利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

68 条记录 (耗时 0.05 秒)

    Method for screening compounds for the treatment of neoplasia
    31.
    发明授权
    Method for screening compounds for the treatment of neoplasia 失效
    筛选化合物治疗瘤形成的方法

    公开(公告)号：US06569638B1

    公开(公告)日：2003-05-27

    申请号：US09517734

    申请日：2000-03-03

    申请人： I. Bernard Weinstein ,  W. Joseph Thompson ,  Jae-Won Soh ,  Li Liu ,  Han Li

    发明人： I. Bernard Weinstein ,  W. Joseph Thompson ,  Jae-Won Soh ,  Li Liu ,  Han Li

    IPC分类号： C12Q148

    CPC分类号： G01N33/5011

    摘要： This invention provides a method to identify compounds potentially useful for the treatment and prevention of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with its ability to elevate JNK kinase activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibition, an ability to elevate JNK kinase activity, growth inhibition and apoptosis induction are desirable for the treatment of neoplasia.

    摘要翻译： 本发明提供了一种鉴定潜在可用于治疗和预防哺乳动物瘤形成的化合物的方法。 测定化合物的磷酸二酯酶抑制活性及其提高JNK激酶活性的能力。 还测定了对培养的肿瘤细胞的生长抑制和凋亡诱导作用。 表现出磷酸二酯酶抑制，提高JNK激酶活性的能力，生长抑制和细胞凋亡诱导的化合物对于治疗瘤形成是理想的。

    TABLE ATTRIBUTE MANAGEMENT FOR REPLICATED DATA TABLES
    35.
    发明申请
    TABLE ATTRIBUTE MANAGEMENT FOR REPLICATED DATA TABLES 有权
    表格替代数据表的属性管理

    公开(公告)号：US20150088823A1

    公开(公告)日：2015-03-26

    申请号：US14078123

    申请日：2013-11-12

    申请人： Yingyu Chen ,  Han Li ,  Yihan Song

    发明人： Yingyu Chen ,  Han Li ,  Yihan Song

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30578

    摘要： A table selector may receive a selection of a replicated table storing data replicated from an original table of a first system, the replicated table being stored using a second system and currently executing a process of receiving the replicated data. A suspension manager may suspend the process of receiving the replicated data, and a table attribute manager may change a replicated table attribute of the replicated table, while the process of receiving the replicated data is suspended. The suspension manager may then resume the process of receiving the replicated data.

    摘要翻译： 表选择器可以接收存储从第一系统的原始表复制的数据的复制表的选择，所述复制表使用第二系统存储并且当前正在执行接收复制数据的过程。 暂停管理员可以暂停接收复制数据的过程，并且表属性管理器可以在暂停接收复制数据的过程时更改复制表的复制表属性。 然后，暂停管理器可以恢复接收复制数据的处理。

    POWER MODULE AND CIRCUIT BOARD ASSEMBLY THEREOF
    37.
    发明申请
    POWER MODULE AND CIRCUIT BOARD ASSEMBLY THEREOF 有权
    电源模块和电路板组件

    公开(公告)号：US20110032683A1

    公开(公告)日：2011-02-10

    申请号：US12851237

    申请日：2010-08-05

    申请人： Han Li ,  Gang Liu ,  Jing Chen ,  Jinfa Zhang

    发明人： Han Li ,  Gang Liu ,  Jing Chen ,  Jinfa Zhang

    IPC分类号： H05K7/02

    CPC分类号： H05K7/1432 ,  H01F27/292 ,  H01F2027/408 ,  H02M3/33592 ,  Y02B70/1475

    摘要： A power module includes a first bobbin, a primary winding coil, a circuit board assembly and a first magnetic core assembly. The primary winding coil is wound around the first bobbin. The circuit board assembly includes a printed circuit board, a second winding structure, at least one current-sensing element, a rectifier circuit and an electrical connector. The second winding structure has an output terminal. The current-sensing element includes a first conductor. The first conductor is a conductive sheet. A first end of the first conductor is in contact with the output terminal of the second winding structure. A second end of the first conductor is connected to the rectifier circuit. The primary winding coil is aligned with the second winding structure of the circuit board assembly and arranged within the first magnetic core assembly. The primary winding coil and the electrical connector are electrically connected with a system board.

    摘要翻译： 功率模块包括第一线圈架，初级绕组线圈，电路板组件和第一磁芯组件。 初级绕组线圈缠绕在第一线轴上。 电路板组件包括印刷电路板，第二绕组结构，至少一个电流感测元件，整流器电路和电连接器。 第二绕组结构具有输出端子。 电流检测元件包括第一导体。 第一导体是导电片。 第一导体的第一端与第二绕组结构的输出端接触。 第一导体的第二端连接到整流电路。 初级绕组线圈与电路板组件的第二绕组结构对准并且布置在第一磁芯组件内。 初级绕组线圈和电连接器与系统板电连接。

    Method and apparatus for transcoding coded video image data
    39.
    发明授权
    Method and apparatus for transcoding coded video image data 失效
    用于对编码的视频图像数据进行代码转换的方法和装置

    公开(公告)号：US06912253B1

    公开(公告)日：2005-06-28

    申请号：US09657434

    申请日：2000-09-07

    申请人： Han Li ,  Toshio Miki ,  Yasuhiro Ogiri

    发明人： Han Li ,  Toshio Miki ,  Yasuhiro Ogiri

    IPC分类号： G06T9/00 ,  H04N7/26 ,  H04B1/66 ,  H04N7/12 ,  H04N7/36

    CPC分类号： H04N19/40 ,  H04N19/48 ,  H04N19/51 ,  H04N19/587

    摘要： A transcoding apparatus converts first coded data obtained from a plurality of frames forming a video image by means of a coding algorithms including an interframe prediction coding algorithm with motion compensation into second coded data having a different structure. More specifically, the transcoding apparatus takes a portion of frames which have had the interframe prediction coding and are included in the plurality of frames forming the video image as processing object frames, and from at least the first coded data corresponding to the processing object frames, generates the second coded data corresponding to coded data which are to be obtained when performing the interframe prediction coding on the processing object frames with reference to second reference frames which are different from first reference frames referenced in the interframe prediction coding of the processing object frames. In order to the second coded data, the transcoding apparatus has a motion information calculating portion for calculating motion information to be included in the second coded data using at least motion information contained in said processing object data.

    摘要翻译： 代码转换装置通过包括具有运动补偿的帧间预测编码算法的编码算法将形成视频图像的多个帧获得的第一编码数据转换为具有不同结构的第二编码数据。 更具体地，代码转换装置取得具有帧间预测编码的帧的一部分，并且将构成视频图像的多个帧包括在作为处理对象帧的帧中，并且从至少对应于处理对象帧的第一编码数据， 产生对应于在对处理对象帧执行帧间预测编码时要获得的编码数据的第二编码数据，该第二编码数据参照与处理对象帧的帧间预测编码中参考的第一参考帧不同的第二参考帧。 为了第二编码数据，代码转换装置具有运动信息计算部分，用于使用至少包含在所述处理对象数据中的运动信息来计算要包括在第二编码数据中的运动信息。

    Method of gene delivery using wildtype adeno associated viral (AAV) vectors with insertions
    40.
    发明授权
    Method of gene delivery using wildtype adeno associated viral (AAV) vectors with insertions 失效
    使用具有插入的野生型腺相关病毒（AAV）载体的基因递送方法

    公开(公告)号：US6153436A

    公开(公告)日：2000-11-28

    申请号：US4877

    申请日：1998-01-09

    申请人： Paul L. Hermonat ,  J. Gerald Quirk ,  Brian Bishop ,  Han Li

    发明人： Paul L. Hermonat ,  J. Gerald Quirk ,  Brian Bishop ,  Han Li

    IPC分类号： A61K48/00 ,  C12N15/864 ,  C12N15/86

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2750/14143

    摘要： The present invention provides a method of human gene therapy using AAV vectors with essentially wildtype phenotype. Genes of 900 bases or less can be inserted into wildtype AAV and still allow the resulting vector to have a largely wildtype phenotype. For example, several antisense genes could be inserted and still allow packaging. Such wildtype vectors have several advantages. First, high titers of such vectors is easy to accomplish. Second, the vectors, since they include the Rep78 gene, integrate specifically into human chromosome 19. Third, such vectors, being wildtype, spread after their initial introduction. Another method for use of large wildtype AAV genomes is as complementors for fully defective AAV vectors. Such complementors can be delivered by virus infection and, be introduced easily into 100% of the cells used to produce virus. Viral infection is superior to synthetic techniques for introducing DNA into tissue culture producer cells. When large essentially wildtype AAV complementor virus are used in conjunction with AAV vector virus allowing for the introduction of both vectors into all cells, high titers of recombinant AAV virus is achieved.

    摘要翻译： 本发明提供使用基本上野生型表型的AAV载体的人基因治疗方法。 将900个碱基以下的基因插入到野生型AAV中，并且仍然允许所得载体具有很大的野生型表型。 例如，可以插入几个反义基因并仍然允许包装。 这种野生型载体具有几个优点。 首先，这种载体的高滴度很容易完成。 第二，载体，因为它们包括Rep78基因，特异性整合入人染色体19。第三，这种载体，野生型，在其初次引入后扩散。 使用大型野生型AAV基因组的另一种方法是完全缺陷的AAV载体的补体。 这样的补体可以通过病毒感染递送，并且容易地引入用于产生病毒的100％的细胞中。 病毒感染优于将DNA引入组织培养生产细胞的合成技术。 当大的基本野生型AAV补体病毒与AAV载体病毒结合使用时，允许将两种载体引入所有细胞，实现了高效价的重组AAV病毒。