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    BRAIN CONDITION MONITORING BASED ON CO-ACTIVATION OF NEURAL NETWORKS
    31.
    发明申请
    BRAIN CONDITION MONITORING BASED ON CO-ACTIVATION OF NEURAL NETWORKS 有权
    基于神经网络共同启动的脑条件监测

    公开(公告)号：US20120271148A1

    公开(公告)日：2012-10-25

    申请号：US13446598

    申请日：2012-04-13

    申请人： Dwight E. Nelson

    发明人： Dwight E. Nelson

    IPC分类号： A61B5/0476 ,  A61B6/00 ,  A61B5/055

    CPC分类号： A61B5/4064 ,  A61B5/04008 ,  A61B5/0476 ,  A61B5/055 ,  A61B5/4088 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/36171

    摘要： A brain condition can be tracked based on identification of co-activation of two antagonistic networks of a patient's brain. Various embodiments concerns methods and devices for sensing one or more signals indicative of brain activity, detecting one or more episodes of default mode network activation based on the one or more signals, detecting one or more episodes of salience network activation based on the one or more signals, and identifying one or more episodes of temporal co-activation of the default mode network and the salience network based on the detected one or more episodes of default mode network activation and the one or more episodes of salience network activation. The brain condition can be tracked and treated based on the identification of the one or more episodes of co-activation.

    摘要翻译： 可以基于识别患者大脑的两个拮抗网络的共同激活来跟踪脑部状况。 各种实施例涉及用于感测指示大脑活动的一个或多个信号的方法和装置，基于所述一个或多个信号检测一个或多个默认模式网络激活事件，基于所述一个或多个信号检测一个或多个显着性网络激活事件 信号，以及基于检测到的一个或多个默认模式网络激活和一个或多个突发性网络激活事件来识别默认模式网络和显着网络的一个或多个时间共同激活事件。 可以基于识别一次或多次共同激活的情况来跟踪和治疗脑部状况。

    Brain condition monitoring based on co-activation of neural networks
    32.
    发明授权
    Brain condition monitoring based on co-activation of neural networks 有权
    基于神经网络协同激活的脑状态监测

    公开(公告)号：US09173609B2

    公开(公告)日：2015-11-03

    申请号：US13446598

    申请日：2012-04-13

    申请人： Dwight E. Nelson

    发明人： Dwight E. Nelson

    IPC分类号： A61B5/00 ,  A61N1/36 ,  A61B5/04 ,  A61B5/0476 ,  A61B5/055

    CPC分类号： A61B5/4064 ,  A61B5/04008 ,  A61B5/0476 ,  A61B5/055 ,  A61B5/4088 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/36171

    摘要： A brain condition can be tracked based on identification of co-activation of two antagonistic networks of a patient's brain. Various embodiments concerns methods and devices for sensing one or more signals indicative of brain activity, detecting one or more episodes of default mode network activation based on the one or more signals, detecting one or more episodes of salience network activation based on the one or more signals, and identifying one or more episodes of temporal co-activation of the default mode network and the salience network based on the detected one or more episodes of default mode network activation and the one or more episodes of salience network activation. The brain condition can be tracked and treated based on the identification of the one or more episodes of co-activation.

    摘要翻译： 可以基于识别患者大脑的两个拮抗网络的共同激活来跟踪脑部状况。 各种实施例涉及用于感测指示大脑活动的一个或多个信号的方法和装置，基于所述一个或多个信号检测一个或多个默认模式网络激活事件，基于所述一个或多个信号检测一个或多个显着性网络激活事件 信号，以及基于检测到的一个或多个默认模式网络激活和一个或多个突发性网络激活事件来识别默认模式网络和显着网络的一个或多个时间共同激活事件。 可以基于识别一次或多次共同激活的情况来跟踪和治疗脑部状况。

    ELECTRICAL THERAPY FOR FACILITATING INTER-AREA BRAIN SYNCHRONIZATION
    34.
    发明申请
    ELECTRICAL THERAPY FOR FACILITATING INTER-AREA BRAIN SYNCHRONIZATION 有权
    用于促进区域内大脑同步的电疗法

    公开(公告)号：US20120271374A1

    公开(公告)日：2012-10-25

    申请号：US13446678

    申请日：2012-04-13

    申请人： Dwight E. Nelson ,  Rahul Gupta

    发明人： Dwight E. Nelson ,  Rahul Gupta

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0534 ,  A61B5/0476 ,  A61B5/0484 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/36185

    摘要： Methods and apparatuses are described for monitoring synchronization of two or more brain areas and delivering an electrical therapy to the brain to facilitate synchronization of the two or more brain areas. The electrical therapy can be titrated to improve synchronization between the two or more areas of the brain based on the one or more signals, the synchronization between the two or more areas of the brain occurring in response to the patient being exposed to external sensory stimulus, wherein the electrical therapy does not independently cause activation of either of the two or more areas of the brain.

    摘要翻译： 描述了用于监测两个或更多个脑区域的同步并且向大脑递送电疗法以促进两个或更多个脑区域的同步的方法和装置。 基于一个或多个信号可以滴定电疗法以改善大脑两个或更多个区域之间的同步，响应于患者暴露于外部感觉刺激而发生的大脑的两个或更多个区域之间的同步， 其中所述电疗法不独立地引起脑的两个或更多个区域中的任一个的激活。

    METHOD AND APPARATUS FOR EVENT-TRIGGERED REINFORCEMENT OF A FAVORABLE BRAIN STATE
    35.
    发明申请
    METHOD AND APPARATUS FOR EVENT-TRIGGERED REINFORCEMENT OF A FAVORABLE BRAIN STATE 有权
    一种有利于大脑的事件触发加强的方法和装置

    公开(公告)号：US20120071947A1

    公开(公告)日：2012-03-22

    申请号：US13090672

    申请日：2011-04-20

    申请人： Rahul Gupta ,  Gabriela C. Molnar ,  Dwight E. Nelson

    发明人： Rahul Gupta ,  Gabriela C. Molnar ,  Dwight E. Nelson

    IPC分类号： A61N1/05

    CPC分类号： A61N1/3606 ,  A61B5/4064 ,  A61B5/4082 ,  A61B5/4094 ,  A61B5/6868 ,  A61N1/0529 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/36167

    摘要： Methods and apparatuses are disclosed for potentiating a favorable brain state that is associated with relief in symptoms of a brain condition. Techniques include monitoring one or more brain signals and detecting an episode of a favorable brain state based on the one or more brain signals, the favorable brain state associated with a decrease in one or more symptoms of a brain condition of the patient. Then, in response to the detection of the favorable brain state episode, electrical stimulation that potentiates the favorable brain state is delivered to the brain of the patient, the electrical stimulation delivered within a window of time opened for detection of each favorable brain state episode.

    摘要翻译： 公开了用于增强与大脑状​​况症状缓解相关的有利的脑状态的方法和装置。 技术包括基于一个或多个脑信号监测一个或多个脑信号和检测有利的脑状态的发作，所述脑信号与患者的脑部状况的一个或多个症状的减少有关的有利的脑状态。 然后，响应于有利的脑状态发作的检测，将有利的脑状态的电刺激递送到患者的大脑，在打开每个有利的脑状态发作的时间窗口内递送电刺激。

    AUTOMATED SELECTION AND TITRATION OF SENSORY STIMULI TO INDUCE A TARGET PATTERN OF AUTONOMIC NERVOUS SYSTEM ACTIVITY
    38.
    发明申请
    AUTOMATED SELECTION AND TITRATION OF SENSORY STIMULI TO INDUCE A TARGET PATTERN OF AUTONOMIC NERVOUS SYSTEM ACTIVITY 审中-公开

    公开(公告)号：US20200302825A1

    公开(公告)日：2020-09-24

    申请号：US16824078

    申请日：2020-03-19

    申请人： Dan Sachs ,  Dwight E. Nelson

    发明人： Dan Sachs ,  Dwight E. Nelson

    IPC分类号： G09B19/00 ,  A61B5/16 ,  A61B5/00 ,  G09B5/02

    摘要： Systems and techniques are disclosed for aspects of processing physiological signals in connection with the selection and output of sensory stimuli. In an example, a system for modulating the cognitive state or physiological activity of a human subject may be used in a variety of settings, such as for offering exposure therapy or other forms of guided psychological treatment, based on the presentation and control of a sensory stimulus to a human subject. In another example, a system for generating or training a physiological response model may be established to classify or identify a cognitive response state from sensory stimulus, such as media content, based on the identification of a physiologic or cognitive response state produced from physiological response signals during exposure to the sensory stimulus.

    Urgency therapy with neuromodulation and C-afferent nerve desensitization
    40.
    发明授权
    Urgency therapy with neuromodulation and C-afferent nerve desensitization 有权
    紧急治疗与神经调节和C传入神经脱敏

    公开(公告)号：US09289607B2

    公开(公告)日：2016-03-22

    申请号：US13817486

    申请日：2011-08-16

    申请人： Xin Su ,  Gregory F. Molnar ,  Dwight E. Nelson

    发明人： Xin Su ,  Gregory F. Molnar ,  Dwight E. Nelson

    IPC分类号： A61N1/02 ,  A61N1/36 ,  A61M5/142 ,  A61M5/172 ,  G06F19/00 ,  A61K31/165

    CPC分类号： A61N1/36007 ,  A61K31/165 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/054 ,  A61M2210/1085 ,  A61N1/36057 ,  A61N1/3606 ,  A61N1/36071 ,  A61N1/36171 ,  G06F19/00 ,  G06F19/3468 ,  G06F19/3481

    摘要： Systems (10), devices (16), and methods may be used for treating bladder dysfunction, such as urgency and pelvic pain. In one example, a method includes administering a pharmacological agent to a patient (14) in a dosage sufficient to desensitize a C-afferent nerve fiber of the patient. Additionally, the method includes delivering stimulation to activate a nerve fiber proximate to the C-afferent nerve fiber via an electrode (19A, 19B, 21A, 21B, 29A-29D) electrically coupled to an implantable medical device (16). In some examples, the nerve fiber may be different than the C-afferent nerve fiber, the stimulation of the nerve fiber may elicit an inhibitory physiological response related to voiding in the patient, and/or the stimulation substantially may not activate the C-afferent nerve fiber after desensitization of the nerve fiber via the administration of the pharmacological agent.

    摘要翻译： 系统（10），装置（16）和方法可用于治疗膀胱功能障碍，如紧急和盆腔疼痛。 在一个实例中，一种方法包括以足以使患者的C型传入神经纤维脱敏的剂量向患者（14）施用药理学试剂。 另外，该方法包括递送刺激以通过电耦合到可植入医疗装置（16）的电极（19A，19B，21A，21B，29A-29D）激活靠近C型传入神经纤维的神经纤维。 在一些实例中，神经纤维可能与C传入神经纤维不同，神经纤维的刺激可能引起与患者排尿有关的抑制性生理反应，和/或刺激基本上不能激活C传入 神经纤维通过施用药理学神经纤维脱敏后。