公开(公告)号：US07517965B2

公开(公告)日：2009-04-14

申请号：US10522086

申请日：2003-07-17

申请人： Takaki Koga ,  Tsukasa Suzuki ,  Hiroyuki Saito

发明人： Takaki Koga ,  Tsukasa Suzuki ,  Hiroyuki Saito

IPC分类号： C07K16/00

CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/76

摘要： The present invention provides anti-aPC antibodies that suppress the inactivation of activated protein C (aPC), and uses thereof. The present inventors screened anti-aPC antibodies, and succeeded in isolating anti-aPC antibodies comprising the activity of suppressing aPC inactivation in blood. The antibodies of the present invention can be used to maintain aPC activity by suppressing aPC inactivation, and can thus be used to sustain aPC bioactivities, such as the activity of suppressing activation of the blood coagulation system, and anti-inflammatory activity. In addition, the present invention provides uses of the antibodies of the present invention in aPC therapy for diseases such as thrombosis and sepsis. The therapeutic effect of aPC can be prolonged in treatment that uses aPC administration by allowing an antibody of the present invention to bind with aPC. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.

摘要翻译： 本发明提供抑制活化蛋白C（aPC）失活的抗-APC抗体及其用途。 本发明人筛选了抗-APC抗体，并成功地分离了包含抑制血液中的aPC失活活性的抗-APC抗体。 本发明的抗体可用于通过抑制aPC灭活来维持PCPC活性，因此可用于维持aPC生物活性，例如抑制血液凝固系统活化的活性和抗炎活性。 此外，本发明提供本发明的抗体在aPC治疗中用于血栓形成和败血症等疾病的用途。 通过使本发明的抗体与aPC结合，可以延长使用aPC施用的治疗中aPC的治疗效果。 本发明的抗体可用于治疗和预防诸如血栓形成和败血症等疾病。

公开(公告)号：US20090074874A1

公开(公告)日：2009-03-19

申请号：US12226693

申请日：2007-04-24

申请人： Yuko Amano ,  Yasuki Kato ,  Mitsunori Harada ,  Naoya Shibata ,  Hiroyuki Saito

发明人： Yuko Amano ,  Yasuki Kato ,  Mitsunori Harada ,  Naoya Shibata ,  Hiroyuki Saito

IPC分类号： A61K9/10

CPC分类号： A61K31/4745 ,  A61K9/1075 ,  A61K31/704 ,  A61K47/6907

摘要： The present invention provides a method of encapsulating a low molecular weight drug in a polymer micelle, the method comprising the steps of: (a) dissolving or dispersing the drug having an electric charge in an aqueous medium; (b) preparing an aqueous medium containing a polymer micelle comprising a block copolymer having an overall hydrophobic region and a hydrophilic region, the overall hydrophobic region containing hydrophobic side chains and side chains having an electric charge opposite to that of the low molecular weight drug in random order; (c) mixing the aqueous medium having the low molecular weight drug dissolved or dispersed therein and the aqueous medium containing the polymer micelle; and (d) adjusting the pH of the mixed aqueous medium to a pH at which the encapsulation of the low molecular weight drug is stabilized.

摘要翻译： 本发明提供一种将低分子量药物包封在聚合物胶束中的方法，该方法包括以下步骤：（a）将具有电荷的药物溶解或分散在水性介质中; （b）制备含有聚合物胶束的水性介质，所述聚合物胶束包含具有总疏水区域和亲水区域的嵌段共聚物，所述整个疏水区域含有疏水侧链和具有与低分子量药物相反的电荷的侧链 随机顺序; （c）将溶解或分散在其中的低分子量药物的水性介质和含有聚合物胶束的水性介质混合; 和（d）将混合水性介质的pH调节至低分子量药物的包封稳定的pH。

公开(公告)号：US07481506B2

公开(公告)日：2009-01-27

申请号：US11445286

申请日：2006-06-02

申请人： Hiroyuki Saito ,  Nobutsune Kobayashi

发明人： Hiroyuki Saito ,  Nobutsune Kobayashi

IPC分类号： B41J29/38

CPC分类号： B41J29/38

摘要： In a printing apparatus which prints using a printhead, a printing controller for feedback-controlling driving of a motor includes a control information generation unit which generates control information for a driving torque of the motor on the basis of a first driving pattern, a comparison unit which compares the control information and a threshold for determining an overload on driving of the motor, and a setting unit which sets a second driving pattern for changing a load on driving of the motor by the control information, instead of the first driving pattern, on the basis of the comparison result of the comparison unit. Control of the motor is switched in accordance with the load state.

摘要翻译： 在使用打印头进行打印的打印装置中，用于对马达进行反馈控制的打印控制器包括：控制信息生成单元，其基于第一驱动模式生成用于马达的驱动转矩的控制信息;比较单元 其比较控制信息和用于确定电动机的驱动过载的阈值;以及设定单元，其通过控制信息而不是第一驱动模式来设置用于改变电动机的驱动负载的第二驱动模式，而不是第一驱动模式 比较单位的比较结果的基础。 根据负载状态切换电动机的控制。

公开(公告)号：US20080048382A1

公开(公告)日：2008-02-28

申请号：US11831114

申请日：2007-07-31

申请人： Yuichiro Suzuki ,  Hiroyuki Saito ,  Kentaro Onuma ,  Hiroyuki Kakishima

发明人： Yuichiro Suzuki ,  Hiroyuki Saito ,  Kentaro Onuma ,  Hiroyuki Kakishima

IPC分类号： B65H7/02 ,  G06K7/015

CPC分类号： B65H5/062 ,  B65H7/02 ,  B65H2220/01 ,  B65H2220/09 ,  B65H2404/14 ,  B65H2513/104 ,  B65H2513/50 ,  B65H2553/51 ,  B65H2557/33 ,  B65H2220/02

摘要： A conveyance apparatus increases the conveyance precision of a conveyance unit. The conveyance apparatus has first and second conveyance rollers. The conveyance apparatus includes a DC motor serving as a driving source for the conveyance rollers, a first encoder which outputs a first pulse signal in accordance with rotation of the first conveyance roller, a second encoder which outputs a second pulse signal in accordance with rotation of the second conveyance roller, and a control unit having a first mode in which the DC motor is controlled based on first information about the first pulse signal when executing a conveyance operation to convey a sheet by using the first and second conveyance rollers, and a second mode in which the DC motor is controlled based on second information about the second pulse signal when executing a conveyance operation to convey a sheet by using the second conveyance roller.

摘要翻译： 输送装置增加输送单元的输送精度。 输送装置具有第一输送辊和第二输送辊。 输送装置包括作为输送辊的驱动源的直流电动机，第一编码器，其根据第一输送辊的旋转输出第一脉冲信号;第二编码器，其根据旋转方向输出第二脉冲信号 第二传送辊和控制单元，其具有第一模式，其中当执行通过使用第一和第二传送辊传送纸张的传送操作时，基于关于第一脉冲信号的第一信息来控制DC电动机，以及第二传送辊 模式，其中当执行通过使用第二传送辊传送片材的传送操作时，基于关于第二脉冲信号的第二信息来控制DC电动机。

公开(公告)号：US20070036785A1

公开(公告)日：2007-02-15

申请号：US11585172

申请日：2006-10-24

申请人： Tadamitsu Kishimoto ,  Asao Katsume ,  Hiroyuki Saito

发明人： Tadamitsu Kishimoto ,  Asao Katsume ,  Hiroyuki Saito

IPC分类号： A61K39/395

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/01 ,  A61K38/00 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2319/00 ,  C12N15/8509

摘要： Pharmaceutical compositions for prevention or treatment of diseases caused by interleukin-6 production, comprising an antibody to interleukin-6 receptor (IL-6R antibody). As the IL-6R antibody, an antibody of animals other than the human such as mice, rats, etc., a chimeric antibody between these and a human antibody, a reshaped human antibody, etc. may be used. The pharmaceutical compositions are useful for prevention or treatment of diseases caused by interleukin-6 production such as plasmacytosis, anti-IgGl-emia, anemia, nephritis, etc.

摘要翻译： 用于预防或治疗由白细胞介素-6产生引起的疾病的药物组合物，其包含白细胞介素-6受体抗体（IL-6R抗体）。 作为IL-6R抗体，除了人以外的动物的抗体，例如小鼠，大鼠等，可以使用它们与人抗体之间的嵌合抗体，重构的人抗体等。 药物组合物可用于预防或治疗由白细胞介素-6产生引起的疾病，如浆细胞病，抗IgG1-emia，贫血，肾炎等。

公开(公告)号：US20070002118A1

公开(公告)日：2007-01-04

申请号：US11508982

申请日：2006-08-24

申请人： Hiroyuki Saito ,  Haruo Uchida ,  Nozomu Nishiberi ,  Koya Iwakura ,  Kentaro Onuma ,  Kenji Shigeno ,  Motoyuki Taguchi ,  Shinya Sonoda

发明人： Hiroyuki Saito ,  Haruo Uchida ,  Nozomu Nishiberi ,  Koya Iwakura ,  Kentaro Onuma ,  Kenji Shigeno ,  Motoyuki Taguchi ,  Shinya Sonoda

IPC分类号： B41J2/01

CPC分类号： B41J3/4071 ,  B41J3/60 ,  B65H85/00 ,  B65H2301/33214 ,  B65H2301/33312

摘要： Disclosed is a recording apparatus that helps to achieve a reduction in size and cost. The recording apparatus has a U-turn sheet feeding mechanism for reversing and feeding a recording medium and a duplex transport mechanism for reversing the recording medium and performing printing on both sides thereof, in which the same transport path serves as a transport path for transporting the recording medium from a U-turn sheet feeding roller to a main transport roller for transporting the recording medium to a printing portion and as a transport path for reversal in duplex transport. Further, a transport roller provided in the transport path from the U-turn sheet feeding roller to the main transport roller for transporting the recording medium to the printing portion is the same as a transport roller for duplex transport. A single transport roller serves both as the U-turn transport roller and as the duplex transport roller.

摘要翻译： 公开了一种有助于实现尺寸和成本的减小的记录装置。 记录装置具有用于反转和馈送记录介质的U形舌片进给机构和用于反转记录介质并在其两侧执行打印的双面传送机构，其中相同的传送路径用作传送路径 记录介质从U形片材进给辊到用于将记录介质传送到打印部分的主传送辊以及用于双面传送的反转的传送路径。 此外，设置在从U形舌片进给辊到用于将记录介质传送到打印部分的主传送辊的传送路径中的传送辊与用于双面传送的传送辊相同。 单个输送辊既用作U形转运辊，也用作双面输送辊。

公开(公告)号：US20060269613A1

公开(公告)日：2006-11-30

申请号：US10570819

申请日：2004-09-06

申请人： Yasuaki Ogawa ,  Shoko Nagasaki ,  Chieko Tsuchiya ,  Sohei Higashi ,  Hiroyuki Saito

发明人： Yasuaki Ogawa ,  Shoko Nagasaki ,  Chieko Tsuchiya ,  Sohei Higashi ,  Hiroyuki Saito

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K38/17 ,  A61K31/4745

CPC分类号： A61K9/5153

摘要： A drug and a biodegradable polymer having at least one carboxyl group are encapsulated into nanoparticle which is formed by a block copolymer having a hydrophilic segment and a hydrophobic segment. This invention thus provides a drug-encapsulated nanoparticle which shows an increased in vivo drug-stability.

摘要翻译： 具有至少一个羧基的药物和可生物降解的聚合物被包封成由具有亲水链段和疏水链段的嵌段共聚物形成的纳米粒子。 因此，本发明提供了显示体内药物稳定性增加的药物包封的纳米颗粒。

公开(公告)号：US07028819B2

公开(公告)日：2006-04-18

申请号：US10131248

申请日：2002-04-25

申请人： Hiroyuki Saito ,  Tatsuya Yoshida ,  Shinichi Sakamoto ,  Mitsuru Koni ,  Kiyoshi Horibe

发明人： Hiroyuki Saito ,  Tatsuya Yoshida ,  Shinichi Sakamoto ,  Mitsuru Koni ,  Kiyoshi Horibe

IPC分类号： B60L9/00 ,  G06F15/50

CPC分类号： B60G17/0185 ,  B60G17/0195 ,  B60G2600/08 ,  B60L1/00 ,  B60R16/0315 ,  B60R2016/0322 ,  B60R2021/0104 ,  B60R2021/01061 ,  B60R2021/01115 ,  F16F15/02

摘要： A power supply line is wired in a loop from a battery power supply, and a power supply relay circuit is installed intermediately of the power supply line such that power is supplied from the power supply relay circuit to an electric load connected to a terminal unit of an intensive wiring line. By this arrangement, not only wires for control signals but also wires for power supply can be reduced. The terminal unit may serve also as the power supply relay circuit.

公开(公告)号：US07006488B1

公开(公告)日：2006-02-28

申请号：US09616672

申请日：2000-07-14

申请人： Hiroyuki Saito

发明人： Hiroyuki Saito

IPC分类号： H04L12/66

CPC分类号： H04L45/02 ,  H04L12/5601 ,  H04L45/48 ,  H04L2012/561 ,  H04L2012/562 ,  H04L2012/5685

摘要： According to a first aspect of the present invention, an objective function is defined for minimizing a number of candidate tree graphs for accommodating the communication paths and a first constraint equation is defined for causing all of the candidate tree graphs to form a tree. A second constraint equation is defined for accommodating the communication paths in one of the candidate tree graphs. A third constraint equation is defined for determining whether each of the candidate tree graphs is used to accommodate the communication paths. A mathematical programming problem formed by the objective function, and the first, second and third constraint equations is solved to obtain a plurality of trees in which the communication paths can be accommodated.

摘要翻译： 根据本发明的第一方面，定义了用于最小化用于容纳通信路径的候选树图的数量的目标函数，并且定义了用于使所有候选树图形成树的第一约束方程。 定义第二约束方程用于在一个候选树图中容纳通信路径。 定义第三约束方程用于确定每个候选树图是否用于容纳通信路径。 解决了由目标函数形成的数学规划问题以及第一，第二和第三约束方程，以获得可以容纳通信路径的多个树。

公开(公告)号：US06900555B2

公开(公告)日：2005-05-31

申请号：US10118245

申请日：2002-04-09

申请人： Shinichi Sakamoto ,  Tatsuya Yoshida ,  Mitsuru Koni ,  Hiroyuki Saito ,  Kiyoshi Horibe

发明人： Shinichi Sakamoto ,  Tatsuya Yoshida ,  Mitsuru Koni ,  Hiroyuki Saito ,  Kiyoshi Horibe

IPC分类号： B60R16/02 ,  B60J1/17 ,  B60J5/00 ,  B60Q1/04 ,  B60Q1/26 ,  B60Q1/34 ,  B60Q1/44 ,  B60Q3/02 ,  B60R1/07 ,  B60R16/023 ,  B60R16/03 ,  B60R22/48 ,  B60S1/08 ,  B60S1/58 ,  E05B83/36 ,  H02J1/06 ,  H02J7/00 ,  H60L1/00

CPC分类号： H02J1/06 ,  B60R16/03 ,  B60R16/0315 ,  Y10T307/461 ,  Y10T307/477

摘要： An electrical power supply system for a vehicle is provided, which can eliminate proliferation of adverse effect on other control modules caused within one of a plurality of control modules. This is accomplished by provision of the power supply system comprising: battery 10 for supplying power; power line PL in a loop lay-out; a plurality of control modules BCM 100, VCM 110, FIM 120, DDM 130, RIM 140, CCM 150 and PDM 160 for a plurality of accessory systems, which are connected via said power line PL in loop lay-out, wherein a power control module (PCM) 20 for controlling the engine is connected to the power supply source via another power line 22 different from the power line PL.

摘要翻译： 提供了一种用于车辆的电力供应系统，其可以消除在多个控制模块之一内引起的对其它控制模块的不利影响的扩散。 这是通过提供电源系统来实现的，包括：用于供电的电池10; 电力线PL循环布置; 用于多个附属系统的多个控制模块BCM 100，VCM 110，FIM 120，DDM 130，RIM 140，CCM 150和PDM 160，其经由环路布局中的所述电力线PL连接，其中功率控制 用于控制发动机的模块（PCM）20经由与电力线PL不同的另一电力线22连接到电源。