公开(公告)号：US5527800A

公开(公告)日：1996-06-18

申请号：US182239

申请日：1994-01-18

申请人： Giichi Goto ,  Yuji Ishihara ,  Keisuke Hirai

发明人： Giichi Goto ,  Yuji Ishihara ,  Keisuke Hirai

IPC分类号： C07D209/86 ,  C07D209/90 ,  C07D211/26 ,  C07D223/18 ,  C07D223/22 ,  C07D225/08 ,  C07D267/18 ,  C07D307/91 ,  C07D401/06 ,  C07D413/06 ,  C07D471/06 ,  C07D487/06 ,  A61K31/495 ,  A61K31/44 ,  A61K31/50 ,  A61K31/55 ,  C07D319/06 ,  C07D401/00 ,  C07D451/00 ,  C07D487/00

CPC分类号： C07D307/91 ,  C07D209/86 ,  C07D209/90 ,  C07D211/26 ,  C07D223/18 ,  C07D223/22 ,  C07D225/08 ,  C07D267/18 ,  C07D401/06 ,  C07D413/06 ,  C07D471/06 ,  C07D487/06

摘要： A novel compound of the formula: ##STR1## wherein Ar represents an optionally substituted tricyclic condensed benzene ring group which includes at least one heterocyclic ring as a component ring; n represents an integer from 2 to 10; R.sup.1 represents H or an optionally substituted hydrocarbon group, which may be different from one another in the repetition of n; and Y represents an optionally substituted 4-piperidinyl, 1-piperazinyl or 4-benzyl-1-piperidinyl group, or a salt thereof, inhibiting excellent cholinesterase inhibitory activity and monoamine reuptake inhibitory activity, thus being useful as therapeutic and/or prophylactic medicaments of senile dementia.

摘要翻译： 一种下式的新化合物：其中Ar表示任选取代的三环稠合苯环，其包含至少一个杂环作为组分环; n表示2〜10的整数， R1表示H或任选取代的烃基，其可以在重复n时彼此不同; Y表示任选取代的4-哌啶基，1-哌嗪基或4-苄基-1-哌啶基或其盐，其抑制优异的胆碱酯酶抑制活性和单胺再摄取抑制活性，因此可用作治疗和/或预防药物 老年性痴呆。

公开(公告)号：US5047430A

公开(公告)日：1991-09-10

申请号：US342965

申请日：1989-04-25

申请人： Giichi Goto ,  Terumi Nakajima

发明人： Giichi Goto ,  Terumi Nakajima

IPC分类号： C07C231/02 ,  C07C237/10 ,  C07C237/22

CPC分类号： C07C237/22 ,  Y02P20/55

摘要： A compound is provided which has the formula ##STR1## wherein m is an integer of 1 to 3;n is an integer of 1 or 2;p is an integer of 1 or 2;q is an integer of 1 to 6;x is an integer of 2 to 6;Ph is phenyleneor a pharmceutically acceptable salt thereof. Also provided is a method for glutamate receptor inhibition which comprises administering to a mammal in need thereof an effective amount of said compound or a pharmaceutically acceptable salt thereof. Compositions for glutamate receptor inhibition are provided which contain an effective amount of said compound to provide a glutamate receptor inhibition effect, together with at least one pharmaceutically acceptable carrier, dilient or excipient therefor.

公开(公告)号：US4990511A

公开(公告)日：1991-02-05

申请号：US388676

申请日：1989-08-02

申请人： Terumi Nakajima ,  Koichi Shudo ,  Giichi Goto

发明人： Terumi Nakajima ,  Koichi Shudo ,  Giichi Goto

IPC分类号： C07C235/34 ,  C07C237/10 ,  C07D211/16 ,  C07D211/32 ,  C07D295/13 ,  C07D295/185

CPC分类号： C07D295/185 ,  C07C235/34 ,  C07C237/10 ,  C07D211/16 ,  C07D211/32 ,  C07D295/13

摘要： Amide compounds having glutamate receptor-inhibiting activity and having the formula: ##STR1## (wherein R.sub.1 and R.sub.2 each is hydrogen atom, an alkyl group or an acyl group, or ##STR2## is a cyclic amino group, m is an integer of 1 to 3, n is an integer of 0 to 4, x is an integer of 2 to 6 and y is an integer of 0 to 3) or salts thereof, are provided. The compounds are useful as a medicine for therapy or/and prevention of sequelae of cerebral apoplexy in warm-blooded animals.

公开(公告)号：US4778801A

公开(公告)日：1988-10-18

申请号：US67218

申请日：1987-06-29

申请人： Giichi Goto ,  Yoshiaki Saji

发明人： Giichi Goto ,  Yoshiaki Saji

IPC分类号： A61K31/4427 ,  A61K31/445 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D209/46 ,  C07D317/00 ,  C07D401/06 ,  C07D471/04 ,  C07D491/10 ,  C07D491/113 ,  C07D519/00 ,  A61K31/40

CPC分类号： C07D401/06 ,  C07D471/04 ,  C07D491/10

摘要： A compound of the formula ##STR1## wherein X is hydrogen, halogen or nitro; Ar is phenyl or naphthyridinyl which may optionally be substituted; and either one of Z.sup.1 and Z.sup.2 is hydrogen and the other is lower alkanoyloxy or hydroxy, each of Z.sup.1 and Z.sup.2 is lower alkoxy, or Z.sup.1 and Z.sup.2 combinedly represent hydroxyimino or oxo; and a salt thereof, act on the central nervous system but are weak in adverse effects such as hypnotic and muscle relaxant effects.

公开(公告)号：US4082780A

公开(公告)日：1978-04-04

申请号：US744185

申请日：1976-11-22

申请人： Takuichi Miki ,  Kentaro Hiraga ,  Giichi Goto

发明人： Takuichi Miki ,  Kentaro Hiraga ,  Giichi Goto

IPC分类号： A61K31/565 ,  C07J1/00

CPC分类号： C07J1/007 ,  C07J1/0059

摘要： Novel estradiol derivatives of the formula ##STR1## wherein R.sup.1 means an alkyl group of two or more carbon atoms, and R.sup.2 is hydrogen or an acyl group, have antiestrogen activity and are useful as antiestrogen drugs.