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公开(公告)号：US20090069215A1
公开(公告)日：2009-03-12
申请号：US12282787
申请日：2007-03-12
摘要： The invention is related to an acylated, single-chain insulin comprising the B- and the A-chain of human insulin or an analogue thereof connected by a connecting peptide, wherein a lysine residue being substituted for the natural amino acid residue in at least one of the positions B20, B21 or B22 in the human insulin B-chain is chemically modified by acylation.
摘要翻译： 本发明涉及包含通过连接肽连接的人胰岛素的B链和A链的酰化单链胰岛素，其中赖氨酸残基被至少一个取代了天然氨基酸残基 的人胰岛素B链中的位置B20，B21或B22通过酰化进行化学修饰。
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公开(公告)号：US20060258561A1
公开(公告)日：2006-11-16
申请号：US11226870
申请日：2005-09-09
申请人： Per Balschmidt , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
发明人： Per Balschmidt , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
IPC分类号： A61K38/28 , A61K31/522 , A61K31/513 , A61K31/426 , A61K31/4196 , A61K31/4184 , A61K31/4166 , A61K33/32
CPC分类号： A61K31/4166 , A61K31/4184 , A61K31/4196 , A61K31/426 , A61K31/513 , A61K31/522 , A61K33/30 , A61K38/28 , A61K45/06
摘要： This invention relates to NPH-insulin (crystalline preparations) that are prepared in the presence of certain high-affinity ligands for the HisB10 Zn2+-sites of the R-state insulin hexamer. Preparation of NPH-insulin in the presence of high-affinity ligand results in crystalline NPH-insulin suspensions that are absorbed more slowly from subcutis than regular NPH-insulin. Hence the resulting action profile is longer and the spike is less pronounced than observed with regular NPH-insulin
摘要翻译： 本发明涉及在R状态胰岛素六聚体的HisB10 Zn 2+ 2+的某些高亲和力配体存在下制备的NPH-胰岛素（结晶制剂）。 在高亲和力配体的存在下制备NPH-胰岛素导致结晶NPH-胰岛素悬浮液比皮下组织比常规NPH-胰岛素更慢吸收。 因此，所得到的作用谱更长，并且峰值不如用常规NPH-胰岛素观察到的
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公开(公告)号：US20050059611A1
公开(公告)日：2005-03-17
申请号：US10963289
申请日：2004-10-12
申请人： Anker Jorgensen , Peter Madsen
发明人： Anker Jorgensen , Peter Madsen
IPC分类号： C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/42 , C07C311/47 , C07C317/42 , C07C323/44 , C07D209/48 , C07D257/04 , C07D271/06 , C07D319/08 , C07D319/20 , C07D333/36 , A61K38/04 , A61K31/16 , A61K31/195
CPC分类号： C07D209/48 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/42 , C07C311/47 , C07C317/42 , C07C323/44 , C07C2601/14 , C07C2601/16 , C07D257/04 , C07D271/06 , C07D319/08 , C07D319/20 , C07D333/36
摘要： A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein a glucagon antagonistic action is beneficial, such as hyperglycemia, Type 1 diabetes, Type 2 diabetes, disorders of the lipid metabolism and obesity.
摘要翻译： 一类新颖的化合物，其作用是拮抗胰高血糖素激素对胰高血糖素受体的作用。 由于它们对胰高血糖素受体的拮抗作用，这些化合物可能适用于治疗和/或预防任何疾病和病症，其中胰高血糖素拮抗作用是有益的，例如高血糖症，1型糖尿病，2型糖尿病， 脂质代谢和肥胖。
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公开(公告)号：US5962449A
公开(公告)日：1999-10-05
申请号：US623447
申请日：1996-03-28
申请人： Peter Madsen , Knud Erik Andersen , Rolf Hohlweg , Florenzio Zaragossa Dorwald , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen
发明人： Peter Madsen , Knud Erik Andersen , Rolf Hohlweg , Florenzio Zaragossa Dorwald , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen
IPC分类号： A61K31/195 , A61K31/55 , A61P25/04 , A61P29/00 , C07C227/16 , C07C229/56 , C07D223/28 , C07D401/12 , A01N43/46 , C07D221/06 , C07D265/34 , C07D487/00
CPC分类号： C07D223/28 , C07C229/56 , C07D401/12 , C07C2103/32
摘要： The present invention relates to novel N-substituted amino acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新的N-取代氨基酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床治疗 其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用的疼痛，痛觉过敏和/或炎性病症。
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公开(公告)号：US5916889A
公开(公告)日：1999-06-29
申请号：US943726
申请日：1997-10-03
申请人： Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
发明人： Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
IPC分类号： C07D295/06 , A61K31/4427 , A61K31/4436 , A61K31/444 , A61K31/495 , A61K31/496 , A61K31/55 , A61P3/08 , A61P17/04 , A61P25/06 , A61P29/00 , C07D213/74 , C07D213/79 , C07D213/80 , C07D295/073 , C07D295/12 , C07D295/14 , C07D295/155 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D405/06
CPC分类号： C07D213/74 , C07D213/79 , C07D295/073 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07C2103/78
摘要： The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译： 本发明涉及以下通式的1,4-二取代哌嗪其中X，Y，Z，R 1，R 2和r如在本说明书的详细部分或其盐中所定义，其制备方法，组合物 并且用于临床治疗疼痛，痛觉过敏和/或炎性疾病，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及它们用于治疗由...引起的或与之相关的适应症 胰岛素拮抗肽的分泌和循环，例如 非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。
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公开(公告)号：US5912262A
公开(公告)日：1999-06-15
申请号：US957163
申请日：1997-10-24
申请人： Rolf Hohlweg , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Uffe Bang Olsen , Peter Madsen , Zdenek Polivka , Otylie Konigova , Frantisek Miksik , Martina Kovandova , Alexandra Silhankova , Karel Sindelar
发明人： Rolf Hohlweg , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Uffe Bang Olsen , Peter Madsen , Zdenek Polivka , Otylie Konigova , Frantisek Miksik , Martina Kovandova , Alexandra Silhankova , Karel Sindelar
IPC分类号： C07D321/12 , A61K31/335 , A61K31/357 , A61K31/4406 , A61K31/55 , A61P3/08 , A61P25/00 , A61P29/00 , C07D273/00 , C07D273/01 , C07D405/06 , C07D405/12 , C07D413/06 , A61K31/40
CPC分类号： C07D405/06 , C07D405/12 , C07D413/06
摘要： The present invention relates to novel N-substituted amino alcohols, amino acids and acid derivatives thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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公开(公告)号：US5827856A
公开(公告)日：1998-10-27
申请号：US627750
申请日：1996-04-02
申请人： Knud Erik Andersen , Rolf Hohlweg , Tine Krogh J.o slashed.rgensen , Peter Madsen , Henrik Sune Andersen , Uffe Bang Olsen , Polivka Zdenek , Silhankova Alexandra , Sidelar Karel
发明人： Knud Erik Andersen , Rolf Hohlweg , Tine Krogh J.o slashed.rgensen , Peter Madsen , Henrik Sune Andersen , Uffe Bang Olsen , Polivka Zdenek , Silhankova Alexandra , Sidelar Karel
IPC分类号： A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/453 , A61K31/4535 , A61K31/473 , A61P3/08 , A61P25/04 , A61P25/06 , A61P29/00 , C07D211/60 , C07D211/78 , C07D405/12 , C07D409/12 , A01N43/42
CPC分类号： C07D211/60 , A61K31/445 , A61K31/453 , A61K31/4535 , A61K31/473
摘要： The present invention provides a novel method for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明提供了一种用于临床治疗疼痛，痛觉过敏和/或炎性病症的新方法，其中C纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用。
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公开(公告)号：US5753643A
公开(公告)日：1998-05-19
申请号：US862169
申请日：1997-05-22
申请人： Henrik Sune Andersen , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen
发明人： Henrik Sune Andersen , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen
IPC分类号： A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/55 , A61P3/08 , A61P3/10 , A61P25/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D211/60 , C07D401/06 , C07D409/06 , C07D417/06 , C07D207/12
CPC分类号： C07D401/06 , C07D211/60 , C07D409/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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公开(公告)号：US09242011B2
公开(公告)日：2016-01-26
申请号：US12935438
申请日：2009-03-31
CPC分类号： A61K47/48284 , A61K47/643 , C07K14/62
摘要： Insulin albumin conjugates consisting of an insulin analogue, a bifunctional linker and albumin can efficiently be used to treat diabetic patients.
摘要翻译： 由胰岛素类似物，双功能接头和白蛋白组成的胰岛素白蛋白结合物可有效地用于治疗糖尿病患者。
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公开(公告)号：US08853155B2
公开(公告)日：2014-10-07
申请号：US13805774
申请日：2011-06-21
CPC分类号： C07K14/62
摘要： The present invention is related to insulin derivatives containing additional disulfide bonds and methods of making such.
摘要翻译： 本发明涉及含有二硫键的胰岛素衍生物及其制备方法。
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