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公开(公告)号：US11229909B2
公开(公告)日：2022-01-25
申请号：US17254469
申请日：2020-05-26
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
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公开(公告)号：US20200373340A1
公开(公告)日：2020-11-26
申请号：US15929760
申请日：2020-05-20
Applicant: Illumina, Inc.
Inventor： Arvin Emadi , Arnaud Rival , Ali Agah
IPC: H01L27/146 , H01L23/00
Abstract: Disclosed in one example is an apparatus including a substrate, a sensor over the substrate including an active surface and a sensor bond pad, a molding layer over the substrate and covering sides of the sensor, the molding layer having a molding height relative to a top surface of the substrate that is greater than a height of the active surface of the sensor relative to the top surface of the substrate, and a lidding layer over the molding layer and over the active surface. The lidding layer and the molding layer form a space over the active surface of the sensor that defines a flow channel.
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公开(公告)号：US12165939B2
公开(公告)日：2024-12-10
申请号：US18463354
申请日：2023-09-08
Applicant: Illumina, Inc.
Inventor： Arvin Emadi , Arnaud Rival , Ali Agah , Tara Bozorg-Grayeli
Abstract: Provided herein include various examples of an apparatus, a sensor system and examples of a method for manufacturing aspects of an apparatus, a sensor system. The apparatus may include a die. The apparatus may also include a substrate comprising a cavity. The die may be oriented in a portion of the cavity in the substrate, where the orientation defines a first space in the cavity adjacent to a first edge of the upper surface of the die and a second space in the cavity adjacent to the second edge of the upper surface of the die. The apparatus may further include fluidics fan-out regions comprising a first cured material deposited in the first space and the second space, a surface of the fluidics fan-out regions being contiguous with the upper surface of the die.
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公开(公告)号：US12062419B2
公开(公告)日：2024-08-13
申请号：US17683426
申请日：2022-03-01
Applicant: ILLUMINA, INC.
Inventor： Craig Ciesla , Ali Agah , Stanley Hong , Tarun Khurana , Aathavan Karunakaran , Arvin Emadi , Merek Siu
IPC: G16B50/30 , B01L3/00 , G11C13/02 , G16B30/10 , C12Q1/6874
CPC classification number: G16B50/30 , B01L3/5027 , G11C13/02 , G16B30/10 , C12Q1/6874
Abstract: A system writes input data to a storage device as machine-written polynucleotides; and reads machine written polynucleotides from the storage device as output data. The storage device includes a flow cell including a plurality of storage wells in which machine written polynucleotides may be stored. The storage device may include a set of electrodes corresponding to the storage wells that allow for selective interactions with wells across the surface of a flow cell. Operation of the storage device may include receiving a read request associated with a particular location in the storage device, creating a copy of a nucleotide sequence located at the particular location in the storage device, transferring the copy of the nucleotide sequence to a read location, and reading the copy of the nucleotide sequence at the read location.
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公开(公告)号：US20230420312A1
公开(公告)日：2023-12-28
申请号：US18463354
申请日：2023-09-08
Applicant: Illumina, Inc.
Inventor： Arvin Emadi , Arnaud Rival , Ali Agah , Tara Bozorg-Grayeli
CPC classification number: H01L23/053 , H01L23/3185 , H01L24/48 , H01L23/481 , H01L24/73 , H01L24/16 , B81B1/002 , H01L23/15 , G01N2021/6439
Abstract: Provided herein include various examples of an apparatus, a sensor system and examples of a method for manufacturing aspects of an apparatus, a sensor system. The apparatus may include a die. The apparatus may also include a substrate comprising a cavity. The die may be oriented in a portion of the cavity in the substrate, where the orientation defines a first space in the cavity adjacent to a first edge of the upper surface of the die and a second space in the cavity adjacent to the second edge of the upper surface of the die. The apparatus may further include fluidics fan-out regions comprising a first cured material deposited in the first space and the second space, a surface of the fluidics fan-out regions being contiguous with the upper surface of the die.
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Patent Agency Ranking
公开(公告)号：US11798854B2
公开(公告)日：2023-10-24
申请号：US17820659
申请日：2022-08-18
Applicant: Illumina, Inc.
Inventor： Arvin Emadi , Arnaud Rival , Ali Agah , Tara Bozorg-Grayeli
CPC classification number: H01L23/053 , B81B1/002 , H01L23/15 , H01L23/3185 , H01L23/481 , H01L24/16 , H01L24/48 , H01L24/73 , G01N21/6428 , G01N2021/6439 , H01L2224/16227 , H01L2224/2919 , H01L2224/48227 , H01L2224/73215
Abstract: Provided herein include various examples of an apparatus, a sensor system and examples of a method for manufacturing aspects of an apparatus, a sensor system. The apparatus may include a die. The apparatus may also include a substrate comprising a cavity. The die may be oriented in a portion of the cavity in the substrate, where the orientation defines a first space in the cavity adjacent to a first edge of the upper surface of the die and a second space in the cavity adjacent to the second edge of the upper surface of the die. The apparatus may further include fluidics fan-out regions comprising a first cured material deposited in the first space and the second space, a surface of the fluidics fan-out regions being contiguous with the upper surface of the die.
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公开(公告)号：US11476171B2
公开(公告)日：2022-10-18
申请号：US17179783
申请日：2021-02-19
Applicant: Illumina, Inc.
Inventor： Arvin Emadi , Arnaud Rival , Ali Agah , Tara Bozorg-Grayeli
Abstract: Provided herein include various examples of an apparatus, a sensor system and examples of a method for manufacturing aspects of an apparatus, a sensor system. The apparatus may include a die. The apparatus may also include a substrate comprising a cavity. The die may be oriented in a portion of the cavity in the substrate, where the orientation defines a first space in the cavity adjacent to a first edge of the upper surface of the die and a second space in the cavity adjacent to the second edge of the upper surface of the die. The apparatus may further include fluidics fan-out regions comprising a first cured material deposited in the first space and the second space, a surface of the fluidics fan-out regions being contiguous with the upper surface of the die.
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公开(公告)号：US20220254452A1
公开(公告)日：2022-08-11
申请号：US17683426
申请日：2022-03-01
Applicant: ILLUMINA, INC.
Inventor： Craig Ciesla , Ali Agah , Stanley Hong , Tarun Khurana , Aathavan Karunakaran , Arvin Emadi , Merek Siu
Abstract: A system writes input data to a storage device as machine-written polynucleotides; and reads machine written polynucleotides from the storage device as output data. The storage device includes a flow cell including a plurality of storage wells in which machine written polynucleotides may be stored. The storage device may include a set of electrodes corresponding to the storage wells that allow for selective interactions with wells across the surface of a flow cell. Operation of the storage device may include receiving a read request associated with a particular location in the storage device, creating a copy of a nucleotide sequence located at the particular location in the storage device, transferring the copy of the nucleotide sequence to a read location, and reading the copy of the nucleotide sequence at the read location.
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公开(公告)号：US20220097060A1
公开(公告)日：2022-03-31
申请号：US17550063
申请日：2021-12-14
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
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公开(公告)号：US20210272863A1
公开(公告)日：2021-09-02
申请号：US17179783
申请日：2021-02-19
Applicant: Illumina, Inc.
Inventor： Arvin Emadi , Arnaud Rival , Ali Agah , Tara Bozorg-Grayeli
Abstract: Provided herein include various examples of an apparatus, a sensor system and examples of a method for manufacturing aspects of an apparatus, a sensor system. The apparatus may include a die. The apparatus may also include a substrate comprising a cavity. The die may be oriented in a portion of the cavity in the substrate, where the orientation defines a first space in the cavity adjacent to a first edge of the upper surface of the die and a second space in the cavity adjacent to the second edge of the upper surface of the die. The apparatus may further include fluidics fan-out regions comprising a first cured material deposited in the first space and the second space, a surface of the fluidics fan-out regions being contiguous with the upper surface of the die.
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