公开(公告)号：US07932100B2

公开(公告)日：2011-04-26

申请号：US12162789

申请日：2007-03-30

申请人： Miki Ogawa ,  Masato Minami ,  Takeshi Imamura ,  Takashi Ikeda ,  Kazumichi Nakahama

发明人： Miki Ogawa ,  Masato Minami ,  Takeshi Imamura ,  Takashi Ikeda ,  Kazumichi Nakahama

IPC分类号： G01N33/553

CPC分类号： G01N33/54373 ,  Y10S436/807

摘要： The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential ψ1 of the magnetic label in the sample solution, the surface potential ψ2 of the detecting parts and the surface potential ψ3 of the non-detecting part satisfy any one of the following relationships i) to iv): i) ψ1ψ3>0 and ψ2=0, ii) ψ1ψ2 0, and |ψ2|>|ψ3|, and iv) ψ1ψ2

摘要翻译： 本发明提供了一种通过使样品溶液与包括检测部分和非检测部分的检测元件接触来检测样品溶液中目标物质的存在或浓度来检测目标物质的方法， 或存在于检测部件表面附近的磁性标签（磁性标记）的数量，并提供目标物质检测试剂盒。 样品溶液中的磁性标记的表面电位ψ1，检测部分的表面电位ψ2和非检测部分的表面电位ψ3满足以下关系式i）至iv）中的任何一个：i）ψ1ψ3> 0 ψ2= 0，ii）ψ1ψ2<0和ψ3= 0，iii）ψ1ψ2<0，ψ2ψ3> 0和ψ2|> |ψ3|，以及iv）ψ1ψ2<0和ψ2ψ3<0; 并且由磁性标签承载的目标物质由被检测部分承载的主要捕获体俘获，或者由被检测部分承载的主要捕获体捕获的目标物质被由磁性标签承载的二次捕获体俘获。

公开(公告)号：US20110019195A1

公开(公告)日：2011-01-27

申请号：US12895776

申请日：2010-09-30

申请人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

发明人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

IPC分类号： G01N21/59

CPC分类号： G01N21/05 ,  G01N21/554 ,  G01N21/645 ,  G01N21/66 ,  G01N2021/0346

摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.

摘要翻译： 一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置， 当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置 基于在照射光时来自多个物体的光输出的总和的属性的变化。

公开(公告)号：US08110250B2

公开(公告)日：2012-02-07

申请号：US13033198

申请日：2011-02-23

申请人： Tetsunori Ojima ,  Miki Ogawa

发明人： Tetsunori Ojima ,  Miki Ogawa

IPC分类号： B05D5/06

CPC分类号： G01N21/554 ,  Y10T436/10

摘要： A chemical sensor that utilizes localized surface Plasmon resonance including a substrate, metal-containing particles and dielectric particles, wherein the metal-containing particles and the dielectric particles are disposed on the substrate, is used as a chemical sensor element. Thereby, a chemical sensor element having a sufficient detecting sensitivity when localized surface Plasmon resonance is utilized, and a method for the fabrication thereof, can be provided.

摘要翻译： 作为化学传感器元件使用利用局部表面等离子体共振的化学传感器，包括基板，含金属颗粒和电介质颗粒，其中含金属颗粒和电介质颗粒设置在基板上。 因此，可以提供当使用局部表面等离子体共振时具有足够的检测灵敏度的化学传感器元件及其制造方法。

公开(公告)号：US08023109B2

公开(公告)日：2011-09-20

申请号：US12895776

申请日：2010-09-30

申请人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

发明人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

IPC分类号： G01N21/27 ,  G01N21/64

CPC分类号： G01N21/05 ,  G01N21/554 ,  G01N21/645 ,  G01N21/66 ,  G01N2021/0346

摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.

摘要翻译： 一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置， 当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置 基于在照射光时来自多个物体的光输出的总和的属性的变化。

公开(公告)号：US07920266B2

公开(公告)日：2011-04-05

申请号：US11941517

申请日：2007-11-16

申请人： Miki Ogawa ,  Takeshi Imamura

发明人： Miki Ogawa ,  Takeshi Imamura

IPC分类号： G01N21/00

CPC分类号： G01N21/554

摘要： There is provided a detection apparatus detecting target substance in a sample by utilizing plasmon resonance including a substrate and a plurality of metal-containing members arranged on the substrate, wherein the metal-containing members are shaped tubular and the metal-containing members are arranged on the substrate with a given orientation. By use hereof, a detection apparatus and a detection method enabling highly sensitive detection on target substance are provided.

摘要翻译： 提供一种检测装置，通过利用包括基板和布置在基板上的多个含金属构件的等离子体共振来检测样品中的目标物质，其中含金属的构件是成形管状的，并且含金属构件布置在 具有给定取向的基板。 通过使用本发明，提供了能够对目标物质进行高灵敏度检测的检测装置和检测方法。

公开(公告)号：US20100216253A1

公开(公告)日：2010-08-26

申请号：US10548442

申请日：2004-08-18

申请人： Hidenori Shiotsuka ,  Takeshi Imamura ,  Tsuyoshi Nomoto ,  Miki Ogawa

发明人： Hidenori Shiotsuka ,  Takeshi Imamura ,  Tsuyoshi Nomoto ,  Miki Ogawa

IPC分类号： G01N33/53 ,  C07K7/08 ,  C07H21/04 ,  C12N15/63 ,  G01N30/00

CPC分类号： C07K17/14 ,  C07K7/08 ,  C07K17/08 ,  C12N11/14 ,  G01N33/54353 ,  G01N33/552

摘要： The invention provides an organic material-immobilizing structure employing new immobilization means, characterized in that at least a part of the surface of the substrate is comprised of one or more members containing silicon oxide, the organic material is bound to the surface of the substrate through a binding domain bound to the organic material and containing an amino acid sequence capable of binding to silicon oxide, selected from the group consisting of amino acid sequences of SEQ ID NOS: 1 and 2: Val-Ser-Pro-Met-Arg-Ser-Ala-Thr-Thr-His-Thr-Val; and Ile-Pro-Met-His-Val-His-His-Lys-His-Pro-His-Val, and derivatives thereof.

摘要翻译： 本发明提供一种使用新的固定装置的有机材料固定结构，其特征在于，基底表面的至少一部分由含有氧化硅的一种或多种构件组成，有机材料通过 与有机材料结合并含有能够结合氧化硅的氨基酸序列的结合结构域，其选自SEQ ID NO：1和2的氨基酸序列：Val-Ser-Pro-Met-Arg-Ser -Ala-Thr-Thr-His-Thr-Val; 和Ile-Pro-Met-His-Val-His-His-Lys-His-Pro-His-Val及其衍生物。

公开(公告)号：US20090148346A1

公开(公告)日：2009-06-11

申请号：US12065720

申请日：2006-10-03

申请人： Kazuhiro Ban ,  Kazumichi Nakahama ,  Miki Ogawa

发明人： Kazuhiro Ban ,  Kazumichi Nakahama ,  Miki Ogawa

IPC分类号： G01N21/00 ,  C08L33/02

CPC分类号： B82Y30/00 ,  B82Y15/00 ,  G01N33/54393

摘要： A structural member having a binding functional group on a substrate for binding a capturing molecule capable of capturing a target substance, characterized in that the substrate binds to one end of a polymer which includes at the other end those to which the binding functional group is bound and those to which a suppressing functional group for suppressing adsorption of biological molecules to the structural member and that the suppressing functional group is also bound to a side chain of the polymer.

摘要翻译： 一种在底物上具有结合能捕获靶物​​质的捕获分子的结合官能团的结构部件，其特征在于，所述底物与聚合物的一端结合，所述聚合物的另一端包含结合官能团所结合的那些 以及抑制生物分子吸附到结构构件上的抑制官能团，抑制官能团也与聚合物的侧链结合的那些。

公开(公告)号：US20080297802A1

公开(公告)日：2008-12-04

申请号：US12125543

申请日：2008-05-22

申请人： Miki Ogawa ,  Norihiko Utsunomiya

发明人： Miki Ogawa ,  Norihiko Utsunomiya

IPC分类号： G01N21/55 ,  G01N1/00

CPC分类号： G01N21/554 ,  B01L3/5025 ,  B01L3/50857 ,  G01N2021/258

摘要： A detecting element and a detecting device having high sensitivity, and a production method thereof are provided. The detecting element for detecting a target substance in a sample includes a substrate and a metal structure. The substrate has a pore in which the thickness direction of the substrate corresponds to the depth direction of the pore and in which part of the substrate forming the pore constitutes part of the outer surface of the substrate. The metal structure exists in the pore, and has a ring shape.

摘要翻译： 提供了具有高灵敏度的检测元件和检测装置及其制造方法。 用于检测样品中的目标物质的检测元件包括基板和金属结构。 衬底具有孔，其中衬底的厚度方向对应于孔的深度方向，并且其中形成孔的衬底的一部分构成衬底的外表面的一部分。 金属结构存在于孔中，具有环状。

公开(公告)号：US20080117423A1

公开(公告)日：2008-05-22

申请号：US11941517

申请日：2007-11-16

申请人： Miki Ogawa ,  Takeshi Imamura

发明人： Miki Ogawa ,  Takeshi Imamura

IPC分类号： G01N21/55

CPC分类号： G01N21/554

摘要： There is provided a detection apparatus detecting target substance in a sample by utilizing plasmon resonance including a substrate and a plurality of metal-containing members arranged on the substrate, wherein the metal-containing members are shaped tubular and the metal-containing members are arranged on the substrate with a given orientation. By use hereof, a detection apparatus and a detection method enabling highly sensitive detection on target substance are provided.

摘要翻译： 提供一种检测装置，通过利用包括基板和布置在基板上的多个含金属构件的等离子体共振来检测样品中的目标物质，其中含金属的构件是成形管状的，并且含金属构件布置在 具有给定取向的基板。 通过使用本发明，提供了能够对目标物质进行高灵敏度检测的检测装置和检测方法。

公开(公告)号：US20070105087A1

公开(公告)日：2007-05-10

申请号：US11592313

申请日：2006-11-03

申请人： Kazuhiro Ban ,  Miki Ogawa ,  Norihiko Utsunomiya ,  Hiroyuki Hashimoto ,  Manabu Komatsu ,  Yohei Murayama

发明人： Kazuhiro Ban ,  Miki Ogawa ,  Norihiko Utsunomiya ,  Hiroyuki Hashimoto ,  Manabu Komatsu ,  Yohei Murayama

IPC分类号： C12Q1/00 ,  C12M3/00

CPC分类号： G01N33/6848 ,  G01N33/5082

摘要： A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of the proteins from the biological tissue, wherein the proteins or the degradation products obtained by the action of the enzyme are brought into contact with a member consisting of a metal.

摘要翻译： 一种用于将蛋白质固定在生物组织中的生物组织处理底物或蛋白质的降解产物，所述底物包括：与生物组织形成接触表面的多孔体，多孔体在孔中保留用于获得蛋白质的酶或 使来自生物组织的蛋白质的降解产物与由金属构成的构件接触，其中通过酶的作用获得的蛋白质或降解产物与金属接触。