公开(公告)号：US08088817B2

公开(公告)日：2012-01-03

申请号：US12737807

申请日：2009-08-25

申请人： Kenji Kawashima ,  Noriko Kawashima ,  Hiroshi Enomoto ,  Minoru Yamamoto ,  Masaaki Murai

发明人： Kenji Kawashima ,  Noriko Kawashima ,  Hiroshi Enomoto ,  Minoru Yamamoto ,  Masaaki Murai

IPC分类号： A61K31/4025 ,  A61K31/401 ,  C07D207/34 ,  C07D405/04 ,  C07D409/04

CPC分类号： C07D207/34 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

摘要： A compound represented by the following formula (1) or a salt thereof: The compound has an inhibitory activity on the production of interleukin-6, and is therefore useful as a therapeutic agent for a disease associated with interleukin-6, ocular inflammatory diseases and the like. In the formula, R1 represents a halogen atom, a hydrogen atom, a lower alkyl group which may have a substituent, a formyl group, or a lower alkylcarbonyl group which may have a substituent, R2 represents a bicyclic hydrocarbon group which may have a substituent or a bicyclic heterocyclic group which may have a substituent, R3 represents a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, or an acyl group.

摘要翻译： 由下式（1）表示的化合物或其盐：该化合物对白细胞介素-6的产生具有抑制活性，因此可用作与白介素-6，眼炎性疾病相关疾病的治疗剂， 类似。 式中，R 1表示卤素原子，氢原子，可具有取代基的低级烷基，甲酰基或可具有取代基的低级烷基羰基，R 2表示可具有取代基的二环烃基， 或可以具有取代基的二环杂环基，R 3表示氢原子，可以具有取代基的低级烷基，可以具有取代基的芳基或酰基。

公开(公告)号：US07906511B2

公开(公告)日：2011-03-15

申请号：US11887308

申请日：2006-03-31

申请人： Hisashi Tajima ,  Takahiro Honda ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

发明人： Hisashi Tajima ,  Takahiro Honda ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

IPC分类号： C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K31/5377

CPC分类号： C07D401/14 ,  C07D239/42 ,  C07D401/12 ,  C07D409/12

摘要： The present invention has its object to study synthesis of novel cyclic compounds having a pyrimidinylalkylthio group and to find pharmacological actions of the compounds. According to the present invention, a compound represented by the formula (1) or a salt thereof is provided. In the formula, the ring X represents: R1 and R2 independently represent a hydrogen atom, an alkyl group, an aryl group, an aromatic heterocyclic group or the like; R3 represents a hydrogen atom, a halogen atom, a hydroxy group, an alkoxy group, an aryloxy group, an alkyl group, an aryl group, an amino group, an alkylamino group or the like; A1 represents a sulfur atom or the like; and A2 represents an alkylene group.

摘要翻译： 本发明的目的是研究具有嘧啶基烷硫基的新型环状化合物的合成，并找到化合物的药理作用。 根据本发明，提供由式（1）表示的化合物或其盐。 在该式中，环X表示：R 1和R 2分别表示氢原子，烷基，芳基，芳香族杂环基等， R 3表示氢原子，卤素原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基等; A1表示硫原子等; A2表示亚烷基。

公开(公告)号：US07726646B2

公开(公告)日：2010-06-01

申请号：US10509382

申请日：2003-03-17

申请人： Koji Sugiyama ,  Hiroshi Taira ,  Minoru Yamamoto ,  Keiji Seo ,  Takashi Okumura ,  Katsuhiko Shimada ,  Mutsuo Naoe

发明人： Koji Sugiyama ,  Hiroshi Taira ,  Minoru Yamamoto ,  Keiji Seo ,  Takashi Okumura ,  Katsuhiko Shimada ,  Mutsuo Naoe

IPC分类号： B65H1/00

CPC分类号： B41J29/023 ,  B41J13/0081 ,  B65H1/04 ,  B65H1/266 ,  B65H2405/311

摘要： A sheet in accordance with the present invention includes sheets as print mediums for a printer and a package member surrounding the sheets which have been stacked up. The sheet package is configured so that the sheets can be set in the printer together with the package member exposing part of the sheets. The package member is integrally provided with a flap part which can expose part of the sheets by being opened when the sheet package is set in the printer and cover the exposed part of the sheets by being closed when the sheet package is not used.

摘要翻译： 根据本发明的片材包括作为打印机的打印介质的纸张和围绕已堆叠的纸张的包装件。 片材包装被配置为使得片材可以与暴露片材的一部分的包装构件一起设置在打印机中。 包装件一体地设置有翼片部件，当片材包装被设置在打印机中时可以使打印部分的片材暴露，并且当不使用片材包装时通过关闭来遮盖片材的暴露部分。

公开(公告)号：US07534802B2

公开(公告)日：2009-05-19

申请号：US10548283

申请日：2004-03-05

申请人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimasa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto ,  Masakazu Ban

发明人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimasa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto ,  Masakazu Ban

IPC分类号： C07D401/14 ,  A61K31/444

CPC分类号： C07D401/12 ,  C07D213/32 ,  C07D401/14

摘要： A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a pharmaceutical. Compound represented by the following general formula [I] or salts thereof are useful as therapeutic agents for diseases in which angiogenesis or augmentation of vascular permeability is involved. In the formula, ring “A” is a benzene ring or an aromatic five- or six-memberd heterocycle which can be fused with a cycloalkane ring, “B” is alkylene, R1 and R2, the same or different, are H, OH, substituted or unsubstituted alkoxy and the like, X and Y, the same or different, are group(s) selected from H, halogen, OH, substituted or unsubstituted alkoxy and the like respectively, p is 0, 1 or 2, and q is 0 or 1.

摘要翻译： 本发明的目的是提供一种新颖的具有4-吡啶基烷硫基作为取代基的五元或六元杂环衍生物或其盐，其可用作药物。 由以下通式[I]表示的化合物或其盐可用作涉及血管生成或增加血管通透性的疾病的治疗剂。 在该式中，环“A”是可以与环烷烃环稠合的苯环或芳族五元或六元杂环，“B”是亚烷基，R 1和R 2相同或不同，是H，OH 取代或未取代的烷氧基等，X和Y相同或不同，分别为选自H，卤素，OH，取代或未取代的烷氧基等的基团，p为0,1或2，q为0,1或2，q为 是0或1。

公开(公告)号：US07415163B2

公开(公告)日：2008-08-19

申请号：US10996229

申请日：2004-11-23

申请人： Noriyuki Nishi ,  Hisakazu Kuramoto ,  Takuma Suzuki ,  Minoru Yamamoto

发明人： Noriyuki Nishi ,  Hisakazu Kuramoto ,  Takuma Suzuki ,  Minoru Yamamoto

IPC分类号： G06K9/40 ,  H04N1/32 ,  H04N1/00 ,  H04N1/41 ,  H04N1/413

CPC分类号： H04N19/117 ,  H04N19/176 ,  H04N19/186 ,  H04N19/527 ,  H04N19/60

摘要： An image noise reducing method that can properly reduce both block noise and mosquito noise without deterioration of the image quality is provided. The method includes creating a first luminance component image data with the boundaries of the blocks thereof smoothened, creating a second luminance component image data with its entirety smoothened from the first luminance component image data, creating edge image data by subtracting the second luminance component image data from the first luminance component image data, creating corrected edge image data by applying correction to the edge image data under given conditions, and creating third luminance component image data by adding the corrected edge image data to the second luminance component image data. For color-difference component image data, first color-difference component image data with its entirety smoothened is created from the color-difference component image data. The third luminance component image data and the first color-difference component image data are finally outputted.

摘要翻译： 提供了可以适当地降低块噪声和蚊式噪声而不降低图像质量的图像噪声降低方法。 该方法包括：创建其平滑块的边界的第一亮度分量图像数据，创建从第一亮度分量图像数据整体整合的第二亮度分量图像数据，通过减去第二亮度分量图像数据来产生边缘图像数据 从第一亮度分量图像数据，通过在给定条件下对边缘图像数据应用校正来创建校正的边缘图像数据，并且通过将校正的边缘图像数据与第二亮度分量图像数据相加来创建第三亮度分量图像数据。 对于色差分量图像数据，从色差分量图像数据创建整体平滑化的第一色差分量图像数据。 最后输出第三亮度分量图像数据和第一色差分量图像数据。

公开(公告)号：US07409103B2

公开(公告)日：2008-08-05

申请号：US10996243

申请日：2004-11-23

申请人： Noriyuki Nishi ,  Hisakazu Kuramoto ,  Takuma Suzuki ,  Minoru Yamamoto

发明人： Noriyuki Nishi ,  Hisakazu Kuramoto ,  Takuma Suzuki ,  Minoru Yamamoto

IPC分类号： G06K9/40 ,  G06K9/00 ,  H04N5/217 ,  H04B1/66

CPC分类号： H04N9/646 ,  G06T5/002 ,  G06T2207/10024 ,  G06T2207/20192 ,  H04N9/045 ,  H04N19/117 ,  H04N19/186 ,  H04N19/527

摘要： An image noise reducing method that can properly reduce CCD noise which emerges in an image imported from a digital camera is provided. The method includes applying a first filtering step to luminance component image data of the image with each pixel of the luminance component image data being designated as a target pixel, thereby creating luminance component image data with its entirety smoothened, and applying a second filtering step to color-difference component image data of the image with each pixel of the color-difference component image data being designated as a target pixel, thereby creating color-difference component image data with its entirety smoothened.

摘要翻译： 提供了可以适当地减少从数字照相机导入的图像中出现的CCD噪声的图像噪声降低方法。 该方法包括：将亮度分量图像数据的每个像素指定为目标像素，对图像的亮度分量图像数据应用第一滤波步骤，从而创建整体平滑的亮度分量图像数据，并将第二滤波步骤应用于 将色差分量图像数据的每个像素指定为目标像素的图像的色差分量图像数据，从而产生整体平滑的色差分量图像数据。

公开(公告)号：USD562887S1

公开(公告)日：2008-02-26

申请号：US29167846

申请日：2002-09-23

申请人： Keiji Seo ,  Motoaki Yamanashi ,  Minoru Yamamoto

设计人： Keiji Seo ,  Motoaki Yamanashi ,  Minoru Yamamoto

公开(公告)号：US07257877B2

公开(公告)日：2007-08-21

申请号：US10876912

申请日：2004-06-25

申请人： Masashi Hanaoka ,  Kenichi Hayashi ,  Minoru Yamamoto

发明人： Masashi Hanaoka ,  Kenichi Hayashi ,  Minoru Yamamoto

IPC分类号： B23P13/04 ,  G02B6/34

CPC分类号： G02B1/11 ,  G02B5/1852 ,  Y10T29/49995

摘要： A grating forming method for forming a fine grating with a grating period of at most 1 μm on a surface of a blank material including (1) feeding realatively a diamond cutting tool and the blank material in a groove extended direction while rotating the diamond cutting tool about the axial line and (2) cutting the surface of the blank material with a blade tip part of the diamond cutting tool to form the grooves while rotating and feeding the diamond cutting tool. When the fine grating with the grating period of “P” μm is formed and the feed amount per revolution of the diamond cutting tool is set to be “S” μm, the feed amount per revolution “S”, with which the diamond cutting tool is fed in the groove extended direction while rotating the diamond cutting tool about the axial line, is set to satisfy the following conditional expression: S

摘要翻译： 一种光栅形成方法，用于在坯料的表面上形成光栅周期至多为1um的精细光栅，包括（1）在使金刚石切割工具旋转的同时实际上进给金刚石切削工具和坯料，沿着槽延伸方向 围绕轴线和（2）用金刚石切割工具的刀片尖部切割坯料的表面，以在旋转和馈送金刚石切割工具的同时形成凹槽。 当形成光栅周期为“P”mum的精细光栅时，金刚石切削刀具的每转进给量设定为“S”mum，每转“S”的进给量，金刚石刀具 在金刚石切削工具绕轴线旋转的同时沿槽延伸方向进给，设定为满足以下条件表达式：S <2.9P 3。 这种条件是将表达式应用于坯料，成型模具，模制产品和用于制造成型模具的主构件。

公开(公告)号：US07117255B1

公开(公告)日：2006-10-03

申请号：US09714234

申请日：2000-11-17

申请人： Minoru Yamamoto ,  Takashi Kaneda ,  Yuji Iwasaki ,  Hiroki Ueda

发明人： Minoru Yamamoto ,  Takashi Kaneda ,  Yuji Iwasaki ,  Hiroki Ueda

IPC分类号： G06F15/16

CPC分类号： H04L67/02 ,  H04L67/142

摘要： A server capable of eliminating the inconvenience which is caused when a request is made after a “back” operation on a client's browser. A request from a client is received, and processed in compliance with the received request. Confirmation information for confirming a display status of the client side is affixed to a result of process, stored, and transmitted. When a request is made again from the client, the confirmation information included in the request is extracted, and it is determined whether the extracted confirmation information extracted coincides with the stored confirmation information. A process performed in compliance with the request is withheld if it is determined that the two sets of confirmation information do not coincide.

摘要翻译： 一种服务器，能够消除在客户端的浏览器进行“后退”操作之后进行请求时引起的不便。 接收到来自客户端的请求，并根据接收到的请求进行处理。 用于确认客户端的显示状态的确认信息被附加到处理，存储和发送的结果。 当从客户端再次请求时，提取包括在请求中的确认信息，并且确定所提取的提取的确认信息是否与存储的确认信息一致。 如果确定两组确认信息不一致，则拒绝按照该请求执行的过程。

公开(公告)号：US20060108960A1

公开(公告)日：2006-05-25

申请号：US10521549

申请日：2003-04-21

申请人： Michiharu Tanaka ,  Hirokazu Kariyazaki ,  Minoru Yamamoto

发明人： Michiharu Tanaka ,  Hirokazu Kariyazaki ,  Minoru Yamamoto

IPC分类号： B25J15/02

CPC分类号： B25J9/1676 ,  B25J9/1674 ,  B25J19/06 ,  B25J21/00 ,  G05B19/4061 ,  G05B19/416 ,  G05B2219/49138 ,  G05B2219/49152 ,  G05B2219/49158

摘要： A robot control apparatus with great safety is provided by detecting access of a teacher to a robot and automatically reducing the operating speed of the robot when the teacher accesses the robot. The robot control device equipped with a pendant (10) to be manipulated by a teacher, for controlling the operation of a robot on the basis of an operation command from the pendant (10), includes a detecting device (8) for detecting the position of the teacher; a signal processing unit (11) for receiving a signal from the detecting device to produce the position information of the teacher; and a limited speed selecting unit (12) for selecting the operating speed of the robot on the basis of the position information. The robot is controlled at the maximum speed set at the operating speed selected by the limited speed selecting unit (12) on the basis of the operation command from the pendant (10).

摘要翻译： 通过检测教师对机器人的访问并且当教师访问机器人时自动降低机器人的操作速度来提供具有极大安全性的机器人控制装置。 根据来自吊坠（10）的操作命令，配备有由教师操纵的用于控制机器人的操作的吊坠（10）的机器人控制装置包括：检测装置（8），用于检测位置 的老师 信号处理单元（11），用于从所述检测装置接收信号以产生所述教师的位置信息; 以及用于基于位置信息来选择机器人的操作速度的限速选择单元（12）。 基于来自吊坠（10）的操作命令，以由受限速度选择单元（12）选择的操作速度设定的最大速度控制机器人。