 , A61K31/55 , C07D471/22
Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.
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公开(公告)号：US20250011353A1
公开(公告)日：2025-01-09
申请号：US18678775
申请日：2024-05-30
Applicant: Gilead Sciences, Inc.
Inventor： Yueh Hwa S. Chang , Jason A. Davy , Maria M. Esanu , Julie Farand , Karan S. Gandhi , Tezcan Guney , Huy V. Huynh , Darryl Kato , Youri Kim , Lennie J.K. Lin , Yu-Hsuan Liu , James B.C. Mack , Jaspal S. Phull , Ho-Yan Sun , Tram T. Truong , Sergiy Vshyvenko , Lihong Wang , Tao Wu , Di Wu , Yao Zou
IPC: C07F9/6558 , B01J31/22 , B01J31/24 , C07D311/18 , C07F5/02 , C07F9/06
Abstract: The present disclosure relates generally to processes for preparing a compound useful in the prevention or treatment of a Retroviridae viral infection, including an infection caused by the human immunodeficiency virus (HIV).
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公开(公告)号：US12162844B2
公开(公告)日：2024-12-10
申请号：US18181336
申请日：2023-03-09
Applicant: Gilead Sciences, Inc.
Inventor： Hang Chu , Juan A. Guerrero , Anna E. Hurtley , Tae H. Hwang , Lan Jiang , Darryl Kato , Tetsuya Kobayashi , John E. Knox , Scott E. Lazerwith , Xiaofen Li , David W. Lin , Jonathan W. Medley , Michael L. Mitchell , Devan Naduthambi , Zachary Newby , Neil H. Squires , Vickie H. Tsui , Chandrasekar Venkataramani , William J. Watkins , Hong Yang
IPC: C07D513/08 , A61K31/553 , C07D267/20 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/10 , C07D513/20 , C07D513/22 , A61K45/06
Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
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公开(公告)号：US12084467B2
公开(公告)日：2024-09-10
申请号：US18061127
申请日：2022-12-02
Applicant: Gilead Sciences, Inc.
Inventor： Zhimin Du , Julie Farand , Tezcan Guney , Darryl Kato , John O. Link , James B. C. Mack , Dong Min Mun , William J. Watkins , Jennifer R. Zhang
IPC: C07F9/6503 , A61K45/06 , C07D401/14
CPC classification number: C07F9/65038 , A61K45/06 , C07D401/14
Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.
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公开(公告)号：US20240132527A1
公开(公告)日：2024-04-25
申请号：US18236532
申请日：2023-08-22
Applicant: Gilead Sciences, Inc.
Inventor： Julie Farand , Michael Graupe , Tezcan Guney , Darryl Kato , Jiayao Li , John O. Link , James B. C. Mack , Dong Min Mun , Roland D. Saito , William J. Watkins , Jennifer R. Zhang
IPC: C07F9/09
CPC classification number: C07F9/095
Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.
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