公开(公告)号：US20130206199A1

公开(公告)日：2013-08-15

申请号：US13572481

申请日：2012-08-10

申请人： Matthew Lassiter ,  David Thomas ,  James Luke

发明人： Matthew Lassiter ,  David Thomas ,  James Luke

IPC分类号： H01L31/058 ,  H01L35/28 ,  H01L31/052

CPC分类号： H01L35/28 ,  H01L31/052 ,  H01L31/0547 ,  H01L35/30 ,  Y02E10/52

摘要： A thermoelectric generator and methods of fabricating a thermoelectric generator are disclosed. An exemplary thermoelectric generator includes an upper electrode, a lower electrode, and a thermocouple disposed between the upper electrode and the lower electrode. The upper electrode, the lower electrode, and the thermocouple are configured to effect heat flux laterally through the thermocouple. In a further aspect, the thermoelectric generator is integrated with a solar cell to form a solar/thermal energy conversion device

摘要翻译： 公开了一种热电发电机和制造热电发电机的方法。 示例性的热电发电机包括上电极，下电极和设置在上电极和下电极之间的热电偶。 上电极，下电极和热电偶被配置为通过热电偶横向地实现热通量。 在另一方面，热电发电机与太阳能电池集成以形成太阳能/热能转换装置

公开(公告)号：US20130096049A1

公开(公告)日：2013-04-18

申请号：US13805888

申请日：2011-06-01

申请人： Elaine Ferguson ,  David Thomas ,  Timothy Walsh

发明人： Elaine Ferguson ,  David Thomas ,  Timothy Walsh

IPC分类号： A61K47/48 ,  A61K45/06

CPC分类号： A61K47/4823 ,  A61K45/06 ,  A61K47/61

摘要： The invention concerns a novel antimicrobial peptide (AMP) polymer conjugate comprising at least one AMP, typically colistin, and a dextrin polymer wherein said dextrin polymer has a molecular weight between 5,000-60,000 g/mol and is modified by the additions of pendant groups which increase the stability of the conjugate and so delays its degradation thereby slowing the rate at which the AMP is released.

摘要翻译： 本发明涉及包含至少一种AMP（通常为粘菌素）和糊精聚合物的新型抗微生物肽（AMP）聚合物缀合物，其中所述糊精聚合物的分子量为5,000-60,000g / mol，并通过添加侧基进行修饰， 增加共轭物的稳定性，因此延缓其降解，从而减缓AMP释放的速率。

公开(公告)号：US08222291B2

公开(公告)日：2012-07-17

申请号：US12897760

申请日：2010-10-04

申请人： Gunnar J. Hanson ,  David Thomas ,  Nizal Chandrakumar ,  Susan Harran

发明人： Gunnar J. Hanson ,  David Thomas ,  Nizal Chandrakumar ,  Susan Harran

IPC分类号： A61K31/40 ,  C07D207/04

CPC分类号： C07D207/16 ,  C07D249/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/14 ,  C07D487/14

摘要： The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.

公开(公告)号：US07820807B2

公开(公告)日：2010-10-26

申请号：US12420481

申请日：2009-04-08

申请人： David Thomas ,  Mark De Boer ,  Pieter C. J. M. Res ,  Peter J. Simons

发明人： David Thomas ,  Mark De Boer ,  Pieter C. J. M. Res ,  Peter J. Simons

IPC分类号： C12N15/13 ,  C12N15/12 ,  C12N5/10

CPC分类号： A61K39/39541 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/2878 ,  C07K2317/31 ,  A61K2300/00

摘要： Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.

摘要翻译： 公开了可以结合并刺激专业和非专业人抗原呈递细胞（“APC”）的激动剂抗CD40分子，包括单克隆抗体，增强CD40L对CD40阳性细胞的刺激作用和/或诱导表型成熟 的单核细胞来源的树突状细胞。 提供了几种这样的单克隆抗体，并且生产它们的细胞系已经保藏在美国典型培养物保藏中心。

公开(公告)号：US20090008872A1

公开(公告)日：2009-01-08

申请号：US11824671

申请日：2007-07-02

申请人： Jeffrey W. Ryan ,  David Thomas

发明人： Jeffrey W. Ryan ,  David Thomas

IPC分类号： B65H29/22 ,  B65H31/02

CPC分类号： B65H31/34 ,  B65H2404/1114 ,  B65H2601/521

摘要： A flexible blade for use in a paddle wheel drive element is disclosed. This flexible blade, usually made from rubber or other flexible materials is horizontally split into two sections to provide reduced audible noise when the blade contacts and moves paper sheets.

公开(公告)号：US20070244053A1

公开(公告)日：2007-10-18

申请号：US11638218

申请日：2006-12-12

申请人： Allan Kirk ,  David Harlan ,  David Thomas ,  Michael Kauffman ,  Linda Burkly

发明人： Allan Kirk ,  David Harlan ,  David Thomas ,  Michael Kauffman ,  Linda Burkly

IPC分类号： A61K39/395 ,  A61K38/00 ,  C07K14/705 ,  C07K16/28 ,  A61K38/17

CPC分类号： A61K38/13 ,  A61K31/00 ,  A61K31/445 ,  A61K31/57 ,  A61K38/17 ,  A61K39/395 ,  A61K39/39541 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/545 ,  C07K14/70521 ,  C07K16/2875 ,  C07K2317/24 ,  A61K2300/00

摘要： Compositions and methods disclosed herein capitalize on the discovery that rejection of a tissue graft can be inhibited using a CD40:CD154 binding interrupter, either alone or in combination with another immunomodulator or immunosuppressor. An advantageous, synergistic combination includes a CD40:CD154 binding interrupter and a CD28 signaling interrupter. An exemplary CD40:CD154 binding interrupter is an anti-CD154 monoclonal antibody, such as an antibody having the antigen-specific binding characteristics of the 5c8 monoclonal antibody. An exemplary CD28 signaling interrupter is a CTLA4-Ig fusion protein. The disclosed compositions and methods unexpectedly can be used to prolong survival of grafted tissue in a recipient host, to reverse acute graft rejection, and to attenuate immunological consequences of the failure of grafted tissue.

摘要翻译： 本文中公开的组合物和方法利用CD40：CD154结合中断器单独或与另一种免疫调节剂或免疫抑制剂组合来抑制组织移植物的排斥的发现。 有利的协同组合包括CD40：CD154结合中断和CD28信号传导中断。 示例性CD40：CD154结合中断剂是抗CD154单克隆抗体，例如具有5c8单克隆抗体的抗原特异性结合特征的抗体。 示例性的CD28信号传导中断是CTLA4-Ig融合蛋白。 所公开的组合物和方法意外地可以用于延长受体宿主中移植组织的存活，逆转急性移植物排斥反应，并减轻移植组织失败的免疫学后果。

公开(公告)号：US20070190053A1

公开(公告)日：2007-08-16

申请号：US11527700

申请日：2006-09-25

申请人： Susan Kalled ,  David Thomas

发明人： Susan Kalled ,  David Thomas

IPC分类号： A61K39/395

CPC分类号： C07K16/2875 ,  A61K38/00 ,  A61K2039/505

摘要： This invention relates to methods for treatment of nephritis associated with immune complex disease using anti-CD40L compounds. According to one embodiment of this invention, anti-CD40L compounds are administered to a patient with immune complex disease who has received a kidney allograft, to inhibit the development of immune complex glomerulonephritis within the grafted kidney.

摘要翻译： 本发明涉及使用抗CD40L化合物治疗与免疫复合物疾病相关的肾炎的方法。 根据本发明的一个实施方案，将抗CD40L化合物给予具有接受肾同种异体移植的免疫复合物疾病的患者，以抑制移植肾内免疫复合物肾小球肾炎的发展。

公开(公告)号：US20070111494A1

公开(公告)日：2007-05-17

申请号：US11598066

申请日：2006-11-13

申请人： David Thomas ,  Philip Bentley

发明人： David Thomas ,  Philip Bentley

IPC分类号： H01L21/44

CPC分类号： B65H20/14 ,  B65H2301/51422 ,  C23C18/1619 ,  H05K1/0393 ,  H05K3/0085 ,  H05K2203/0746 ,  H05K2203/1545 ,  H05K2203/1572

摘要： A method of handling a length of flexible planar material, comprises conveying the material (1) past a first contacting point (2), and applying a flow of fluid (6) to the material thereby applying a drag force on the material which induces a tensile force in the material with respect to the contacting point. Apparatus for performing the method is also disclosed.

摘要翻译： 一种处理长度的柔性平面材料的方法包括将材料（1）输送通过第一接触点（2），并且向材料施加流体流（6），从而在材料上施加阻力，所述阻力引起材料 材料相对于接触点的张力。 还公开了用于执行该方法的装置。

公开(公告)号：US20070069453A1

公开(公告)日：2007-03-29

申请号：US11238722

申请日：2005-09-29

申请人： David Thomas ,  Kenneth Smith ,  Jeffrey Ryan ,  Christopher Pearce

发明人： David Thomas ,  Kenneth Smith ,  Jeffrey Ryan ,  Christopher Pearce

IPC分类号： B65H31/00

CPC分类号： B65H29/14 ,  B65H29/26 ,  B65H29/46 ,  B65H2404/64 ,  B65H2511/514 ,  B65H2701/1313 ,  B65H2220/01

摘要： A print media sheets trailing edge knockdown stacking assistance system, in a compiler or other stacking system with a substantial sheet gravity drop, activated for each ejected sheet to move substantially linearly and perpendicularly downwardly from above, but adjacent to, the sheet ejection position to engage a sheet end area and rapidly push it down towards the underlying stack of sheets and into engagement with any sheet compiling device, then automatically rapidly reciprocally lifting up out of the way above the sheet ejection position before another sheet is ejected, without any significant pause between its up and down movements.

摘要翻译： 在具有大量片重力下降的编译器或其他堆叠系统中的打印介质片后缘击倒堆叠辅助系统被激活，用于每个喷射的片材从上方基本上线性地并且垂直向下移动，但是与片材排出位置相邻 片材端部区域，并迅速将其向下推向下方的片材堆叠并与任何片材编制装置接合，然后在另一张片材弹出之前自动快速往上提升出纸张排出位置之上的方式，而不会在 它的上下运动。

公开(公告)号：US20070048180A1

公开(公告)日：2007-03-01

申请号：US11437275

申请日：2006-05-18

申请人： Jean-Christophe Gabriel ,  Vikram Joshi ,  Joseph Niemann ,  Alexander Star ,  David Thomas ,  Christian Valcke

发明人： Jean-Christophe Gabriel ,  Vikram Joshi ,  Joseph Niemann ,  Alexander Star ,  David Thomas ,  Christian Valcke

IPC分类号： G01N31/22

CPC分类号： G01N33/497 ,  B82Y15/00

摘要： Nanoelectronic sensors, including sensors for detecting analytes such as CO2, NO, anesthesia gases, and the like in human breath. An integrated multivalent monitor system is described which permits two or more analytes to be measured in breath, for example to monitor pulmonary conditions such as asthma. The monitor system may be configured to be compact, light weight, inexpensive, and to include a microprocessor capable of both analyzing measurements to determine patient status, and storing measurement history. Wireless embodiments provide such enhancements as remote monitoring.

摘要翻译： 纳米电子传感器，包括用于在人呼吸中检测诸如CO 2，NO，麻醉气体等分析物的传感器。 描述了一种综合多价监测系统，其允许在呼吸中测量两种或更多种分析物，例如监测肺部疾病如哮喘。 监视器系统可以被配置为紧凑，重量轻，便宜，并且包括能够分析测量以确定患者状态并存储测量历史的微处理器。 无线实施例提供诸如远程监视的增强。