公开(公告)号：US09630978B2

公开(公告)日：2017-04-25

申请号：US15089342

申请日：2016-04-01

Applicant: Gilead Sciences, Inc.

Inventor： Zhenhong R. Cai ,  Haolun Jin ,  Scott E. Lazerwith ,  Hyung-Jung Pyun

IPC: C07D513/22 ,  A61K31/4985 ,  A61K31/5365 ,  A61K45/06 ,  C07D491/22 ,  C07D498/16 ,  C07D498/22 ,  A61K31/4375 ,  C07D491/14 ,  C07D498/14

CPC classification number: C07D513/22 ,  A61K31/4375 ,  A61K31/4985 ,  A61K31/5365 ,  A61K45/06 ,  C07D491/14 ,  C07D491/22 ,  C07D498/14 ,  C07D498/16 ,  C07D498/22

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A, A′, R1 and R2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US09421214B2

公开(公告)日：2016-08-23

申请号：US14329694

申请日：2014-07-11

Applicant: GILEAD SCIENCES, INC.

Inventor： Mingzhe Ji ,  Scott E. Lazerwith ,  Hyung-Jung Pyun

IPC: C07D221/18 ,  A61K31/553 ,  C07D498/18 ,  A61K31/537 ,  C07D471/18 ,  A61K31/4985 ,  A61K45/06 ,  C07D471/14 ,  C07D498/14

CPC classification number: A61K31/4985 ,  A61K31/537 ,  A61K31/553 ,  A61K45/06 ,  C07D471/14 ,  C07D471/18 ,  C07D498/14 ,  C07D498/18

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, Y1, Y2, or L are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。 所述化合物具有下式（I）：其包括立体异构体及其药学上可接受的盐，其中R 1，X，Y 1，Y 2或L如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：US20160176870A1

公开(公告)日：2016-06-23

申请号：US14977347

申请日：2015-12-21

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Zhenhong R. Cai ,  Jeromy J. Cottell ,  Mingzhe Ji ,  Haolun Jin ,  Scott E. Lazerwith ,  Philip Anthony Morganelli ,  Hyung-jung Pyun

IPC: C07D471/04 ,  A61K45/06 ,  C07D491/20 ,  A61K31/4985 ,  C07D491/147

CPC classification number: A61K31/4985 ,  A61K45/06 ,  C07D471/04 ,  C07D491/147 ,  C07D491/20

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A′, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。 所述化合物具有下式（Ia）：包括立体异构体及其药学上可接受的盐，其中A'，R 1，R 2和R 3如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：US09321753B2

公开(公告)日：2016-04-26

申请号：US13939695

申请日：2013-07-11

Applicant: Gilead Sciences, Inc.

Inventor： Eda Canales ,  Michael O'Neil Hanrahan Clarke ,  Scott E. Lazerwith ,  Willard Lew ,  Philip Anthony Morganelli ,  William J. Watkins

IPC: A61K31/4436 ,  A61K31/381 ,  A61K45/06 ,  C07D409/12

CPC classification number: C07D409/12 ,  A61K31/381 ,  A61K31/4436 ,  A61K45/06

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

公开(公告)号：US08822430B2

公开(公告)日：2014-09-02

申请号：US13956195

申请日：2013-07-31

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Eda Canales ,  Aesop Cho ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Michael Graupe ,  Hongyan Guo ,  Randall L. Halcomb ,  Darryl Kato ,  Choung U. Kim ,  Thorsten A. Kirschberg ,  Evan S. Krygowski ,  Scott E. Lazerwith ,  John O. Link ,  Hongtao Liu ,  Qi Liu ,  Richard L. Mackman ,  Michael L. Mitchell ,  Jay P. Parrish ,  Hyung-Jung Pyun ,  Joseph H. Saugier ,  Scott D. Schroeder ,  Jianyu Sun ,  James G. Taylor ,  James D. Trenkle ,  Winston C. Tse ,  Randall W. Vivian ,  William J. Watkins ,  Lianhong Xu

IPC: C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04 ,  A61K31/4178 ,  A61K31/7068 ,  A61K31/7052 ,  A61K31/4184 ,  A61P1/16 ,  A61P31/14

CPC classification number: C07D403/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/435 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/55 ,  A61K45/06 ,  A61P31/12 ,  C07D207/16 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D491/113 ,  C07D495/04 ,  C07F5/025

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130323203A1

公开(公告)日：2013-12-05

申请号：US13958424

申请日：2013-08-02

Applicant: Gilead Sciences, Inc.

Inventor： Eda Canales ,  Lee S. Chong ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Scott E. Lazerwith ,  Willard Lew ,  Michael Mertzman Belmont ,  Philip Anthony Morganelli ,  William J. Watkins

IPC: C07D333/38 ,  A61K31/4545 ,  A61K45/06 ,  C07D409/12 ,  A61K31/381 ,  A61K31/501 ,  C07D493/04 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/497 ,  C07D413/12 ,  A61K31/427 ,  C07D409/14 ,  A61K31/4025

CPC classification number: C07D333/38 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/427 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K45/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D493/04

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

公开(公告)号：US20130315861A1

公开(公告)日：2013-11-28

申请号：US13939695

申请日：2013-07-11

Applicant: Gilead Sciences, Inc.

Inventor： Eda Canales ,  Michael O'Neil Hanrahan Clarke ,  Scott E. Lazerwith ,  Willard Lew ,  Philip Anthony Morganelli ,  William J. Watkins

IPC: C07D409/12 ,  A61K45/06 ,  A61K31/381 ,  A61K31/4436

CPC classification number: C07D409/12 ,  A61K31/381 ,  A61K31/4436 ,  A61K45/06

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

公开(公告)号：US20250042915A1

公开(公告)日：2025-02-06

申请号：US18743475

申请日：2024-06-14

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Xinpei Cai ,  Eda Y. Canales ,  Weng K. Chang ,  Gregory F. Chin ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Jessica L. McKinley ,  Michael R. Mish ,  Devan Naduthambi ,  Jason K. Perry ,  Kevin X. Rodriguez ,  Scott D. Schroeder ,  Christopher J. Swank ,  Joshua J. Van Veldhuizen

IPC: C07D495/04 ,  A61P31/14 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D491/107 ,  C07D491/113 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present disclosure relates to compounds of Formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.

公开(公告)号：US12208110B2

公开(公告)日：2025-01-28

申请号：US17502559

申请日：2021-10-15

Applicant: Gilead Sciences, Inc.

Inventor： Scott E. Lazerwith ,  Jonathan William Medley ,  Philip A. Morganelli ,  Thomas P. Stratton ,  Peiyuan Wang

IPC: A61K31/685

Abstract: The present disclosure relates to compounds of Formula I, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for treatment of viral infections, for example for treatment of paramyxoviridae, pneumoviridae, picornaviridae, flaviviridae, filoviridae, arenaviridae, orthomyxovirus, and coronaviridae infections.

公开(公告)号：US20240116946A1

公开(公告)日：2024-04-11

申请号：US18376159

申请日：2023-10-03

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Xinpei Cai ,  Eda Y. Canales ,  Weng K. Chang ,  Gregory F. Chin ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Jessica L. McKinley ,  Michael R. Mish ,  Devan Naduthambi ,  Jason K. Perry ,  Kevin X. Rodriguez ,  Scott D. Schroeder ,  Christopher J. Swank ,  Joshua J. Van Veldhuizen

IPC: C07D495/04 ,  C07D401/04 ,  C07D519/00

CPC classification number: C07D495/04 ,  C07D401/04 ,  C07D519/00

Abstract: The present disclosure relates to compounds of Formula I:




and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.