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公开(公告)号：US20180221348A1
公开(公告)日：2018-08-09
申请号：US15831703
申请日：2017-12-05
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Allen Yu Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC: A61K31/427 , A61K31/5377
CPC classification number: A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
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![Substituted pyrido[1′,2′:4,5]pyrazino[1,2-a]azepines for treating viral infections](/abs-image/US/2016/10/04/US09458159B2/abs.jpg.150x150.jpg)
32.发明授权Substituted pyrido[1′,2′:4,5]pyrazino[1,2-a]azepines for treating viral infections 有权取代吡啶并[1'，2'：4,5]吡嗪并[1,2-a]吖庚因用于治疗病毒感染公开(公告)号：US09458159B2
公开(公告)日：2016-10-04
申请号：US14329697
申请日：2014-07-11
Applicant: GILEAD SCIENCES, INC.
Inventor： Manoj C. Desai , Mingzhe Ji , Haolun Jin , Teresa Alejandra Trejo Martin , Hyung-Jung Pyun
IPC: A61K31/498 , C07D241/38 , C07D471/18 , C07D471/14
CPC classification number: A61K31/4985 , C07D471/14 , C07D471/18
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R1, R5, W, X, Y1, Y2, and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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公开(公告)号：US08841278B2
公开(公告)日：2014-09-23
申请号：US14045717
申请日：2013-10-03
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Eda Canales , Aesop Cho , Jeromy J. Cottell , Manoj C. Desai , Michael Graupe , Hongyan Guo , Randall L. Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan S. Krygowski , Scott E. Lazerwith , John O. Link , Hongtao Liu , Qi Liu , Richard L. Mackman , Michael L. Mitchell , Jay P. Parrish , Hyung-Jung Pyun , Joseph H. Saugier , Scott D. Schroeder , Jianyu Sun , James G. Taylor , James D. Trenkle , Winston C. Tse , Randall W. Vivian , William J. Watkins , Lianhong Xu
IPC: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4178 , A61K31/7068 , A61K31/7052 , A61K31/4184 , A61P1/16 , A61P31/14
CPC classification number: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20140081022A1
公开(公告)日：2014-03-20
申请号：US14089633
申请日：2013-11-25
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D475/06
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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公开(公告)号：US08629142B2
公开(公告)日：2014-01-14
申请号：US13679803
申请日：2012-11-16
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04 , A61K31/519 , A61P31/12 , A61P35/00
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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Patent Agency Ranking
公开(公告)号：US20130071354A1
公开(公告)日：2013-03-21
申请号：US13679803
申请日：2012-11-16
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan Mc Fadden , Paul A. Roethle , Hong Yang
IPC: C07D487/04 , A61K31/5377 , A61K38/21 , A61K38/16 , A61K31/683 , A61K31/7072 , A61K31/708 , A61K31/573 , A61K31/519 , A61K31/7056
CPC classification number: A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
Abstract translation: 提供了式II的TLR的调节剂：其药学上可接受的盐，含有这些化合物的组合物和包括施用这些化合物的治疗方法。
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公开(公告)号：US20240043458A1
公开(公告)日：2024-02-08
申请号：US18374108
申请日：2023-09-28
Applicant: Gilead Sciences, Inc.
Inventor： Eda Y. Canales , Manoj C. Desai , Eric Gorman , Jiayao Li , Roland D. Saito , James G. Taylor , Nathan E. Wright
IPC: C07F9/6558 , C07D401/14
CPC classification number: C07F9/65583 , C07D401/14
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US11827662B2
公开(公告)日：2023-11-28
申请号：US17715366
申请日：2022-04-07
Applicant: Gilead Sciences, Inc.
Inventor： Eda Y. Canales , Manoj C. Desai , Eric Gorman , Jiayao Li , Roland D. Saito , James G. Taylor , Nathan E. Wright
IPC: C07D401/14 , C07F9/6558
CPC classification number: C07F9/65583 , C07D401/14
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：US11110091B2
公开(公告)日：2021-09-07
申请号：US16201221
申请日：2018-11-27
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Randall L. Halcomb , Paul Hrvatin , Hon Chung Hui , Ryan McFadden , Paul A. Roethle , Hong Yang
IPC: C07D243/00 , C07D403/10 , C07D403/12 , C07D487/22 , A61K31/519 , C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04 , A61K31/5377 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , C07D475/10 , A61K31/527 , A61K31/551 , A61K45/06
Abstract: Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
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公开(公告)号：US20210053988A1
公开(公告)日：2021-02-25
申请号：US16868119
申请日：2020-05-06
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Zhenhong R. Cai , Xiaowu Chen , Jeromy J. Cottell , Manoj C. Desai , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Michael R. Mish , Philip Anthony Morganelli , Hyung-Jung Pyun , James G. Taylor , Teresa Alejandra Trejo Martin
IPC: C07D498/14 , A61K31/537 , C07D471/22 , A61K31/529 , A61K31/551 , A61K31/498 , C07D471/18 , A61K45/06 , C07D498/18 , A61K31/4985 , C07D487/14 , A61K31/553
Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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